piezo-type mechanosensitive ion channel component 1 (PIEZO1) - coding DNA reference sequence

(used for variant description)

(last modified September 11, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_001142864.2 in the PIEZO1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering PIEZO1 transcript NM_001142864.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGGAGCCGCACGTGCTCGGCGCGGTCCTGTACTGGCTGCTGCTGCCCTGCGCGCTGCTG       c.60
 M  E  P  H  V  L  G  A  V  L  Y  W  L  L  L  P  C  A  L  L         p.20

      | 02   .         .         .         .         .         .    g.35541
 GCTG | CCTGCCTGCTCCGCTTCAGCGGACTCTCGCTGGTCTACCTGCTCTTCCTGCTGCTG    c.120
 A  A |   C  L  L  R  F  S  G  L  S  L  V  Y  L  L  F  L  L  L      p.40

          .         .         .         . | 03       .         .    g.42562
 CTGCCCTGGTTCCCCGGCCCCACCCGATGCGGCCTCCAAG | GTCACACAGGCCGCCTCCTG    c.180
 L  P  W  F  P  G  P  T  R  C  G  L  Q  G |   H  T  G  R  L  L      p.60

          .         .         .         .         .         .       g.42622
 CGGGCATTGCTGGGCCTCAGCCTGCTCTTCCTGGTGGCCCATCTCGCCCTCCAGATCTGC       c.240
 R  A  L  L  G  L  S  L  L  F  L  V  A  H  L  A  L  Q  I  C         p.80

          .         .         .         .    | 04    .         .    g.42886
 CTGCATATTGTGCCCCGCCTGGACCAGCTCCTGGGACCCAGCT | GCAGCCGCTGGGAGACC    c.300
 L  H  I  V  P  R  L  D  Q  L  L  G  P  S  C |   S  R  W  E  T      p.100

          .         .       | 05 .         .         .         .    g.43382
 CTCTCGCGACACATAGGGGTCACAAG | GCTGGACCTGAAGGACATCCCCAACGCCATCCGG    c.360
 L  S  R  H  I  G  V  T  R  |  L  D  L  K  D  I  P  N  A  I  R      p.120

          .         .         .         .         .         .       g.43442
 CTGGTGGCCCCTGACCTGGGCATCTTGGTGGTCTCCTCTGTCTGCCTCGGCATCTGCGGG       c.420
 L  V  A  P  D  L  G  I  L  V  V  S  S  V  C  L  G  I  C  G         p.140

          .         .         .         .      | 06  .         .    g.46243
 CGCCTTGCAAGGAACACCCGGCAGAGCCCACATCCACGGGAGCTG | GATGATGATGAGAGG    c.480
 R  L  A  R  N  T  R  Q  S  P  H  P  R  E  L   | D  D  D  E  R      p.160

          .         .         .         .         .         .       g.46303
 GATGTGGATGCCAGCCCGACGGCAGGGCTGCAGGAAGCAGCAACGCTGGCCCCTACACGG       c.540
 D  V  D  A  S  P  T  A  G  L  Q  E  A  A  T  L  A  P  T  R         p.180

          .         .         .         .         .         .       g.46363
 AGGTCACGGCTGGCCGCTCGTTTCCGAGTCACGGCCCACTGGCTGCTGGTGGCGGCTGGG       c.600
 R  S  R  L  A  A  R  F  R  V  T  A  H  W  L  L  V  A  A  G         p.200

          .         .         .     | 07   .         .         .    g.46550
 CGGGTCCTGGCCGTAACACTGCTTGCACTGGCAG | GCATCGCCCACCCCTCGGCCCTCTCC    c.660
 R  V  L  A  V  T  L  L  A  L  A  G |   I  A  H  P  S  A  L  S      p.220

          .         .         .         .         .         .       g.46610
 AGTGTCTACCTGCTGCTCTTCCTGGCCCTCTGCACCTGGTGGGCCTGCCACTTTCCCATC       c.720
 S  V  Y  L  L  L  F  L  A  L  C  T  W  W  A  C  H  F  P  I         p.240

          .         .         .         .         .         .       g.46670
 AGCACTCGGGGCTTCAGCAGACTCTGCGTCGCGGTGGGGTGCTTCGGCGCCGGCCATCTC       c.780
 S  T  R  G  F  S  R  L  C  V  A  V  G  C  F  G  A  G  H  L         p.260

          .         .         .         .         .         .       g.46730
 ATCTGCCTCTACTGCTACCAGATGCCCTTGGCACAGGCTCTGCTCCCGCCTGCCGGCATC       c.840
 I  C  L  Y  C  Y  Q  M  P  L  A  Q  A  L  L  P  P  A  G  I         p.280

          | 08         .         .         .         .         .    g.46911
 TGGGCTAG | GGTGCTGGGTCTCAAGGACTTCGTGGGTCCCACCAACTGCTCCAGCCCCCAC    c.900
 W  A  R  |  V  L  G  L  K  D  F  V  G  P  T  N  C  S  S  P  H      p.300

          .         .         .         .         .         .       g.46971
 GCGCTGGTCCTCAACACCGGCCTGGACTGGCCTGTGTATGCCAGCCCCGGCGTCCTCCTG       c.960
 A  L  V  L  N  T  G  L  D  W  P  V  Y  A  S  P  G  V  L  L         p.320

