plastin 3 (PLS3) - coding DNA reference sequence

(used for variant description)

(last modified October 22, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_005032.5 in the PLS3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012518.1, covering PLS3 transcript NM_005032.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5030
  ttattaatcccacaagattgtgtgaatgtgtactccgagccaggcacgttggacttcta       c.-361

 .         .         .         .         .         .                g.5090
 acttcctcttagcccaagtaggaaggggagactcaggcgctggggaccattctcctctcc       c.-301

 .         .         .         .         .         .                g.5150
 ctgcagcagagttgcagtccctatccctcctgggtgcccatccccgtgcctattttcctg       c.-241

 .         .         .         .         .         .                g.5210
 gatccccacccagttgatgtgacaggctcgtggcccaatccccttcctggttcccaggcc       c.-181

 .         .         .         .         .         .                g.5270
 gactgctagcaccacccgagccaatggcggcggccgaggggcggagggggctggcaggag       c.-121

 .         .         .         .         .         .                g.5330
 gggagggagcgctggctttagagccacagctgcaaagattccgaggtgcagaagttgtct       c.-61

 .         .         .         .         .         .  | 02          g.54357
 gagtgcgttggtcggcggcagtcgggccagacccaggactctgcgactttac | atctttaa    c.-1

          .         .         .         .         .         .       g.54417
 ATGGATGAGATGGCTACCACTCAGATTTCCAAAGATGAGCTTGATGAACTCAAAGAGGCC       c.60
 M  D  E  M  A  T  T  Q  I  S  K  D  E  L  D  E  L  K  E  A         p.20

          .    | 03    .         .         .         .         .    g.66399
 TTTGCAAAAGTTG | ATCTCAACAGCAACGGATTCATTTGTGACTATGAACTTCATGAGCTC    c.120
 F  A  K  V  D |   L  N  S  N  G  F  I  C  D  Y  E  L  H  E  L      p.40

          .         .         .         .         .         .       g.66459
 TTCAAGGAAGCTAATATGCCATTACCAGGATATAAAGTGAGAGAAATTATTCAGAAACTC       c.180
 F  K  E  A  N  M  P  L  P  G  Y  K  V  R  E  I  I  Q  K  L         p.60

          .         .         .         .         .        | 04.    g.73307
 ATGCTGGATGGTGACAGGAATAAAGATGGGAAAATAAGTTTTGACGAATTTGTTTAT | ATT    c.240
 M  L  D  G  D  R  N  K  D  G  K  I  S  F  D  E  F  V  Y   | I      p.80

          .         .         .         .         .         .       g.73367
 TTTCAAGAGGTAAAAAGTAGTGATATTGCCAAGACCTTCCGCAAAGCAATCAACAGGAAA       c.300
 F  Q  E  V  K  S  S  D  I  A  K  T  F  R  K  A  I  N  R  K         p.100

          .         .         .         .         .         .       g.73427
 GAAGGTATTTGTGCTCTGGGTGGAACTTCAGAGTTGTCCAGCGAAGGAACACAGCATTCT       c.360
 E  G  I  C  A  L  G  G  T  S  E  L  S  S  E  G  T  Q  H  S         p.120

         | 05.         .         .         .         .         .    g.73994
 TACTCAG | AGGAAGAAAAATATGCTTTTGTTAACTGGATAAACAAAGCTTTGGAAAATGAT    c.420
 Y  S  E |   E  E  K  Y  A  F  V  N  W  I  N  K  A  L  E  N  D      p.140

          .         .         .         .         .         .       g.74054
 CCTGATTGTAGACATGTTATACCAATGAACCCTAACACCGATGACCTGTTCAAAGCTGTT       c.480
 P  D  C  R  H  V  I  P  M  N  P  N  T  D  D  L  F  K  A  V         p.160

          .         . | 06       .         .         .         .    g.78146
 GGTGATGGAATTGTGCTTTG | TAAAATGATTAACCTTTCAGTTCCTGATACCATTGATGAA    c.540
 G  D  G  I  V  L  C  |  K  M  I  N  L  S  V  P  D  T  I  D  E      p.180

