phosphatidylinositol glycan anchor biosynthesis, class M (PIGM) - coding DNA reference sequence

(used for variant description)

(last modified December 19, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_145167.2 in the PIGM gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012238.1, covering PIGM transcript NM_145167.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               agcggaagcgagac       c.-241

 .         .         .         .         .         .                g.5074
 cgtccatccagaggaaggcaagtttttggctcgggcggctgagaagaccgcgcggggctg       c.-181

 .         .         .         .         .         .                g.5134
 gagacaggtagcagtacgggggcggggcttcatgccggatgtgatagtctgcagtcgttt       c.-121

 .         .         .         .         .         .                g.5194
 cggttggcagcctggcgggtgggagatgcggcggccacctgctgcaaagaaccgaaggga       c.-61

 .         .         .         .         .         .                g.5254
 aggttagaagtacgaaggcagtttggagctggggctaagcagctgtcgcacggtcagatc       c.-1

          .         .         .         .         .         .       g.5314
 ATGGGCTCCACCAAGCACTGGGGCGAATGGCTCCTGAACTTGAAGGTGGCTCCAGCCGGC       c.60
 M  G  S  T  K  H  W  G  E  W  L  L  N  L  K  V  A  P  A  G         p.20

          .         .         .         .         .         .       g.5374
 GTCTTTGGTGTGGCCTTTCTAGCCAGAGTCGCCCTGGTTTTCTATGGCGTCTTCCAGGAC       c.120
 V  F  G  V  A  F  L  A  R  V  A  L  V  F  Y  G  V  F  Q  D         p.40

          .         .         .         .         .         .       g.5434
 CGGACCCTGCACGTGAGGTATACGGACATCGACTACCAGGTCTTCACCGACGCCGCGCGC       c.180
 R  T  L  H  V  R  Y  T  D  I  D  Y  Q  V  F  T  D  A  A  R         p.60

          .         .         .         .         .         .       g.5494
 TTCGTCACGGAGGGGCGCTCGCCTTACCTGAGAGCCACGTACCGTTACACCCCGCTGCTG       c.240
 F  V  T  E  G  R  S  P  Y  L  R  A  T  Y  R  Y  T  P  L  L         p.80

          .         .         .         .         .         .       g.5554
 GGTTGGCTCCTCACTCCCAACATCTACCTCAGCGAGCTCTTTGGAAAGTTTCTCTTCATC       c.300
 G  W  L  L  T  P  N  I  Y  L  S  E  L  F  G  K  F  L  F  I         p.100

          .         .         .         .         .         .       g.5614
 AGCTGCGACCTCCTCACCGCTTTCCTCTTATACCGCCTGCTGCTGCTGAAGGGGCTGGGG       c.360
 S  C  D  L  L  T  A  F  L  L  Y  R  L  L  L  L  K  G  L  G         p.120

          .         .         .         .         .         .       g.5674
 CGCCGCCAGGCTTGTGGCTACTGTGTCTTTTGGCTTCTTAACCCCCTGCCTATGGCAGTA       c.420
 R  R  Q  A  C  G  Y  C  V  F  W  L  L  N  P  L  P  M  A  V         p.140

          .         .         .         .         .         .       g.5734
 TCCAGCCGCGGTAATGCGGACTCTATTGTCGCCTCCCTGGTCCTGATGGTCCTCTACTTG       c.480
 S  S  R  G  N  A  D  S  I  V  A  S  L  V  L  M  V  L  Y  L         p.160

          .         .         .         .         .         .       g.5794
 ATAAAGAAAAGACTCGTCGCGTGTGCAGCTGTATTCTATGGTTTCGCGGTGCATATGAAG       c.540
 I  K  K  R  L  V  A  C  A  A  V  F  Y  G  F  A  V  H  M  K         p.180

          .         .         .         .         .         .       g.5854
 ATATATCCAGTGACTTACATCCTTCCCATAACCCTCCACCTGCTTCCAGATCGCGACAAT       c.600
 I  Y  P  V  T  Y  I  L  P  I  T  L  H  L  L  P  D  R  D  N         p.200

          .         .         .         .         .         .       g.5914
 GACAAAAGCCTCCGTCAATTCCGGTACACTTTCCAGGCTTGTTTGTACGAGCTCCTGAAA       c.660
 D  K  S  L  R  Q  F  R  Y  T  F  Q  A  C  L  Y  E  L  L  K         p.220

          .         .         .         .         .         .       g.5974
 AGGCTGTGTAATCGGGCTGTGCTGCTGTTTGTAGCAGTTGCTGGACTCACGTTTTTTGCC       c.720
 R  L  C  N  R  A  V  L  L  F  V  A  V  A  G  L  T  F  F  A         p.240

          .         .         .         .         .         .       g.6034
 CTGAGCTTTGGTTTTTACTATGAGTACGGCTGGGAATTTTTGGAACACACCTACTTTTAT       c.780
 L  S  F  G  F  Y  Y  E  Y  G  W  E  F  L  E  H  T  Y  F  Y         p.260

