proteolipid protein 1 (PLP1) - coding DNA reference sequence

(used for variant description)

(last modified September 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000533.3 in the PLP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008863.1, covering PLP1 transcript NM_000533.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5365
           tcaatcagaaagcccttttcattgcaggagaagaggacaaagatactcag       c.-121

 .         .         .         .         .         .                g.5425
 agagaaaaagtaaaagaccgaagaaggaggctggagagaccaggatccttccagctgaac       c.-61

 .         .         .         .         .         .                g.5485
 aaagtcagccacaaagcagactagccagccggctacaattggagtcagagtcccaaagac       c.-1

      | 02   .         .         .         .         .         .    g.14128
 ATGG | GCTTGTTAGAGTGCTGTGCAAGATGTCTGGTAGGGGCCCCCTTTGCTTCCCTGGTG    c.60
 M  G |   L  L  E  C  C  A  R  C  L  V  G  A  P  F  A  S  L  V      p.20

          .         .         .         .         .         .       g.14188
 GCCACTGGATTGTGTTTCTTTGGGGTGGCACTGTTCTGTGGCTGTGGACATGAAGCCCTC       c.120
 A  T  G  L  C  F  F  G  V  A  L  F  C  G  C  G  H  E  A  L         p.40

          .         .         .         .         .         .       g.14248
 ACTGGCACAGAAAAGCTAATTGAGACCTATTTCTCCAAAAACTACCAAGACTATGAGTAT       c.180
 T  G  T  E  K  L  I  E  T  Y  F  S  K  N  Y  Q  D  Y  E  Y         p.60

          .  | 03      .         .         .         .         .    g.15004
 CTCATCAATGT | GATCCATGCCTTCCAGTATGTCATCTATGGAACTGCCTCTTTCTTCTTC    c.240
 L  I  N  V  |  I  H  A  F  Q  Y  V  I  Y  G  T  A  S  F  F  F      p.80

          .         .         .         .         .         .       g.15064
 CTTTATGGGGCCCTCCTGCTGGCTGAGGGCTTCTACACCACCGGCGCAGTCAGGCAGATC       c.300
 L  Y  G  A  L  L  L  A  E  G  F  Y  T  T  G  A  V  R  Q  I         p.100

          .         .         .         .         .         .       g.15124
 TTTGGCGACTACAAGACCACCATCTGCGGCAAGGGCCTGAGCGCAACGGTAACAGGGGGC       c.360
 F  G  D  Y  K  T  T  I  C  G  K  G  L  S  A  T  V  T  G  G         p.120

          .         .         .         .         .         .       g.15184
 CAGAAGGGGAGGGGTTCCAGAGGCCAACATCAAGCTCATTCTTTGGAGCGGGTGTGTCAT       c.420
 Q  K  G  R  G  S  R  G  Q  H  Q  A  H  S  L  E  R  V  C  H         p.140

          .         .         .    | 04    .         .         .    g.16315
 TGTTTGGGAAAATGGCTAGGACATCCCGACAAG | TTTGTGGGCATCACCTATGCCCTGACC    c.480
 C  L  G  K  W  L  G  H  P  D  K   | F  V  G  I  T  Y  A  L  T      p.160

          .         .         .         .         .         .       g.16375
 GTTGTGTGGCTCCTGGTGTTTGCCTGCTCTGCTGTGCCTGTGTACATTTACTTCAACACC       c.540
 V  V  W  L  L  V  F  A  C  S  A  V  P  V  Y  I  Y  F  N  T         p.180

          .         .         .         .         .         .       g.16435
 TGGACCACCTGCCAGTCTATTGCCTTCCCCAGCAAGACCTCTGCCAGTATAGGCAGTCTC       c.600
 W  T  T  C  Q  S  I  A  F  P  S  K  T  S  A  S  I  G  S  L         p.200

          .         .   | 05     .         .         .         .    g.16965
 TGTGCTGATGCCAGAATGTATG | GTGTTCTCCCATGGAATGCTTTCCCTGGCAAGGTTTGT    c.660
 C  A  D  A  R  M  Y  G |   V  L  P  W  N  A  F  P  G  K  V  C      p.220

          .         .         .       | 06 .         .         .    g.17847
 GGCTCCAACCTTCTGTCCATCTGCAAAACAGCTGAG | TTCCAAATGACCTTCCACCTGTTT    c.720
 G  S  N  L  L  S  I  C  K  T  A  E   | F  Q  M  T  F  H  L  F      p.240

          .         .         .         .   | 07     .         .    g.19034
 ATTGCTGCATTTGTGGGGGCTGCAGCTACACTGGTTTCCCTG | CTCACCTTCATGATTGCT    c.780
 I  A  A  F  V  G  A  A  A  T  L  V  S  L   | L  T  F  M  I  A      p.260

          .         .         .         .         .                 g.19088
 GCCACTTACAACTTTGCCGTCCTTAAACTCATGGGCCGAGGCACCAAGTTCTGA             c.834
 A  T  Y  N  F  A  V  L  K  L  M  G  R  G  T  K  F  X               p.277

          .         .         .         .         .         .       g.19148
 tcccccgtagaaatccccctttctctaatagcgaggctctaaccacacagcctacaatgc       c.*60

