phospholipase C, beta 4 (PLCB4) - coding DNA reference sequence

(used for variant description)

(last modified February 16, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000933.3 in the PLCB4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000020.10, covering PLCB4 transcript NM_000933.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.243761
                                              gtcttgaatataatc       c.-1

          .         .         .         .         .         .       g.243821
 ATGGCCAAACCTTATGAATTTAACTGGCAGAAGGAAGTTCCCTCCTTTTTGCAAGAAGGA       c.60
 M  A  K  P  Y  E  F  N  W  Q  K  E  V  P  S  F  L  Q  E  G         p.20

          .         .     | 02   .         .         .         .    g.273108
 GCAGTTTTTGACAGATACGAGGAG | GAATCCTTTGTGTTTGAACCCAACTGCCTCTTCAAA    c.120
 A  V  F  D  R  Y  E  E   | E  S  F  V  F  E  P  N  C  L  F  K      p.40

          .         .         .         .      | 03  .         .    g.273969
 GTGGATGAGTTTGGCTTCTTTCTGACATGGAGAAGTGAAGGCAAG | GAAGGACAGGTGCTA    c.180
 V  D  E  F  G  F  F  L  T  W  R  S  E  G  K   | E  G  Q  V  L      p.60

          .         .         .         .      | 04  .         .    g.274855
 GAATGCTCCCTCATCAACAGTATTCGGTCGGGAGCCATACCAAAG | GATCCCAAAATCTTG    c.240
 E  C  S  L  I  N  S  I  R  S  G  A  I  P  K   | D  P  K  I  L      p.80

          .         .         .         .         .         .       g.274915
 GCTGCTCTTGAAGCTGTTGGAAAATCAGAAAATGATCTGGAAGGGCGGATAGTTTGTGTC       c.300
 A  A  L  E  A  V  G  K  S  E  N  D  L  E  G  R  I  V  C  V         p.100

          .         .         .         .         .         .       g.274975
 TGCAGTGGCACAGATCTAGTGAACATTAGTTTTACCTACATGGTGGCTGAAAATCCAGAA       c.360
 C  S  G  T  D  L  V  N  I  S  F  T  Y  M  V  A  E  N  P  E         p.120

           | 05        .         .         .         .         .    g.298893
 GTAACTAAG | CAATGGGTAGAAGGCCTGAGATCAATCATACACAACTTCAGGGCCAACAAC    c.420
 V  T  K   | Q  W  V  E  G  L  R  S  I  I  H  N  F  R  A  N  N      p.140

          .         .          | 06        .         .         .    g.301438
 GTCAGTCCAATGACATGCCTCAAGAAACA | CTGGATGAAATTGGCATTTATGACCAACACA    c.480
 V  S  P  M  T  C  L  K  K  H  |  W  M  K  L  A  F  M  T  N  T      p.160

          .         .    | 07    .         .         .         .    g.307197
 AATGGTAAAATTCCAGTTAGGAG | TATTACTAGAACATTTGCATCGGGAAAAACAGAAAAG    c.540
 N  G  K  I  P  V  R  S  |  I  T  R  T  F  A  S  G  K  T  E  K      p.180

          .         .         .         .      | 08  .         .    g.308264
 GTGATCTTTCAAGCACTCAAGGAGTTAGGTCTTCCCAGTGGAAAG | AATGATGAAATTGAG    c.600
 V  I  F  Q  A  L  K  E  L  G  L  P  S  G  K   | N  D  E  I  E      p.200

          .         .         .         .         .         .       g.308324
 CCCACAGCATTTTCTTATGAAAAGTTCTATGAACTGACACAAAAGATTTGTCCTCGGACA       c.660
 P  T  A  F  S  Y  E  K  F  Y  E  L  T  Q  K  I  C  P  R  T         p.220

          .         .       | 09 .         .         .         .    g.309027
 GATATAGAAGATCTTTTCAAAAAAAT | CAATGGAGACAAAACTGATTATTTAACGGTAGAC    c.720
 D  I  E  D  L  F  K  K  I  |  N  G  D  K  T  D  Y  L  T  V  D      p.240

