phospholipase C, epsilon 1 (PLCE1) - coding DNA reference sequence

(used for variant description)

(last modified July 25, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_016341.3 in the PLCE1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015799.1, covering PLCE1 transcript NM_016341.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           cgctgggcaacgtgggcaacgcggcgggcggcgg       c.-601

 .         .         .         .         .         .                g.5094
 gctcgcgcggcgggaggggcagcggcggcgcgcccgggctctacctcccgggctctgcct       c.-541

 .         .         .         .         .         .                g.5154
 cccgggctctgcctctcgggcacttgcctggctcctgcgcgttcctgggcatcggctctg       c.-481

 .         .         .         .         .         .                g.5214
 cagctgacacacagtagcggggacacccgacgccgctagcgacaggcgcgcggacggctg       c.-421

 .         .         .         .         .         .      | 02      g.41698
 gtcccagagggacgctgcgcttggggacgccggcgagactcgccaggagccaagag | gaaa    c.-361

 .         .         .         .         .         .                g.41758
 caggaatcattcaaactggattttaaaatcattgcaaatcagtgatggatcagaagttgc       c.-301

 .         .         .         .         .         .                g.41818
 agagtgcaatcccgagtaaaagtcttcaaaaaattttgcttcaggtaacagaggaaggaa       c.-241

 .         .         .         .         .         .                g.41878
 aattgatctaccaccttaaaaccctgatctagaaaaaatatatattcatgataggaagtt       c.-181

 .         .         .         .         .         .                g.41938
 ataactaagaaaatttatttgcctcttaatgctcctgaatgaaaggaattatccctttgt       c.-121

 .         .         .         .         .         .                g.41998
 tctttgggaggacttgtgtatctgagattgttgtaataatcagtcattttattaaaacct       c.-61

 .         .         .         .         .         .                g.42058
 tgacatgatcaccagggaggaaaaatagagcaatagtcaaaacctgtgtgttagtccaag       c.-1

          .         .         .         .         .         .       g.42118
 ATGACTTCTGAAGAAATGACAGCTTCTGTTCTCATACCTGTGACTCAGAGAAAAGTGGTT       c.60
 M  T  S  E  E  M  T  A  S  V  L  I  P  V  T  Q  R  K  V  V         p.20

          .         .         .         .         .         .       g.42178
 TCTGCCCAGTCGGCTGCAGATGAAAGTAGTGAAAAGGTCTCAGACATCAATATTTCAAAA       c.120
 S  A  Q  S  A  A  D  E  S  S  E  K  V  S  D  I  N  I  S  K         p.40

          .         .         .         .         .         .       g.42238
 GCACATACTGTCAGACGAAGTGGGGAGACTTCTCATACCATCTCACAACTGAACAAACTT       c.180
 A  H  T  V  R  R  S  G  E  T  S  H  T  I  S  Q  L  N  K  L         p.60

          .         .         .         .         .         .       g.42298
 AAAGAAGAACCTTCTGGAAGCAACTTGCCAAAGATTCTCTCAATAGCGAGGGAGAAAATA       c.240
 K  E  E  P  S  G  S  N  L  P  K  I  L  S  I  A  R  E  K  I         p.80

          .         .         .         .         .         .       g.42358
 GTGAGTGATGAGAACAGTAATGAAAAATGTTGGGAGAAAATCATGCCAGATTCTGCGAAA       c.300
 V  S  D  E  N  S  N  E  K  C  W  E  K  I  M  P  D  S  A  K         p.100

          .         .         .         .         .         .       g.42418
 AACCTTAACATTAACTGCAACAACATATTGAGAAACCATCAGCATGGCCTTCCTCAGAGA       c.360
 N  L  N  I  N  C  N  N  I  L  R  N  H  Q  H  G  L  P  Q  R         p.120

          .         .         .         .         .         .       g.42478
 CAATTTTATGAAATGTACAACTCTGTTGCTGAGGAAGACTTGTGTTTAGAAACTGGAATT       c.420
 Q  F  Y  E  M  Y  N  S  V  A  E  E  D  L  C  L  E  T  G  I         p.140

          .         .         .         .         .         .       g.42538
 CCTTCTCCACTGGAAAGAAAGGTGTTCCCTGGAATTCAACTGGAACTAGACAGACCTTCC       c.480
 P  S  P  L  E  R  K  V  F  P  G  I  Q  L  E  L  D  R  P  S         p.160

          .         .         .         .         .         .       g.42598
 ATGGGCATTAGTCCTTTAGGAAATCAGTCAGTGATCATAGAGACAGGCAGAGCACACCCT       c.540
 M  G  I  S  P  L  G  N  Q  S  V  I  I  E  T  G  R  A  H  P         p.180

          .         .         .         .         .         .       g.42658
 GACAGCAGAAGGGCAGTATTTCATTTTCATTATGAAGTTGACAGAAGAATGTCAGACACT       c.600
 D  S  R  R  A  V  F  H  F  H  Y  E  V  D  R  R  M  S  D  T         p.200

