procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) - coding DNA reference sequence

(used for variant description)

(last modified April 30, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_182943.2 in the PLOD2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009251.1, covering PLOD2 transcript NM_182943.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   acaccgccctcccgccagactcccgg       c.-481

 .         .         .         .         .         .                g.5086
 cggctcctcctccctctcccaaacccactcccaaagctaagtgcaggcttccccgttcca       c.-421

 .         .         .         .         .         .                g.5146
 gccagaagcgctgcgtgagcctccacacgtagccgcaggcagctccttaaatagcgtccg       c.-361

 .         .         .         .         .         .                g.5206
 cgctgagcaaacagtccagacgtggggcccaggagggcgagctgaggcgaccgcaccggg       c.-301

 .         .         .         .         .         .                g.5266
 cgcgcagcggcggcgggtcagccggcggccaatagccagggcgcggcccgccccgtcgcc       c.-241

 .         .         .         .         .         .                g.5326
 tcccctcggggagcctataaggcctccgcagcgccccgggcgcctgctgctccgtgcctc       c.-181

 .         .         .         .         .         .                g.5386
 caccgacgacctcactcagctgcgttacgcgccgctccggctgccggccgcgcgccttgc       c.-121

 .         .         .         .         .         .                g.5446
 ccgccggctcccgcccgcaatcggcggctcagggcggacccgggtctctgcgttctcgcg       c.-61

 .         .         .         .         .         .                g.5506
 agaagcgcggcgctgcggggccgtgggcgcctgagcccgcgcggccctcgagggccgaat       c.-1

          .         .         .         .         .         .       g.5566
 ATGGGGGGATGCACGGTGAAGCCTCAGCTGCTGCTCCTGGCGCTCGTCCTCCACCCCTGG       c.60
 M  G  G  C  T  V  K  P  Q  L  L  L  L  A  L  V  L  H  P  W         p.20

          .         .         .         .          | 02        .    g.42277
 AATCCCTGTCTGGGTGCGGACTCGGAGAAGCCCTCGAGCATCCCCACAG | ATAAATTATTA    c.120
 N  P  C  L  G  A  D  S  E  K  P  S  S  I  P  T  D |   K  L  L      p.40

          .         .         .         .         .         .       g.42337
 GTCATAACTGTAGCAACAAAAGAAAGTGATGGATTCCATCGATTTATGCAGTCAGCCAAA       c.180
 V  I  T  V  A  T  K  E  S  D  G  F  H  R  F  M  Q  S  A  K         p.60

          .         .  | 03      .         .         .         .    g.45286
 TATTTCAATTATACTGTGAAG | GTCCTTGGTCAAGGAGAAGAATGGAGAGGTGGTGATGGA    c.240
 Y  F  N  Y  T  V  K   | V  L  G  Q  G  E  E  W  R  G  G  D  G      p.80

          .         .         .         .         .         .       g.45346
 ATTAATAGTATTGGAGGGGGCCAGAAAGTGAGATTAATGAAAGAAGTCATGGAACACTAT       c.300
 I  N  S  I  G  G  G  Q  K  V  R  L  M  K  E  V  M  E  H  Y         p.100

          .         .         .         | 04         .         .    g.56069
 GCTGATCAAGATGATCTGGTTGTCATGTTTACTGAATG | CTTTGATGTCATATTTGCTGGT    c.360
 A  D  Q  D  D  L  V  V  M  F  T  E  C  |  F  D  V  I  F  A  G      p.120

          .         .         .         .         .         .       g.56129
 GGTCCAGAAGAAGTTCTAAAAAAATTCCAAAAGGCAAACCACAAAGTGGTCTTTGCAGCA       c.420
 G  P  E  E  V  L  K  K  F  Q  K  A  N  H  K  V  V  F  A  A         p.140

          .         .         .         .         .         .       g.56189
 GATGGAATTTTGTGGCCAGATAAAAGACTAGCAGACAAGTATCCTGTTGTGCACATTGGG       c.480
 D  G  I  L  W  P  D  K  R  L  A  D  K  Y  P  V  V  H  I  G         p.160