          .         .     | 10   .         .         .         .    g.316036
 CAATTAGTGAGCTTTCTAAATGAA | CATCAACGAGATCCTCGATTGAATGAAATTTTATTT    c.780
 Q  L  V  S  F  L  N  E   | H  Q  R  D  P  R  L  N  E  I  L  F      p.260

          .         .         .         .         .         .       g.316096
 CCATTTTATGATGCCAAAAGGGCAATGCAGATCATTGAGATGTATGAACCTGATGAAGAT       c.840
 P  F  Y  D  A  K  R  A  M  Q  I  I  E  M  Y  E  P  D  E  D         p.280

          .    | 11    .         .         .         .         .    g.320194
 TTGAAGAAAAAAG | GCCTTATATCAAGTGATGGGTTTTGCAGATATCTGATGTCAGATGAA    c.900
 L  K  K  K  G |   L  I  S  S  D  G  F  C  R  Y  L  M  S  D  E      p.300

          .         .         .         .         .         .       g.320254
 AACGCCCCAGTCTTCCTAGATCGTTTAGAACTTTACCAAGAAATGGACCATCCTCTGGCT       c.960
 N  A  P  V  F  L  D  R  L  E  L  Y  Q  E  M  D  H  P  L  A         p.320

          .         .         .         .         .         .       g.320314
 CACTACTTCATCAGTTCTTCCCATAACACTTATCTCACTGGCAGACAGTTCGGCGGGAAG       c.1020
 H  Y  F  I  S  S  S  H  N  T  Y  L  T  G  R  Q  F  G  G  K         p.340

          .         .         .         .     | 12   .         .    g.323425
 TCTTCGGTAGAAATGTACAGACAGGTTCTCCTGGCTGGTTGCAG | ATGTGTTGAACTTGAC    c.1080
 S  S  V  E  M  Y  R  Q  V  L  L  A  G  C  R  |  C  V  E  L  D      p.360

          .         .         .         .         .         .       g.323485
 TGCTGGGATGGAAAAGGTGAAGACCAAGAACCAATAATAACTCATGGAAAAGCAATGTGT       c.1140
 C  W  D  G  K  G  E  D  Q  E  P  I  I  T  H  G  K  A  M  C         p.380

          .         | 13         .         .         .         .    g.325867
 ACAGATATCCTTTTTAAG | GATGTAATTCAAGCCATCAAGGAAACTGCATTTGTCACATCA    c.1200
 T  D  I  L  F  K   | D  V  I  Q  A  I  K  E  T  A  F  V  T  S      p.400

          .         .         .         | 14         .         .    g.326499
 GAATATCCTGTAATTCTCTCCTTTGAAAATCACTGCAG | CAAATATCAACAGTACAAGATG    c.1260
 E  Y  P  V  I  L  S  F  E  N  H  C  S  |  K  Y  Q  Q  Y  K  M      p.420

          .         .         .         .         .         .       g.326559
 TCCAAATATTGCGAAGATCTATTTGGGGATCTCCTGTTGAAACAAGCACTTGAATCACAT       c.1320
 S  K  Y  C  E  D  L  F  G  D  L  L  L  K  Q  A  L  E  S  H         p.440

     | 15    .         .         .         .         .         .    g.329591
 CCA | CTTGAACCAGGCAGGGCTTTGCCATCCCCCAATGACCTCAAAAGAAAAATACTCATA    c.1380
 P   | L  E  P  G  R  A  L  P  S  P  N  D  L  K  R  K  I  L  I      p.460

          .         .         .     | 16   .         .         .    g.331495
 AAAAACAAGCGGCTGAAACCTGAAGTTGAAAAAA | AACAGCTGGAAGCTTTGAGAAGCATG    c.1440
 K  N  K  R  L  K  P  E  V  E  K  K |   Q  L  E  A  L  R  S  M      p.480

          .         .         .         .         .         .       g.331555
 ATGGAAGCTGGAGAATCTGCCTCCCCAGCAAACATCTTAGAGGACGATAATGAAGAGGAG       c.1500
 M  E  A  G  E  S  A  S  P  A  N  I  L  E  D  D  N  E  E  E         p.500