          .         .         .         .         .         .       g.42718
 TTCTGTACCCTATCAGAAAACTTAATTTTAGACGATTGTGGAAATTGTGTACCACTACCT       c.660
 F  C  T  L  S  E  N  L  I  L  D  D  C  G  N  C  V  P  L  P         p.220

          .         .         .         .         .         .       g.42778
 GGGGGTGAGGAGAAGCAAAAGAAAAACTATGTGGCATATACCTGTAAACTGATGGAATTG       c.720
 G  G  E  E  K  Q  K  K  N  Y  V  A  Y  T  C  K  L  M  E  L         p.240

          .         .         .         .         .         .       g.42838
 GCCAAAAATTGTGATAATAAGAATGAGCAGCTGCAGTGTGATCATTGTGACACCTTGAAT       c.780
 A  K  N  C  D  N  K  N  E  Q  L  Q  C  D  H  C  D  T  L  N         p.260

          .         .         .         .         .         .       g.42898
 GATAAATACTTTTGCTTTGAAGGCTCTTGTGAGAAGGTTGACATGGTATATTCAGGTGAT       c.840
 D  K  Y  F  C  F  E  G  S  C  E  K  V  D  M  V  Y  S  G  D         p.280

          .         .         .         .         .         .       g.42958
 AGCTTTTGTAGGAAAGACTTTACTGACAGTCAAGCTGCCAAGACCTTTTTGAGCCATTTT       c.900
 S  F  C  R  K  D  F  T  D  S  Q  A  A  K  T  F  L  S  H  F         p.300

          .         .         .         .         .         .       g.43018
 GAGGACTTCCCTGATAATTGTGATGATGTAGAAGAAGACGCTTTTAAAAGCAAAAAGGAG       c.960
 E  D  F  P  D  N  C  D  D  V  E  E  D  A  F  K  S  K  K  E         p.320

          .         .         .         .         .         .       g.43078
 CGATCCACTTTGTTAGTCAGGAGATTCTGTAAAAATGACAGAGAAGTTAAGAAATCTGTG       c.1020
 R  S  T  L  L  V  R  R  F  C  K  N  D  R  E  V  K  K  S  V         p.340

          .         .         .         .         .         .       g.43138
 TATACTGGAACAAGAGCAATTGTGAGAACTCTGCCTTCTGGCCACATTGGGCTGACTGCA       c.1080
 Y  T  G  T  R  A  I  V  R  T  L  P  S  G  H  I  G  L  T  A         p.360

          .         .         .         .         .         .       g.43198
 TGGAGTTACATAGATCAGAAGAGAAATGGTCCCTTACTGCCTTGTGGGAGAGTAATGGAA       c.1140
 W  S  Y  I  D  Q  K  R  N  G  P  L  L  P  C  G  R  V  M  E         p.380

          .         .         .         .         .         .       g.43258
 CCCCCGTCAACAGTGGAGATAAGGCAAGATGGGAGCCAACGTCTGTCAGAAGCCCAGTGG       c.1200
 P  P  S  T  V  E  I  R  Q  D  G  S  Q  R  L  S  E  A  Q  W         p.400

        | 03 .         .         .         .         .         .    g.143239
 TATCCT | ATCTACAATGCAGTGAGAAGAGAAGAAACAGAAAATACAGTTGGATCTCTACTC    c.1260
 Y  P   | I  Y  N  A  V  R  R  E  E  T  E  N  T  V  G  S  L  L      p.420

          .         .         .         .         .         .       g.143299
 CATTTCCTCACCAAGCTCCCAGCCTCCGAGACAGCCCATGGAAGGATAAGCGTTGGTCCA       c.1320
 H  F  L  T  K  L  P  A  S  E  T  A  H  G  R  I  S  V  G  P         p.440

          .         .         .         .         .         .       g.143359
 TGCTTAAAGCAATGTGTCCGAGACACTGTATGTGAGTATCGCGCCACCCTCCAAAGGACT       c.1380
 C  L  K  Q  C  V  R  D  T  V  C  E  Y  R  A  T  L  Q  R  T         p.460

          .         .         .         .         .         .       g.143419
 TCAATATCGCAGTACATCACCGGTTCTCTCCTAGAAGCAACCACGTCTTTGGGAGCAAGA       c.1440
 S  I  S  Q  Y  I  T  G  S  L  L  E  A  T  T  S  L  G  A  R         p.480

          .         .         .         .         .   | 04     .    g.182199
 AGTGGCCTTCTCAGTACTTTTGGAGGATCCACTGGACGAATGATGCTGAAAG | AACGCCAG    c.1500
 S  G  L  L  S  T  F  G  G  S  T  G  R  M  M  L  K  E |   R  Q      p.500

          .         .         .         .         .         .       g.182259
 CCAGGCCCCTCTGTGGCCAATTCCAATGCCCTCCCTTCAAGTTCAGCTGGGATCAGCAAG       c.1560
 P  G  P  S  V  A  N  S  N  A  L  P  S  S  S  A  G  I  S  K         p.520

