phospholipase C, zeta 1 (PLCZ1) - coding DNA reference sequence

(used for variant description)

(last modified September 13, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_033123.3 in the PLCZ1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052826.1, covering PLCZ1 transcript NM_033123.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   tcacaatgggaattcagaccaaaagg       c.-241

 .         .         .         .         .         .                g.5086
 aaaaaatgacagtcacctgacagtgtggtgcccagccaaccagctatacctcttttgaag       c.-181

 .         .         .         .         .  | 02      .             g.5568
 attttaagaacttagcctcctgaacagtcttcttcgaaagtg | aaaagtggtaacagctga    c.-121

 .         .         .         .         .         .                g.5628
 tgagtatcaagaaattattttctgcaaaggggcagagttaattgtatttggaacccatga       c.-61

 .         .         .         .         .         .                g.5688
 cagcacctactggggaaagacttctaagtgaggagaaacggctctacaggtcatgaaact       c.-1

          .  | 03      .         .         .         .         .    g.6764
 ATGGAAATGAG | ATGGTTTTTGTCAAAGATTCAGGATGACTTCAGAGGTGGAAAAATTAAC    c.60
 M  E  M  R  |  W  F  L  S  K  I  Q  D  D  F  R  G  G  K  I  N      p.20

          .         .         .         .         .         .       g.6824
 CTAGAAAAAACTCAGAGGTTACTTGAAAAATTAGATATTCGGTGCAGTTATATTCATGTG       c.120
 L  E  K  T  Q  R  L  L  E  K  L  D  I  R  C  S  Y  I  H  V         p.40

          .      | 04  .         .         .         .         .    g.19562
 AAACAGATTTTTAAG | GACAATGACAGGCTGAAACAAGGAAGAATCACCATAGAAGAATTT    c.180
 K  Q  I  F  K   | D  N  D  R  L  K  Q  G  R  I  T  I  E  E  F      p.60

          .         .         .         .         .         .       g.19622
 AGAGCAATTTATCGAATTATCACGCACAGAGAAGAAATTATTGAGATTTTCAACACATAT       c.240
 R  A  I  Y  R  I  I  T  H  R  E  E  I  I  E  I  F  N  T  Y         p.80

          .         .         .         .         .         .       g.19682
 TCTGAAAACCGGAAAATTCTTTTAGCAAGTAATCTGGCTCAATTTCTGACACAAGAACAA       c.300
 S  E  N  R  K  I  L  L  A  S  N  L  A  Q  F  L  T  Q  E  Q         p.100

          .         .         .         .         .         .       g.19742
 TATGCAGCTGAGATGAGTAAAGCTATTGCTTTTGAGATCATTCAGAAATACGAGCCTATC       c.360
 Y  A  A  E  M  S  K  A  I  A  F  E  I  I  Q  K  Y  E  P  I         p.120

         | 05.         .         .         .         .         .    g.23480
 GAAGAAG | TTAGGAAAGCACACCAAATGTCATTAGAAGGTTTTACAAGATACATGGATTCA    c.420
 E  E  V |   R  K  A  H  Q  M  S  L  E  G  F  T  R  Y  M  D  S      p.140

          .         .         .         .         .         .       g.23540
 CGTGAATGTCTACTGTTTAAAAATGAATGTAGAAAAGTTTATCAAGATATGACTCATCCA       c.480
 R  E  C  L  L  F  K  N  E  C  R  K  V  Y  Q  D  M  T  H  P         p.160

          .         .         .         .         .         .       g.23600
 TTAAATGATTATTTTATTTCATCTTCACATAACACATATTTGGTATCTGATCAATTATTG       c.540
 L  N  D  Y  F  I  S  S  S  H  N  T  Y  L  V  S  D  Q  L  L         p.180

          .         .          | 06        .         .         .    g.30104
 GGACCAAGTGACCTTTGGGGATATGTAAG | TGCCCTTGTGAAAGGATGCCGTTGTTTGGAG    c.600
 G  P  S  D  L  W  G  Y  V  S  |  A  L  V  K  G  C  R  C  L  E      p.200

          .         .         .         .         .         .       g.30164
 ATTGACTGCTGGGATGGAGCACAAAATGAACCTGTTGTATATCATGGCTACACACTCACA       c.660
 I  D  C  W  D  G  A  Q  N  E  P  V  V  Y  H  G  Y  T  L  T         p.220

          .         .         .         .         .     | 07   .    g.37750
 AGCAAACTTCTGTTTAAAACTGTTATCCAAGCTATACACAAGTATGCATTCATG | ACATCT    c.720
 S  K  L  L  F  K  T  V  I  Q  A  I  H  K  Y  A  F  M   | T  S      p.240

          .         .         .         .         .         .       g.37810
 GACTACCCAGTGGTGCTCTCTTTAGAAAATCACTGCTCCACTGCCCAACAAGAAGTAATG       c.780
 D  Y  P  V  V  L  S  L  E  N  H  C  S  T  A  Q  Q  E  V  M         p.260

          .         .         .         .         .         .       g.37870
 GCAGACAATTTGCAGGCTACTTTTGGAGAGTCCTTGCTTTCTGATATGCTTGATGATTTT       c.840
 A  D  N  L  Q  A  T  F  G  E  S  L  L  S  D  M  L  D  D  F         p.280