          .         .         .         .         .         .       g.47031
 CTGCTGTGCTACGCCACGGCCTCTCTGCGCAAGCTCCGCGCGTACCGCCCCTCCGGCCAG       c.1020
 L  L  C  Y  A  T  A  S  L  R  K  L  R  A  Y  R  P  S  G  Q         p.340

  | 09       .         .         .         .         .         .    g.47210
  | AGGAAGGAGGCGGCAAAGGGGTATGAGGCTCGGGAGCTGGAGCTAGCAGAGCTGGACCAG    c.1080
  | R  K  E  A  A  K  G  Y  E  A  R  E  L  E  L  A  E  L  D  Q      p.360

          .         .        | 10.         .         .         .    g.47351
 TGGCCCCAGGAACGGGAGTCTGACCAG | CACGTGGTGCCCACAGCACCCGACACCGAGGCT    c.1140
 W  P  Q  E  R  E  S  D  Q   | H  V  V  P  T  A  P  D  T  E  A      p.380

          .         .         .         .         .      | 11  .    g.48230
 GATAACTGCATCGTGCACGAGCTGACCGGCCAGAGCTCCGTCCTGCGGCGGCCTG | TGCGG    c.1200
 D  N  C  I  V  H  E  L  T  G  Q  S  S  V  L  R  R  P  V |   R      p.400

          .         .         .         .         .         .       g.48290
 CCCAAGCGGGCTGAGCCCAGGGAGGCGTCTCCGCTCCACAGCCTGGGCCACCTCATCATG       c.1260
 P  K  R  A  E  P  R  E  A  S  P  L  H  S  L  G  H  L  I  M         p.420

          .         .         .       | 12 .         .         .    g.48580
 GACCAGAGCTATGTGTGCGCGCTCATTGCCATGATG | GTATGGAGCATCACCTACCACAGC    c.1320
 D  Q  S  Y  V  C  A  L  I  A  M  M   | V  W  S  I  T  Y  H  S      p.440

          .         .         .         .         .         .       g.48640
 TGGCTGACCTTCGTACTGCTGCTCTGGGCCTGCCTCATCTGGACGGTGCGCAGCCGCCAC       c.1380
 W  L  T  F  V  L  L  L  W  A  C  L  I  W  T  V  R  S  R  H         p.460

          .         .         .         .         .         .       g.48700
 CAACTGGCCATGCTGTGCTCGCCCTGCATCCTGCTGTATGGGATGACGCTGTGCTGCCTA       c.1440
 Q  L  A  M  L  C  S  P  C  I  L  L  Y  G  M  T  L  C  C  L         p.480

          .         .         .         .         .         .       g.48760
 CGCTACGTGTGGGCCATGGACCTGCGCCCTGAGCTGCCCACCACCCTGGGCCCCGTCAGC       c.1500
 R  Y  V  W  A  M  D  L  R  P  E  L  P  T  T  L  G  P  V  S         p.500

          .         .         .         .         .        | 13.    g.49721
 CTGCGCCAGCTGGGGCTGGAGCACACCCGCTACCCCTGTCTGGACCTTGGTGCCATG | TTG    c.1560
 L  R  Q  L  G  L  E  H  T  R  Y  P  C  L  D  L  G  A  M   | L      p.520

          .         .         .         .         .         .       g.49781
 CTCTACACCCTGACCTTCTGGCTCCTGCTGCGCCAGTTTGTGAAAGAGAAGCTGCTGAAG       c.1620
 L  Y  T  L  T  F  W  L  L  L  R  Q  F  V  K  E  K  L  L  K         p.540

          .         .         .         .          | 14        .    g.49922
 TGGGCAGAGTCTCCAGCTGCGCTGACGGAGGTCACCGTGGCAGACACAG | AGCCCACGCGG    c.1680
 W  A  E  S  P  A  A  L  T  E  V  T  V  A  D  T  E |   P  T  R      p.560

          .         .         .         .         .         .       g.49982
 ACGCAGACGCTGTTGCAGAGCCTGGGGGAGCTGGTGAAGGGCGTGTACGCCAAGTACTGG       c.1740
 T  Q  T  L  L  Q  S  L  G  E  L  V  K  G  V  Y  A  K  Y  W         p.580

          .         .         .         .         .         .       g.50042
 ATCTATGTGTGTGCTGGCATGTTCATCGTGGTCAGCTTCGCCGGCCGCCTCGTGGTCTAC       c.1800
 I  Y  V  C  A  G  M  F  I  V  V  S  F  A  G  R  L  V  V  Y         p.600

          .         .         .         .         | 15         .    g.50178
 AAGATTGTCTACATGTTCCTCTTCCTGCTCTGCCTCACCCTCTTCCAG | GTCTACTACAGC    c.1860
 K  I  V  Y  M  F  L  F  L  L  C  L  T  L  F  Q   | V  Y  Y  S      p.620

          .         .         .         .         .         .       g.50238
 CTGTGGCGGAAGCTGCTCAAGGCCTTCTGGTGGCTCGTGGTGGCCTACACCATGCTGGTC       c.1920
 L  W  R  K  L  L  K  A  F  W  W  L  V  V  A  Y  T  M  L  V         p.640