          .         .         .         .         .         .       g.182319
 GAGCTGATCGATCTGCAGCCTCTCATCCAGTTCCCAGAGGAAGTCGCCAGCATCCTGATG       c.1620
 E  L  I  D  L  Q  P  L  I  Q  F  P  E  E  V  A  S  I  L  M         p.540

          .         .         .         .         .         .       g.182379
 GAGCAAGAGCAGACTATTTACCGCAGGGTCTTGCCAGTCGACTACCTTTGCTTCTTAACA       c.1680
 E  Q  E  Q  T  I  Y  R  R  V  L  P  V  D  Y  L  C  F  L  T         p.560

          .         .         .         .         .         .       g.182439
 CGGGACTTGGGCACTCCTGAATGCCAGAGCTCCTTGCCCTGCCTCAAAGCATCCATCTCA       c.1740
 R  D  L  G  T  P  E  C  Q  S  S  L  P  C  L  K  A  S  I  S         p.580

          .         .         .         .         .         .       g.182499
 GCGTCGATTCTTACCACTCAGAATGGAGAGCACAATGCCCTTGAAGATCTGGTGATGAGG       c.1800
 A  S  I  L  T  T  Q  N  G  E  H  N  A  L  E  D  L  V  M  R         p.600

           | 05        .         .         .         .         .    g.238368
 TTTAATGAG | GTGAGCTCCTGGGTGACATGGCTGATCCTCACGGCAGGCTCCATGGAGGAG    c.1860
 F  N  E   | V  S  S  W  V  T  W  L  I  L  T  A  G  S  M  E  E      p.620

          .         .         .         .         .         .       g.238428
 AAGCGAGAAGTCTTTTCATATTTGGTGCATGTGGCCAAATGCTGCTGGAACATGGGCAAC       c.1920
 K  R  E  V  F  S  Y  L  V  H  V  A  K  C  C  W  N  M  G  N         p.640

          .         .         .      | 06  .         .         .    g.245090
 TACAACGCTGTCATGGAGTTCTTGGCTGGCCTCAG | GTCAAGAAAAGTTTTAAAAATGTGG    c.1980
 Y  N  A  V  M  E  F  L  A  G  L  R  |  S  R  K  V  L  K  M  W      p.660

          .         .         .         .         .         .       g.245150
 CAGTTCATGGACCAGTCTGATATTGAGACCATGAGGAGCCTGAAGGATGCTATGGCCCAG       c.2040
 Q  F  M  D  Q  S  D  I  E  T  M  R  S  L  K  D  A  M  A  Q         p.680

          .         .         .         .         .         .       g.245210
 CATGAGTCCTCTTGTGAGTACAGAAAGGTGGTGACACGTGCCCTGCACATCCCTGGCTGT       c.2100
 H  E  S  S  C  E  Y  R  K  V  V  T  R  A  L  H  I  P  G  C         p.700

          .         .         .         .         .         .       g.245270
 AAGGTGGTTCCATTCTGTGGGGTGTTTCTGAAGGAGCTCTGTGAAGTGCTTGACGGCGCC       c.2160
 K  V  V  P  F  C  G  V  F  L  K  E  L  C  E  V  L  D  G  A         p.720

          .         .         .         .         .     | 07   .    g.246932
 TCCGGTCTCATGAAGCTTTGCCCGCGGTACAATTCCCAAGAAGAAACTTTAGAG | TTTGTA    c.2220
 S  G  L  M  K  L  C  P  R  Y  N  S  Q  E  E  T  L  E   | F  V      p.740

          .         .         .         .         .         .       g.246992
 GCAGATTACAGTGGACAAGATAATTTCTTACAACGAGTGGGACAAAATGGCTTAAAGAAT       c.2280
 A  D  Y  S  G  Q  D  N  F  L  Q  R  V  G  Q  N  G  L  K  N         p.760

          .         .         .         .         .         .       g.247052
 TCGGAGAAGGAGTCCACTGTCAACAGCATCTTTCAGGTCATCCGGAGCTGCAATCGAAGT       c.2340
 S  E  K  E  S  T  V  N  S  I  F  Q  V  I  R  S  C  N  R  S         p.780

          .         .         .         .         .         .       g.247112
 CTGGAGACAGACGAGGAGGACAGCCCCAGTGAAGGAAACAGCTCCAGGAAAAGCTCCTTG       c.2400
 L  E  T  D  E  E  D  S  P  S  E  G  N  S  S  R  K  S  S  L         p.800

          .         . | 08       .         .         .         .    g.256997
 AAGGATAAAAGCCGATGGCA | GTTTATAATTGGAGATTTGTTGGATTCAGACAATGACATC    c.2460
 K  D  K  S  R  W  Q  |  F  I  I  G  D  L  L  D  S  D  N  D  I      p.820

