phosphoinositide-3-kinase adaptor protein 1 (PIK3AP1) - coding DNA reference sequence

(used for variant description)

(last modified August 20, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_152309.2 in the PIK3AP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering PIK3AP1 transcript NM_152309.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     gaagcgcc       c.-121

 .         .         .         .         .         .                g.5068
 agagcggcggccggtcccgcgcggagcccggcgcccctccagcccgagccaggacgccgc       c.-61

 .         .         .         .         .         .                g.5128
 cggccccggtcccggccccgggcacgcagcgagccagggatgtgagcggcgccccgcggc       c.-1

          .    | 02    .         .         .         .         .    g.15586
 ATGGCAGCCTCAG | GGGTGCCCAGAGGATGCGACATCCTCATCGTCTACAGCCCGGATGCC    c.60
 M  A  A  S  G |   V  P  R  G  C  D  I  L  I  V  Y  S  P  D  A      p.20

          .         .         .         .         .         .       g.15646
 GAGGAATGGTGCCAGTACCTGCAGACCCTGTTCCTGTCCAGTCGGCAGGTCCGCAGCCAG       c.120
 E  E  W  C  Q  Y  L  Q  T  L  F  L  S  S  R  Q  V  R  S  Q         p.40

          .         .         .         .         .         .       g.15706
 AAGATACTGACTCACAGGCTGGGCCCCGAGGCCTCCTTCTCGGCAGAGGACCTAAGCCTT       c.180
 K  I  L  T  H  R  L  G  P  E  A  S  F  S  A  E  D  L  S  L         p.60

          .         .         .         .         .         .       g.15766
 TTCCTCAGCACCCGCTGTGTCGTGGTGCTGCTGTCCGCGGAGCTGGTGCAGCACTTCCAC       c.240
 F  L  S  T  R  C  V  V  V  L  L  S  A  E  L  V  Q  H  F  H         p.80

          .         .         .         .         .         .       g.15826
 AAGCCCGCCTTGCTGCCCCTGCTGCAGAGAGCTTTCCATCCTCCGCACCGCGTGGTCAGG       c.300
 K  P  A  L  L  P  L  L  Q  R  A  F  H  P  P  H  R  V  V  R         p.100

          .         .         .         .         .         .       g.15886
 CTGCTCTGCGGCGTGCGGGACAGCGAGGAGTTCCTAGACTTCTTTCCAGATTGGGCCCAT       c.360
 L  L  C  G  V  R  D  S  E  E  F  L  D  F  F  P  D  W  A  H         p.120

          .         .         .         .         .         .       g.15946
 TGGCAGGAGCTCACCTGTGACGATGAGCCAGAGACCTACGTGGCAGCTGTGAAAAAAGCC       c.420
 W  Q  E  L  T  C  D  D  E  P  E  T  Y  V  A  A  V  K  K  A         p.140

          . | 03       .         .         .         .         .    g.68638
 ATTTCCGAAG | ATTCTGGCTGTGACTCAGTCACTGACACTGAGCCTGAGGACGAGAAGGTT    c.480
 I  S  E  D |   S  G  C  D  S  V  T  D  T  E  P  E  D  E  K  V      p.160

          .         .         .         .         .         .       g.68698
 GTTTCCTACTCGAAGCAGCAGAACCTGCCGACGGTGACTTCACCTGGGAACCTGATGGTG       c.540
 V  S  Y  S  K  Q  Q  N  L  P  T  V  T  S  P  G  N  L  M  V         p.180

          .         .        | 04.         .         .         .    g.72713
 GTGCAGCCGGACCGCATTCGCTGTGGG | GCAGAAACCACTGTCTATGTTATTGTGAGATGT    c.600
 V  Q  P  D  R  I  R  C  G   | A  E  T  T  V  Y  V  I  V  R  C      p.200

