phosphoinositide-3-kinase, regulatory subunit 2 (beta) (PIK3R2) - coding DNA reference sequence

(used for variant description)

(last modified June 24, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_005027.3 in the PIK3R2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033010.1, covering PIK3R2 transcript NM_005027.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 gtggcggcggcggaggcggggatcccgcggctgcggcgacggtggccgcggtggagccac       c.-481

 .         .         .         .         .         .       | 02     g.7282
 ggggcgggcttggcttggtgtgacggcggctgcggcggcggtggcggccgcgaccag | gtc    c.-421

 .         .         .         .         .         .                g.7342
 ggcgtcctcagctggccgagcatggtggcagcctgcacccttggctcccttgtctggtgc       c.-361

 .         .         .         .         .         .                g.7402
 agccagcagagccgccagccttgggcgcccatggccctccgtgtgagggcgtgagcggcc       c.-301

 .         .         .         .         .         .                g.7462
 tgccccagcctcacctgctgatggaggactcaatggcccagtgacctgacaccacaccac       c.-241

 .         .         .         .         .         .                g.7522
 caactccctcccaccagctgacgaatggtggacccagtgacgagtggcccttgtaagggt       c.-181

 .         .         .         .         .         .                g.7582
 catggaataatttgaagcgaggcatgagcggcccctgtggtcgcctgtgactgctggaga       c.-121

 .         .         .         .         .         .                g.7642
 tagaggtcccagcaccccaagccaacccagcggaccctcccagccctgcttcaaccaatg       c.-61

 .         .         .         .         .         .                g.7702
 gggccagtggggctccaagcagccacctaaccatccagaccccaccccactcacgcggcc       c.-1

          .         .         .         .         .         .       g.7762
 ATGGCGGGCCCTGAGGGCTTCCAGTACCGCGCTCTGTACCCGTTCCGCCGGGAGCGGCCG       c.60
 M  A  G  P  E  G  F  Q  Y  R  A  L  Y  P  F  R  R  E  R  P         p.20

          .         .         .         .         .         .       g.7822
 GAGGACCTGGAGCTGCTGCCCGGCGACGTGCTGGTAGTGAGCCGGGCGGCCTTGCAGGCG       c.120
 E  D  L  E  L  L  P  G  D  V  L  V  V  S  R  A  A  L  Q  A         p.40

          .         .         .         .         .         .       g.7882
 CTGGGCGTGGCCGAGGGTGGCGAGCGCTGCCCACAGAGCGTGGGCTGGATGCCCGGCCTC       c.180
 L  G  V  A  E  G  G  E  R  C  P  Q  S  V  G  W  M  P  G  L         p.60

          .         .         .         .         .         .       g.7942
 AACGAGCGCACACGGCAGCGAGGTGACTTCCCTGGCACCTATGTGGAGTTCCTGGGGCCC       c.240
 N  E  R  T  R  Q  R  G  D  F  P  G  T  Y  V  E  F  L  G  P         p.80

          .         .         .         .         .         .       g.8002
 GTGGCCCTGGCCCGGCCCGGCCCTCGCCCACGGGGCCCCCGCCCACTGCCCGCCAGGCCC       c.300
 V  A  L  A  R  P  G  P  R  P  R  G  P  R  P  L  P  A  R  P         p.100

          .         .   | 03     .         .         .         .    g.12331
 CGTGATGGGGCCCCTGAGCCAG | GCCTCACACTCCCCGACTTGCCCGAGCAGTTCTCCCCA    c.360
 R  D  G  A  P  E  P  G |   L  T  L  P  D  L  P  E  Q  F  S  P      p.120

          .         .         .         .         .      | 04  .    g.12746
 CCTGATGTGGCTCCCCCTCTTCTGGTGAAGCTTGTGGAGGCCATTGAAAGGACAG | GGCTG    c.420
 P  D  V  A  P  P  L  L  V  K  L  V  E  A  I  E  R  T  G |   L      p.140

          .         .         .         .       | 05 .         .    g.12890
 GACAGCGAATCTCACTACCGCCCGGAGCTGCCCGCACCGCGTACAG | ACTGGTCCCTGAGC    c.480
 D  S  E  S  H  Y  R  P  E  L  P  A  P  R  T  D |   W  S  L  S      p.160