          .         .   | 05     .         .         .         .    g.59889
 AAACGCTATCTGAATTCAGGAG | GATTTATTGGCTATGCTCCATATGTCAACCGTATAGTT    c.540
 K  R  Y  L  N  S  G  G |   F  I  G  Y  A  P  Y  V  N  R  I  V      p.180

          .         .         .         .         .         .       g.59949
 CAACAATGGAATCTCCAGGATAATGATGATGATCAGCTCTTTTACACTAAAGTTTACATT       c.600
 Q  Q  W  N  L  Q  D  N  D  D  D  Q  L  F  Y  T  K  V  Y  I         p.200

          .      | 06  .         .         .         .         .    g.62198
 GATCCACTGAAAAGG | GAAGCTATTAACATCACATTGGATCACAAATGCAAAATTTTCCAG    c.660
 D  P  L  K  R   | E  A  I  N  I  T  L  D  H  K  C  K  I  F  Q      p.220

          .          | 07        .         .         .         .    g.63684
 ACCTTAAATGGAGCTGTAG | ATGAAGTTGTTTTAAAATTTGAAAATGGCAAAGCCAGAGCT    c.720
 T  L  N  G  A  V  D |   E  V  V  L  K  F  E  N  G  K  A  R  A      p.240

          .         .         .         .         .        | 08.    g.74597
 AAGAATACATTTTATGAAACATTACCAGTGGCAATTAATGGAAATGGACCCACCAAG | ATT    c.780
 K  N  T  F  Y  E  T  L  P  V  A  I  N  G  N  G  P  T  K   | I      p.260

          .         .         .         .         .         .       g.74657
 CTCCTGAATTATTTTGGAAACTATGTACCCAATTCATGGACACAGGATAATGGCTGCACT       c.840
 L  L  N  Y  F  G  N  Y  V  P  N  S  W  T  Q  D  N  G  C  T         p.280

          .         .         .          | 09        .         .    g.77805
 CTTTGTGAATTCGATACAGTCGACTTGTCTGCAGTAGAT | GTCCATCCAAACGTATCAATA    c.900
 L  C  E  F  D  T  V  D  L  S  A  V  D   | V  H  P  N  V  S  I      p.300

          .         .         .         .         .         .       g.77865
 GGTGTTTTTATTGAGCAACCAACCCCTTTTCTACCTCGGTTTCTGGACATATTGTTGACA       c.960
 G  V  F  I  E  Q  P  T  P  F  L  P  R  F  L  D  I  L  L  T         p.320

          .         .         .         .      | 10  .         .    g.79602
 CTGGATTACCCAAAAGAAGCACTTAAACTTTTTATTCATAACAAA | GAAGTTTATCATGAA    c.1020
 L  D  Y  P  K  E  A  L  K  L  F  I  H  N  K   | E  V  Y  H  E      p.340

          .         .         .         .         .         .       g.79662
 AAGGACATCAAGGTATTTTTTGATAAAGCTAAGCATGAAATCAAAACTATAAAAATAGTA       c.1080
 K  D  I  K  V  F  F  D  K  A  K  H  E  I  K  T  I  K  I  V         p.360

          .         .         .         .        | 11.         .    g.81235
 GGACCAGAAGAAAATCTAAGTCAAGCGGAAGCCAGAAACATGGGAAT | GGACTTTTGCCGT    c.1140
 G  P  E  E  N  L  S  Q  A  E  A  R  N  M  G  M  |  D  F  C  R      p.380

          .         .         .         .         .         .       g.81295
 CAGGATGAAAAGTGTGATTATTACTTTAGTGTGGATGCAGATGTTGTTTTGACAAATCCA       c.1200
 Q  D  E  K  C  D  Y  Y  F  S  V  D  A  D  V  V  L  T  N  P         p.400

          .         .         .   | 12     .         .         .    g.84660
 AGGACTTTAAAAATTTTGATTGAACAAAACAG | AAAGATCATTGCTCCTCTTGTAACTCGT    c.1260
 R  T  L  K  I  L  I  E  Q  N  R  |  K  I  I  A  P  L  V  T  R      p.420

          .         .         .         .         .         .       g.84720
 CATGGAAAGCTGTGGTCCAATTTCTGGGGAGCATTGAGTCCTGATGGATACTATGCACGA       c.1320
 H  G  K  L  W  S  N  F  W  G  A  L  S  P  D  G  Y  Y  A  R         p.440

