paired-like homeobox 2b (PHOX2B) - coding DNA reference sequence

(used for variant description)

(last modified October 14, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_003924.3 in the PHOX2B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008243.1, covering PHOX2B transcript NM_003924.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 ttaaattctaattagagatgcaggaatcaatgatagggaggttggacagctcagttcccc       c.-301

 .         .         .         .         .         .                g.5120
 agtgccagcccaatagacggatgagttattgtcatgtaaaaagcgccagcaataagacca       c.-241

 .         .         .         .         .         .                g.5180
 accgctttgctattgtccaagtggaaagagccaagtttattatgaggactatatgctcta       c.-181

 .         .         .         .         .         .                g.5240
 gagacctcagacaaggcatctcataggaggctttttcataaaactaggctctgctggtag       c.-121

 .         .         .         .         .         .                g.5300
 taaggaggccagtttggaggcaggcgttgagctgtgcacatctccccactccagccacct       c.-61

 .         .         .         .         .         .                g.5360
 tctccatatccatcttttatttcatttttccacttggctgagccatccagaaccttttca       c.-1

          .         .         .         .         .         .       g.5420
 ATGTATAAAATGGAATATTCTTACCTCAATTCCTCTGCCTACGAGTCCTGTATGGCTGGG       c.60
 M  Y  K  M  E  Y  S  Y  L  N  S  S  A  Y  E  S  C  M  A  G         p.20

          .         .         .         .         .         .       g.5480
 ATGGACACCTCGAGCCTGGCTTCAGCCTATGCTGACTTCAGTTCCTGCAGCCAGGCCAGT       c.120
 M  D  T  S  S  L  A  S  A  Y  A  D  F  S  S  C  S  Q  A  S         p.40

          .         .         .         .         .         .       g.5540
 GGCTTCCAGTATAACCCGATAAGGACCACTTTTGGGGCCACGTCCGGCTGCCCTTCCCTC       c.180
 G  F  Q  Y  N  P  I  R  T  T  F  G  A  T  S  G  C  P  S  L         p.60

          .         .         .         .         .         .       g.5600
 ACGCCGGGATCCTGCAGCCTGGGCACCCTCAGGGACCACCAGAGCAGTCCGTACGCCGCA       c.240
 T  P  G  S  C  S  L  G  T  L  R  D  H  Q  S  S  P  Y  A  A         p.80

   | 02      .         .         .         .         .         .    g.6493
 G | TTCCTTACAAACTCTTCACGGACCACGGCGGCCTCAACGAGAAGCGCAAGCAGCGGCGC    c.300
 V |   P  Y  K  L  F  T  D  H  G  G  L  N  E  K  R  K  Q  R  R      p.100

          .         .         .         .         .         .       g.6553
 ATCCGCACCACTTTCACCAGTGCCCAGCTCAAAGAGCTGGAAAGGGTCTTCGCGGAGACT       c.360
 I  R  T  T  F  T  S  A  Q  L  K  E  L  E  R  V  F  A  E  T         p.120

          .         .         .         .         .         .       g.6613
 CACTACCCCGACATCTACACTCGGGAGGAGCTGGCCCTGAAGATCGACCTCACAGAGGCG       c.420
 H  Y  P  D  I  Y  T  R  E  E  L  A  L  K  I  D  L  T  E  A         p.140

           | 03        .         .         .         .         .    g.7699
 CGAGTCCAG | GTGTGGTTCCAGAACCGCCGCGCCAAGTTTCGCAAGCAGGAGCGCGCAGCG    c.480
 R  V  Q   | V  W  F  Q  N  R  R  A  K  F  R  K  Q  E  R  A  A      p.160

          .         .         .         .         .         .       g.7759
 GCAGCCGCAGCGGCCGCGGCCAAGAACGGCTCCTCGGGCAAAAAGTCTGACTCTTCCAGG       c.540
 A  A  A  A  A  A  A  K  N  G  S  S  G  K  K  S  D  S  S  R         p.180

          .         .         .         .         .         .       g.7819
 GACGACGAGAGCAAAGAGGCCAAGAGCACTGACCCGGACAGCACTGGGGGCCCAGGTCCC       c.600
 D  D  E  S  K  E  A  K  S  T  D  P  D  S  T  G  G  P  G  P         p.200

          .         .         .         .         .         .       g.7879
 AATCCCAACCCCACCCCCAGCTGCGGGGCGAATGGAGGCGGCGGCGGCGGGCCCAGCCCG       c.660
 N  P  N  P  T  P  S  C  G  A  N  G  G  G  G  G  G  P  S  P         p.220

          .         .         .         .         .         .       g.7939
 GCTGGAGCTCCGGGGGCGGCGGGGCCCGGGGGCCCGGGAGGCGAACCCGGCAAGGGCGGC       c.720
 A  G  A  P  G  A  A  G  P  G  G  P  G  G  E  P  G  K  G  G         p.240

          .         .         .         .         .         .       g.7999
 GCAGCAGCAGCGGCGGCGGCCGCGGCAGCGGCGGCGGCGGCAGCGGCAGCGGCGGCAGCT       c.780
 A  A  A  A  A  A  A  A  A  A  A  A  A  A  A  A  A  A  A  A         p.260

          .         .         .         .         .         .       g.8059
 GGAGGCCTGGCTGCGGCTGGGGGCCCTGGACAAGGCTGGGCTCCCGGCCCCGGCCCCATC       c.840
 G  G  L  A  A  A  G  G  P  G  Q  G  W  A  P  G  P  G  P  I         p.280