          .         .         .         .         .         .       g.50298
 CTCATCGCCGTCTACACCTTCCAGTTCCAGGACTTCCCTGCCTACTGGCGCAACCTCACT       c.1980
 L  I  A  V  Y  T  F  Q  F  Q  D  F  P  A  Y  W  R  N  L  T         p.660

          .        | 16.         .         .         .         .    g.50469
 GGCTTCACCGACGAGCA | GCTGGGGGACCTGGGCCTGGAGCAGTTCAGCGTGTCCGAGCTC    c.2040
 G  F  T  D  E  Q  |  L  G  D  L  G  L  E  Q  F  S  V  S  E  L      p.680

          .         .         .         .         .         .       g.50529
 TTCTCCAGCATCCTGGTGCCCGGCTTCTTCCTCCTGGCCTGCATCCTGCAGCTGCACTAC       c.2100
 F  S  S  I  L  V  P  G  F  F  L  L  A  C  I  L  Q  L  H  Y         p.700

          .         .         .         .         .         .       g.50589
 TTCCACAGGCCCTTCATGCAGCTCACCGACATGGAGCACGTGTCCCTGCCTGGCACGCGC       c.2160
 F  H  R  P  F  M  Q  L  T  D  M  E  H  V  S  L  P  G  T  R         p.720

          .         . | 17       .         .         .         .    g.50950
 CTCCCGCGCTGGGCTCACAG | GCAGGATGCAGTGAGTGGGACCCCACTGCTGCGGGAGGAG    c.2220
 L  P  R  W  A  H  R  |  Q  D  A  V  S  G  T  P  L  L  R  E  E      p.740

          .         .         .         .         .         .       g.51010
 CAGCAGGAGCATCAGCAGCAGCAGCAGGAGGAGGAGGAGGAGGAGGAGGACTCCAGGGAC       c.2280
 Q  Q  E  H  Q  Q  Q  Q  Q  E  E  E  E  E  E  E  D  S  R  D         p.760

          .         .         .         .          | 18        .    g.51230
 GAGGGGCTGGGCGTGGCCACTCCCCACCAGGCCACGCAGGTGCCTGAAG | GGGCAGCCAAG    c.2340
 E  G  L  G  V  A  T  P  H  Q  A  T  Q  V  P  E  G |   A  A  K      p.780

          .         .         .         .         .         .       g.51290
 TGGGGCCTGGTGGCTGAGCGGCTGCTGGAGCTGGCAGCCGGCTTCTCGGACGTCCTCTCA       c.2400
 W  G  L  V  A  E  R  L  L  E  L  A  A  G  F  S  D  V  L  S         p.800

          .         .         .         .         .         .       g.51350
 CGCGTGCAGGTGTTCCTGCGGCGGCTGCTGGAGCTTCACGTTTTCAAGCTGGTGGCCCTG       c.2460
 R  V  Q  V  F  L  R  R  L  L  E  L  H  V  F  K  L  V  A  L         p.820

          .         .        | 19.         .         .         .    g.51543
 TACACCGTCTGGGTGGCCCTGAAGGAG | GTGTCGGTGATGAACCTGCTGCTGGTGGTGCTG    c.2520
 Y  T  V  W  V  A  L  K  E   | V  S  V  M  N  L  L  L  V  V  L      p.840

          .         .         .         .         .         .       g.51603
 TGGGCCTTCGCCCTGCCCTACCCACGCTTCCGGCCCATGGCCTCCTGCCTGTCCACCGTG       c.2580
 W  A  F  A  L  P  Y  P  R  F  R  P  M  A  S  C  L  S  T  V         p.860

          .         .         .         .         .         .       g.51663
 TGGACCTGCGTCATCATCGTGTGTAAGATGCTGTACCAGCTCAAGGTTGTCAACCCCCAG       c.2640
 W  T  C  V  I  I  V  C  K  M  L  Y  Q  L  K  V  V  N  P  Q         p.880

          .         .     | 20   .         .         .         .    g.52268
 GAGTATTCCAGCAACTGCACCGAG | CCCTTCCCCAACAGCACCAACTTGCTGCCCACGGAG    c.2700
 E  Y  S  S  N  C  T  E   | P  F  P  N  S  T  N  L  L  P  T  E      p.900

          .         .         .         .         .         .       g.52328
 ATCAGCCAGTCCCTGCTGTACCGGGGGCCCGTGGACCCTGCCAACTGGTTTGGGGTGCGG       c.2760
 I  S  Q  S  L  L  Y  R  G  P  V  D  P  A  N  W  F  G  V  R         p.920

          .         .         . | 21       .         .         .    g.52459
 AAAGGGTTCCCCAACCTGGGCTACATCCAG | AACCACCTGCAAGTGCTGCTGCTGCTGGTA    c.2820
 K  G  F  P  N  L  G  Y  I  Q   | N  H  L  Q  V  L  L  L  L  V      p.940

          .         .         .         .         .         .       g.52519
 TTCGAGGCCATCGTGTACCGGCGCCAGGAGCACTACCGCCGGCAGCACCAGCTGGCCCCG       c.2880
 F  E  A  I  V  Y  R  R  Q  E  H  Y  R  R  Q  H  Q  L  A  P         p.960