          .         .         .         .         .         .       g.72773
 AAGCTGGATGACAGGGTGGCGACAGAAGCAGAGTTTTCTCCTGAGGATTCTCCCTCTGTA       c.660
 K  L  D  D  R  V  A  T  E  A  E  F  S  P  E  D  S  P  S  V         p.220

          .         .         .         .         .   | 05     .    g.73879
 AGGATGGAAGCCAAGGTGGAGAATGAGTACACCATTTCAGTGAAGGCTCCCA | ACCTTTCA    c.720
 R  M  E  A  K  V  E  N  E  Y  T  I  S  V  K  A  P  N |   L  S      p.240

          .         .         .         .         .         .       g.73939
 TCTGGGAACGTTTCTCTGAAGATATATTCTGGAGACTTAGTGGTGTGTGAAACCGTTATC       c.780
 S  G  N  V  S  L  K  I  Y  S  G  D  L  V  V  C  E  T  V  I         p.260

          .         .         .         .         .         .       g.73999
 AGCTATTATACTGACATGGAAGAAATTGGGAATTTATTGTCCAATGCCGCGAATCCTGTG       c.840
 S  Y  Y  T  D  M  E  E  I  G  N  L  L  S  N  A  A  N  P  V         p.280

          .      | 06  .         .         .         .         .    g.74187
 GAATTCATGTGTCAG | GCCTTTAAAATTGTGCCCTACAACACAGAGACCCTTGATAAACTG    c.900
 E  F  M  C  Q   | A  F  K  I  V  P  Y  N  T  E  T  L  D  K  L      p.300

          .         .         .         .         .         .       g.74247
 CTAACCGAATCCCTGAAGAACAATATCCCTGCAAGCGGACTGCACCTCTTTGGAATCAAC       c.960
 L  T  E  S  L  K  N  N  I  P  A  S  G  L  H  L  F  G  I  N         p.320

          .         .         | 07         .         .         .    g.76699
 CAGCTGGAAGAAGAAGATATGATGACAA | ATCAGAGGGATGAAGAGCTGCCCACCCTGTTG    c.1020
 Q  L  E  E  E  D  M  M  T  N |   Q  R  D  E  E  L  P  T  L  L      p.340

          .         .         .         .         .         .       g.76759
 CATTTTGCTGCGAAGTATGGACTGAAGAACCTCACTGCCTTGTTGCTCACCTGCCCAGGA       c.1080
 H  F  A  A  K  Y  G  L  K  N  L  T  A  L  L  L  T  C  P  G         p.360

          .         .         .         .         .         .       g.76819
 GCCCTGCAGGCGTACAGCGTGGCCAACAAGCATGGCCACTACCCCAACACCATCGCTGAG       c.1140
 A  L  Q  A  Y  S  V  A  N  K  H  G  H  Y  P  N  T  I  A  E         p.380

          .         .         .         .      | 08  .         .    g.79875
 AAACACGGCTTCAGGGACCTGCGGCAGTTCATCGACGAGTATGTG | GAAACGGTGGACATG    c.1200
 K  H  G  F  R  D  L  R  Q  F  I  D  E  Y  V   | E  T  V  D  M      p.400

          .         .         .         .         .         .       g.79935
 CTCAAGAGTCACATTAAAGAGGAACTGATGCACGGGGAGGAGGCTGATGCTGTGTACGAG       c.1260
 L  K  S  H  I  K  E  E  L  M  H  G  E  E  A  D  A  V  Y  E         p.420

          .         .         .         .         .         .       g.79995
 TCCATGGCCCACCTTTCCACAGACCTGCTTATGAAATGCTCGCTCAACCCCGGCTGTGAC       c.1320
 S  M  A  H  L  S  T  D  L  L  M  K  C  S  L  N  P  G  C  D         p.440

          .         .         .         .         .      | 09  .    g.97034
 GAGGATCTCTATGAGTCCATGGCTGCCTTTGTCCCAGCTGCCACTGAAGACCTCT | ATGTT    c.1380
 E  D  L  Y  E  S  M  A  A  F  V  P  A  A  T  E  D  L  Y |   V      p.460