          .         .         .         .         .         .       g.257057
 TTTGAGCAATCCAAAGAATACGACTCTCATGGTTCAGAGGACTCACAGAAGGCCTTCGAC       c.2520
 F  E  Q  S  K  E  Y  D  S  H  G  S  E  D  S  Q  K  A  F  D         p.840

          .         .         .         .         .         .       g.257117
 CATGGGACGGAGCTCATCCCTTGGTACGTGCTGTCCATCCAAGCCGATGTGCACCAGTTC       c.2580
 H  G  T  E  L  I  P  W  Y  V  L  S  I  Q  A  D  V  H  Q  F         p.860

          .         .         .         .         .         .       g.257177
 CTGCTGCAGGGGGCCACGGTCATCCACTACGACCAGGACACACACCTCTCTGCCCGCTGC       c.2640
 L  L  Q  G  A  T  V  I  H  Y  D  Q  D  T  H  L  S  A  R  C         p.880

          .         .         .         .         .         .       g.257237
 TTCCTCCAGCTTCAGCCCGACAATAGCACCTTGACCTGGGTAAAGCCCACAACTGCCTCC       c.2700
 F  L  Q  L  Q  P  D  N  S  T  L  T  W  V  K  P  T  T  A  S         p.900

          .         .         .         .         .         .       g.257297
 CCAGCCAGCAGTAAAGCAAAACTTGGTGTACTTAATAACACAGCTGAGCCTGGAAAATTC       c.2760
 P  A  S  S  K  A  K  L  G  V  L  N  N  T  A  E  P  G  K  F         p.920

          .         .         .         .         .         .       g.257357
 CCACTACTGGGTAATGCTGGATTAAGTAGCCTGACGGAAGGGGTCTTGGATCTTTTTGCA       c.2820
 P  L  L  G  N  A  G  L  S  S  L  T  E  G  V  L  D  L  F  A         p.940

          .         .         .         .         .         .       g.257417
 GTGAAGGCTGTATACATGGGCCACCCTGGCATTGATATACACACTGTGTGTGTTCAGAAC       c.2880
 V  K  A  V  Y  M  G  H  P  G  I  D  I  H  T  V  C  V  Q  N         p.960

          .         .         .         .         .         .       g.257477
 AAACTGGGTAGCATGTTCCTGTCAGAGACTGGTGTGACATTGCTCTATGGGCTTCAGACC       c.2940
 K  L  G  S  M  F  L  S  E  T  G  V  T  L  L  Y  G  L  Q  T         p.980

          .         .         .         .         .         .       g.257537
 ACAGACAACAGATTATTGCACTTCGTGGCACCAAAGCACACAGCTAAAATGCTCTTCAGC       c.3000
 T  D  N  R  L  L  H  F  V  A  P  K  H  T  A  K  M  L  F  S         p.1000

          .         .         .         .         .         .       g.257597
 GGATTATTGGAACTCACTAGAGCTGTGAGAAAGATGAGGAAATTCCCTGACCAAAGACAG       c.3060
 G  L  L  E  L  T  R  A  V  R  K  M  R  K  F  P  D  Q  R  Q         p.1020

          .         .         .       | 09 .         .         .    g.263351
 CAGTGGCTGCGGAAACAGTACGTCAGCCTTTATCAG | GAGGATGGACGGTATGAAGGCCCA    c.3120
 Q  W  L  R  K  Q  Y  V  S  L  Y  Q   | E  D  G  R  Y  E  G  P      p.1040

          .         .         .         .         .         .       g.263411
 ACTTTGGCTCACGCTGTGGAGTTGTTTGGTGGCAGACGGTGGAGTGCTCGAAACCCCAGC       c.3180
 T  L  A  H  A  V  E  L  F  G  G  R  R  W  S  A  R  N  P  S         p.1060

          .         .         .         .         .         .       g.263471
 CCCGGAACATCAGCAAAGAATGCTGAGAAGCCCAATATGCAGAGAAACAATACCCTGGGC       c.3240
 P  G  T  S  A  K  N  A  E  K  P  N  M  Q  R  N  N  T  L  G         p.1080

          .         .         .          | 10        .         .    g.265222
 ATAAGCACTACCAAGAAAAAGAAGAAAATCCTCATGAGG | GGTGAGAGTGGAGAGGTAACT    c.3300
 I  S  T  T  K  K  K  K  K  I  L  M  R   | G  E  S  G  E  V  T      p.1100

          .         .         .         .         .         .       g.265282
 GACGATGAGATGGCAACCCGAAAGGCCAAGATGCACAAAGAGTGTCGAAGCCGGAGTGGT       c.3360
 D  D  E  M  A  T  R  K  A  K  M  H  K  E  C  R  S  R  S  G         p.1120

          .         .         .        | 11.         .         .    g.265927
 TCTGATCCTCAAGACATTAATGAACAAGAAGAATCAG | AGGTGAATGCCATCGCTAACCCT    c.3420
 S  D  P  Q  D  I  N  E  Q  E  E  S  E |   V  N  A  I  A  N  P      p.1140