          .         .         .         .         .         .       g.52579
 CTGCCTGCCCAGGCCGTGTTTGCCAGCGGCACCCGCCAGCAGCTGGACCAGGATCTGCTC       c.2940
 L  P  A  Q  A  V  F  A  S  G  T  R  Q  Q  L  D  Q  D  L  L         p.980

          .         .         .         .         .  | 22      .    g.53063
 GGCTGCCTCAAGTACTTCATCAACTTCTTCTTCTACAAATTCGGGCTGGAG | ATCTGCTTC    c.3000
 G  C  L  K  Y  F  I  N  F  F  F  Y  K  F  G  L  E   | I  C  F      p.1000

          .         .         .         .         .         .       g.53123
 CTGATGGCCGTGAACGTGATCGGGCAGCGCATGAACTTTCTGGTGACCCTGCACGGTTGC       c.3060
 L  M  A  V  N  V  I  G  Q  R  M  N  F  L  V  T  L  H  G  C         p.1020

          .         .         .         .         .         .       g.53183
 TGGCTGGTGGCCATCCTCACCCGCAGGCACCGCCAGGCCATTGCCCGCCTCTGGCCCAAC       c.3120
 W  L  V  A  I  L  T  R  R  H  R  Q  A  I  A  R  L  W  P  N         p.1040

          .         .         .         .         .         .       g.53243
 TACTGCCTCTTCCTGGCGCTGTTCCTGCTGTACCAGTACCTGCTGTGCCTGGGGATGCCC       c.3180
 Y  C  L  F  L  A  L  F  L  L  Y  Q  Y  L  L  C  L  G  M  P         p.1060

          .       | 23 .         .         .         .         .    g.57347
 CCGGCCCTGTGCATTG | ATTATCCCTGGCGCTGGAGCCGGGCCGTCCCCATGAACTCCGCA    c.3240
 P  A  L  C  I  D |   Y  P  W  R  W  S  R  A  V  P  M  N  S  A      p.1080

          .         .         .         .         .         .       g.57407
 CTCATCAAGTGGCTGTACCTGCCTGATTTCTTCCGGGCCCCCAACTCCACCAACCTCATC       c.3300
 L  I  K  W  L  Y  L  P  D  F  F  R  A  P  N  S  T  N  L  I         p.1100

   | 24      .         .         .         .         .         .    g.57831
 A | GCGACTTTCTCCTGCTGCTGTGCGCCTCCCAGCAGTGGCAGGTGTTCTCAGCTGAGCGC    c.3360
 S |   D  F  L  L  L  L  C  A  S  Q  Q  W  Q  V  F  S  A  E  R      p.1120

          .         .         .         .         .         .       g.57891
 ACAGAGGAGTGGCAGCGCATGGCTGGCGTCAACACCGACCGCCTGGAGCCGCTGCGGGGG       c.3420
 T  E  E  W  Q  R  M  A  G  V  N  T  D  R  L  E  P  L  R  G         p.1140

          .         .         .      | 25  .         .         .    g.58031
 GAGCCCAACCCCGTGCCCAACTTTATCCACTGCAG | GTCCTACCTTGACATGCTGAAGGTG    c.3480
 E  P  N  P  V  P  N  F  I  H  C  R  |  S  Y  L  D  M  L  K  V      p.1160

          .         .         .         .         .         .       g.58091
 GCCGTCTTCCGATACCTGTTCTGGCTGGTGCTGGTGGTGGTGTTTGTCACGGGGGCCACC       c.3540
 A  V  F  R  Y  L  F  W  L  V  L  V  V  V  F  V  T  G  A  T         p.1180

          .         .         .         .         .         .       g.58151
 CGCATCAGCATCTTCGGGCTGGGCTACCTGCTGGCCTGCTTCTACCTGCTGCTCTTCGGC       c.3600
 R  I  S  I  F  G  L  G  Y  L  L  A  C  F  Y  L  L  L  F  G         p.1200

          .         .         .         .         .         .       g.58211
 ACGGCCCTGCTGCAGAGGGACACACGGGCCCGCCTCGTGCTGTGGGACTGCCTCATTCTG       c.3660
 T  A  L  L  Q  R  D  T  R  A  R  L  V  L  W  D  C  L  I  L         p.1220

          .         .         .          | 26        .         .    g.58342
 TACAACGTCACCGTCATCATCTCCAAGAACATGCTGTCG | CTCCTGGCCTGCGTCTTCGTG    c.3720
 Y  N  V  T  V  I  I  S  K  N  M  L  S   | L  L  A  C  V  F  V      p.1240

          .         .         .         .         .         .       g.58402
 GAGCAGATGCAGACCGGCTTCTGCTGGGTCATCCAGCTCTTCAGCCTTGTATGCACCGTC       c.3780
 E  Q  M  Q  T  G  F  C  W  V  I  Q  L  F  S  L  V  C  T  V         p.1260

          .       | 27 .         .         .         .         .    g.58553
 AAGGGCTACTATGACC | CCAAGGAGATGATGGACAGAGACCAGGACTGCCTGCTGCCTGTG    c.3840
 K  G  Y  Y  D  P |   K  E  M  M  D  R  D  Q  D  C  L  L  P  V      p.1280