          .         .         .         .         .         .       g.97094
 GAAATGCTTCAGGCCAGTACATCTAACCCAATCCCTGGAGATGGTTTCTCTCGGGCCACT       c.1440
 E  M  L  Q  A  S  T  S  N  P  I  P  G  D  G  F  S  R  A  T         p.480

          .         .         .  | 10      .         .         .    g.98646
 AAGGACTCTATGATCCGCAAGTTTTTAGAAG | GCAACAGCATGGGAATGACCAATCTGGAG    c.1500
 K  D  S  M  I  R  K  F  L  E  G |   N  S  M  G  M  T  N  L  E      p.500

          .         .         .         .         .         .       g.98706
 AGAGATCAGTGCCATCTTGGTCAGGAAGAAGATGTTTATCACACGGTGGATGACGATGAG       c.1560
 R  D  Q  C  H  L  G  Q  E  E  D  V  Y  H  T  V  D  D  D  E         p.520

          .         .         .         .         .         .       g.98766
 GCCTTTTCTGTGGACCTGGCCAGCAGGCCCCCTGTCCCAGTGCCCAGACCAGAGACCACT       c.1620
 A  F  S  V  D  L  A  S  R  P  P  V  P  V  P  R  P  E  T  T         p.540

          .         .         .         .          | 11        .    g.101996
 GCTCCTGGTGCTCACCAGCTGCCTGACAACGAACCATACATTTTTAAAG | TTTTTGCAGAA    c.1680
 A  P  G  A  H  Q  L  P  D  N  E  P  Y  I  F  K  V |   F  A  E      p.560

          .         .         .         .         .      | 12  .    g.104970
 AAAAGTCAAGAGCGGCCTGGGAATTTCTACGTTTCCTCAGAGAGCATCAGGAAAG | GGCCG    c.1740
 K  S  Q  E  R  P  G  N  F  Y  V  S  S  E  S  I  R  K  G |   P      p.580

          .         .         .         .         .         .       g.105030
 CCCGTCAGACCATGGAGGGACAGGCCCCAGTCGAGTATATATGACCCTTTTGCGGGAATG       c.1800
 P  V  R  P  W  R  D  R  P  Q  S  S  I  Y  D  P  F  A  G  M         p.600

          .         .         .         .         .         .       g.105090
 AAAACGCCAGGCCAGCGGCAGCTTATCACCCTCCAGGAGCAGGTGAAGCTGGGCATTGTC       c.1860
 K  T  P  G  Q  R  Q  L  I  T  L  Q  E  Q  V  K  L  G  I  V         p.620

          .         .         .         .         .         .       g.105150
 AACGTGGATGAGGCTGTGCTCCACTTCAAAGAGTGGCAGCTCAACCAGAAGAAACGATCG       c.1920
 N  V  D  E  A  V  L  H  F  K  E  W  Q  L  N  Q  K  K  R  S         p.640

          .         .  | 13      .         .         .         .    g.108850
 GAGTCCTTTCGTTTCCAGCAG | GAAAATCTTAAACGGCTAAGAGACAGCATCACCCGAAGA    c.1980
 E  S  F  R  F  Q  Q   | E  N  L  K  R  L  R  D  S  I  T  R  R      p.660

          .         .         .     | 14   .         .         .    g.115681
 CAGAGAGAGAAGCAAAAATCAGGAAAGCAGACAG | ACTTGGAGATCACGGTCCCAATTCGG    c.2040
 Q  R  E  K  Q  K  S  G  K  Q  T  D |   L  E  I  T  V  P  I  R      p.680

          .         .         .         .         .         .       g.115741
 CACTCACAGCACCTGCCTGCAAAAGTGGAGTTTGGAGTCTATGAGAGTGGCCCCAGGAAA       c.2100
 H  S  Q  H  L  P  A  K  V  E  F  G  V  Y  E  S  G  P  R  K         p.700