          .         .         .         .         .         .       g.6094
 CACCTGACTAGGCGGGATATCCGTCACAACTTTTCTCCGTACTTCTACATGCTGTATTTG       c.840
 H  L  T  R  R  D  I  R  H  N  F  S  P  Y  F  Y  M  L  Y  L         p.280

          .         .         .         .         .         .       g.6154
 ACTGCAGAGAGCAAGTGGAGTTTTTCCCTGGGAATTGCTGCATTCCTGCCACAGCTCATC       c.900
 T  A  E  S  K  W  S  F  S  L  G  I  A  A  F  L  P  Q  L  I         p.300

          .         .         .         .         .         .       g.6214
 TTGCTTTCAGCTGTGTCTTTCGCCTATTACAGAGACCTCGTTTTTTGTTGTTTTCTTCAT       c.960
 L  L  S  A  V  S  F  A  Y  Y  R  D  L  V  F  C  C  F  L  H         p.320

          .         .         .         .         .         .       g.6274
 ACGTCCATTTTTGTGACTTTTAACAAAGTCTGCACCTCCCAGTACTTTCTTTGGTACCTC       c.1020
 T  S  I  F  V  T  F  N  K  V  C  T  S  Q  Y  F  L  W  Y  L         p.340

          .         .         .         .         .         .       g.6334
 TGCTTACTGCCTCTTGTGATGCCACTAGTCAGAATGCCTTGGAAAAGAGCTGTAGTTCTC       c.1080
 C  L  L  P  L  V  M  P  L  V  R  M  P  W  K  R  A  V  V  L         p.360

          .         .         .         .         .         .       g.6394
 CTAATGTTATGGTTTATAGGGCAGGCCATGTGGCTGGCTCCTGCCTATGTTCTAGAGTTT       c.1140
 L  M  L  W  F  I  G  Q  A  M  W  L  A  P  A  Y  V  L  E  F         p.380

          .         .         .         .         .         .       g.6454
 CAAGGAAAGAACACCTTTCTGTTTATTTGGTTAGCTGGTTTGTTCTTTCTTCTTATCAAT       c.1200
 Q  G  K  N  T  F  L  F  I  W  L  A  G  L  F  F  L  L  I  N         p.400

          .         .         .         .         .         .       g.6514
 TGTTCCATCCTGATTCAAATTATTTCCCATTACAAAGAAGAACCCCTGACAGAGAGAATC       c.1260
 C  S  I  L  I  Q  I  I  S  H  Y  K  E  E  P  L  T  E  R  I         p.420

          .                                                         g.6526
 AAATATGACTAG                                                       c.1272
 K  Y  D  X                                                         p.423

          .         .         .         .         .         .       g.6586
 tgtatgttccacaccctctgctactgtgttacattctgattgtcttgtatggaccagaag       c.*60

          .         .         .         .         .         .       g.6646
 agagctttgggacattttttctgaacattctaagcattctagtgaaagttcccatgttcc       c.*120

          .         .         .         .         .         .       g.6706
 aacagaacttaaaagcaatgtttgccttatatataaaagggacacaataattgaggtcca       c.*180

          .         .         .         .         .         .       g.6766
 ccttctaggaaatcctaggactcgtttatttgggacatggtgggaataaaggtcacatat       c.*240

          .         .         .         .         .         .       g.6826
 tggaaaatggaaaggctgatgaaactatcagatactaaaacattcttaaaatagaggaat       c.*300

          .         .         .         .         .         .       g.6886
 atagttagagacatcaggtttaagccagtatttgttcctgttttacaatgcttctgtctt       c.*360

          .         .         .         .         .         .       g.6946
 aagctgtgtcttaacttttaacacccatcttttctttctaaagctttcctgacagctgtg       c.*420

          .         .         .         .         .         .       g.7006
 aaaatccaaaaaatattcttaaactgtgtatggtggcccttgcctgtagtctcagcactt       c.*480

          .         .         .         .         .         .       g.7066
 tgggaggctgaggtgggagggtcgcttgagttcaggagttctagacccacctggggcaag       c.*540

          .         .         .         .         .         .       g.7126
 atggtgagacctagtctcaaaaaaaaaaaaaaaaattagccaggtgttgtggtgcacccc       c.*600

          .         .         .         .         .         .       g.7186
 tgtagtcatagctgcatgggaggctgaggtgggagaattgcttgagcccagagcaagacc       c.*660

          .         .         .         .         .         .       g.7246
 ctgtctcaaaaaaaaaaaaaaaaaaaaaaaggaaaggacaactttttagatagaaaagta       c.*720

          .         .         .         .         .         .       g.7306
 ttaaataatactaagatgcttagtagtattattttagagagttttaaacttctatattaa       c.*780

          .         .         .         .         .         .       g.7366
 atgtggggtcttacaagataatccaaagactttgggaggccaaggcgggcagatcacgag       c.*840

          .         .         .         .         .         .       g.7426
 gtcaggagattgagaccatcctggctaacacggtgaaacccctctctactaaaaatacaa       c.*900

