phosphoinositide-3-kinase, regulatory subunit 5 (PIK3R5) - coding DNA reference sequence

(used for variant description)

(last modified July 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001142633.2 in the PIK3R5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_030374.1, covering PIK3R5 transcript NM_001142633.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   tgggcagatg       c.-121

 .         .         .         .         .         .                g.5070
 ctgcggctcgccgcgcggctccagctggggcgcggtggtcccgacggtcacccgaatcgc       c.-61

 .         .         .         .         .       | 02 .             g.59218
 agggagtcgccgctggagaggggctcggcgcccggcggggactgcag | gcgatgacccagg    c.-1

          .         .         .         .         .         .       g.59278
 ATGCAGCCAGGGGCCACGACATGCACGGAGGACCGCATCCAGCATGCCCTGGAACGCTGC       c.60
 M  Q  P  G  A  T  T  C  T  E  D  R  I  Q  H  A  L  E  R  C         p.20

          .         .         .         .    | 03    .         .    g.61555
 CTGCATGGACTCAGCCTCAGCCGCCGCTCCACCTCCTGGTCAG | CTGGGCTGTGTCTGAAC    c.120
 L  H  G  L  S  L  S  R  R  S  T  S  W  S  A |   G  L  C  L  N      p.40

          .         .         .         .         .         .       g.61615
 TGCTGGAGCCTGCAGGAGCTGGTCAGCAGGGACCCGGGCCACTTCCTTATCCTCCTTGAG       c.180
 C  W  S  L  Q  E  L  V  S  R  D  P  G  H  F  L  I  L  L  E         p.60

          .         .     | 04   .         .         .         .    g.65011
 CAGATCCTGCAGAAGACCCGAGAG | GTCCAGGAGAAGGGCACCTACGACCTGCTCACCCCG    c.240
 Q  I  L  Q  K  T  R  E   | V  Q  E  K  G  T  Y  D  L  L  T  P      p.80

          .         .         .    | 05    .         .         .    g.65824
 CTGGCCCTGCTCTTCTATTCCACTGTTCTTTGT | ACACCACACTTCCCACCAGACTCGGAT    c.300
 L  A  L  L  F  Y  S  T  V  L  C   | T  P  H  F  P  P  D  S  D      p.100

          .         .         .         .         .         .       g.65884
 CTCCTTCTGAAGGCAGCCAGCACCTACCACCGGTTCCTGACCTGGCCTGTTCCTTACTGC       c.360
 L  L  L  K  A  A  S  T  Y  H  R  F  L  T  W  P  V  P  Y  C         p.120

          .         .         .         .         .   | 06     .    g.77065
 AGCATCTGCCAGGAGCTGCTCACCTTCATTGATGCTGAACTCAAGGCCCCAG | GGATCTCC    c.420
 S  I  C  Q  E  L  L  T  F  I  D  A  E  L  K  A  P  G |   I  S      p.140

          .         .         .         .         .         .       g.77125
 TACCAGAGACTGGTGAGGGCTGAGCAGGGCCTGCCCATCAGGAGTCACCGCAGCTCCACC       c.480
 Y  Q  R  L  V  R  A  E  Q  G  L  P  I  R  S  H  R  S  S  T         p.160

    | 07     .         .         .         .         .         .    g.79858
 GT | CACCGTGCTGCTGCTGAACCCAGTGGAAGTGCAGGCCGAGTTCCTTGCTGTAGCCAAT    c.540
 V  |  T  V  L  L  L  N  P  V  E  V  Q  A  E  F  L  A  V  A  N      p.180

          .         .         .         .         .         .       g.79918
 AAGCTGAGTACGCCCGGACACTCGCCTCACAGTGCCTACACCACCCTGCTCCTGCACGCC       c.600
 K  L  S  T  P  G  H  S  P  H  S  A  Y  T  T  L  L  L  H  A         p.200