          .         .         .         .         .         .       g.265987
 CCAAACCCCCTCCCTTCCAGAAGAGCCCACTCTTTGACCACAGCTGGGTCCCCCAACTTG       c.3480
 P  N  P  L  P  S  R  R  A  H  S  L  T  T  A  G  S  P  N  L         p.1160

          .         .         .         .         .         .       g.266047
 GCTGCCGGGACGTCATCTCCCATCAGGCCAGTGTCCTCCCCTGTGCTGTCTTCTTCAAAC       c.3540
 A  A  G  T  S  S  P  I  R  P  V  S  S  P  V  L  S  S  S  N         p.1180

          .     | 12   .         .         .         .         .    g.269857
 AAGAGCCCATCCAG | TGCTTGGAGCAGTAGTAGCTGGCACGGGCGGATCAAAGGCGGCATG    c.3600
 K  S  P  S  S  |  A  W  S  S  S  S  W  H  G  R  I  K  G  G  M      p.1200

          .         .         .         .         .         .       g.269917
 AAGGGATTTCAGAGCTTCATGGTTTCAGATAGCAACATGAGTTTTGTTGAATTTGTTGAG       c.3660
 K  G  F  Q  S  F  M  V  S  D  S  N  M  S  F  V  E  F  V  E         p.1220

          .        | 13.         .         .         .         .    g.270068
 CTGTTCAAATCATTCAG | TGTCAGGAGCCGCAAGGACCTGAAGGATCTGTTTGATGTCTAT    c.3720
 L  F  K  S  F  S  |  V  R  S  R  K  D  L  K  D  L  F  D  V  Y      p.1240

          .         .         .         .         .         .       g.270128
 GCAGTGCCCTGCAACCGATCTGGCTCCGAGTCAGCCCCACTCTACACCAACCTGACAATT       c.3780
 A  V  P  C  N  R  S  G  S  E  S  A  P  L  Y  T  N  L  T  I         p.1260

          .         .         .     | 14   .         .         .    g.273531
 GATGAAAACACCAGCGATCTTCAGCCTGACCTAG | ATCTGTTGACCAGAAATGTCTCGGAT    c.3840
 D  E  N  T  S  D  L  Q  P  D  L  D |   L  L  T  R  N  V  S  D      p.1280

          .         .         .         .         .         .       g.273591
 TTGGGGTTGTTCATTAAGAGTAAACAGCAGCTATCGGACAACCAGAGGCAGATATCTGAT       c.3900
 L  G  L  F  I  K  S  K  Q  Q  L  S  D  N  Q  R  Q  I  S  D         p.1300

          .         .         .         .         .         .       g.273651
 GCCATTGCTGCTGCAAGCATTGTGACAAATGGCACTGGGATTGAGAGCACATCTCTGGGC       c.3960
 A  I  A  A  A  S  I  V  T  N  G  T  G  I  E  S  T  S  L  G         p.1320

          .         .         .         .         .         .       g.273711
 ATTTTTGGGGTGGGCATACTTCAGCTCAACGATTTCCTCGTGAATTGCCAAGGAGAACAC       c.4020
 I  F  G  V  G  I  L  Q  L  N  D  F  L  V  N  C  Q  G  E  H         p.1340

          .         .         .    | 15    .         .         .    g.276685
 TGCACTTATGATGAAATCCTCAGCATCATCCAG | AAGTTCGAGCCTAGCATCAGTATGTGT    c.4080
 C  T  Y  D  E  I  L  S  I  I  Q   | K  F  E  P  S  I  S  M  C      p.1360

          .         .         .      | 16  .         .         .    g.276829
 CATCAGGGACTAATGTCATTTGAAGGGTTTGCCAG | GTTTCTGATGGATAAAGAAAATTTT    c.4140
 H  Q  G  L  M  S  F  E  G  F  A  R  |  F  L  M  D  K  E  N  F      p.1380

          .         .         .         .         .         .       g.276889
 GCCTCAAAAAATGATGAGTCACAGGAGAACATTAAAGAACTGCAGCTACCCCTCTCATAC       c.4200
 A  S  K  N  D  E  S  Q  E  N  I  K  E  L  Q  L  P  L  S  Y         p.1400

          .         .         .         .         .         .       g.276949
 TATTACATCGAATCTTCGCACAATACCTACCTCACGGGCCATCAGCTCAAAGGAGAATCC       c.4260
 Y  Y  I  E  S  S  H  N  T  Y  L  T  G  H  Q  L  K  G  E  S         p.1420

          .         .  | 17      .         .         .         .    g.279979
 TCGGTAGAACTCTACAGCCAG | GTCCTTTTGCAAGGCTGTCGAAGTGTAGAATTGGACTGC    c.4320
 S  V  E  L  Y  S  Q   | V  L  L  Q  G  C  R  S  V  E  L  D  C      p.1440