          .         .         .         | 13         .         .    g.87260
 TCTGAAGATTATGTGGATATTGTTCAAGGGAATAGAGT | AGGAGTATGGAATGTCCCATAT    c.1380
 S  E  D  Y  V  D  I  V  Q  G  N  R  V  |  G  V  W  N  V  P  Y      p.460

          .         .         .         .         .         .       g.87320
 ATGGCTAATGTGTACTTAATTAAAGGAAAGACACTCCGATCAGAGATGAATGAAAGGAAC       c.1440
 M  A  N  V  Y  L  I  K  G  K  T  L  R  S  E  M  N  E  R  N         p.480

          .         .         .         .         .         .       g.87380
 TATTTTGTTCGTGATAAACTGGATCCTGATATGGCTCTTTGCCGAAATGCTAGAGAAATG       c.1500
 Y  F  V  R  D  K  L  D  P  D  M  A  L  C  R  N  A  R  E  M         p.500

  | 14       .         .         .         .         .         .    g.88631
  | ACTTTACAAAGGGAAAAAGACTCCCCTACTCCGGAAACATTCCAAATGCTCAGCCCCCCA    c.1560
  | T  L  Q  R  E  K  D  S  P  T  P  E  T  F  Q  M  L  S  P  P      p.520

     | 15    .         .         .         .         .         .    g.89657
 AAG | GGTGTATTTATGTACATTTCTAATAGACATGAATTTGGAAGGCTATTATCCACTGCT    c.1620
 K   | G  V  F  M  Y  I  S  N  R  H  E  F  G  R  L  L  S  T  A      p.540

          .         .         .         .         .        | 16.    g.93146
 AATTACAATACTTCCCATTATAACAATGACCTCTGGCAGATTTTTGAAAATCCTGTG | GAC    c.1680
 N  Y  N  T  S  H  Y  N  N  D  L  W  Q  I  F  E  N  P  V   | D      p.560

          .         .         .         .         .         .       g.93206
 TGGAAGGAAAAGTATATAAACCGTGATTATTCAAAGATTTTCACTGAAAATATAGTTGAA       c.1740
 W  K  E  K  Y  I  N  R  D  Y  S  K  I  F  T  E  N  I  V  E         p.580

     | 17    .         .         .         .         .         .    g.93887
 CAG | CCCTGTCCAGATGTCTTTTGGTTCCCCATATTTTCTGAAAAAGCCTGTGATGAATTG    c.1800
 Q   | P  C  P  D  V  F  W  F  P  I  F  S  E  K  A  C  D  E  L      p.600

          .         .         .         .         | 18         .    g.95084
 GTAGAAGAAATGGAACATTACGGCAAATGGTCTGGGGGAAAACATCAT | GATAGCCGTATA    c.1860
 V  E  E  M  E  H  Y  G  K  W  S  G  G  K  H  H   | D  S  R  I      p.620

          .         .         .         .         .         .       g.95144
 TCTGGTGGTTATGAAAATGTCCCAACTGATGATATCCACATGAAGCAAGTTGATCTGGAG       c.1920
 S  G  G  Y  E  N  V  P  T  D  D  I  H  M  K  Q  V  D  L  E         p.640

          .         .         .         .         .         .       g.95204
 AATGTATGGCTTCATTTTATCCGGGAGTTCATTGCACCAGTTACACTGAAGGTCTTTGCA       c.1980
 N  V  W  L  H  F  I  R  E  F  I  A  P  V  T  L  K  V  F  A         p.660

          .      | 19  .         .         .         .         .    g.95373
 GGCTATTATACGAAG | GGATTTGCACTACTGAATTTTGTAGTAAAATACTCCCCTGAACGA    c.2040
 G  Y  Y  T  K   | G  F  A  L  L  N  F  V  V  K  Y  S  P  E  R      p.680

          .         .         .         .         .         .       g.95433
 CAGCGTTCTCTTCGTCCTCATCATGATGCTTCTACATTTACCATAAACATTGCACTTAAT       c.2100
 Q  R  S  L  R  P  H  H  D  A  S  T  F  T  I  N  I  A  L  N         p.700