          .         .         .         .         .         .       g.7486
 aaaattagccgggcgtggtgggtgcctgtagtcccagctactcctcgggaggctgaggca       c.*960

          .         .         .         .         .         .       g.7546
 ggagaatggcgtgaactccggaggtggagcctgtagtgagccgagatggcaccactgcgc       c.*1020

          .         .         .         .         .         .       g.7606
 tccagcctgggcgacagagcaagactccatatcaaaaaaaaaaaaaaaaaaagataatcc       c.*1080

          .         .         .         .         .         .       g.7666
 aaagaatttaaattgtaatcatgtttcatgtatttgttttattacttacttttatagcac       c.*1140

          .         .         .         .         .         .       g.7726
 ttagtcccagtggtattagactgctatttggtttcatacaaaaaggattaaatttaaatt       c.*1200

          .         .         .         .         .         .       g.7786
 cattcatgtttagacttgagttattacatttttaaaactatcatcttgcctttaatgttt       c.*1260

          .         .         .         .         .         .       g.7846
 gtggtcctacacaaactattagtacatttcagtatcctcttacccctttgtttttaagtt       c.*1320

          .         .         .         .         .         .       g.7906
 tttgattgctaaagcaagacttttttcttctagaatttaagtcaaccaagtgttatctat       c.*1380

          .         .         .         .         .         .       g.7966
 gttgtaaaaatggataatagtagattttaggtgataaaacaacttgttagtaagacattt       c.*1440

          .         .         .         .         .         .       g.8026
 cctagcttaaaaaaaaaaatcaaaaattccatgatagaaatgcagacctgtgagggaaac       c.*1500

          .         .         .         .         .         .       g.8086
 tcctgaaaagcataagaagcatcccagagagccatgggttttctagaccagagaatttag       c.*1560

          .         .         .         .         .         .       g.8146
 agggagattgtggaactgaggcttaggtggtcagatcgtttcccttatcactgtaatatt       c.*1620

          .         .         .         .         .         .       g.8206
 tctgggggaaaaatgctttctgagttgtttaaacaagcatccttacatttttttttttaa       c.*1680

          .         .         .         .         .         .       g.8266
 ttaaacagcctgtctaggcttgggattccctaatactacagtagcagtatatgaatatga       c.*1740

          .         .         .         .         .         .       g.8326
 ttttgtgattgtgttttttaaaagataagtaatttgatgaactgttcttttgcagtcaga       c.*1800

          .         .         .         .         .         .       g.8386
 aaacactcacaaaaagacaaaaaaagttccacagtattatatttcatgtcagttcaggcc       c.*1860

          .         .         .         .         .         .       g.8446
 taaaatcctttgcaaataagatgtttataggctggtcacaattaacaatgttattattgg       c.*1920

          .         .         .         .         .         .       g.8506
 cagcacttcttggatggataccttttgggacctttcattagaaagagggaaagaatgggg       c.*1980

          .         .         .         .         .         .       g.8566
 tggttttgtatgggctcctgtttggggtaaaaatagcagagtcagttgctgaggacaatg       c.*2040

          .         .         .         .         .         .       g.8626
 accttccttataacatttagtttcatacccatattaggtcttgtcttgaggaccctttat       c.*2100

          .         .         .         .         .         .       g.8686
 atgtgcttgtttactagtggccttccagccatagcattcttacctttttttcctattcta       c.*2160

          .         .         .         .         .         .       g.8746
 agaattaaaaaaaaaaattatagagccagcaagggaggaggcaggaaacagaaatcgaat       c.*2220

          .         .         .         .         .         .       g.8806
 ttcatcattccagtatagttgtccctttttttgtatttctgacttggttttataattata       c.*2280

          .         .         .         .         .         .       g.8866
 tttacttactaattattgttttttaacattctttattgtggcttactcttcatacttaga       c.*2340

          .         .         .         .         .         .       g.8926
 attgaaattgttggacatcacatgtatattcacattataaatacatcattcttccactgt       c.*2400

          .         .         .         .         .         .       g.8986
 tagacctttagattgcttccagtttttaatattctaaataagactttcaacattttctgt       c.*2460

          .         .         .         .         .         .       g.9046
 gttttagctcattctcttaggacattcttagaagttagaaacatttctgctgggatcgtt       c.*2520

          .         .         .         .         .         .       g.9106
 ggagggaacttcaaactttggaatctttcctgcaagaaattctttaccaaagaaaggcag       c.*2580

          .         .         .         .         .         .       g.9166
 gtgtttcttaaagggatgcaaaagatattttgcactttgtatgttccaaaacatttagta       c.*2640

          .         .         .         .         .         .       g.9226
 agttaactaaaaaaatgagttaatttggtttcttgggggattttaattttttaatttgtt       c.*2700

          .         .         .         .         .         .       g.9286
 ttctggttatgtaaaaaaaatgttttttttttgcttcttatcacaatccttttgtttcct       c.*2760

          .         .         .                                     g.9322
 ttttaatcctttaataacaccttcaaattttataag                               c.*2796

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphatidylinositol glycan anchor biosynthesis, class M protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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