          .         .         .         .         .         .       g.280039
 TGGGACGGAGACGATGGGATGCCCATCATTTATCATGGACATACGCTGACAACCAAGATC       c.4380
 W  D  G  D  D  G  M  P  I  I  Y  H  G  H  T  L  T  T  K  I         p.1460

           | 18        .         .         .         .         .    g.281548
 CCCTTCAAG | GAAGTGGTTGAAGCCATTGATCGCAGTGCCTTCATCAACTCTGACCTGCCA    c.4440
 P  F  K   | E  V  V  E  A  I  D  R  S  A  F  I  N  S  D  L  P      p.1480

          .         .         .         .         .         .       g.281608
 ATCATCATATCGATTGAGAACCACTGTTCATTGCCTCAGCAACGAAAAATGGCAGAAATT       c.4500
 I  I  I  S  I  E  N  H  C  S  L  P  Q  Q  R  K  M  A  E  I         p.1500

        | 19 .         .         .         .         .         .    g.284627
 TTCAAG | ACTGTGTTTGGAGAAAAGCTGGTGACTAAATTCTTATTTGAGACTGATTTCTCA    c.4560
 F  K   | T  V  F  G  E  K  L  V  T  K  F  L  F  E  T  D  F  S      p.1520

          .         .         .         .         .         .       g.284687
 GATGATCCAATGCTTCCTTCACCTGACCAACTCAGAAAGAAAGTTCTTCTTAAAAACAAG       c.4620
 D  D  P  M  L  P  S  P  D  Q  L  R  K  K  V  L  L  K  N  K         p.1540

          .         .         .         .      | 20  .         .    g.290808
 AAGCTAAAAGCCCATCAGACGCCAGTGGATATCTTAAAGCAAAAG | GCTCATCAGTTAGCA    c.4680
 K  L  K  A  H  Q  T  P  V  D  I  L  K  Q  K   | A  H  Q  L  A      p.1560

          .         .         .         .         .         .       g.290868
 TCTATGCAAGTGCAGGCTTATAATGGTGGGAATGCCAACCCCCGACCTGCCAATAATGAG       c.4740
 S  M  Q  V  Q  A  Y  N  G  G  N  A  N  P  R  P  A  N  N  E         p.1580

          .         .         .         .         .      | 21  .    g.294806
 GAAGAGGAAGATGAGGAGGACGAATATGATTATGACTATGAATCCCTTTCTGATG | ACAAC    c.4800
 E  E  E  D  E  E  D  E  Y  D  Y  D  Y  E  S  L  S  D  D |   N      p.1600

          .         .         .         .         .         .       g.294866
 ATTCTGGAAGACAGACCTGAAAATAAATCATGTAATGACAAGCTTCAGTTTGAATATAAT       c.4860
 I  L  E  D  R  P  E  N  K  S  C  N  D  K  L  Q  F  E  Y  N         p.1620

          .         .         .         .         .        | 22.    g.295862
 GAAGAAATCCCAAAGAGGATAAAGAAAGCAGATAACTCTGCTTGCAACAAAGGAAAG | GTT    c.4920
 E  E  I  P  K  R  I  K  K  A  D  N  S  A  C  N  K  G  K   | V      p.1640

          .         .         .         .         .         .       g.295922
 TATGATATGGAACTGGGAGAAGAATTTTATCTTGATCAGAATAAAAAGGAAAGCAGACAG       c.4980
 Y  D  M  E  L  G  E  E  F  Y  L  D  Q  N  K  K  E  S  R  Q         p.1660

          .         .         .         .         .      | 23  .    g.304524
 ATTGCACCAGAGCTTTCTGACCTTGTAATCTATTGTCAAGCAGTAAAATTTCCAG | GACTG    c.5040
 I  A  P  E  L  S  D  L  V  I  Y  C  Q  A  V  K  F  P  G |   L      p.1680

          .         .         .         .         .         .       g.304584
 TCAACTCTAAATGCATCTGGCTCTAGCAGAGGAAAAGAAAGGAAAAGCAGGAAGTCCATT       c.5100
 S  T  L  N  A  S  G  S  S  R  G  K  E  R  K  S  R  K  S  I         p.1700

          .         .         .         .         .         .       g.304644
 TTTGGCAACAATCCGGGCAGAATGAGCCCAGGGGAGACAGCATCATTTAACAAAACATCT       c.5160
 F  G  N  N  P  G  R  M  S  P  G  E  T  A  S  F  N  K  T  S         p.1720

         | 24.         .         .         .         .         .    g.309443
 GGAAAAA | GTTCCTGTGAAGGCATTCGACAGACCTGGGAGGAATCTTCTTCCCCTCTCAAC    c.5220
 G  K  S |   S  C  E  G  I  R  Q  T  W  E  E  S  S  S  P  L  N      p.1740

          .         .         .         .         .         .       g.309503
 CCAACCACGTCCCTCAGTGCTATCATTAGAACTCCCAAATGTTATCATATCTCGTCGCTG       c.5280
 P  T  T  S  L  S  A  I  I  R  T  P  K  C  Y  H  I  S  S  L         p.1760

