phosphatidylinositol glycan anchor biosynthesis, class B (PIGB) - coding DNA reference sequence

(used for variant description)

(last modified August 7, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_004855.4 in the PIGB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering PIGB transcript NM_004855.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             gactgttctgcgcctg       c.-301

 .         .         .         .         .         .                g.5076
 ctccacgtcactaaactcgctaccgcctgctcccctccagagaccgggggccttccagca       c.-241

 .         .         .         .         .         .                g.5136
 gttttcggacccccgagcacagagaccgccaagccaaaggcgagtagcaatccctcggtt       c.-181

 .         .         .         .         .         .                g.5196
 cggaaacggcgaaaggaaaccgcaaggaggccaccacgtcgggtgggagctacgaagttg       c.-121

 .         .         .         .         .         .                g.5256
 cccgttcccggttacttccgggcttgcgagcgacgactgctctcaaaggccaaacttaat       c.-61

 .         .         .         .         .         .                g.5316
 ggatggacgagcagcgcgctactgcagctttcttccgccttaggaaggtggcggccaggg       c.-1

          .         .         .         .         .         .       g.5376
 ATGAGGAGGCCCCTAAGCAAGTGCGGAATGGAGCCGGGGGGCGGAGATGCCAGCCTCACT       c.60
 M  R  R  P  L  S  K  C  G  M  E  P  G  G  G  D  A  S  L  T         p.20

          .         .         .         .         .         .       g.5436
 TTGCATGGTCTCCAGAACCGCTCCCACGGCAAGATAAAGCTGCGAAAGAGAAAGTCTACC       c.120
 L  H  G  L  Q  N  R  S  H  G  K  I  K  L  R  K  R  K  S  T         p.40

          .         .         .         .    | 02    .         .    g.6357
 TTGTACTTCAACACCCAGGAGAAGAGCGCCAGGCGCCGCGGGG | ATCTTCTTGGAGAAAAT    c.180
 L  Y  F  N  T  Q  E  K  S  A  R  R  R  G  D |   L  L  G  E  N      p.60

          .         .         .         .         .         .       g.6417
 ATTTATCTGCTCTTGTTTACCATAGCTTTACGAATATTAAACTGCTTTTTAGTGCAGACA       c.240
 I  Y  L  L  L  F  T  I  A  L  R  I  L  N  C  F  L  V  Q  T         p.80

          .         .         .         .         .          | 03    g.7339
 AGTTTTGTTCCAGATGAATACTGGCAGTCTCTTGAAGTTTCACATCACATGGTTTTCAA | T    c.300
 S  F  V  P  D  E  Y  W  Q  S  L  E  V  S  H  H  M  V  F  N  |      p.100

          .         .         .         .         .         .       g.7399
 TATGGTTATTTGACTTGGGAATGGACAGAGAGACTGAGGAGTTACACTTATCCCTTAATC       c.360
 Y  G  Y  L  T  W  E  W  T  E  R  L  R  S  Y  T  Y  P  L  I         p.120

          .         .         .         .         .        | 04.    g.13599
 TTTGCAAGCATTTACAAGATTCTTCATCTTTTAGGGAAAGATAGTGTTCAGTTGCTG | ATT    c.420
 F  A  S  I  Y  K  I  L  H  L  L  G  K  D  S  V  Q  L  L   | I      p.140

          .         .         .         .         .         .       g.13659
 TGGATTCCTAGACTTGCCCAAGCACTTCTGTCTGCTGTAGCAGATGTGAGACTTTACTCA       c.480
 W  I  P  R  L  A  Q  A  L  L  S  A  V  A  D  V  R  L  Y  S         p.160

          .         .         .         .   | 05     .         .    g.15807
 TTAATGAAGCAACTAGAAAATCAGGAAGTGGCAAGATGGGTG | TTTTTTTGCCAGTTGTGC    c.540
 L  M  K  Q  L  E  N  Q  E  V  A  R  W  V   | F  F  C  Q  L  C      p.180

          .         .         .         .         .         .       g.15867
 TCCTGGTTCACATGGTATTGCTGTACCAGAACCCTTACAAACACCATGGAAACTGTTCTC       c.600
 S  W  F  T  W  Y  C  C  T  R  T  L  T  N  T  M  E  T  V  L         p.200

          .         .         .         .         .    | 06    .    g.19939
 ACTATAATTGCTCTTTTCTACTATCCTTTGGAAGGTTCAAAGTCTATGAACAG | TGTCAAA    c.660
 T  I  I  A  L  F  Y  Y  P  L  E  G  S  K  S  M  N  S  |  V  K      p.220

          .         .         .         .         .         .       g.19999
 TACTCATCCCTGGTGGCACTTGCCTTCATAATTCGTCCCACAGCTGTCATTCTGTGGACA       c.720
 Y  S  S  L  V  A  L  A  F  I  I  R  P  T  A  V  I  L  W  T         p.240

          .         .         .         .         .         .       g.20059
 CCTTTGCTCTTCAGACATTTCTGTCAAGAACCAAGAAAGCTTGATCTTATTCTACATCAT       c.780
 P  L  L  F  R  H  F  C  Q  E  P  R  K  L  D  L  I  L  H  H         p.260