          . | 17       .         .         .         .         .    g.337486
 ATCGAAAGTG | CTGACCAAGAGGAGGAAGCTCACCCCGAATTCAAATTTGGAAATGAACTT    c.1560
 I  E  S  A |   D  Q  E  E  E  A  H  P  E  F  K  F  G  N  E  L      p.520

          .         .         .         .         .  | 18      .    g.343872
 TCTGCTGATGACTTGGGTCACAAGGAAGCTGTTGCAAATAGCGTCAAGAAG | GGCCTGGTC    c.1620
 S  A  D  D  L  G  H  K  E  A  V  A  N  S  V  K  K   | G  L  V      p.540

          .         .         .         .         .         .       g.343932
 ACTGTAGAAGATGAGCAGGCGTGGATGGCATCTTATAAATATGTAGGTGCTACCACTAAT       c.1680
 T  V  E  D  E  Q  A  W  M  A  S  Y  K  Y  V  G  A  T  T  N         p.560

          .         .         .         .         .         .       g.343992
 ATCCATCCATATTTGTCCACAATGATCAACTACGCCCAGCCTGTAAAGTTTCAAGGTTTC       c.1740
 I  H  P  Y  L  S  T  M  I  N  Y  A  Q  P  V  K  F  Q  G  F         p.580

          .    | 19    .         .         .         .         .    g.344626
 CATGTGGCAGAAG | AACGCAATATTCATTATAACATGTCTTCTTTTAATGAATCAGTCGGT    c.1800
 H  V  A  E  E |   R  N  I  H  Y  N  M  S  S  F  N  E  S  V  G      p.600

          .         .         .         | 20         .         .    g.345025
 CTTGGCTACTTGAAGACACATGCAATTGAATTTGTCAA | TTATAACAAACGGCAAATGAGT    c.1860
 L  G  Y  L  K  T  H  A  I  E  F  V  N  |  Y  N  K  R  Q  M  S      p.620

          .         .         .         .         .         .       g.345085
 CGCATTTACCCCAAGGGAGGCCGAGTCGATTCCAGTAATTACATGCCTCAGATTTTCTGG       c.1920
 R  I  Y  P  K  G  G  R  V  D  S  S  N  Y  M  P  Q  I  F  W         p.640

          .         .         .         .    | 21    .         .    g.347000
 AACGCTGGCTGCCAGATGGTTTCACTGAACTATCAAACCCCAG | ATTTAGCGATGCAATTG    c.1980
 N  A  G  C  Q  M  V  S  L  N  Y  Q  T  P  D |   L  A  M  Q  L      p.660

          .         .         .      | 22  .         .         .    g.355778
 AATCAGGGAAAATTTGAGTATAATGGATCGTGCGG | GTACCTTCTCAAACCAGATTTCATG    c.2040
 N  Q  G  K  F  E  Y  N  G  S  C  G  |  Y  L  L  K  P  D  F  M      p.680

          .         .         .         .         .         .       g.355838
 AGGCGGCCTGATCGAACATTTGACCCCTTCTCTGAAACTCCTGTTGATGGTGTTATTGCA       c.2100
 R  R  P  D  R  T  F  D  P  F  S  E  T  P  V  D  G  V  I  A         p.700

          .         | 23         .         .         .         .    g.357285
 GCCACTTGCTCAGTGCAG | GTTATATCAGGTCAATTCTTATCAGATAAGAAAATTGGCACC    c.2160
 A  T  C  S  V  Q   | V  I  S  G  Q  F  L  S  D  K  K  I  G  T      p.720

          .         .         .         .         .         .       g.357345
 TACGTAGAGGTGGATATGTATGGGTTGCCCACTGACACCATACGTAAGGAATTCCGAACT       c.2220
 Y  V  E  V  D  M  Y  G  L  P  T  D  T  I  R  K  E  F  R  T         p.740