          .         .         .         .         .         .       g.309563
 AATGAAAATGCCGCCAAACGTCTGTGTCGCAGGTATTCTCAGAAACTGACCCAGCACACC       c.5340
 N  E  N  A  A  K  R  L  C  R  R  Y  S  Q  K  L  T  Q  H  T         p.1780

          .         .         .         .         .         .       g.309623
 GCCTGTCAGCTGCTGAGAACTTACCCTGCTGCCACCCGCATCGACTCTTCCAACCCGAAC       c.5400
 A  C  Q  L  L  R  T  Y  P  A  A  T  R  I  D  S  S  N  P  N         p.1800

          .         .         .         .         .         | 25    g.315495
 CCCCTCATGTTCTGGCTCCATGGGATACAGCTTGTGGCACTCAACTACCAGACTGATG | AT    c.5460
 P  L  M  F  W  L  H  G  I  Q  L  V  A  L  N  Y  Q  T  D  D |       p.1820

          .         .         .         .         .         .       g.315555
 CTCCCTTTACATTTAAATGCTGCAATGTTTGAGGCAAATGGTGGTTGTGGTTATGTATTG       c.5520
 L  P  L  H  L  N  A  A  M  F  E  A  N  G  G  C  G  Y  V  L         p.1840

          .         .         .         .         .         .       g.315615
 AAACCTCCAGTTCTGTGGGACAAGAACTGCCCCATGTATCAGAAGTTTTCTCCACTAGAA       c.5580
 K  P  P  V  L  W  D  K  N  C  P  M  Y  Q  K  F  S  P  L  E         p.1860

          .         .         .         .   | 26     .         .    g.317456
 AGAGATCTGGACAGCATGGATCCTGCAGTCTATTCTTTAACT | ATTGTCTCTGGTCAGAAT    c.5640
 R  D  L  D  S  M  D  P  A  V  Y  S  L  T   | I  V  S  G  Q  N      p.1880

          .         .         .         .         .         .       g.317516
 GTGTGCCCCAGTAATAGCATGGGAAGCCCGTGCATTGAAGTCGACGTCCTGGGCATGCCT       c.5700
 V  C  P  S  N  S  M  G  S  P  C  I  E  V  D  V  L  G  M  P         p.1900

          .         .         .         .         .         .       g.317576
 CTGGACAGCTGCCATTTCCGCACAAAGCCCATCCATCGAAACACCCTGAACCCCATGTGG       c.5760
 L  D  S  C  H  F  R  T  K  P  I  H  R  N  T  L  N  P  M  W         p.1920

          .         .         .         .         .         .       g.317636
 AACGAGCAGTTTCTGTTCCACGTTCACTTCGAAGATCTTGTATTTCTTCGTTTTGCAGTT       c.5820
 N  E  Q  F  L  F  H  V  H  F  E  D  L  V  F  L  R  F  A  V         p.1940

          .         .         .         .         .         .       g.317696
 GTGGAAAACAATAGTTCAGCGGTAACTGCTCAGAGAATCATTCCACTGAAAGCTTTAAAA       c.5880
 V  E  N  N  S  S  A  V  T  A  Q  R  I  I  P  L  K  A  L  K         p.1960

      | 27   .         .         .         .         .         .    g.319648
 CGAG | GATATCGACATCTTCAGCTGCGAAACCTTCACAATGAAGTCTTGGAGATTTCTAGT    c.5940
 R  G |   Y  R  H  L  Q  L  R  N  L  H  N  E  V  L  E  I  S  S      p.1980

          .         .         .         .         .         .       g.319708
 TTATTCATTAACAGCAGAAGGATGGAAGAAAATTCCTCTGGCAATACCATGTCAGCCTCT       c.6000
 L  F  I  N  S  R  R  M  E  E  N  S  S  G  N  T  M  S  A  S         p.2000

     | 28    .         .         .         .         .         .    g.324322
 TCG | ATGTTTAATACAGAAGAAAGAAAATGTTTGCAGACTCACAGAGTCACGGTGCATGGG    c.6060
 S   | M  F  N  T  E  E  R  K  C  L  Q  T  H  R  V  T  V  H  G      p.2020

          .         .         .         .         .         .       g.324382
 GTCCCAGGGCCAGAGCCCTTTACCGTTTTCACTATTAATGGAGGCACCAAGGCAAAGCAG       c.6120
 V  P  G  P  E  P  F  T  V  F  T  I  N  G  G  T  K  A  K  Q         p.2040

          .   | 29     .         .         .         .         .    g.327606
 CTTCTGCAGCAA | ATTCTGACAAATGAACAAGACATCAAACCTGTTACCACAGACTATTTT    c.6180
 L  L  Q  Q   | I  L  T  N  E  Q  D  I  K  P  V  T  T  D  Y  F      p.2060

          .         .         .         .         .         .       g.327666
 TTGATGGAAGAAAAATATTTTATATCTAAAGAAAAGAATGAATGTAGGAAACAACCATTC       c.6240
 L  M  E  E  K  Y  F  I  S  K  E  K  N  E  C  R  K  Q  P  F         p.2080