          .         .         .         .         .         .       g.58613
 GAGGAGGCTGGCATCATCTGGGACAGCGTCTGCTTCTTCTTCCTGCTGCTGCAGCGCCGC       c.3900
 E  E  A  G  I  I  W  D  S  V  C  F  F  F  L  L  L  Q  R  R         p.1300

          .         .         .         .         .         .       g.58673
 GTCTTCCTTAGCCATTACTACCTGCACGTCAGGGCCGACCTCCAGGCCACCGCCCTGCTA       c.3960
 V  F  L  S  H  Y  Y  L  H  V  R  A  D  L  Q  A  T  A  L  L         p.1320

          | 28         .         .         .         .         .    g.59332
 GCCTCCAG | GGGCTTCGCCCTCTACAACGCTGCCAACCTCAAGAGCATTGACTTTCACCGC    c.4020
 A  S  R  |  G  F  A  L  Y  N  A  A  N  L  K  S  I  D  F  H  R      p.1340

          .         .         .         | 29         .         .    g.59467
 AGGATAGAGGAGAAGTCCCTGGCCCAGCTGAAAAGACA | GATGGAGCGTATCCGTGCCAAG    c.4080
 R  I  E  E  K  S  L  A  Q  L  K  R  Q  |  M  E  R  I  R  A  K      p.1360

          .         .         .         .         .         .       g.59527
 CAGGAGAAGCACAGGCAGGGCCGGGTGGACCGCAGTCGCCCCCAGGACACCCTGGGCCCC       c.4140
 Q  E  K  H  R  Q  G  R  V  D  R  S  R  P  Q  D  T  L  G  P         p.1380

          .         .   | 30     .         .         .         .    g.59922
 AAGGACCCCGGCCTGGAGCCAG | GGCCCGACAGTCCAGGGGGCTCCTCCCCGCCACGGAGG    c.4200
 K  D  P  G  L  E  P  G |   P  D  S  P  G  G  S  S  P  P  R  R      p.1400

          .         .         .     | 31   .         .         .    g.61019
 CAGTGGTGGCGGCCCTGGCTGGACCACGCCACAG | TCATCCACTCCGGGGACTACTTCCTG    c.4260
 Q  W  W  R  P  W  L  D  H  A  T  V |   I  H  S  G  D  Y  F  L      p.1420

          .         .         .         .         .         .       g.61079
 TTTGAGTCCGACAGTGAGGAAGAGGAGGAGGCTGTTCCTGAAGACCCGAGGCCGTCGGCA       c.4320
 F  E  S  D  S  E  E  E  E  E  A  V  P  E  D  P  R  P  S  A         p.1440

          .      | 32  .         .         .         .         .    g.61681
 CAGAGTGCCTTCCAG | CTGGCGTACCAGGCATGGGTGACCAACGCCCAGGCGGTGCTGAGG    c.4380
 Q  S  A  F  Q   | L  A  Y  Q  A  W  V  T  N  A  Q  A  V  L  R      p.1460

          .         .         .         .         .         | 33    g.61815
 CGGCGGCAGCAGGAGCAGGAGCAGGCAAGGCAGGAACAGGCAGGACAGCTACCCACAG | GA    c.4440
 R  R  Q  Q  E  Q  E  Q  A  R  Q  E  Q  A  G  Q  L  P  T  G |       p.1480

          .         .         .         .         .      | 34  .    g.61960
 GGTGGTCCCAGCCAGGAGGTGGAGCCAGCAGAGGGCCCCGAGGAGGCAGCGGCAG | GCCGG    c.4500
 G  G  P  S  Q  E  V  E  P  A  E  G  P  E  E  A  A  A  G |   R      p.1500

          .         .         .         .         .         .       g.62020
 AGCCATGTGGTGCAGAGGGTGCTGAGCACGGCGCAGTTCCTGTGGATGCTGGGGCAGGCG       c.4560
 S  H  V  V  Q  R  V  L  S  T  A  Q  F  L  W  M  L  G  Q  A         p.1520

          .         .         .         .         .         .       g.62080
 CTAGTGGATGAGCTGACACGCTGGCTGCAGGAGTTCACCCGGCACCACGGCACCATGAGC       c.4620
 L  V  D  E  L  T  R  W  L  Q  E  F  T  R  H  H  G  T  M  S         p.1540

          .         .         .         .         | 35         .    g.62287
 GACGTGCTGCGGGCAGAGCGCTACCTCCTCACACAGGAGCTCCTGCAG | GGCGGCGAAGTG    c.4680
 D  V  L  R  A  E  R  Y  L  L  T  Q  E  L  L  Q   | G  G  E  V      p.1560

          .         .         .         .         .         .       g.62347
 CACAGGGGCGTGCTGGATCAGCTGTACACAAGCCAGGCCGAGGCCACGCTGCCAGGCCCC       c.4740
 H  R  G  V  L  D  Q  L  Y  T  S  Q  A  E  A  T  L  P  G  P         p.1580

          .         .         .      | 36  .         .         .    g.62592
 ACCGAGGCCCCCAATGCCCCAAGCACCGTGTCCAG | TGGGCTGGGCGCGGAGGAGCCACTC    c.4800
 T  E  A  P  N  A  P  S  T  V  S  S  |  G  L  G  A  E  E  P  L      p.1600

