protein kinase domain containing, cytoplasmic (PKDCC) - coding DNA reference sequence

(used for variant description)

(last modified July 31, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_138370.2 in the PKDCC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering PKDCC transcript NM_138370.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5059
  aggcaagtgtcaggccgatgtgtcgcccgcgaggggccggggtcggggccgccggggcc       c.-121

 .         .         .         .         .         .                g.5119
 atgcgcgcgggctgggcagggggccggcggggcgcagagcggagccgcctcggagcctga       c.-61

 .         .         .         .         .         .                g.5179
 gccgcccggggccggggccggggagccgcgcggggccggccggccggggggaggggagcg       c.-1

          .         .         .         .         .         .       g.5239
 ATGCGGCGCCGGCGGGCGGCAGTGGCCGCGGGTTTCTGCGCCTCCTTCCTGCTGGGCTCC       c.60
 M  R  R  R  R  A  A  V  A  A  G  F  C  A  S  F  L  L  G  S         p.20

          .         .         .         .         .         .       g.5299
 GTCCTCAACGTGCTCTTCGCTCCGGGCTCGGAGCCTCCGAGGCCAGGCCAGTCCCCTGAG       c.120
 V  L  N  V  L  F  A  P  G  S  E  P  P  R  P  G  Q  S  P  E         p.40

          .         .         .         .         .         .       g.5359
 CCTTCGCCGGCCCCGGGTCCGGGCCGTCGCGGGGGCCGCGGGGAGCTGGCCCGGCAGATC       c.180
 P  S  P  A  P  G  P  G  R  R  G  G  R  G  E  L  A  R  Q  I         p.60

          .         .         .         .         .         .       g.5419
 CGGGCGCGCTACGAGGAGGTGCAGCGCTATTCCCGCGGGGGCCCCGGGCCCGGGGCGGGC       c.240
 R  A  R  Y  E  E  V  Q  R  Y  S  R  G  G  P  G  P  G  A  G         p.80

          .         .         .         .         .         .       g.5479
 CGGCCGGAGCGGCGGCGCCTGATGGACCTGGCTCCGGGCGGGCCCGGCCTGCCGCGCCCC       c.300
 R  P  E  R  R  R  L  M  D  L  A  P  G  G  P  G  L  P  R  P         p.100

          .         .         .         .         .         .       g.5539
 CGGCCCCCTTGGGCCCGGCCCCTGTCCGACGGCGCCCCAGGCTGGCCCCCGGCTCCCGGC       c.360
 R  P  P  W  A  R  P  L  S  D  G  A  P  G  W  P  P  A  P  G         p.120

          .         .         .         .         .         .       g.5599
 CCAGGCTCCCCCGGCCCGGGCCCGCGCCTGGGCTGCGCCGCGCTTCGCAACGTGTCCGGC       c.420
 P  G  S  P  G  P  G  P  R  L  G  C  A  A  L  R  N  V  S  G         p.140

          .         .         .         .         .         .       g.5659
 GCGCAGTACATGGGCTCAGGCTACACCAAGGCCGTGTACCGGGTCCGCCTGCCCGGCGGT       c.480
 A  Q  Y  M  G  S  G  Y  T  K  A  V  Y  R  V  R  L  P  G  G         p.160

          .         .         .         .         .         .       g.5719
 GCCGCGGTGGCGCTCAAGGCGGTGGACTTTAGCGGCCACGATCTGGGCAGCTGCGTGCGC       c.540
 A  A  V  A  L  K  A  V  D  F  S  G  H  D  L  G  S  C  V  R         p.180

          .         .         .         .         .         .       g.5779
 GAGTTCGGGGTACGGAGGGGCTGCTATCGGCTGGCGGCCCACAAGCTGCTTAAGGAGATG       c.600
 E  F  G  V  R  R  G  C  Y  R  L  A  A  H  K  L  L  K  E  M         p.200

          .         .         .          | 02        .         .    g.10239
 GTGCTGCTGGAGCGGCTGCGGCACCCCAACGTGCTGCAG | CTCTATGGCTACTGCTACCAG    c.660
 V  L  L  E  R  L  R  H  P  N  V  L  Q   | L  Y  G  Y  C  Y  Q      p.220

          .         .         .         .         .         .       g.10299
 GACAGCGAGGACATCCCAGACACCCTGACCACCATCACGGAGCTGGGCGCCCCTGTAGAA       c.720
 D  S  E  D  I  P  D  T  L  T  T  I  T  E  L  G  A  P  V  E         p.240

          .         .         .         .   | 03     .         .    g.11033
 ATGATCCAGCTGCTGCAAACTTCCTGGGAGGATCGATTCCGA | ATCTGCCTGAGCCTGGGC    c.780
 M  I  Q  L  L  Q  T  S  W  E  D  R  F  R   | I  C  L  S  L  G      p.260

          .         .         .         .         .         .       g.11093
 CGCCTCCTCCACCACCTGGCCCACTCCCCACTGGGCTCCGTCACTCTGCTGGACTTCCGC       c.840
 R  L  L  H  H  L  A  H  S  P  L  G  S  V  T  L  L  D  F  R         p.280

          .         .         .         .         .         .       g.11153
 CCTCGGCAGTTTGTGCTGGTGGATGGGGAGCTCAAAGTGACGGACCTGGATGACGCACGT       c.900
 P  R  Q  F  V  L  V  D  G  E  L  K  V  T  D  L  D  D  A  R         p.300

