plasminogen (PLG) - coding DNA reference sequence

(used for variant description)

(last modified April 19, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_000301.3 in the PLG gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering PLG transcript NM_000301.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         gaatcattaacttaatttgactatctggtttgtggatgcgtttactctcatg       c.-61

 .         .         .         .         .         .                g.5112
 taagtcaacaacatcctgggattgggacccactttctgggcactgctggccagtcccaaa       c.-1

          .         .         .         .          | 02        .    g.9225
 ATGGAACATAAGGAAGTGGTTCTTCTACTTCTTTTATTTCTGAAATCAG | GTCAAGGAGAG    c.60
 M  E  H  K  E  V  V  L  L  L  L  L  F  L  K  S  G |   Q  G  E      p.20

          .         .         .         .         .         .       g.9285
 CCTCTGGATGACTATGTGAATACCCAGGGGGCTTCACTGTTCAGTGTCACTAAGAAGCAG       c.120
 P  L  D  D  Y  V  N  T  Q  G  A  S  L  F  S  V  T  K  K  Q         p.40

          .         .         .         .         .         .       g.9345
 CTGGGAGCAGGAAGTATAGAAGAATGTGCAGCAAAATGTGAGGAGGACGAAGAATTCACC       c.180
 L  G  A  G  S  I  E  E  C  A  A  K  C  E  E  D  E  E  F  T         p.60

       | 03  .         .         .         .         .         .    g.10562
 TGCAG | GGCATTCCAATATCACAGTAAAGAGCAACAATGTGTGATAATGGCTGAAAACAGG    c.240
 C  R  |  A  F  Q  Y  H  S  K  E  Q  Q  C  V  I  M  A  E  N  R      p.80

          .         .         .         .         .   | 04     .    g.13892
 AAGTCCTCCATAATCATTAGGATGAGAGATGTAGTTTTATTTGAAAAGAAAG | TGTATCTC    c.300
 K  S  S  I  I  I  R  M  R  D  V  V  L  F  E  K  K  V |   Y  L      p.100

          .         .         .         .         .         .       g.13952
 TCAGAGTGCAAGACTGGGAATGGAAAGAACTACAGAGGGACGATGTCCAAAACAAAAAAT       c.360
 S  E  C  K  T  G  N  G  K  N  Y  R  G  T  M  S  K  T  K  N         p.120

          .         .         .         .        | 05.         .    g.15806
 GGCATCACCTGTCAAAAATGGAGTTCCACTTCTCCCCACAGACCTAG | ATTCTCACCTGCT    c.420
 G  I  T  C  Q  K  W  S  S  T  S  P  H  R  P  R  |  F  S  P  A      p.140

          .         .         .         .         .         .       g.15866
 ACACACCCCTCAGAGGGACTGGAGGAGAACTACTGCAGGAATCCAGACAACGATCCGCAG       c.480
 T  H  P  S  E  G  L  E  E  N  Y  C  R  N  P  D  N  D  P  Q         p.160

          .         .         .         .         .         .       g.15926
 GGGCCCTGGTGCTATACTACTGATCCAGAAAAGAGATATGACTACTGCGACATTCTTGAG       c.540
 G  P  W  C  Y  T  T  D  P  E  K  R  Y  D  Y  C  D  I  L  E         p.180

         | 06.         .         .         .         .         .    g.17654
 TGTGAAG | AGGAATGTATGCATTGCAGTGGAGAAAACTATGACGGCAAAATTTCCAAGACC    c.600
 C  E  E |   E  C  M  H  C  S  G  E  N  Y  D  G  K  I  S  K  T      p.200

          .         .         .         .         .         .       g.17714
 ATGTCTGGACTGGAATGCCAGGCCTGGGACTCTCAGAGCCCACACGCTCATGGATACATT       c.660
 M  S  G  L  E  C  Q  A  W  D  S  Q  S  P  H  A  H  G  Y  I         p.220

          | 07         .         .         .         .         .    g.19504
 CCTTCCAA | ATTTCCAAACAAGAACCTGAAGAAGAATTACTGTCGTAACCCCGATAGGGAG    c.720
 P  S  K  |  F  P  N  K  N  L  K  K  N  Y  C  R  N  P  D  R  E      p.240