          .     | 07   .         .         .         .         .    g.25378
 TTTTTACCTGTAGG | CTTTGTTACTTTGAGTTTGTCTCTGATGATTGATCGTATTTTTTTT    c.840
 F  L  P  V  G  |  F  V  T  L  S  L  S  L  M  I  D  R  I  F  F      p.280

        | 08 .         .         .         .         .         .    g.26731
 GGCCAA | TGGACTCTGGTTCAATTTAATTTTTTGAAATTTAACGTGCTGCAGAACTGGGGA    c.900
 G  Q   | W  T  L  V  Q  F  N  F  L  K  F  N  V  L  Q  N  W  G      p.300

          .         .         .         .         .         .       g.26791
 ACATTTTATGGTTCTCATCCATGGCACTGGTACTTCAGTCAAGGATTTCCAGTTATCTTG       c.960
 T  F  Y  G  S  H  P  W  H  W  Y  F  S  Q  G  F  P  V  I  L         p.320

          .         .         .         .         .         .       g.26851
 GGTACTCACTTACCCTTCTTTATTCATGGCTGCTATCTAGCACCAAAGAGATACCGGATA       c.1020
 G  T  H  L  P  F  F  I  H  G  C  Y  L  A  P  K  R  Y  R  I         p.340

          .         .         .         | 09         .         .    g.27825
 CTTTTGGTGACTGTGCTGTGGACACTGCTTGTTTATAG | CATGTTGAGCCACAAAGAATTC    c.1080
 L  L  V  T  V  L  W  T  L  L  V  Y  S  |  M  L  S  H  K  E  F      p.360

          .         .         .         .    | 10    .         .    g.36781
 AGGTTTATTTATCCAGTTTTACCATTCTGTATGGTGTTCTGTG | GATACTCATTAACCCAC    c.1140
 R  F  I  Y  P  V  L  P  F  C  M  V  F  C  G |   Y  S  L  T  H      p.380

          .         .         .         .         .         .       g.36841
 CTGAAAACATGGAAGAAACCAGCTCTAAGTTTCCTGTTTTTATCAAATTTGTTCCTCGCC       c.1200
 L  K  T  W  K  K  P  A  L  S  F  L  F  L  S  N  L  F  L  A         p.400

          .         .         .         .         .         .       g.36901
 CTTTATACTGGTTTAGTTCATCAACGAGGTACTCTTGATGTCATGAGTCATATTCAAAAA       c.1260
 L  Y  T  G  L  V  H  Q  R  G  T  L  D  V  M  S  H  I  Q  K         p.420

          .         .         .         .         .         .       g.36961
 GTTTGTTACAACAATCCCAATAAATCTTCAGCTTCAATATTTATAATGATGCCTTGCCAC       c.1320
 V  C  Y  N  N  P  N  K  S  S  A  S  I  F  I  M  M  P  C  H         p.440

          .        | 11.         .         .         .         .    g.40906
 TCTACTCCTTATTACAG | CCATGTTCACTGCCCACTTCCCATGAGATTTCTCCAGTGCCCG    c.1380
 S  T  P  Y  Y  S  |  H  V  H  C  P  L  P  M  R  F  L  Q  C  P      p.460

          .         .         .         .         .         .       g.40966
 CCAGACCTGACTGGAAAAAGTCATTATCTTGATGAAGCAGATGTATTTTACCTAAATCCC       c.1440
 P  D  L  T  G  K  S  H  Y  L  D  E  A  D  V  F  Y  L  N  P         p.480

          .         .         .         .         .         .       g.41026
 TTAAACTGGTTACATAGAGAGTTTCATGATGATGCATCATTGCCTACTCACTTGATCACC       c.1500
 L  N  W  L  H  R  E  F  H  D  D  A  S  L  P  T  H  L  I  T         p.500

          .         | 12         .         .         .         .    g.41393
 TTCAGCATTTTGGAAGAG | GAAATAAGCGCTTTCCTAATTTCAAGCAATTATAAAAGAACT    c.1560
 F  S  I  L  E  E   | E  I  S  A  F  L  I  S  S  N  Y  K  R  T      p.520

          .         .         .         .         .         .       g.41453
 GCTGTTTTCTTCCACACTCACTTGCCAGAGGGTCGAATTGGAAGTCACATATATGTCTAT       c.1620
 A  V  F  F  H  T  H  L  P  E  G  R  I  G  S  H  I  Y  V  Y         p.540

          .         .         .         .                           g.41498
 GAACGGAAGTTAAAAGGGAAATTCAACATGAAGATGAAATTCTGA                      c.1665
 E  R  K  L  K  G  K  F  N  M  K  M  K  F  X                        p.554

          .         .         .         .         .         .       g.41558
 actttcctagataaattaacattgctgggtggaaatattcagatgctgcttaaatacttc       c.*60

          .         .         .         .         .         .       g.41618
 ggtaaacactgggtaagattcatggaacttagaaaaaagctgtatgaactgctttaccaa       c.*120

          .         .         .         .         .         .       g.41678
 atatcactactgaggaaatgtataaaataccacatagtataaaattacatgttaatacaa       c.*180

          .         .         .                                     g.41714
 tgccagattttaaataaagacctttagttttcctca                               c.*216

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphatidylinositol glycan anchor biosynthesis, class B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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