          .         .  | 20      .         .         .         .    g.95662
 AACGTGGGAGAAGACTTTCAG | GGAGGTGGTTGCAAATTTCTAAGGTACAATTGCTCTATT    c.2160
 N  V  G  E  D  F  Q   | G  G  G  C  K  F  L  R  Y  N  C  S  I      p.720

          .         .         .         .         .         .       g.95722
 GAGTCACCACGAAAAGGCTGGAGCTTCATGCATCCTGGGAGACTCACACATTTGCATGAA       c.2220
 E  S  P  R  K  G  W  S  F  M  H  P  G  R  L  T  H  L  H  E         p.740

          .         .         .         .         .                 g.95779
 GGACTTCCTGTTAAAAATGGAACAAGATACATTGCAGTGTCATTTATAGATCCCTAA          c.2277
 G  L  P  V  K  N  G  T  R  Y  I  A  V  S  F  I  D  P  X            p.758

          .         .         .         .         .         .       g.95839
 gttatttacttttcattgaattgaaatttattttggatgaatgactggcatgaacacgtc       c.*60

          .         .         .         .         .         .       g.95899
 tttgaagttgtggctgagaagatgagaggaatatttaaataacatcaacagaacaacttc       c.*120

          .         .         .         .         .         .       g.95959
 actttgggccaaacatttgaaaaactttttataaaaaattgtttgatatttcttaatgtc       c.*180

          .         .         .         .         .         .       g.96019
 tgctctgagccttaaaacacagattgaagaagaaaagaaagaaaaaacttaaatatttat       c.*240

          .         .         .         .         .         .       g.96079
 ttctatgctttgttgcctctgagaataatgacaatttatgaatttgtgtttcaaattgat       c.*300

          .         .         .         .         .         .       g.96139
 aaaatatttaggtacaaataacaagactaataatattttcttatttaaaaaaagcatggg       c.*360

          .         .         .         .         .         .       g.96199
 aagatttttatttatcaaaatatagaggaaatgtagacaaaatggatataaatgaaaatt       c.*420

          .         .         .         .         .         .       g.96259
 accatgttgtaaaaccttgaaaatcagattctaactggatttgtatgcaactaagtattt       c.*480

          .         .         .         .         .         .       g.96319
 ttctgaacacctatgcaggtcttatttacagtagttactaagggaacacacaaagaatta       c.*540

          .         .         .         .         .         .       g.96379
 cacaacgttttcctcaagaaaatggtacaaaacacaaccgaggagcgtatacagttgaaa       c.*600

          .         .         .         .         .         .       g.96439
 acatttttgttttgattggaaggcagattattttatattagtattaaaaatcaaacccta       c.*660

          .         .         .         .         .         .       g.96499
 tgtttctttcagatgaatcttccaaagtggattatattaagcaggtattagatttaggaa       c.*720

          .         .         .         .         .         .       g.96559
 aacctttccatttcttaaagtattatcaagtgtcaagatcagcaagtgtccttaagtcaa       c.*780

          .         .         .         .         .         .       g.96619
 acaggttttttttgttgttgtttttgctttgtttccttttttagaaagttctagaaaata       c.*840

          .         .         .         .         .         .       g.96679
 ggaaaacgaaaaatttcattgagatgagtagtgcatttaattattttttaaaaaactttt       c.*900

          .         .         .         .         .         .       g.96739
 taagtacttgaattttatatcaggaaaacaaagttgttgagccttgcttcttccgttttg       c.*960

          .         .         .         .         .         .       g.96799
 ccctttgtctcgctccttattctttttttggggggagggttatttgcttttttatcttcc       c.*1020

          .         .         .         .         .         .       g.96859
 tggcataatttccattttattcttctgagtgtctatgttaacttccctctatcccgctta       c.*1080

          .         .         .         .         .         .       g.96919
 taaaaaaattctccaacaaaaatacttgttgacttgatgttttatcacttctctaagtaa       c.*1140

          .         .         .         .         .         .       g.96979
 ggttgaaatatccttattgtagctactgtttttaatgtaaaggttaaacttgaaaagaaa       c.*1200

          .         .         .         .         .         .       g.97039
 ttcttaatcacggtgccaaaattcattttctaacaccatgtgttagaaaattataaaaaa       c.*1260

          .                                                         g.97056
 taaaataattttagaaa                                                  c.*1277

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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