          .         .         .         .         .         .       g.115801
 AGTGTCATTCCCCCTAGGACGGAGCTGAGACGAGGAGACTGGAAAACAGACAGCACCTCC       c.2160
 S  V  I  P  P  R  T  E  L  R  R  G  D  W  K  T  D  S  T  S         p.720

          . | 15       .         .         .         .         .    g.121523
 AGCACAGCAA | GTAGCACAAGTAACCGCTCCAGCACCCGGAGCCTCCTCAGTGTGAGCAGC    c.2220
 S  T  A  S |   S  T  S  N  R  S  S  T  R  S  L  L  S  V  S  S      p.740

          .         .  | 16      .         .         .         .    g.123163
 GGGATGGAAGGGGACAACGAG | GATAATGAAGTCCCTGAGGTTACCAGAAGTCGCAGTCCA    c.2280
 G  M  E  G  D  N  E   | D  N  E  V  P  E  V  T  R  S  R  S  P      p.760

          .         .         .         .         .         .       g.123223
 GGCCCCCCACAAGTGGATGGGACACCCACCATGTCCCTCGAGAGACCCCCCAGGGTGCCT       c.2340
 G  P  P  Q  V  D  G  T  P  T  M  S  L  E  R  P  P  R  V  P         p.780

          .         . | 17       .         .         .         .    g.129928
 CCGAGAGCTGCCTCACAGAG | GCCTCCGACCAGGGAGACCTTCCATCCTCCTCCACCTGTT    c.2400
 P  R  A  A  S  Q  R  |  P  P  T  R  E  T  F  H  P  P  P  P  V      p.800

          .                                                         g.129946
 CCACCCAGAGGACGCTGA                                                 c.2418
 P  P  R  G  R  X                                                   p.805

          .         .         .         .         .         .       g.130006
 ttccacctcctaaaacctgcctacttcaggactttaagactcacagtcttcagcctgtta       c.*60

          .         .         .         .         .         .       g.130066
 atgatgtcttcatgttgagttttatagcatgactgttgaccttaagatccattctcattg       c.*120

          .         .         .         .         .         .       g.130126
 ctgataatgctgcagccctgctggtttgggcttgcctcgaagattttattaaggcacgaa       c.*180

          .         .         .         .         .         .       g.130186
 gaagtgaaaaactaagggcttcattcaccatcaccaagtatatcgaaccatatacttgtt       c.*240

          .         .         .         .         .         .       g.130246
 tgccaaaaggatgaagacttaatcgaaatacttacctctaatttgccatatcagaagcct       c.*300

          .         .         .         .         .         .       g.130306
 aaaaagaatgatcataaatgtacttcaccagtgattttactgaaatgcacttatattagt       c.*360

          .         .         .         .         .         .       g.130366
 ctttatgtatttgctagttcagcctgatttctagaagaggttatagtgtgagacttgtag       c.*420

          .         .         .         .         .         .       g.130426
 tattcaagtaagataagtgacctaattttaaaataattcttctacttttctgtatattca       c.*480

          .         .         .         .         .         .       g.130486
 gcagggtatttaagtgctagggctggtcacacacaaccaactgaaaaagactagagggat       c.*540

          .         .         .         .         .         .       g.130546
 tagtacaaactcctcttatacagaaggcaaatctgaggttccacagaagtctggaaccaa       c.*600

          .         .         .         .         .         .       g.130606
 gactattcagttggttaaataaagaggttagtctagactgggcctgctcattctaggtca       c.*660

          .         .         .         .         .         .       g.130666
 ccacattttccatctccaaatagccaggccctctctccctcaagaaatgcccagatgtag       c.*720

          .         .         .         .         .         .       g.130726
 aaattcatcagtgcctattggtcttccagaattttccatcttccgtatctcccaggcatg       c.*780

          .         .         .         .         .         .       g.130786
 agactaccaagtttgtttgttttctttccaatttgggaatttatacttcagtatggtttc       c.*840