          .         .         .         .         .         .       g.12950
 GACGTGGATCAGTGGGACACGGCAGCCCTGGCTGACGGCATTAAGAGCTTCCTGCTGGCA       c.540
 D  V  D  Q  W  D  T  A  A  L  A  D  G  I  K  S  F  L  L  A         p.180

          .         .         .         .         .         | 06    g.13103
 CTGCCCGCGCCGCTCGTGACCCCCGAGGCCTCGGCCGAGGCGCGCCGGGCCCTGCGGG | AG    c.600
 L  P  A  P  L  V  T  P  E  A  S  A  E  A  R  R  A  L  R  E |       p.200

          .         .         .         .         .         .       g.13163
 GCCGCGGGGCCCGTGGGGCCGGCGCTGGAGCCACCGACGCTGCCGCTGCACCGCGCGCTC       c.660
 A  A  G  P  V  G  P  A  L  E  P  P  T  L  P  L  H  R  A  L         p.220

          .         .         .         .         .         .       g.13223
 ACGCTGCGCTTCCTGCTCCAGCACCTGGGCCGCGTGGCCCGCCGCGCCCCGGCCCTGGGT       c.720
 T  L  R  F  L  L  Q  H  L  G  R  V  A  R  R  A  P  A  L  G         p.240

          .         .         .         .         .         .       g.13283
 CCCGCGGTCCGGGCCCTGGGCGCCACCTTTGGGCCGCTGCTGCTGCGCGCGCCGCCGCCG       c.780
 P  A  V  R  A  L  G  A  T  F  G  P  L  L  L  R  A  P  P  P         p.260

          .         .         .      | 07  .         .         .    g.13813
 CCGTCCTCGCCGCCGCCAGGGGGCGCTCCCGACGG | GAGTGAGCCCAGCCCTGACTTCCCG    c.840
 P  S  S  P  P  P  G  G  A  P  D  G  |  S  E  P  S  P  D  F  P      p.280

          .         .         .         .         .         .       g.13873
 GCGCTGCTGGTGGAGAAGCTGCTTCAGGAACACTTGGAAGAGCAGGAGGTTGCGCCCCCA       c.900
 A  L  L  V  E  K  L  L  Q  E  H  L  E  E  Q  E  V  A  P  P         p.300

   | 08      .         .         .         .         .         .    g.14083
 G | CGCTGCCGCCTAAACCCCCCAAGGCAAAGCCGGCCCCCACAGTCCTGGCCAATGGAGGG    c.960
 A |   L  P  P  K  P  P  K  A  K  P  A  P  T  V  L  A  N  G  G      p.320

          .         .         .         .         . | 09       .    g.14240
 AGCCCACCCTCCCTGCAGGATGCTGAGTGGTACTGGGGGGACATTTCAAG | GGAGGAGGTG    c.1020
 S  P  P  S  L  Q  D  A  E  W  Y  W  G  D  I  S  R  |  E  E  V      p.340

          .         .         .         .         .         .       g.14300
 AACGAGAAACTCCGGGACACTCCCGATGGCACCTTCCTAGTCCGAGATGCTTCTAGCAAG       c.1080
 N  E  K  L  R  D  T  P  D  G  T  F  L  V  R  D  A  S  S  K         p.360

          .         .          | 10        .         .         .    g.14820
 ATCCAGGGCGAGTACACGCTGACCCTCAG | GAAAGGCGGGAACAATAAGCTGATCAAGGTC    c.1140
 I  Q  G  E  Y  T  L  T  L  R  |  K  G  G  N  N  K  L  I  K  V      p.380

          .         .         .         .         .         .       g.14880
 TTCCACCGAGATGGGCACTATGGCTTCTCAGAGCCACTCACCTTCTGCTCCGTTGTGGAC       c.1200
 F  H  R  D  G  H  Y  G  F  S  E  P  L  T  F  C  S  V  V  D         p.400

          .         .         .         .         .         .       g.14940
 CTCATCAATCACTACCGCCACGAGTCTCTGGCCCAGTACAATGCCAAGCTGGACACACGG       c.1260
 L  I  N  H  Y  R  H  E  S  L  A  Q  Y  N  A  K  L  D  T  R         p.420