          .         .         .         .         .        | 08.    g.80589
 TTCCAGGCCACCTTTGGGGCCCACTGTGACGTCCCGGGCCTGCACTGCAGGCTACAG | GCC    c.660
 F  Q  A  T  F  G  A  H  C  D  V  P  G  L  H  C  R  L  Q   | A      p.220

          .         .         .         .         .         .       g.80649
 AAGACCCTGGCAGAGCTTGAGGACATCTTCACGGAGACCGCAGAGGCACAGGAGCTGGCA       c.720
 K  T  L  A  E  L  E  D  I  F  T  E  T  A  E  A  Q  E  L  A         p.240

          .         .         .         .         .         .       g.80709
 TCTGGCATCGGGGATGCTGCAGAGGCCCGGCGGTGGCTCAGGACCAAGCTGCAGGCGGTG       c.780
 S  G  I  G  D  A  A  E  A  R  R  W  L  R  T  K  L  Q  A  V         p.260

          .         .         .  | 09      .         .         .    g.81519
 GGAGAAAAAGCTGGCTTCCCTGGGGTGTTAG | ACACTGCAAAACCAGGGAAGCTCCACACC    c.840
 G  E  K  A  G  F  P  G  V  L  D |   T  A  K  P  G  K  L  H  T      p.280

          .         .         .         .         .      | 10  .    g.81826
 ATCCCCATCCCTGTCGCCAGGTGCTACACCTACAGCTGGAGCCAGGACAGCTTTG | ACATC    c.900
 I  P  I  P  V  A  R  C  Y  T  Y  S  W  S  Q  D  S  F  D |   I      p.300

          .         .         .         .         .         .       g.81886
 CTGCAGGAAATCCTGCTCAAGGAACAGGAGCTACTCCAGCCAGGGATCCTGGGAGATGAT       c.960
 L  Q  E  I  L  L  K  E  Q  E  L  L  Q  P  G  I  L  G  D  D         p.320

          .         .         .         .         .         .       g.81946
 GAAGAGGAGGAAGAGGAGGAGGAGGAGGTGGAGGAGGACTTGGAAACTGACGGGCACTGT       c.1020
 E  E  E  E  E  E  E  E  E  V  E  E  D  L  E  T  D  G  H  C         p.340

          .         .         .         .         .         .       g.82006
 GCCGAGAGAGATTCCCTGCTCTCCACCAGCTCTTTGGCGTCCCATGACTCCACCTTGTCC       c.1080
 A  E  R  D  S  L  L  S  T  S  S  L  A  S  H  D  S  T  L  S         p.360

          .         .         .         .         .         .       g.82066
 CTTGCATCCTCCCAGGCCTCGGGGCCGGCCCTCTCGCGCCATCTGCTGACTTCCTTTGTC       c.1140
 L  A  S  S  Q  A  S  G  P  A  L  S  R  H  L  L  T  S  F  V         p.380

          .         .         .         .         .         .       g.82126
 TCAGGCCTCTCTGATGGCATGGACAGCGGCTACGTGGAGGACAGCGAGGAGAGCTCCTCC       c.1200
 S  G  L  S  D  G  M  D  S  G  Y  V  E  D  S  E  E  S  S  S         p.400

          .         .         .         .         .         .       g.82186
 GAGTGGCCTTGGAGGCGTGGCAGCCAGGAACGCCGAGGCCACCGCAGGCCTGGGCAGAAG       c.1260
 E  W  P  W  R  R  G  S  Q  E  R  R  G  H  R  R  P  G  Q  K         p.420

          .         .         .         .         .         .       g.82246
 TTCATCAGGATCTATAAACTCTTCAAGAGCACCAGCCAGCTGGTACTGCGGAGGGACTCT       c.1320
 F  I  R  I  Y  K  L  F  K  S  T  S  Q  L  V  L  R  R  D  S         p.440