          .         .         .         .         .         .       g.357405
 CGCATGGTTATGAATAATGGACTCAATCCAGTTTACAATGAAGAGTCATTTGTATTTCGG       c.2280
 R  M  V  M  N  N  G  L  N  P  V  Y  N  E  E  S  F  V  F  R         p.760

     | 24    .         .         .         .         .         .    g.359751
 AAG | GTGATCCTGCCGGACCTGGCTGTCTTGAGAATAGCTGTGTATGATGATAACAACAAG    c.2340
 K   | V  I  L  P  D  L  A  V  L  R  I  A  V  Y  D  D  N  N  K      p.780

          .         .         .         .         .         .       g.359811
 CTGATTGGCCAGAGGATCCTCCCGCTTGATGGCCTCCAAGCCGGATATCGACACATTTCC       c.2400
 L  I  G  Q  R  I  L  P  L  D  G  L  Q  A  G  Y  R  H  I  S         p.800

          .         .         .         .         .         .       g.359871
 CTTCGAAATGAGGGAAATAAACCATTATCACTACCAACAATTTTCTGCAATATTGTTCTT       c.2460
 L  R  N  E  G  N  K  P  L  S  L  P  T  I  F  C  N  I  V  L         p.820

          .         .         | 25         .         .         .    g.371538
 AAAACATATGTGCCTGATGGATTTGGAG | ATATCGTGGATGCTTTATCAGATCCAAAGAAA    c.2520
 K  T  Y  V  P  D  G  F  G  D |   I  V  D  A  L  S  D  P  K  K      p.840

          .         .         .         .         .        | 26.    g.372951
 TTTCTCTCAATTACAGAAAAGAGAGCAGACCAAATGAGAGCTATGGGCATTGAAACT | AGT    c.2580
 F  L  S  I  T  E  K  R  A  D  Q  M  R  A  M  G  I  E  T   | S      p.860

          .         .         .         .         .         .       g.373011
 GACATAGCCGACGTGCCCAGTGACACTTCCAAAAATGACAAGAAAGGAAAGGCCAACACC       c.2640
 D  I  A  D  V  P  S  D  T  S  K  N  D  K  K  G  K  A  N  T         p.880

          .         .         .         .         .         .       g.373071
 GCCAAAGCAAATGTGACCCCTCAGAGTAGCTCTGAGCTCAGACCAACCACCACGGCTGCC       c.2700
 A  K  A  N  V  T  P  Q  S  S  S  E  L  R  P  T  T  T  A  A         p.900

          .         .         | 27         .         .         .    g.379959
 CTGGCCTCTGGTGTGGAAGCCAAGAAAG | GTATTGAACTTATCCCTCAAGTAAGGATAGAA    c.2760
 L  A  S  G  V  E  A  K  K  G |   I  E  L  I  P  Q  V  R  I  E      p.920

          .         | 28         .         .         .         .    g.380166
 GACTTAAAGCAGATGAAG | GCTTACTTGAAGCATTTAAAGAAACAGCAGAAGGAGCTAAAT    c.2820
 D  L  K  Q  M  K   | A  Y  L  K  H  L  K  K  Q  Q  K  E  L  N      p.940

          .         .     | 29   .         .         .         .    g.389329
 TCTTTAAAGAAGAAACATGCAAAG | GAACACAGTACCATGCAGAAGTTACACTGCACGCAA    c.2880
 S  L  K  K  K  H  A  K   | E  H  S  T  M  Q  K  L  H  C  T  Q      p.960

          .         .         .         .         .         .       g.389389
 GTTGACAAAATTGTGGCACAGTATGACAAAGAGAAGTCGACTCATGAGAAAATCCTAGAG       c.2940
 V  D  K  I  V  A  Q  Y  D  K  E  K  S  T  H  E  K  I  L  E         p.980

          .         . | 30       .         .         .         .    g.393400
 AAGGCAATGAAGAAGAAGGG | GGGAAGTAATTGTCTCGAAATGAAAAAAGAAACAGAAATC    c.3000
 K  A  M  K  K  K  G  |  G  S  N  C  L  E  M  K  K  E  T  E  I      p.1000