          .         .         . | 11       .         .         .    g.15115
 CTCCTCTACCCTGTGTCCAAATACCAGCAG | GACCAGATTGTCAAGGAGGACAGCGTGGAG    c.1320
 L  L  Y  P  V  S  K  Y  Q  Q   | D  Q  I  V  K  E  D  S  V  E      p.440

          .         .         .         .         .         .       g.15175
 GCAGTGGGCGCCCAGCTTAAGGTCTATCACCAGCAGTACCAGGACAAGAGCCGCGAGTAT       c.1380
 A  V  G  A  Q  L  K  V  Y  H  Q  Q  Y  Q  D  K  S  R  E  Y         p.460

          .         .         .       | 12 .         .         .    g.18006
 GACCAGCTTTATGAAGAGTACACACGGACCTCCCAG | GAGCTGCAGATGAAGCGTACTGCA    c.1440
 D  Q  L  Y  E  E  Y  T  R  T  S  Q   | E  L  Q  M  K  R  T  A      p.480

          .         .         .         .         .         .       g.18066
 ATTGAGGCCTTCAATGAGACTATCAAGATCTTTGAAGAGCAGGGCCAGACTCAAGAGAAA       c.1500
 I  E  A  F  N  E  T  I  K  I  F  E  E  Q  G  Q  T  Q  E  K         p.500

          .         .         .         .         .          | 13    g.18953
 TGCAGCAAGGAATACCTGGAGCGCTTCCGGCGTGAGGGCAACGAGAAAGAGATGCAAAG | G    c.1560
 C  S  K  E  Y  L  E  R  F  R  R  E  G  N  E  K  E  M  Q  R  |      p.520

          .         .         .         .         .         .       g.19013
 ATCCTGCTGAACTCCGAGCGGCTCAAGTCCCGCATTGCCGAGATCCATGAGAGCCGCACG       c.1620
 I  L  L  N  S  E  R  L  K  S  R  I  A  E  I  H  E  S  R  T         p.540

          .         .         .         .         .         .       g.19073
 AAGCTGGAGCAGCAGCTGCGGGCCCAGGCCTCGGACAACAGAGAGATCGACAAGCGCATG       c.1680
 K  L  E  Q  Q  L  R  A  Q  A  S  D  N  R  E  I  D  K  R  M         p.560

          .         .         .         .         .       | 14 .    g.20301
 AACAGCCTCAAGCCGGACCTCATGCAGCTGCGCAAGATCCGAGACCAGTACCTCGT | GTGG    c.1740
 N  S  L  K  P  D  L  M  Q  L  R  K  I  R  D  Q  Y  L  V  |  W      p.580

          .         .         .         .         .         .       g.20361
 CTCACCCAGAAAGGCGCCCGGCAGAAGAAAATCAACGAGTGGCTGGGGATTAAAAATGAG       c.1800
 L  T  Q  K  G  A  R  Q  K  K  I  N  E  W  L  G  I  K  N  E         p.600

          | 15         .         .         .         .         .    g.20600
 ACTGAGGA | CCAGTACGCACTCATGGAGGACGAGGACGATCTCCCGCACCACGAGGAACGC    c.1860
 T  E  D  |  Q  Y  A  L  M  E  D  E  D  D  L  P  H  H  E  E  R      p.620

          .         .         .         .         .         .       g.20660
 ACTTGGTACGTGGGCAAGATCAACCGCACGCAGGCAGAGGAGATGCTGAGTGGCAAGCGG       c.1920
 T  W  Y  V  G  K  I  N  R  T  Q  A  E  E  M  L  S  G  K  R         p.640

          .         .         .         .         .          | 16    g.20910
 GATGGCACCTTCCTCATCCGCGAGAGCAGCCAGCGGGGCTGCTACGCCTGCTCCGTGGT | A    c.1980
 D  G  T  F  L  I  R  E  S  S  Q  R  G  C  Y  A  C  S  V  V  |      p.660

          .         .         .         .         .         .       g.20970
 GTGGACGGCGACACCAAGCACTGCGTCATCTACCGCACGGCCACCGGCTTCGGCTTCGCG       c.2040
 V  D  G  D  T  K  H  C  V  I  Y  R  T  A  T  G  F  G  F  A         p.680