          .         .         .         .         .         .       g.82306
 CGGAGCCTGGAGGGCAGCTCGGACACGGCCCTGCCCCTGAGGCGGGCAGGGAGCCTCTGC       c.1380
 R  S  L  E  G  S  S  D  T  A  L  P  L  R  R  A  G  S  L  C         p.460

          .         .         .         .         .         .       g.82366
 AGCCCCCTGGACGAACCAGTATCACCCCCTTCCCGGGCCCAGCGCTCCCGCTCCCTGCCC       c.1440
 S  P  L  D  E  P  V  S  P  P  S  R  A  Q  R  S  R  S  L  P         p.480

          .         .         .         .         .         .       g.82426
 CAGCCCAAACTCGGTACCCAGCTGCCCAGCTGGCTTCTGGCCCCTGCTTCACGCCCCCAG       c.1500
 Q  P  K  L  G  T  Q  L  P  S  W  L  L  A  P  A  S  R  P  Q         p.500

          .         .         .         .         .         .       g.82486
 CGCCGCCGCCCCTTCCTGAGTGGAGATGAGGATCCCAAGGCTTCCACGCTACGTGTTGTG       c.1560
 R  R  R  P  F  L  S  G  D  E  D  P  K  A  S  T  L  R  V  V         p.520

          .         .         .         .         .       | 11 .    g.83033
 GTCTTTGGCTCCGATCGGATTTCAGGGAAGGTGGCTCGGGCGTACAGCAACCTTCG | GCGG    c.1620
 V  F  G  S  D  R  I  S  G  K  V  A  R  A  Y  S  N  L  R  |  R      p.540

          .         .         .         .         .         .       g.83093
 CTGGAGAACAATCGCCCACTCCTCACACGGTTCTTCAAACTTCAGTTCTTCTACGTGCCT       c.1680
 L  E  N  N  R  P  L  L  T  R  F  F  K  L  Q  F  F  Y  V  P         p.560

          .         .         .         .         .         .       g.83153
 GTGAAGCGAAGTCATGGGACCAGCCCTGGTGCCTGTCCACCCCCTCGGAGCCAGACGCCC       c.1740
 V  K  R  S  H  G  T  S  P  G  A  C  P  P  P  R  S  Q  T  P         p.580

          .         .         .          | 12        .         .    g.83512
 TCACCCCCGACAGACTCCCCTAGGCACGCCAGCCCTGGA | GAGCTGGGCACCACCCCATGG    c.1800
 S  P  P  T  D  S  P  R  H  A  S  P  G   | E  L  G  T  T  P  W      p.600

          .         .         .         .         .         .       g.83572
 GAGGAGAGCACCAATGACATCTCCCACTACCTCGGCATGCTGGACCCCTGGTATGAGCGC       c.1860
 E  E  S  T  N  D  I  S  H  Y  L  G  M  L  D  P  W  Y  E  R         p.620

          .         .         .         .      | 13  .         .    g.84122
 AATGTACTGGGCCTCATGCACCTGCCCCCTGAAGTCCTGTGCCAG | CAGTCCCTGAAGGCT    c.1920
 N  V  L  G  L  M  H  L  P  P  E  V  L  C  Q   | Q  S  L  K  A      p.640

          .         .         .         .         .         .       g.84182
 GAAGCCCAGGCCCTGGAGGGCTCCCCAACCCAGCTGCCCATCCTGGCTGACATGCTACTC       c.1980
 E  A  Q  A  L  E  G  S  P  T  Q  L  P  I  L  A  D  M  L  L         p.660

          .         .         .         .         .     | 14   .    g.84396
 TACTACTGCCGCTTTGCCGCCAGACCGGTGCTGCTGCAAGTCTATCAGACCGAG | CTGACC    c.2040
 Y  Y  C  R  F  A  A  R  P  V  L  L  Q  V  Y  Q  T  E   | L  T      p.680

