phytanoyl-CoA 2-hydroxylase (PHYH) - coding DNA reference sequence

(used for variant description)

(last modified June 14, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_006214.3 in the PHYH gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012862.1, covering PHYH transcript NM_006214.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5028
                                 agtccggggcggcgcctggaggcggagc       c.-61

 .         .         .         .         .         .                g.5088
 cgcccgctgggctaaatggggcagaggccgggaggggtgggggttccccgcgccgcagcc       c.-1

          .         .         .         .         .         .       g.5148
 ATGGAGCAGCTTCGCGCCGCCGCCCGTCTGCAGATTGTTCTGGGCCACCTCGGCCGCCCC       c.60
 M  E  Q  L  R  A  A  A  R  L  Q  I  V  L  G  H  L  G  R  P         p.20

          .      | 02  .         .         .         .         .    g.6930
 TCGGCCGGGGCTGTC | GTAGCTCATCCCACTTCAGGGACTATTTCCTCTGCCAGTTTCCAT    c.120
 S  A  G  A  V   | V  A  H  P  T  S  G  T  I  S  S  A  S  F  H      p.40

          .     | 03   .         .         .         .         .    g.9570
 CCTCAACAATTCCA | GTATACTCTGGATAATAACGTTCTAACCCTGGAACAGAGAAAATTT    c.180
 P  Q  Q  F  Q  |  Y  T  L  D  N  N  V  L  T  L  E  Q  R  K  F      p.60

          .         .         .         .         .         .       g.9630
 TATGAAGAAAATGGGTTTCTAGTAATCAAAAATCTTGTACCTGATGCCGATATTCAACGC       c.240
 Y  E  E  N  G  F  L  V  I  K  N  L  V  P  D  A  D  I  Q  R         p.80

       | 04  .         .         .         .         .         .    g.10589
 TTTCG | GAATGAGTTTGAAAAAATCTGCAGAAAGGAGGTGAAACCATTAGGATTAACAGTA    c.300
 F  R  |  N  E  F  E  K  I  C  R  K  E  V  K  P  L  G  L  T  V      p.100

          .         .         .         .         .         .       g.10649
 ATGAGAGATGTGACCATTTCGAAATCCGAATATGCTCCAAGTGAGAAGATGATCACGAAG       c.360
 M  R  D  V  T  I  S  K  S  E  Y  A  P  S  E  K  M  I  T  K         p.120

          .         .         .         .         .     | 05   .    g.13224
 GTCCAGGATTTCCAGGAAGATAAGGAGCTCTTCAGATACTGCACTCTCCCCGAG | ATTCTG    c.420
 V  Q  D  F  Q  E  D  K  E  L  F  R  Y  C  T  L  P  E   | I  L      p.140

          .         .         .         .         .         .       g.13284
 AAATATGTGGAGTGCTTCACTGGACCTAATATTATGGCCATGCACACAATGTTGATAAAC       c.480
 K  Y  V  E  C  F  T  G  P  N  I  M  A  M  H  T  M  L  I  N         p.160

          .       | 06 .         .         .         .         .    g.16633
 AAACCTCCAGATTCTG | GCAAGAAGACGTCCCGTCACCCCCTGCACCAGGACCTGCACTAT    c.540
 K  P  P  D  S  G |   K  K  T  S  R  H  P  L  H  Q  D  L  H  Y      p.180

          .         .         .         .         .         .       g.16693
 TTCCCCTTCAGGCCCAGCGATCTCATCGTTTGCGCCTGGACGGCGATGGAGCACATCAGC       c.600
 F  P  F  R  P  S  D  L  I  V  C  A  W  T  A  M  E  H  I  S         p.200

          .         .         .         .         .         .       g.16753
 CGGAACAACGGCTGTCTGGTTGTGCTCCCAGGCACACACAAGGGCTCCCTGAAGCCCCAC       c.660
 R  N  N  G  C  L  V  V  L  P  G  T  H  K  G  S  L  K  P  H         p.220

          .         | 07         .         .         .         .    g.21333
 GATTACCCCAAGTGGGAG | GGGGGAGTTAACAAAATGTTCCACGGGATCCAGGACTACGAG    c.720
 D  Y  P  K  W  E   | G  G  V  N  K  M  F  H  G  I  Q  D  Y  E      p.240

          .         .         .         .         .         .       g.21393
 GAAAACAAGGCCCGGGTGCACCTGGTGATGGAGAAGGGCGACACTGTTTTCTTCCATCCT       c.780
 E  N  K  A  R  V  H  L  V  M  E  K  G  D  T  V  F  F  H  P         p.260

          .         .         .         .         | 08         .    g.24032
 TTGCTCATCCACGGATCTGGTCAGAATAAAACCCAGGGATTCCGGAAG | GCAATTTCCTGC    c.840
 L  L  I  H  G  S  G  Q  N  K  T  Q  G  F  R  K   | A  I  S  C      p.280

          .         .         .         .         .         .       g.24092
 CATTTCGCCAGTGCCGATTGCCACTACATTGACGTGAAGGGCACCAGTCAAGAAAACATC       c.900
 H  F  A  S  A  D  C  H  Y  I  D  V  K  G  T  S  Q  E  N  I         p.300

          .         .         .         .         .         .       g.24152
 GAGAAGGAAGTTGTAGGAATAGCACATAAATTCTTTGGAGCTGAAAATAGCGTGAACTTG       c.960
 E  K  E  V  V  G  I  A  H  K  F  F  G  A  E  N  S  V  N  L         p.320

     | 09    .         .         .         .         .              g.26833
 AAG | GATATTTGGATGTTTCGAGCTCGACTTGTGAAAGGAGAAAGAACCAATCTTTGA       c.1017
 K   | D  I  W  M  F  R  A  R  L  V  K  G  E  R  T  N  L  X         p.338

          .         .         .         .         .         .       g.26893
 aatagccatctgctataactctttcaacagaaaaccaaaaccaaacgaaatgtctaagga       c.*60

          .         .         .         .         .         .       g.26953
 aaatgttttcttaatgagatgatgtaaccttttctatcacttgttaaaagcagaaaacat       c.*120

          .         .         .         .         .         .       g.27013
 gtatcaggtacttaattgcatagagttagttttgcagcacaatggtgttgctttaatgga       c.*180

          .         .         .         .         .         .       g.27073
 aaaaaaaaacagtaaaagtgaaatattactgttttaaggaaaactaatttagggtggcag       c.*240

          .         .         .         .         .         .       g.27133
 ccaataaaggtggttggtgtctaatttaagtgttaaatcaatttctttcattcagttagc       c.*300

          .         .         .         .         .         .       g.27193
 tctttacccaagaagaagtgaatgatttggagcttagggtatgttttgtatcccctttct       c.*360

          .         .         .         .         .         .       g.27253
 gataaacccattccctaccaattttatgtcataagagatttttttcccccaaatctagaa       c.*420

          .         .         .         .         .         .       g.27313
 caatgtataatacattcacatctagtcaagggcataggaacggtgtcatggagtccaaat       c.*480

          .         .                                               g.27338
 aaagtggatattcctgctcggacaa                                          c.*505

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phytanoyl-CoA 2-hydroxylase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 18
©2004-2017 Leiden University Medical Center