          .         .         .         .         .         .       g.19564
 CTGCGGCCTTGGTGTTTCACCACCGACCCCAACAAGCGCTGGGAACTTTGTGACATCCCC       c.780
 L  R  P  W  C  F  T  T  D  P  N  K  R  W  E  L  C  D  I  P         p.260

         | 08.         .         .         .         .         .    g.21154
 CGCTGCA | CAACACCTCCACCATCTTCTGGTCCCACCTACCAGTGTCTGAAGGGAACAGGT    c.840
 R  C  T |   T  P  P  P  S  S  G  P  T  Y  Q  C  L  K  G  T  G      p.280

          .         .         .         .         .         .       g.21214
 GAAAACTATCGCGGGAATGTGGCTGTTACCGTGTCCGGGCACACCTGTCAGCACTGGAGT       c.900
 E  N  Y  R  G  N  V  A  V  T  V  S  G  H  T  C  Q  H  W  S         p.300

          .         .         .         .         . | 09       .    g.21510
 GCACAGACCCCTCACACACATAACAGGACACCAGAAAACTTCCCCTGCAA | AAATTTGGAT    c.960
 A  Q  T  P  H  T  H  N  R  T  P  E  N  F  P  C  K  |  N  L  D      p.320

          .         .         .         .         .         .       g.21570
 GAAAACTACTGCCGCAATCCTGACGGAAAAAGGGCCCCATGGTGCCATACAACCAACAGC       c.1020
 E  N  Y  C  R  N  P  D  G  K  R  A  P  W  C  H  T  T  N  S         p.340

          .         .         .         .         .         .       g.21630
 CAAGTGCGGTGGGAGTACTGTAAGATACCGTCCTGTGACTCCTCCCCAGTATCCACGGAA       c.1080
 Q  V  R  W  E  Y  C  K  I  P  S  C  D  S  S  P  V  S  T  E         p.360

          .       | 10 .         .         .         .         .    g.25259
 CAATTGGCTCCCACAG | CACCACCTGAGCTAACCCCTGTGGTCCAGGACTGCTACCATGGT    c.1140
 Q  L  A  P  T  A |   P  P  E  L  T  P  V  V  Q  D  C  Y  H  G      p.380

          .         .         .         .         .         .       g.25319
 GATGGACAGAGCTACCGAGGCACATCCTCCACCACCACCACAGGAAAGAAGTGTCAGTCT       c.1200
 D  G  Q  S  Y  R  G  T  S  S  T  T  T  T  G  K  K  C  Q  S         p.400

          .         .         .         .         .       | 11 .    g.33862
 TGGTCATCTATGACACCACACCGGCACCAGAAGACCCCAGAAAACTACCCAAATGC | TGGC    c.1260
 W  S  S  M  T  P  H  R  H  Q  K  T  P  E  N  Y  P  N  A  |  G      p.420

          .         .         .         .         .         .       g.33922
 CTGACAATGAACTACTGCAGGAATCCAGATGCCGATAAAGGCCCCTGGTGTTTTACCACA       c.1320
 L  T  M  N  Y  C  R  N  P  D  A  D  K  G  P  W  C  F  T  T         p.440

          .         .         .         .         .         .       g.33982
 GACCCCAGCGTCAGGTGGGAGTACTGCAACCTGAAAAAATGCTCAGGAACAGAAGCGAGT       c.1380
 D  P  S  V  R  W  E  Y  C  N  L  K  K  C  S  G  T  E  A  S         p.460

          .         .         .         .         .         | 12    g.34554
 GTTGTAGCACCTCCGCCTGTTGTCCTGCTTCCAGATGTAGAGACTCCTTCCGAAGAAG | AC    c.1440
 V  V  A  P  P  P  V  V  L  L  P  D  V  E  T  P  S  E  E  D |       p.480