          .         .         .         .         .         .       g.8119
 ACCTCCATCCCGGATTCGCTTGGGGGTCCCTTCGCCAGCGTCCTATCTTCGCTCCAAAGA       c.900
 T  S  I  P  D  S  L  G  G  P  F  A  S  V  L  S  S  L  Q  R         p.300

          .         .         .         .                           g.8164
 CCCAACGGTGCCAAAGCCGCCTTAGTGAAGAGCAGTATGTTCTGA                      c.945
 P  N  G  A  K  A  A  L  V  K  S  S  M  F  X                        p.314

          .         .         .         .         .         .       g.8224
 tctggaatcctgcggcggcggcggcggcggcgacagcgggcgagccagggcccgggcggg       c.*60

          .         .         .         .         .         .       g.8284
 cgagtgggcgagcgggtaggcccaaggctattgtcgtcgctgctgccatggctttttcat       c.*120

          .         .         .         .         .         .       g.8344
 tgagggcctaaagtaatcgcgctaagaataaagggaaaacggcgtcgccctcatttcaac       c.*180

          .         .         .         .         .         .       g.8404
 cccactcctacccccttcctcaacccccaaacaaaacaaacaaacttccctggcttcgca       c.*240

          .         .         .         .         .         .       g.8464
 cctgcctggggcctcgcagcggggccagggctccgcctgctgatcgggggttgtgagcag       c.*300

          .         .         .         .         .         .       g.8524
 cgcggcctggacgcggggcactctcagggggctgtgtctgcgtgtcagtttgtgtctgtc       c.*360

          .         .         .         .         .         .       g.8584
 tcggggaatgtgtgtctgtggcccaagcaggtgacaggaagagatggggggcctcaacca       c.*420

          .         .         .         .         .         .       g.8644
 acttagtgacttgtttagaaaaaaaagacaaaaaagtaaaaataaaaacaaaaaagttgg       c.*480

          .         .         .         .         .         .       g.8704
 aaggcagaaaccattaaaaaacaaaaagccaacaacccagaaaggtttaaaaaacataag       c.*540

          .         .         .         .         .         .       g.8764
 gaaaaaaaagacaaattaaaggaggggctaggggagaagctgcagctggagctgaaggct       c.*600

          .         .         .         .         .         .       g.8824
 cgatcttgtgaacccctaaatccgctccctcctaacagcacggattctcttggggctctt       c.*660

          .         .         .         .         .         .       g.8884
 cttcagggaagagtagggacgccgttccagccccccttcctatcgtgtccttgggttcgg       c.*720

          .         .         .         .         .         .       g.8944
 gtcactgcggcgacgacttgctcagactgtcccggcggccggagtgactttctcgcaccc       c.*780

          .         .         .         .         .         .       g.9004
 ccttgcctgtcccacctcgctgaacaccatcccgccattagcgcatcggaaccccacaca       c.*840

          .         .         .         .         .         .       g.9064
 gttgcaactcccaaccccgaatctttgcagccgttcggccctgaaagatgccctatccat       c.*900

          .         .         .         .         .         .       g.9124
 gagatgccttttcatctgcaaactctgcaaaatgtgtctcatgtttcgcaactctttttt       c.*960

          .         .         .         .         .         .       g.9184
 tccccctcgctcccgcctaccccgtcggcattttcttcttccaccagcttttactgaact       c.*1020

          .         .         .         .         .         .       g.9244
 ttttggcactgctttggattggggtcaattgcagtccacgtaactggctgcagagaaatc       c.*1080

          .         .         .         .         .         .       g.9304
 taccgagcaaggaaaaggcacacacacacgtttgcaggggtgtctcggtttgcatttctg       c.*1140

          .         .         .         .         .         .       g.9364
 ttggaatgatccgaactggactcacatcctgtatggtggatggactgtatattgagggtt       c.*1200

          .         .         .         .         .         .       g.9424
 ccattcttcgcgcagtttagacatctctgttttgattctttgttgttgtttttattttaa       c.*1260

          .         .         .         .         .         .       g.9484
 aaggcacaaactctagatattagttgaatgttgaggctttaactttttcggtgtctttct       c.*1320

          .         .         .         .         .         .       g.9544
 acaactgtgttctgtgactcaattgtatcgtgttaatatcagtgcagactgtctcctcta       c.*1380

          .         .         .         .         .         .       g.9604
 cgtgaccgtataatgtttttctcttcttgtagtctctatggcgtgtctttatggtgtaat       c.*1440

          .         .         .         .         .         .       g.9664
 aaggttctcacgggttcaatcttttgtgtttagagaggccacggttcagacaatggtata       c.*1500

          .         .         .         .         .         .       g.9724
 tatttttgttatcaggtgcatgtctgtctgatttctttttttttcctgttggactatgtt       c.*1560

          .         .         .         .         .         .       g.9784
 tgtgaacataattgtcataagttatgtttcagatttttgaatttatttatatgtgttata       c.*1620

          .         .         .         .         .         .       g.9844
 atgaatgcttctatttaaaagggaaatatttctacatgtgcatatagttttccaagagtg       c.*1680

          .         .         .         .                           g.9889
 taccattaacttgattgttgataataaaaacaaaaagcaagtcta                      c.*1725

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Paired-like homeobox 2b protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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