          .         .         .         .         .         .       g.62652
 AGCAGCATGACAGACGACATGGGCAGCCCCCTGAGCACCGGCTACCACACGCGCAGTGGC       c.4860
 S  S  M  T  D  D  M  G  S  P  L  S  T  G  Y  H  T  R  S  G         p.1620

          .         .         .         .         .         .       g.62712
 AGTGAGGAGGCAGTCACCGACCCCGGGGAGCGTGAGGCTGGTGCCTCTCTGTACCAGGGA       c.4920
 S  E  E  A  V  T  D  P  G  E  R  E  A  G  A  S  L  Y  Q  G         p.1640

          .         .         .      | 37  .         .         .    g.62923
 CTGATGCGGACGGCCAGCGAGCTGCTCCTGGACAG | GCGCCTGCGCATCCCAGAGCTGGAG    c.4980
 L  M  R  T  A  S  E  L  L  L  D  R  |  R  L  R  I  P  E  L  E      p.1660

          .         .         .         .         .         .       g.62983
 GAGGCAGAGCTGTTTGCGGAGGGGCAGGGCCGGGCGCTGCGGCTGCTGCGGGCCGTGTAC       c.5040
 E  A  E  L  F  A  E  G  Q  G  R  A  L  R  L  L  R  A  V  Y         p.1680

          .         .         .         .         .         .       g.63043
 CAGTGTGTGGCCGCCCACTCGGAGCTGCTCTGCTACTTCATCATCATCCTCAACCACATG       c.5100
 Q  C  V  A  A  H  S  E  L  L  C  Y  F  I  I  I  L  N  H  M         p.1700

          .         .         .         .         .         .       g.63103
 GTCACGGCCTCCGCCGGCTCGCTGGTGCTGCCCGTGCTCGTCTTCCTGTGGGCCATGCTG       c.5160
 V  T  A  S  A  G  S  L  V  L  P  V  L  V  F  L  W  A  M  L         p.1720

          .         .         .         .         .     | 38   .    g.63244
 TCGATCCCGAGGCCCAGCAAGCGCTTCTGGATGACGGCCATCGTCTTCACCGAG | ATCGCG    c.5220
 S  I  P  R  P  S  K  R  F  W  M  T  A  I  V  F  T  E   | I  A      p.1740

          .         .         .         .         .         .       g.63304
 GTGGTCGTCAAGTACCTGTTCCAGTTTGGGTTCTTCCCCTGGAACAGCCACGTGGTGCTG       c.5280
 V  V  V  K  Y  L  F  Q  F  G  F  F  P  W  N  S  H  V  V  L         p.1760

          .         .         .         .         .         .       g.63364
 CGGCGCTACGAGAACAAGCCCTACTTCCCGCCCCGCATCCTGGGCCTGGAGAAGACTGAC       c.5340
 R  R  Y  E  N  K  P  Y  F  P  P  R  I  L  G  L  E  K  T  D         p.1780

          .         .         .         .         .         .       g.63424
 GGCTACATCAAGTACGACCTGGTGCAGCTCATGGCCCTTTTCTTCCACCGCTCCCAGCTG       c.5400
 G  Y  I  K  Y  D  L  V  Q  L  M  A  L  F  F  H  R  S  Q  L         p.1800

     | 39    .         .         .         .         .         .    g.63591
 CTG | TGCTATGGCCTCTGGGACCATGAGGAGGACTCACCATCCAAGGAGCATGACAAGAGC    c.5460
 L   | C  Y  G  L  W  D  H  E  E  D  S  P  S  K  E  H  D  K  S      p.1820

          .         .         .         .         .         .       g.63651
 GGCGAGGAGGAGCAGGGAGCCGAGGAGGGGCCAGGGGTGCCTGCGGCCACCACCGAAGAC       c.5520
 G  E  E  E  Q  G  A  E  E  G  P  G  V  P  A  A  T  T  E  D         p.1840

          .         .         .         .         .         .       g.63711
 CACATTCAGGTGGAAGCCAGGGTCGGACCCACGGACGGGACCCCAGAACCCCAAGTGGAG       c.5580
 H  I  Q  V  E  A  R  V  G  P  T  D  G  T  P  E  P  Q  V  E         p.1860

          .         .         .         .         .         .       g.63771
 CTCAGGCCCCGTGATACGAGGCGCATCAGTCTACGTTTTAGAAGAAGGAAGAAGGAGGGC       c.5640
 L  R  P  R  D  T  R  R  I  S  L  R  F  R  R  R  K  K  E  G         p.1880

          .         .         | 40         .         .         .    g.64248
 CCAGCACGGAAAGGAGCGGCAGCCATCG | AAGCTGAGGACAGGGAGGAAGAAGAGGGGGAG    c.5700
 P  A  R  K  G  A  A  A  I  E |   A  E  D  R  E  E  E  E  G  E      p.1900

          .         .         .         .         .         .       g.64308
 GAAGAGAAAGAGGCCCCCACGGGGAGAGAGAAGAGGCCAAGCCGCTCTGGAGGAAGAGTA       c.5760
 E  E  K  E  A  P  T  G  R  E  K  R  P  S  R  S  G  G  R  V         p.1920