          .         .         .       | 31 .         .         .    g.395605
 AAAATTCAGACGCTGACATCAGATCACAAATCTAAG | GTCAAAGAGATTGTAGCACAGCAC    c.3060
 K  I  Q  T  L  T  S  D  H  K  S  K   | V  K  E  I  V  A  Q  H      p.1020

          .         .         .         .         .         .       g.395665
 ACAAAGGAATGGTCAGAAATGATCAATACCCACAGTGCTGAGGAGCAAGAAATCCGAGAC       c.3120
 T  K  E  W  S  E  M  I  N  T  H  S  A  E  E  Q  E  I  R  D         p.1040

          .         .         .         .         .         .       g.395725
 CTGCACCTCAGCCAGCAGTGTGAGCTGCTGAAAAAGCTACTCATCAATGCCCACGAGCAG       c.3180
 L  H  L  S  Q  Q  C  E  L  L  K  K  L  L  I  N  A  H  E  Q         p.1060

          .         .         .   | 32     .         .         .    g.404545
 CAAACCCAGCAGCTGAAACTGTCCCATGACAG | GGAAAGCAAGGAAATGCGAGCACACCAG    c.3240
 Q  T  Q  Q  L  K  L  S  H  D  R  |  E  S  K  E  M  R  A  H  Q      p.1080

          .         .         .         .         .         .       g.404605
 GCTAAGATTTCTATGGAAAATAGCAAAGCCATCAGCCAAGATAAATCTATCAAGAATAAA       c.3300
 A  K  I  S  M  E  N  S  K  A  I  S  Q  D  K  S  I  K  N  K         p.1100

          .     | 33   .         .         .         .         .    g.408782
 GCAGAACGGGAAAG | GCGAGTCAGGGAGTTAAACAGCAGCAACACTAAAAAGTTTCTGGAA    c.3360
 A  E  R  E  R  |  R  V  R  E  L  N  S  S  N  T  K  K  F  L  E      p.1120

          .   | 34     .         .         .         .         .    g.409273
 GAAAGAAAGAGA | CTTGCCATGAAGCAGTCCAAAGAAATGGATCAGTTGAAAAAAGTCCAG    c.3420
 E  R  K  R   | L  A  M  K  Q  S  K  E  M  D  Q  L  K  K  V  Q      p.1140

          .         .         .          | 35        .         .    g.412684
 CTTGAACATCTAGAATTCCTAGAGAAACAGAATGAGCAG | CTTTTGAAATCCTGTCATGCA    c.3480
 L  E  H  L  E  F  L  E  K  Q  N  E  Q   | L  L  K  S  C  H  A      p.1160

          .       | 36 .         .         .         .         .    g.414911
 GTGTCCCAAACGCAAG | GCGAAGGAGATGCAGCAGATGGTGAAATTGGAAGCCGAGATGGA    c.3540
 V  S  Q  T  Q  G |   E  G  D  A  A  D  G  E  I  G  S  R  D  G      p.1180

          .         .         .         .                           g.414956
 CCGCAGACCAGCAACAGTAGTATGAAACTCCAAAATGCAAACTGA                      c.3585
 P  Q  T  S  N  S  S  M  K  L  Q  N  A  N  X                        p.1194

          .         .         .         .         .         .       g.415016
 agcagcaaacccacaaagcatcaaaagactcactcacaaacttctgaacacaaactccat       c.*60

          .         .         .         .         .         .       g.415076
 ggatgaaagctgtttattttgtttcctttatgtgtaaacaagatgatatctgaaaccaga       c.*120

          .         .         .         .         .         .       g.415136
 gagacttggaatgtctgactgacttctatttaacagcttgagtattgcatttccttggcc       c.*180

          .         .         .         .         .         .       g.415196
 aaacaaaaatagctacaaatccacaaaaatttactattccagtaaggcagagtccaacca       c.*240

          .         .         .         .         .         .       g.415256
 ttgataatacaacttaaacatgtttgctataaaataccatcacaagtaaatgagcttggt       c.*300