          .         .         .         .         .         .       g.327726
 CAGAGAGCCATTGGTCCAGAAGAGGAGATCATGCAAATTTTAAGCAGCTGGTTTCCAGAA       c.6300
 Q  R  A  I  G  P  E  E  E  I  M  Q  I  L  S  S  W  F  P  E         p.2100

          .         .         .         .   | 30     .         .    g.332930
 GAGGGATACATGGGCAGGATTGTCTTAAAAACCCAGCAGGAA | AACCTAGAAGAGAAAAAC    c.6360
 E  G  Y  M  G  R  I  V  L  K  T  Q  Q  E   | N  L  E  E  K  N      p.2120

          .         .         .         .         .         .       g.332990
 ATTGTTCAAGATGACAAAGAGGTGATCTTGAGCTCAGAGGAGGAGAGTTTCTTTGTCCAA       c.6420
 I  V  Q  D  D  K  E  V  I  L  S  S  E  E  E  S  F  F  V  Q         p.2140

          .         .         .         .         .         .       g.333050
 GTGCATGATGTTTCTCCAGAGCAACCTCGAACAGTCATCAAAGCACCCCGCGTCAGCACT       c.6480
 V  H  D  V  S  P  E  Q  P  R  T  V  I  K  A  P  R  V  S  T         p.2160

          .         .  | 31      .         .         .         .    g.335399
 GCACAGGATGTCATTCAGCAG | ACCTTATGCAAAGCCAAATATTCCTACAGCATCCTGAGC    c.6540
 A  Q  D  V  I  Q  Q   | T  L  C  K  A  K  Y  S  Y  S  I  L  S      p.2180

          .         .         .         .         .         .       g.335459
 AACCCCAATCCAAGCGACTATGTGCTTTTGGAAGAGGTGGTGAAAGACACTACCAACAAG       c.6600
 N  P  N  P  S  D  Y  V  L  L  E  E  V  V  K  D  T  T  N  K         p.2200

          .         .         .         .         .         .       g.335519
 AAGACTACCACACCAAAGTCCTCTCAGCGGGTCCTTCTGGATCAGGAGTGTGTGTTTCAA       c.6660
 K  T  T  T  P  K  S  S  Q  R  V  L  L  D  Q  E  C  V  F  Q         p.2220

          .         .         .         .         .         .       g.335579
 GCCCAAAGCAAGTGGAAAGGTGCAGGAAAATTCATCCTTAAGCTAAAGGAGCAGGTGCAG       c.6720
 A  Q  S  K  W  K  G  A  G  K  F  I  L  K  L  K  E  Q  V  Q         p.2240

  | 32       .         .         .         .         .         .    g.335963
  | GCATCTCGAGAAGATAAAAAGAAAGGCATTTCTTTCGCAAGTGAACTCAAGAAGCTCACC    c.6780
  | A  S  R  E  D  K  K  K  G  I  S  F  A  S  E  L  K  K  L  T      p.2260

          .         .         .         .         .         .       g.336023
 AAGTCAACTAAACAGCCCCGAGGACTTACATCACCTTCTCAGCTCTTGACCTCAGAAAGT       c.6840
 K  S  T  K  Q  P  R  G  L  T  S  P  S  Q  L  L  T  S  E  S         p.2280

          .         .         .         .         .         .       g.336083
 ATCCAAACCAAGGAGGAGAAACCTGTGGGTGGCTTGTCCTCCAGTGACACAATGGATTAC       c.6900
 I  Q  T  K  E  E  K  P  V  G  G  L  S  S  S  D  T  M  D  Y         p.2300

                                                                g.336092
 CGACAGTGA |                                                       c.6910
 R  Q  X                                                         p.2302

          .         .     | 33   .         .         .         .    g.339015
 ctaagggcagcatgtttaacccag | gtgaagatctttaagcaagaagttaaagagtgaaca    c.*60

          .         .         .         .         .         .       g.339075
 tggtggaaaaaatataattattttcatcagacttaaactggaaattgatgatttctgaac       c.*120

          .         .         .         .         .         .       g.339135
 tgaagccttcacacatgtgagatccatgctgaggagaagcaaaatggcacagggctagtt       c.*180

          .         .         .         .         .         .       g.339195
 gccaccaaccaatttactgatgaatgaagcccaggggactgccattttataaatgtcagc       c.*240

          .         .         .         .         .         .       g.339255
 agttggaaaaatcgtcacgaattgacttagagcaagggtcagcaagcttgtctgtaaagg       c.*300

          .         .         .         .         .         .       g.339315
 gccaaacagtaaatattttagggctgggggccataaaatatgttgcaaccacccaattct       c.*360

          .         .         .         .         .         .       g.339375
 gccattgtagtgcaaaagcagccatagacaacacatacatgaacgaacgtggctgtattc       c.*420

          .         .                                               g.339404
 caataaaactttatttatggacactgaaa                                      c.*449

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phospholipase C, epsilon 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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