          .         .         .         .  | 41      .         .    g.64451
 AGGGCGGCCGGGCGGCGGCTGCAGGGCTTCTGCCTGTCCCT | GGCCCAGGGCACATATCGG    c.5820
 R  A  A  G  R  R  L  Q  G  F  C  L  S  L  |  A  Q  G  T  Y  R      p.1940

          .         .         .         .         .         .       g.64511
 CCGCTACGGCGCTTCTTCCACGACATCCTGCACACCAAGTACCGCGCAGCCACCGACGTC       c.5880
 P  L  R  R  F  F  H  D  I  L  H  T  K  Y  R  A  A  T  D  V         p.1960

          .         .         .         .         .         .       g.64571
 TATGCCCTCATGTTCCTGGCTGATGTTGTCGACTTCATCATCATCATTTTTGGCTTCTGG       c.5940
 Y  A  L  M  F  L  A  D  V  V  D  F  I  I  I  I  F  G  F  W         p.1980

           | 42        .         .         .         .         .    g.64732
 GCCTTTGGG | AAGCACTCGGCGGCCACAGACATCACGTCCTCCCTATCAGACGACCAGGTA    c.6000
 A  F  G   | K  H  S  A  A  T  D  I  T  S  S  L  S  D  D  Q  V      p.2000

          .         .         .         .         .         .       g.64792
 CCCGAGGCTTTCCTGGTCATGCTGCTGATCCAGTTCAGTACCATGGTGGTTGACCGCGCC       c.6060
 P  E  A  F  L  V  M  L  L  I  Q  F  S  T  M  V  V  D  R  A         p.2020

          .         .         .         .         .         .       g.64852
 CTCTACCTGCGCAAGACCGTGCTGGGCAAGCTGGCCTTCCAGGTGGCGCTGGTGCTGGCC       c.6120
 L  Y  L  R  K  T  V  L  G  K  L  A  F  Q  V  A  L  V  L  A         p.2040

          .         .         .         .     | 43   .         .    g.65020
 ATCCACCTATGGATGTTCTTCATCCTGCCCGCCGTCACTGAGAG | GATGTTCAACCAGAAT    c.6180
 I  H  L  W  M  F  F  I  L  P  A  V  T  E  R  |  M  F  N  Q  N      p.2060

          .         .         .         .         .         .       g.65080
 GTGGTGGCCCAGCTCTGGTACTTCGTGAAGTGCATCTACTTCGCCCTGTCCGCCTACCAG       c.6240
 V  V  A  Q  L  W  Y  F  V  K  C  I  Y  F  A  L  S  A  Y  Q         p.2080

          .         .         .         .         .         .       g.65140
 ATCCGCTGCGGCTACCCCACCCGCATCCTCGGCAACTTCCTCACCAAGAAGTACAATCAT       c.6300
 I  R  C  G  Y  P  T  R  I  L  G  N  F  L  T  K  K  Y  N  H         p.2100

          .         .    | 44    .         .         .         .    g.65280
 CTCAACCTCTTCCTCTTCCAGGG | GTTCCGGCTGGTGCCGTTCCTGGTGGAGCTGCGGGCA    c.6360
 L  N  L  F  L  F  Q  G  |  F  R  L  V  P  F  L  V  E  L  R  A      p.2120

          .         .         .         .         .         .       g.65340
 GTGATGGACTGGGTGTGGACGGACACCACGCTGTCCCTGTCCAGCTGGATGTGTGTGGAG       c.6420
 V  M  D  W  V  W  T  D  T  T  L  S  L  S  S  W  M  C  V  E         p.2140

          .         .         .         .         .  | 45      .    g.67762
 GACATCTATGCCAACATCTTCATCATCAAATGCAGCCGAGAGACAGAGAAG | AAATACCCG    c.6480
 D  I  Y  A  N  I  F  I  I  K  C  S  R  E  T  E  K   | K  Y  P      p.2160

          .         .         .         .         .         .       g.67822
 CAGCCCAAAGGGCAGAAGAAGAAGAAGATCGTCAAGTACGGCATGGGTGGCCTCATCATC       c.6540
 Q  P  K  G  Q  K  K  K  K  I  V  K  Y  G  M  G  G  L  I  I         p.2180

          .         .         .         .         .         .       g.67882
 CTCTTCCTCATCGCCATCATCTGGTTCCCACTGCTCTTCATGTCGCTGGTGCGCTCCGTG       c.6600
 L  F  L  I  A  I  I  W  F  P  L  L  F  M  S  L  V  R  S  V         p.2200

          .         .         .         .         .         .       g.67942
 GTTGGGGTTGTCAACCAGCCCATCGATGTCACCGTCACCCTGAAGCTGGGCGGCTATGAG       c.6660
 V  G  V  V  N  Q  P  I  D  V  T  V  T  L  K  L  G  G  Y  E         p.2220

  | 46       .         .         .         .         .         .    g.68126
  | CCGCTGTTCACCATGAGCGCCCAGCAGCCGTCCATCATCCCCTTCACGGCCCAGGCCTAT    c.6720
  | P  L  F  T  M  S  A  Q  Q  P  S  I  I  P  F  T  A  Q  A  Y      p.2240

          .         .         .    | 47    .         .         .    g.68260
 GAGGAGCTGTCCCGGCAGTTTGACCCCCAGCCG | CTGGCCATGCAGTTCATCAGCCAGTAC    c.6780
 E  E  L  S  R  Q  F  D  P  Q  P   | L  A  M  Q  F  I  S  Q  Y      p.2260