          .         .         .         .         .         .       g.130846
 aacgcagttatgtttccagagaacatctagaagtggctggaaaccagaagctggggattc       c.*900

          .         .         .         .         .         .       g.130906
 cagggaccccacttagtgctctatttcctttataggttttatttctggtcatagagagag       c.*960

          .         .         .         .         .         .       g.130966
 aaggacctttgactttttcttcgttgaggcttctgaggaggaaaaacaaacctaaaatag       c.*1020

          .         .         .         .         .         .       g.131026
 aaatacagtcagcctttcaaatccatgggttctgtgtccgtggattcaaccaaccttgga       c.*1080

          .         .         .         .         .         .       g.131086
 tcaaaaatatttgaaaaaaaatctacaaagtttcaaaaagcaaaacttgaatttgctgca       c.*1140

          .         .         .         .         .         .       g.131146
 tgccaagaagtatgttgaattcatgtaaatgaagtgatgtgtaggcattgtattagatat       c.*1200

          .         .         .         .         .         .       g.131206
 tataagaaatctagaaatgatttaaagcatacaggaggatgtgcataggttatatgcaaa       c.*1260

          .         .         .         .         .         .       g.131266
 tactatgctattttatatatgggacttgagcatttgtggattttgatactgggggatcct       c.*1320

          .         .         .         .         .         .       g.131326
 ggaaccaatcccccatggataccaaagtacgactgtagttatctattttttacatactta       c.*1380

          .         .         .         .         .         .       g.131386
 ttattaccaccatgctcagtaagtccatttttgcatggaatatggagccttaaaacatgt       c.*1440

          .         .         .         .         .         .       g.131446
 catgaatttggagtccctggcacataaatctaccttcaaatcagaggtccttaatgatgc       c.*1500

          .         .         .         .         .         .       g.131506
 ctaaacatacagtaaaattagaatcagaaatacttctttaaaaaatattcaaaatgtgtt       c.*1560

          .         .         .         .         .         .       g.131566
 tgtttcccatgggattattctctatcccacacgaatgtaaaaaaatccacattaatgatc       c.*1620

          .         .         .         .         .         .       g.131626
 catttaagtatagttttattgggtccttttctaatgattaaaggttctttctcaatttca       c.*1680

          .         .         .         .         .         .       g.131686
 ttcctcagtcctgcaagtaaggactcatactgaagagtactgaaacaaggacttcttgtc       c.*1740

          .         .         .         .         .         .       g.131746
 agaaacagcttctggaatcttgggttttgtttttgttttttgacaaaatacactattggc       c.*1800

          .         .         .         .         .         .       g.131806
 catgtccatcacgagagtgtttgtagtaattaattaccttgtacaggacctggcacttag       c.*1860

          .         .         .         .         .         .       g.131866
 tagcattcttcaaatgttccctcagtgatccttttactctccttgtcacttatttgggag       c.*1920

          .         .         .         .         .         .       g.131926
 aaataggggcacgtgagataagaagaagaataattttgatgttggtatgcttgccctgtt       c.*1980

          .         .         .         .         .         .       g.131986
 acttatagacagtctttgtcataggcaaacttgaatttgatttaaaatagggctgggaaa       c.*2040

          .         .         .         .         .         .       g.132046
 aatattcaataactgtaagcccccttttggatgccaaacttagaattttgtacattctct       c.*2100

          .         .         .         .         .         .       g.132106
 gatgaacaagcatttagatcgtaacatggtaaagcctattaccagccaatgttgttagca       c.*2160

          .         .         .         .         .         .       g.132166
 tctttgtatgcacatcactgtttgtgcaatatatgaatattttgttgcattgtattctta       c.*2220

          .         .         .         .                           g.132211
 tataaaaataagtagaaaacataaaattgaaattgctgatgagaa                      c.*2265

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphoinositide-3-kinase adaptor protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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