          .         .         .         .         .         .       g.84456
 TTCATCACTGGGGAGAAGACGACAGAGATCTTCATCCACTCCTTGGAGCTGGGTCACTCC       c.2100
 F  I  T  G  E  K  T  T  E  I  F  I  H  S  L  E  L  G  H  S         p.700

          .         .         | 15         .         .         .    g.85961
 GCTGCCACACGTGCCATCAAGGCGTCAG | GTCCTGGCAGCAAGCGGCTGGGCATCGATGGC    c.2160
 A  A  T  R  A  I  K  A  S  G |   P  G  S  K  R  L  G  I  D  G      p.720

          .         .         .         .      | 16  .         .    g.88846
 GACCGGGAGGCTGTTCCTCTAACACTACAGATTATTTACAGCAAG | GGGGCCATCAGTGGA    c.2220
 D  R  E  A  V  P  L  T  L  Q  I  I  Y  S  K   | G  A  I  S  G      p.740

          .         .         .         .         .         .       g.88906
 CGAAGTCGCTGGAGCAACCTGGAGAAGGTCTGTACCTCCGTGAACCTCAACAAGGCCTGC       c.2280
 R  S  R  W  S  N  L  E  K  V  C  T  S  V  N  L  N  K  A  C         p.760

          .          | 17        .         .         .         .    g.89041
 CGGAAGCAGGAGGAGCTGG | ATTCCAGCATGGAGGCCCTGACGCTAAACCTGACAGAAGTG    c.2340
 R  K  Q  E  E  L  D |   S  S  M  E  A  L  T  L  N  L  T  E  V      p.780

          .         .         .         .   | 18     .         .    g.89713
 GTGAAAAGGCAGAACTCCAAATCCAAGAAGGGCTTTAACCAG | ATTAGCACATCGCAGATC    c.2400
 V  K  R  Q  N  S  K  S  K  K  G  F  N  Q   | I  S  T  S  Q  I      p.800

          .         .         .         .         .         .       g.89773
 AAAGTGGACAAGGTGCAGATCATCGGCTCCAACAGCTGCCCCTTTGCTGTGTGCCTGGAC       c.2460
 K  V  D  K  V  Q  I  I  G  S  N  S  C  P  F  A  V  C  L  D         p.820

          .         .         .      | 19  .         .         .    g.89951
 CAGGATGAGAGAAAGATCCTGCAGAGTGTAGTCAG | ATGTGAGGTCTCACCGTGCTACAAG    c.2520
 Q  D  E  R  K  I  L  Q  S  V  V  R  |  C  E  V  S  P  C  Y  K      p.840

          .         .         .         .         .         .       g.90011
 CCAGAGAAGAGCGACCTCTCCTCACCACCCCAGACGCCTCCTGACCTGCCGGCCCAGGCC       c.2580
 P  E  K  S  D  L  S  S  P  P  Q  T  P  P  D  L  P  A  Q  A         p.860

          .         .         .         .         .         .       g.90071
 GCACCTGATCTCTGCTCCCTTCTCTGCCTGCCCATCATGACTTTCAGTGGAGCTCTGCCC       c.2640
 A  P  D  L  C  S  L  L  C  L  P  I  M  T  F  S  G  A  L  P         p.880

                                                                    g.90074
 TAG                                                                c.2643
 X                                                                  p.880

          .         .         .         .         .         .       g.90134
 tgtgggcccagcgccagactggacagaagccctggggcaacctcctcggccacccctcca       c.*60

          .         .         .         .         .         .       g.90194
 ggacagtccctctctgtggagaactgaatggccctgtgcagagccatagtcccactgtgg       c.*120

          .         .         .         .         .         .       g.90254
 gtcctgcaatgagcaggggctgggagtagagggtttctggggcctcagggttctgggaaa       c.*180

          .         .         .         .         .         .       g.90314
 gcaacagctatcagagagagaagggccagaccccatagcctcttagattcctggcagtag       c.*240

          .         .         .         .         .         .       g.90374
 aaggagaaggatgggtaaattgacctctgaagtccctgaccattagcatggtctaggatc       c.*300