          .         .         .         .         .         .       g.415316
 gtgaacaactctcctttgtgatgccttaggacatgtttgaactgcagcaaaaaacaaaaa       c.*360

          .         .         .         .         .         .       g.415376
 caaaaaacagtgcattagcaatttcatagcaagtgcatgcactaggaaaagaaaactctg       c.*420

          .         .         .         .         .         .       g.415436
 tctacaagtttattagcagaagtggtggtctgctagacaaataattttgcaaaatttttc       c.*480

          .         .         .         .         .         .       g.415496
 tacatctaagttacctcatcagtaagtgccatgtctctaccatgccatcagaggctaatt       c.*540

          .         .         .         .         .         .       g.415556
 tcctgtaaaagttgtggaaattgttagaacaatagaaaaatagagcagtgtatgtgtgcc       c.*600

          .         .         .         .         .         .       g.415616
 aaaactcatcattactcaaaggagaactgtgttaggcacatttaagaaagtttacatctg       c.*660

          .         .         .         .         .         .       g.415676
 acattgctttataggaattgtttctgcagattccggatattataattcacaccataaaga       c.*720

          .         .         .         .         .         .       g.415736
 ttgtgaagtggttattggcaaacgtttgtaaatgtgaccatgtataaagtatttatactc       c.*780

          .         .         .         .         .         .       g.415796
 tttaattcacactgttagagagcaaaatcatctaagtattgccacatgacaagattagta       c.*840

          .         .         .         .         .         .       g.415856
 aacaggaatactagaactatgtttgcatgatacacaagcaccaataaagactaatccata       c.*900

          .         .         .         .         .         .       g.415916
 cacagttaacctaatgccaaataaatactggttaaataaatgtatggcacagaatataat       c.*960

          .         .         .         .         .         .       g.415976
 ttgactatcaagacttttagcataatgaaaaaccctctctctatatatatatgtgtatat       c.*1020

          .         .         .         .         .         .       g.416036
 gaattatgtgggcattcttgatacttcaagttctagtttgaaaaaaatacataactaatt       c.*1080

          .         .         .         .         .         .       g.416096
 taattttacacaaaaatatttatgcagattttcagaatttcatatcaggaaatgaccttt       c.*1140

          .         .         .         .         .         .       g.416156
 ttatgtctgttaaatatcaaaacaatttgctacagtgttaatctgcatggtctttaagcc       c.*1200

          .         .         .         .         .         .       g.416216
 tgctgtagttgagttgcagacagtgcatgaaaaagtattccgctgggaattgagccatgc       c.*1260

          .         .         .         .         .         .       g.416276
 caccaaagccaagaggagcgcatggaaacccggtagtctagaactaatcagattactgat       c.*1320

          .         .         .         .         .         .       g.416336
 tttagggcacagcaccagatgaattgttgtatatgcttgtaaaaattgattctgtgtgtt       c.*1380

          .         .         .         .         .         .       g.416396
 cctctgaacaaagcggagaaaatgatgataccatcaatattgaaattaaacttccaactt       c.*1440

          .         .         .         .         .         .       g.416456
 ctctaataaaaaattaaaacacgcataacactcgtcaagagtatttgctcccaagacaca       c.*1500

          .         .         .         .         .         .       g.416516
 ttctagcaaatgttttgcctttttcatatacatgatatcatcgttattttcaaagggggc       c.*1560

          .         .         .         .         .         .       g.416576
 ttattaataccctcagcatgtttttcacccaaatgatgcaaaacatgcagattctagttg       c.*1620

          .         .         .         .         .         .       g.416636
 acttcagttgtaatagacttgtttttctcctatttatgatttgaagtggattctgtaaaa       c.*1680

          .         .         .         .         .         .       g.416696
 tatctcttgttcttagtttccttatctgtaaaacagtggagttagactacatatcttttg       c.*1740

          .         .         .         .         .         .       g.416756
 gcactaacatctcatgaaaaattatggttaataaaatatcaccacatttggattgccaat       c.*1800

                                                                    g.416763
 tttcaaa                                                            c.*1807

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phospholipase C, beta 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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