          .         .         .         .         .         .       g.34614
 TGTATGTTTGGGAATGGGAAAGGATACCGAGGCAAGAGGGCGACCACTGTTACTGGGACG       c.1500
 C  M  F  G  N  G  K  G  Y  R  G  K  R  A  T  T  V  T  G  T         p.500

          .         .         .         .         .         .       g.34674
 CCATGCCAGGACTGGGCTGCCCAGGAGCCCCATAGACACAGCATTTTCACTCCAGAGACA       c.1560
 P  C  Q  D  W  A  A  Q  E  P  H  R  H  S  I  F  T  P  E  T         p.520

          .         .        | 13.         .         .         .    g.36835
 AATCCACGGGCGGGTCTGGAAAAAAAT | TACTGCCGTAACCCTGATGGTGATGTAGGTGGT    c.1620
 N  P  R  A  G  L  E  K  N   | Y  C  R  N  P  D  G  D  V  G  G      p.540

          .         .         .         .         .         .       g.36895
 CCCTGGTGCTACACGACAAATCCAAGAAAACTTTACGACTACTGTGATGTCCCTCAGTGT       c.1680
 P  W  C  Y  T  T  N  P  R  K  L  Y  D  Y  C  D  V  P  Q  C         p.560

   | 14      .         .         .         .         .         .    g.39753
 G | CGGCCCCTTCATTTGATTGTGGGAAGCCTCAAGTGGAGCCGAAGAAATGTCCTGGAAGG    c.1740
 A |   A  P  S  F  D  C  G  K  P  Q  V  E  P  K  K  C  P  G  R      p.580

          .         .         .         .         .         .       g.39813
 GTTGTAGGGGGGTGTGTGGCCCACCCACATTCCTGGCCCTGGCAAGTCAGTCTTAGAACA       c.1800
 V  V  G  G  C  V  A  H  P  H  S  W  P  W  Q  V  S  L  R  T         p.600

    | 15     .         .         .         .         .         .    g.41403
 AG | GTTTGGAATGCACTTCTGTGGAGGCACCTTGATATCCCCAGAGTGGGTGTTGACTGCT    c.1860
 R  |  F  G  M  H  F  C  G  G  T  L  I  S  P  E  W  V  L  T  A      p.620

          .        | 16.         .         .         .         .    g.41918
 GCCCACTGCTTGGAGAA | GTCCCCAAGGCCTTCATCCTACAAGGTCATCCTGGGTGCACAC    c.1920
 A  H  C  L  E  K  |  S  P  R  P  S  S  Y  K  V  I  L  G  A  H      p.640

          .         .         .         .         .         .       g.41978
 CAAGAAGTGAATCTCGAACCGCATGTTCAGGAAATAGAAGTGTCTAGGCTGTTCTTGGAG       c.1980
 Q  E  V  N  L  E  P  H  V  Q  E  I  E  V  S  R  L  F  L  E         p.660

          .         .         .         | 17         .         .    g.44140
 CCCACACGAAAAGATATTGCCTTGCTAAAGCTAAGCAG | TCCTGCCGTCATCACTGACAAA    c.2040
 P  T  R  K  D  I  A  L  L  K  L  S  S  |  P  A  V  I  T  D  K      p.680

          .         .         .         .         .         .       g.44200
 GTAATCCCAGCTTGTCTGCCATCCCCAAATTATGTGGTCGCTGACCGGACCGAATGTTTC       c.2100
 V  I  P  A  C  L  P  S  P  N  Y  V  V  A  D  R  T  E  C  F         p.700

          .         .      | 18  .         .         .         .    g.54957
 ATCACTGGCTGGGGAGAAACCCAAG | GTACTTTTGGAGCTGGCCTTCTCAAGGAAGCCCAG    c.2160
 I  T  G  W  G  E  T  Q  G |   T  F  G  A  G  L  L  K  E  A  Q      p.720