          .         .         .         .         .         .       g.11213
 GTGGAGGAGACGCCGTGTGCAGGCAGCACCGACTGCATACTCGAGTTTCCGGCCAGGAAC       c.960
 V  E  E  T  P  C  A  G  S  T  D  C  I  L  E  F  P  A  R  N         p.320

          .         .         .         .         .         .       g.11273
 TTCACCCTGCCCTGCTCAGCCCAGGGCTGGTGCGAGGGCATGAACGAGAAGCGGAACCTC       c.1020
 F  T  L  P  C  S  A  Q  G  W  C  E  G  M  N  E  K  R  N  L         p.340

          .     | 04   .         .         .         .         .    g.11966
 TATAATGCCTACAG | GTTTTTCTTCACATACCTCCTGCCTCACAGTGCCCCGCCTTCACTG    c.1080
 Y  N  A  Y  R  |  F  F  F  T  Y  L  L  P  H  S  A  P  P  S  L      p.360

          .         .         .     | 05   .         .         .    g.12291
 CGTCCTCTGCTGGACAGCATCGTCAACGCCACAG | GAGAGCTCGCCTGGGGGGTGGACGAG    c.1140
 R  P  L  L  D  S  I  V  N  A  T  G |   E  L  A  W  G  V  D  E      p.380

          .         .         .         .         .         .       g.12351
 ACCCTGGCCCAGCTGGAGAAGGTGCTGCACCTGTACCGGAGCGGGCAGTATCTGCAGAAC       c.1200
 T  L  A  Q  L  E  K  V  L  H  L  Y  R  S  G  Q  Y  L  Q  N         p.400

          .         .   | 06     .         .         .         .    g.14238
 TCCACGGCAAGCAGCAGTACCG | AGTACCAGTGTATCCCAGACAGCACCATCCCCCAGGAA    c.1260
 S  T  A  S  S  S  T  E |   Y  Q  C  I  P  D  S  T  I  P  Q  E      p.420

          .         .         .         .         .         .       g.14298
 GACTACCGCTGCTGGCCATCCTACCACCACGGGAGCTGCCTCCTTTCAGTGTTCAACCTG       c.1320
 D  Y  R  C  W  P  S  Y  H  H  G  S  C  L  L  S  V  F  N  L         p.440

          .         .         .         .         .         .       g.14358
 GCTGAGGCTGTGGATGTCTGTGAGAGCCATGCCCAGTGTCGGGCCTTTGTGGTCACCAAC       c.1380
 A  E  A  V  D  V  C  E  S  H  A  Q  C  R  A  F  V  V  T  N         p.460

          .       | 07 .         .         .         .         .    g.14626
 CAGACCACCTGGACAG | GTCGGCAGCTGGTCTTTTTCAAGACTGGATGGAGCCAAGTGGTC    c.1440
 Q  T  T  W  T  G |   R  Q  L  V  F  F  K  T  G  W  S  Q  V  V      p.480

          .         .         .         .                           g.14668
 CCTGATCCCAACAAGACCACATATGTGAAGGCCTCTGGCTGA                         c.1482
 P  D  P  N  K  T  T  Y  V  K  A  S  G  X                           p.493

          .         .         .         .         .         .       g.14728
 cctatctgagggctcggctgaccagctgactatcctcagcagctgggcttgcctgtggag       c.*60

          .         .         .         .         .         .       g.14788
 ggagtgacttgcactggcagcactgcatgtcacctgggaacccctgcagacaaagctaac       c.*120

          .         .         .         .         .         .       g.14848
 atcccagacagacagatgtgaccaggacaaacgtgcaataatgccaaatgttaaaatgtg       c.*180

          .         .         .         .         .         .       g.14908
 agtttaccagcctagctatgggactgctggctcctagtccaggaatcatgggggtatgac       c.*240

          .         .         .         .         .         .       g.14968
 tgcctctccaaccctgtgggctgtaagcaagctcaggctagtctccccactgggggctgt       c.*300

          .         .         .         .         .         .       g.15028
 gcccctccctgggacggttccgtgggcagccccatcactgtgttcaatagtgtgagaatg       c.*360

          .         .         .         .         .         .       g.15088
 tagctaaagcccctgctgctgctgctgcacatgccacagcaggcggtgggggctgcgtgg       c.*420

          .         .         .         .         .         .       g.15148
 ggacaatccatcgtggagtgttctctcagcttaggtctggacaggagacttggcgggaga       c.*480

          .         .         .         .         .         .       g.15208
 tgctccaggatgtgggtgattctgtacctggggaggctatctctgacctcccgacagggg       c.*540

          .         .         .         .         .         .       g.15268
 acactcccaggccagcccaggggtcaggggcagaggtgcacacctcagcatgagccaaga       c.*600

          .         .         .         .         .         .       g.15328
 ctggggtcagggagcaggtgtggtttgagccaggacctggggcgggggtggggccggggc       c.*660

          .         .         .         .         .         .       g.15388
 ctttctgcctcatttgctttcaatgaaagcctcaaagcagccaaaaccaggctttccccc       c.*720

          .         .         .         .         .         .       g.15448
 ttcctcgagtttgaatatccagaatcttttgtacttcttgttggttaaattgtttatttt       c.*780

          .         .         .         .         .         .       g.15508
 tgtaaaaaataaaataaaattagttaataaaatgatgtttcacagcaaactcttccctaa       c.*840

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein kinase domain containing, cytoplasmic protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 29
©2004-2023 Leiden University Medical Center