          .         .         .         .         .         .       g.19208
 tgcgtctcccatcttaactctttgcctttgccaccaactggccctcttcttacttgatga       c.*120

          .         .         .         .         .         .       g.19268
 gtgtaacaagaaaggagagtcttgcagtgattaaggtctctctttggactctcccctctt       c.*180

          .         .         .         .         .         .       g.19328
 atgtacctcttttagtcattttgcttcatagctggttcctgctagaaatgggaaatgcct       c.*240

          .         .         .         .         .         .       g.19388
 aagaagatgacttcccaactgcaagtcacaaaggaatggaggctctaattgaattttcaa       c.*300

          .         .         .         .         .         .       g.19448
 gcatctcctgaggatcagaaagtaatttcttctcaaagggtacttccactgatggaaaca       c.*360

          .         .         .         .         .         .       g.19508
 aagtggaaggaaagatgctcaggtacagagaaggaatgtctttggtcctcttgccatcta       c.*420

          .         .         .         .         .         .       g.19568
 taggggccaaatatattctctttggtgtacaaaatggaattcattctggtctctctatta       c.*480

          .         .         .         .         .         .       g.19628
 ccactgaagatagaagaaaaaagaatgtcagaaaaacaataagagcgtttgcccaaatct       c.*540

          .         .         .         .         .         .       g.19688
 gcctattgcagctgggagaagggggtcaaagcaaggatctttcacccacagaaagagagc       c.*600

          .         .         .         .         .         .       g.19748
 actgaccccgatggcgatggactactgaagccctaactcagccaaccttacttacagcat       c.*660

          .         .         .         .         .         .       g.19808
 aagggagcgtagaatctgtgtagacgaagggggcatctggccttacacctcgttagggaa       c.*720

          .         .         .         .         .         .       g.19868
 gagaaacagggtgttgtcagcatcttctcactcccttctccttgataacagctaccatga       c.*780

          .         .         .         .         .         .       g.19928
 caaccctgtggtttccaaggagctgagaatagaaggaaactagcttacatgagaacagac       c.*840

          .         .         .         .         .         .       g.19988
 tggcctgaggagcagcagttgctggtggctaatggtgtaacctgagatggccctctggta       c.*900

          .         .         .         .         .         .       g.20048
 gacacaggatagataactctttggatagcatgtctttttttctgttaattagttgtgtac       c.*960

          .         .         .         .         .         .       g.20108
 tctggcctctgtcatatcttcacaatggtgctcatttcatgggggtattatccattcagt       c.*1020

          .         .         .         .         .         .       g.20168
 catcgtaggtgatttgaaggtcttgatttgttttagaatgatgcacatttcatgtattcc       c.*1080

          .         .         .         .         .         .       g.20228
 agtttgtttattacttatttggggttgcatcagaaatgtctggagaataattctttgatt       c.*1140

          .         .         .         .         .         .       g.20288
 atgactgttttttaaactaggaaaattggacattaagcatcacaaatgatattaaaaatt       c.*1200

          .         .         .         .         .         .       g.20348
 ggctagttgaatctattgggattttctacaagtattctgcctttgcagaaacagatttgg       c.*1260

          .         .         .         .         .         .       g.20408
 tgaatttgaatctcaatttgagtaatctgatcgttctttctagctaatggaaaatgattt       c.*1320

          .         .         .         .         .         .       g.20468
 tacttagcaatgttatcttggtgtgttaagagttaggtttaacataaaggttattttctc       c.*1380

          .         .         .         .         .         .       g.20528
 ctgatatagatcacataacagaatgcaccagtcatcagctattcagttggtaagcttcca       c.*1440

          .         .         .         .         .         .       g.20588
 ggaaaaaggacaggcagaaagagtttgagacctgaatagctcccagatttcagtcttttc       c.*1500

          .         .         .         .         .         .       g.20648
 ctgtttttgttaactttgggttaaaaaaaaaaaaagtctgattggttttaattgaaggaa       c.*1560

          .         .         .         .         .         .       g.20708
 agatttgtactacagttcttttgttgtaaagagttgtgttgttcttttcccccaaagtgg       c.*1620

          .         .         .         .         .         .       g.20768
 tttcagcaatatttaaggagatgtaagagctttacaaaaagacacttgatacttgttttc       c.*1680

          .         .         .         .         .         .       g.20828
 aaaccagtatacaagataagcttccaggctgcatagaaggaggagagggaaaatgttttg       c.*1740

          .         .         .         .         .         .       g.20888
 taagaaaccaatcaagataaaggacagtgaagtaatccgtaccttgtgttttgttttgat       c.*1800

          .         .         .         .         .         .       g.20948
 ttaataacataacaaataaccaacccttccctgaaaacctcacatgcatacatacacata       c.*1860

          .         .         .         .         .         .       g.21008
 tatacacacacaaagagagttaatcaactgaaagtgtttccttcatttctgatatagaat       c.*1920

          .         .         .         .         .         .       g.21068
 tgcaattttaacacacataaaggataaacttttagaaacttatcttacaaagtgtatttt       c.*1980

          .         .         .         .                           g.21110
 ataaaattaaagaaaataaaattaagaatgttctcaatcaaa                         c.*2022

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Proteolipid protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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