          .         .         .         .         .         .       g.55017
 CTCCCTGTGATTGAGAATAAAGTGTGCAATCGCTATGAGTTTCTGAATGGAAGAGTCCAA       c.2220
 L  P  V  I  E  N  K  V  C  N  R  Y  E  F  L  N  G  R  V  Q         p.740

          .         .         .         .         .  | 19      .    g.55716
 TCCACCGAACTCTGTGCTGGGCATTTGGCCGGAGGCACTGACAGTTGCCAG | GGTGACAGT    c.2280
 S  T  E  L  C  A  G  H  L  A  G  G  T  D  S  C  Q   | G  D  S      p.760

          .         .         .         .         .         .       g.55776
 GGAGGTCCTCTGGTTTGCTTCGAGAAGGACAAATACATTTTACAAGGAGTCACTTCTTGG       c.2340
 G  G  P  L  V  C  F  E  K  D  K  Y  I  L  Q  G  V  T  S  W         p.780

          .         .         .         .         .         .       g.55836
 GGTCTTGGCTGTGCACGCCCCAATAAGCCTGGTGTCTATGTTCGTGTTTCAAGGTTTGTT       c.2400
 G  L  G  C  A  R  P  N  K  P  G  V  Y  V  R  V  S  R  F  V         p.800

          .         .         .                                     g.55869
 ACTTGGATTGAGGGAGTGATGAGAAATAATTAA                                  c.2433
 T  W  I  E  G  V  M  R  N  N  X                                    p.810

          .         .         .         .         .         .       g.55929
 ttggacgggagacagagtgacgcactgactcacctagaggctggaacgtgggtagggatt       c.*60

          .         .         .         .         .         .       g.55989
 tagcatgctggaaataactggcagtaatcaaacgaagacactgtccccagctaccagcta       c.*120

          .         .         .         .         .         .       g.56049
 cgccaaacctcggcattttttgtgttattttctgactgctggattctgtagtaaggtgac       c.*180

          .         .         .         .         .         .       g.56109
 atagctatgacatttgttaaaaataaactctgtacttaactttgatttgagtaaattttg       c.*240

          .         .         .         .         .         .       g.56169
 gttttggtcttcaacattttcatgctctttgttcaccccaccaatttttaaatgggcaga       c.*300

          .         .         .         .         .         .       g.56229
 tggggggatttagctgcttttgataaggaacagctgcacaaaggactgagcaggctgcaa       c.*360

          .         .         .         .         .         .       g.56289
 ggtcacagaggggagagccaagaagttgtccacgcatttacctcatcagctaacgagggc       c.*420

          .         .         .         .         .         .       g.56349
 ttgacatgcatttttactgtctttattcctgacactgagatgaatgttttcaaagctgca       c.*480

          .         .         .         .         .         .       g.56409
 acatgtatggggagtcatgcaaaccgattctgttattgggaatgaaatctgtcaccgact       c.*540

          .         .         .         .         .         .       g.56469
 gcttgacttgagcccaggggacacggagcagagagctgtatatgatggagtgaaccggtc       c.*600

          .         .         .         .         .         .       g.56529
 catggatgtgtaacacaagaccaactgagagtctgaatgttattctggggcacacgtgag       c.*660

          .         .         .         .         .         .       g.56589
 tctaggattggtgccaagagcatgtaaatgaacaacaagcaaatattgaaggtggaccac       c.*720

          .         .         .         .         .         .       g.56649
 ttatttcccattgctaattgcctgcccggttttgaaacagtctgcagtacacacggtcac       c.*780

          .         .         .         .         .         .       g.56709
 aggagaatgacctgtgggagagatacatgtttagaaggaagagaaaggacaaaggcacac       c.*840

          .         .         .         .         .         .       g.56769
 gttttaccatttaaaatattgttaccaaacaaaaatatccattcaaaatacaatttaaca       c.*900

          .         .         .         .         .         .       g.56829
 atgcaacagtcatcttacagcagagaaatgcagagaaaagcaaaactgcaagtgactgtg       c.*960

          .         .         .                                     g.56862
 aataaagggtgaatgtagtctcaaatcctcaaa                                  c.*993

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Plasminogen protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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