          .         .         .         .         .         .       g.68320
 AGCCCTGAGGACATCGTCACGGCGCAGATTGAGGGCAGCTCCGGGGCGCTGTGGCGCATC       c.6840
 S  P  E  D  I  V  T  A  Q  I  E  G  S  S  G  A  L  W  R  I         p.2280

          .         .         .         .         .         .       g.68380
 AGTCCCCCCAGCCGTGCCCAGATGAAGCGGGAGCTCTACAACGGCACGGCCGACATCACC       c.6900
 S  P  P  S  R  A  Q  M  K  R  E  L  Y  N  G  T  A  D  I  T         p.2300

          .         .       | 48 .         .         .         .    g.68515
 CTGCGCTTCACCTGGAACTTCCAGAG | GGACCTGGCGAAGGGAGGCACTGTGGAGTATGCC    c.6960
 L  R  F  T  W  N  F  Q  R  |  D  L  A  K  G  G  T  V  E  Y  A      p.2320

          .         .         .         .         .         .       g.68575
 AACGAGAAGCACATGCTGGCCCTGGCCCCCAACAGCACTGCACGGCGGCAGCTGGCCAGC       c.7020
 N  E  K  H  M  L  A  L  A  P  N  S  T  A  R  R  Q  L  A  S         p.2340

          .         .          | 49        .         .         .    g.68718
 CTGCTCGAGGGCACCTCGGACCAGTCTGT | GGTCATCCCTAATCTCTTCCCCAAGTACATC    c.7080
 L  L  E  G  T  S  D  Q  S  V  |  V  I  P  N  L  F  P  K  Y  I      p.2360

          .         .         .         .          | 50        .    g.68856
 CGTGCCCCCAACGGGCCCGAAGCCAACCCTGTGAAGCAGCTGCAGCCCA | ATGAGGAGGCC    c.7140
 R  A  P  N  G  P  E  A  N  P  V  K  Q  L  Q  P  N |   E  E  A      p.2380

          .         .         .         .         .         .       g.68916
 GACTACCTCGGCGTGCGTATCCAGCTGCGGAGGGAGCAGGGTGCGGGGGCCACCGGCTTC       c.7200
 D  Y  L  G  V  R  I  Q  L  R  R  E  Q  G  A  G  A  T  G  F         p.2400

          .         .         .         .         .         .       g.68976
 CTCGAATGGTGGGTCATCGAGCTGCAGGAGTGCCGGACCGACTGCAACCTGCTGCCCATG       c.7260
 L  E  W  W  V  I  E  L  Q  E  C  R  T  D  C  N  L  L  P  M         p.2420

          .         .         .         .         .       | 51 .    g.69114
 GTCATTTTCAGTGACAAGGTCAGCCCACCGAGCCTCGGCTTCCTGGCTGGCTACGG | CATC    c.7320
 V  I  F  S  D  K  V  S  P  P  S  L  G  F  L  A  G  Y  G  |  I      p.2440

          .         .         .         .         .         .       g.69174
 ATGGGGCTGTACGTGTCCATCGTGCTGGTCATCGGCAAGTTCGTGCGCGGATTCTTCAGC       c.7380
 M  G  L  Y  V  S  I  V  L  V  I  G  K  F  V  R  G  F  F  S         p.2460

          .         .         .         .         .         .       g.69234
 GAGATCTCGCACTCCATTATGTTCGAGGAGCTGCCGTGCGTGGACCGCATCCTCAAGCTC       c.7440
 E  I  S  H  S  I  M  F  E  E  L  P  C  V  D  R  I  L  K  L         p.2480

          .         .         .         .         .         .       g.69294
 TGCCAGGACATCTTCCTGGTGCGGGAGACTCGGGAGCTGGAGCTGGAGGAGGAGTTGTAC       c.7500
 C  Q  D  I  F  L  V  R  E  T  R  E  L  E  L  E  E  E  L  Y         p.2500

          .         .         .         .         .         .       g.69354
 GCCAAGCTCATCTTCCTCTACCGCTCACCGGAGACCATGATCAAGTGGACTCGTGAGAAG       c.7560
 A  K  L  I  F  L  Y  R  S  P  E  T  M  I  K  W  T  R  E  K         p.2520

                                                                    g.69360
 GAGTAG                                                             c.7566
 E  X                                                               p.2521

          .         .         .         .         .         .       g.69420
 gagctgctgctggcgcccgagagggaaggagccggcctgctgggcagcgtggccacaagg       c.*60

          .         .         .         .         .         .       g.69480
 ggcggcactcctcaggccgggggagccactgccccgtccaaggccgccagctgtgatgca       c.*120

          .         .         .         .         .         .       g.69540
 tcctcccggcctgcctgagccctgatgctgctgtcagagaaggacactgcgtccccacgg       c.*180

          .         .         .         .         .         .       g.69600
 cctgcgtggcgctgccgtcccccacgtgtactgtagagttttttttttaattaaaaaatg       c.*240

          .         .                                               g.69627
 ttttatttatacaaatggacaatcaga                                        c.*267

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Piezo-type mechanosensitive ion channel component 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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