          .         .     | 08   .         .         .         .    g.41319
 CCTGATACTCTACCATCACCAGAG | GCACTAAAATTCAAAATATTAGTTAAAAATAAGAAA    c.900
 P  D  T  L  P  S  P  E   | A  L  K  F  K  I  L  V  K  N  K  K      p.300

          .         .         .         .          | 09        .    g.41502
 ATAGGAACCTTAAAGGAAACCCATGAAAGAAAAGGTTCTGATAAGCGTG | GAGACAATCAA    c.960
 I  G  T  L  K  E  T  H  E  R  K  G  S  D  K  R  G |   D  N  Q      p.320

          .         .         .         .         .        | 10.    g.43112
 GACAAGGAAACAGGGGTAAAAAAGTTACCTGGAGTAATGCTTTTCAAGAAAAAGAAG | ACC    c.1020
 D  K  E  T  G  V  K  K  L  P  G  V  M  L  F  K  K  K  K   | T      p.340

          .         .         .         .         .         .       g.43172
 AGGAAGCTAAAAATTGCTCTGGCCTTATCTGATCTTGTCATTTATACGAAAGCTGAGAAA       c.1080
 R  K  L  K  I  A  L  A  L  S  D  L  V  I  Y  T  K  A  E  K         p.360

          .         .         .         .         .         .       g.43232
 TTCAAAAGCTTTCAACATTCAAGATTATATCAGCAATTTAATGAAAATAATTCTATTGGG       c.1140
 F  K  S  F  Q  H  S  R  L  Y  Q  Q  F  N  E  N  N  S  I  G         p.380

          .         .         .     | 11   .         .         .    g.46819
 GAGACACAAGCCCGAAAACTTTCAAAATTGCGAG | TCCATGAGTTTATTTTTCACACCAGG    c.1200
 E  T  Q  A  R  K  L  S  K  L  R  V |   H  E  F  I  F  H  T  R      p.400

          .         .         .         .         .         .       g.46879
 AAGTTCATTACCAGAATATATCCCAAAGCAACAAGAGCAGACTCTTCTAATTTTAATCCC       c.1260
 K  F  I  T  R  I  Y  P  K  A  T  R  A  D  S  S  N  F  N  P         p.420

          .         .         .  | 12      .         .         .    g.48009
 CAAGAATTTTGGAATATAGGTTGTCAAATGG | TGGCTTTAAATTTCCAGACCCCTGGTCTG    c.1320
 Q  E  F  W  N  I  G  C  Q  M  V |   A  L  N  F  Q  T  P  G  L      p.440

          .         .         .         .         .         .       g.48069
 CCCATGGATCTGCAAAATGGGAAATTTTTGGATAATGGTGGTTCTGGATATATTTTGAAA       c.1380
 P  M  D  L  Q  N  G  K  F  L  D  N  G  G  S  G  Y  I  L  K         p.460

          .         .         .         .         .         .       g.48129
 CCACATTTCTTAAGAGAGAGTAAATCATACTTTAACCCAAGTAACATAAAAGAGGGTATG       c.1440
 P  H  F  L  R  E  S  K  S  Y  F  N  P  S  N  I  K  E  G  M         p.480

          .         .  | 13      .         .         .         .    g.54880
 CCAATTACACTTACAATAAGG | CTCATCAGTGGTATCCAGTTGCCTCTTACTCATTCATCA    c.1500
 P  I  T  L  T  I  R   | L  I  S  G  I  Q  L  P  L  T  H  S  S      p.500

          .         .         .         .         .         .       g.54940
 TCTAACAAAGGTGATTCATTAGTAATTATAGAAGTTTTTGGTGTTCCAAATGATCAAATG       c.1560
 S  N  K  G  D  S  L  V  I  I  E  V  F  G  V  P  N  D  Q  M         p.520

          .         .         .  | 14      .         .         .    g.58809
 AAGCAGCAGACTCGTGTAATTAAAAAAAATG | CTTTTAGTCCAAGATGGAATGAAACATTC    c.1620
 K  Q  Q  T  R  V  I  K  K  N  A |   F  S  P  R  W  N  E  T  F      p.540

          .         .         .         .         .         .       g.58869
 ACATTTATTATTCATGTCCCAGAATTGGCATTGATACGTTTTGTTGTTGAAGGTCAAGGT       c.1680
 T  F  I  I  H  V  P  E  L  A  L  I  R  F  V  V  E  G  Q  G         p.560

          .         .         .         .         .         .       g.58929
 TTAATAGCAGGAAATGAATTTCTTGGGCAATATACTTTGCCACTTCTATGCATGAACAAA       c.1740
 L  I  A  G  N  E  F  L  G  Q  Y  T  L  P  L  L  C  M  N  K         p.580

   | 15      .         .         .         .         .         .    g.59794
 G | GTTATCGTCGTATTCCTCTGTTTTCCAGAATGGGTGAGAGCCTTGAGCCTGCTTCACTG    c.1800
 G |   Y  R  R  I  P  L  F  S  R  M  G  E  S  L  E  P  A  S  L      p.600

          .         .                                               g.59821
 TTTGTTTATGTTTGGTACGTCAGATAA                                        c.1827
 F  V  Y  V  W  Y  V  R  X                                          p.608

          .         .         .         .         .         .       g.59881
 cagctaatgataaatgacatatcattagctatgcatcgcaataaaacagccaaaatgaat       c.*60

                                                                    g.59884
 gtc                                                                c.*63

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phospholipase C, zeta 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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