          .         .         .         .         .         .       g.90434
 ctttctagaaggaagatctgaggctctggtgctcagggggatggcttgggccttttctct       c.*360

          .         .         .         .         .         .       g.90494
 caaccttggctgagcctaccccttactttgccaaagacttgaggaccctgtatgtctgga       c.*420

          .         .         .         .         .         .       g.90554
 gttcagtcccctcctctgtggggctcaggtgattgaaatgtggatgaaacatttctctac       c.*480

          .         .         .         .         .         .       g.90614
 ttcaagaccacctctccctgcaaacaccacacacacatggcatgcatgtacgcacatgcg       c.*540

          .         .         .         .         .         .       g.90674
 cacacacacacgcacacacctcaataatttctctcaagtttcctgagtctccagaaaaac       c.*600

          .         .         .         .         .         .       g.90734
 agcactaacgctggacctgtctactctcagaacccggcacagattctctcttgatctcct       c.*660

          .         .         .         .         .         .       g.90794
 tttggaatctgagattcttagaagacaggatagggttaaatttagtagcagctcagttct       c.*720

          .         .         .         .         .         .       g.90854
 agctaaatcactagaggaagttaattaactttaagccttcatttctccagcactaaaatg       c.*780

          .         .         .         .         .         .       g.90914
 gagtggagagttggggtggaaataagacatccttaaaaggttaaattgtctgcaaagcac       c.*840

          .         .         .         .         .         .       g.90974
 ctagcccagtgccgagctcccagtaggtgttcagtaaagcttagtgcctgactttctgaa       c.*900

          .         .         .         .         .         .       g.91034
 cactgattcctcctgtttggagtcactgggatactctcattgccgttgggatgttcctca       c.*960

          .         .         .         .         .         .       g.91094
 ctccttcccagttcgtggctgaggcagaacccagactgaagagggaagagacattccaga       c.*1020

          .         .         .         .         .         .       g.91154
 ggaggattgccttcgtcagggtaaggggtgggctgctcaggggccctacccttcaccccc       c.*1080

          .         .         .         .         .         .       g.91214
 ttctgtatcagattggccctcccactcccatctcactctgcgtgtacaatcttccatatc       c.*1140

          .         .         .         .         .         .       g.91274
 cgcaagttcactggcactcttctggcacctgggcaagatcccagaacagaggatggagtg       c.*1200

          .         .         .         .         .         .       g.91334
 actggcctcacagagcttagtgcccgactcaggggaaatgggactggtgcatgggaaatg       c.*1260

          .         .         .         .         .         .       g.91394
 gtcagcctaggataggacacgagagtctgaaattcaaagcaaccagcttgaagtggtttg       c.*1320

          .         .         .         .         .         .       g.91454
 agaagctggaagcaaacatgggctagagagatagggcagaagtcaagacgaggatctgga       c.*1380

          .         .         .         .         .         .       g.91514
 ctgatgtggagaaagtagccacggaagcatgaactgtatcctgcacaaagtccctcttcc       c.*1440

          .         .         .         .         .         .       g.91574
 ccgcctcctaattcattatgcccaaaaggccttacgtgaaattccagcccagagtactca       c.*1500

          .         .         .         .         .         .       g.91634
 tgacttgagagacgtggacagagccagcttctaccttgcctggccgtctctcccctgtct       c.*1560

          .         .         .         .         .         .       g.91694
 taatgtctgctcttgctctaagctccagaagagtggcgggccatgtatcttcaatatgtt       c.*1620

          .         .         .         .         .         .       g.91754
 tttgctgtatgggcaggttgtcttattatgtgatcaacagatgtccaggaactaatgagt       c.*1680

          .         .         .         .                           g.91797
 ggaatttaatattattgtcaaataaaacttgatttgtcctata                        c.*1723

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphoinositide-3-kinase, regulatory subunit 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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