          .         .         .         .         .         .       g.21030
 GAGCCCTACAACCTGTACGGGTCGCTGAAGGAGCTGGTGCTGCACTACCAGCACGCCTCG       c.2100
 E  P  Y  N  L  Y  G  S  L  K  E  L  V  L  H  Y  Q  H  A  S         p.700

          .         .         .         .         .         .       g.21090
 CTGGTGCAGCACAACGACGCGCTCACCGTCACCCTGGCGCACCCAGTGCGCGCCCCGGGC       c.2160
 L  V  Q  H  N  D  A  L  T  V  T  L  A  H  P  V  R  A  P  G         p.720

          .         .                                               g.21117
 CCCGGCCCGCCGCCTGCCGCCCGCTGA                                        c.2187
 P  G  P  P  P  A  A  R  X                                          p.728

          .         .         .         .         .         .       g.21177
 gcaccgaggacccgccccaagcagagccgcccctgggcccgtctgcgccggaggctgcgg       c.*60

          .         .         .         .         .         .       g.21237
 cggcgggagccacggaccagaccagccacatccaggggtcctcatttctccggctctggc       c.*120

          .         .         .         .         .         .       g.21297
 tcttgtttggggttctctcaccctctttctctttccttccctcccccattctccagatct       c.*180

          .         .         .         .         .         .       g.21357
 ccctctgtctccttttctctgtctttcttggcccctgtctctctccatgttgggggtcct       c.*240

          .         .         .         .         .         .       g.21417
 aactcccccaccccatatctacgtgtcctccgggcattgccctctccatggctctggtca       c.*300

          .         .         .         .         .         .       g.21477
 ccctgaccctctgccctgcccaccgcaggtcccccggggtcccggaagccccttctggct       c.*360

          .         .         .         .         .         .       g.21537
 gcacctgccatgtttacagagggcccctgggctgcgcggccccagcctgggcaccctgat       c.*420

          .         .         .         .         .         .       g.21597
 ttttaagccatagacctggggtcagggcaggaaggaacttcactctgctgcttccgagaa       c.*480

          .         .         .         .         .         .       g.21657
 cctcggccgtgacattcggggccgggcgggacccgccccacagactccaacttcccctcc       c.*540

          .         .         .         .         .         .       g.21717
 aaaccccgaagtgaaacccgccaccgggttacccccacaagggggccgctgcgagaagtt       c.*600

          .         .         .         .         .         .       g.21777
 cacccacccccgaaaaaataattaaactcgcaggccaggcacggtggctcatgcctgtaa       c.*660

          .         .         .         .         .         .       g.21837
 tcccagcactttgggaggccaagacgggcggatcttttgaggtcgggagttggaggccag       c.*720

          .         .         .         .         .         .       g.21897
 cctggccaaaatggcaaaaccccgcatctactaaaatacaaaaattagccgggcgtggtg       c.*780

          .         .         .         .         .         .       g.21957
 gcggccgcctgtaatcccagctacttgggaggctgaggcgtgagaatctcttgaacccag       c.*840

          .         .         .         .         .         .       g.22017
 gagatggaggttgcagtgagcagagatcgtgccactgcactccagcctgggtaacagagg       c.*900

          .         .         .         .         .         .       g.22077
 gagactcctccgtctcaaaaaaataaataaataaacttgtgagctggccccaacccctcc       c.*960

          .         .         .         .         .         .       g.22137
 taggaatcacagctccccgtactggtgccgccgcagtggccaagttgcgacactgcccac       c.*1020

          .         .         .         .         .         .       g.22197
 ggcccctccctctgatgcagattcagggcttctcttcgatcatgttgggttttgattctg       c.*1080

          .         .         .         .         .         .       g.22257
 tttttccttgactgcaaaaccctctttcctctcctcttttgggacaagagccctggtttt       c.*1140

          .         .         .         .         .         .       g.22317
 ctacgctgcccttggccaccacactgcctgccccacgagctgggaggcaggttttgtacg       c.*1200

          .         .         .                                     g.22356
 gtacgttgttattgatatgatataaaacatcaaacgtcg                            c.*1239

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphoinositide-3-kinase, regulatory subunit 2 (beta) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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