          .         .         .         .   | 07     .         .    g.79005
 AGAGCAATCAACAAGAAGAAACTTACACCCTTCATCATTCAG | GAAAACTTGAACTTGGCA    c.600
 R  A  I  N  K  K  K  L  T  P  F  I  I  Q   | E  N  L  N  L  A      p.200

          .         .         .         .         .         .       g.79065
 CTGAACTCTGCTTCTGCCATTGGGTGTCATGTTGTGAACATTGGTGCAGAAGATTTGAGG       c.660
 L  N  S  A  S  A  I  G  C  H  V  V  N  I  G  A  E  D  L  R         p.220

          .         .         .         .         .         .       g.79125
 GCTGGGAAACCTCATCTGGTTTTGGGACTGCTTTGGCAGATCATTAAGATCGGTTTGTTC       c.720
 A  G  K  P  H  L  V  L  G  L  L  W  Q  I  I  K  I  G  L  F         p.240

          .         .         | 08         .         .         .    g.80974
 GCTGACATTGAATTAAGCAGGAATGAAG | CCTTGGCTGCTTTACTCCGAGATGGTGAGACT    c.780
 A  D  I  E  L  S  R  N  E  A |   L  A  A  L  L  R  D  G  E  T      p.260

          .         .         .         .         .         .       g.81034
 TTGGAGGAACTTATGAAATTGTCTCCAGAAGAGCTTCTGCTTAGATGGGCAAACTTTCAT       c.840
 L  E  E  L  M  K  L  S  P  E  E  L  L  L  R  W  A  N  F  H         p.280

          .         .         .         .         .  | 09      .    g.84523
 TTGGAAAACTCGGGCTGGCAAAAAATTAACAACTTTAGTGCTGACATCAAG | GATTCCAAA    c.900
 L  E  N  S  G  W  Q  K  I  N  N  F  S  A  D  I  K   | D  S  K      p.300

          .         .         .         .         .         .       g.84583
 GCCTATTTCCATCTTCTCAATCAAATCGCACCAAAAGGACAAAAGGAAGGTGAACCACGG       c.960
 A  Y  F  H  L  L  N  Q  I  A  P  K  G  Q  K  E  G  E  P  R         p.320

          .         .        | 10.         .         .         .    g.87452
 ATAGATATTAACATGTCAGGTTTCAAT | GAAACAGATGATTTGAAGAGAGCTGAGAGTATG    c.1020
 I  D  I  N  M  S  G  F  N   | E  T  D  D  L  K  R  A  E  S  M      p.340

          .         .         .         .         .         .       g.87512
 CTTCAACAAGCAGATAAATTAGGTTGCAGACAGTTTGTTACCCCTGCTGATGTTGTCAGT       c.1080
 L  Q  Q  A  D  K  L  G  C  R  Q  F  V  T  P  A  D  V  V  S         p.360

          .         .         .         .         .         .       g.87572
 GGAAACCCCAAACTCAACTTAGCTTTCGTGGCTAACCTGTTTAATAAATACCCAGCACTA       c.1140
 G  N  P  K  L  N  L  A  F  V  A  N  L  F  N  K  Y  P  A  L         p.380

          .         .         .         .    | 11    .         .    g.89152
 ACTAAGCCAGAGAACCAGGATATTGACTGGACTCTATTAGAAG | GAGAAACTCGTGAAGAA    c.1200
 T  K  P  E  N  Q  D  I  D  W  T  L  L  E  G |   E  T  R  E  E      p.400

          .         .         .         .         .         .       g.89212
 AGAACCTTCCGTAACTGGATGAACTCTCTTGGTGTCAATCCTCACGTAAACCATCTCTAT       c.1260
 R  T  F  R  N  W  M  N  S  L  G  V  N  P  H  V  N  H  L  Y         p.420

    | 12     .         .         .         .         .         .    g.90244
 GC | TGACCTGCAAGATGCCCTGGTAATCTTACAGTTATATGAACGAATTAAAGTTCCTGTT    c.1320
 A  |  D  L  Q  D  A  L  V  I  L  Q  L  Y  E  R  I  K  V  P  V      p.440

          .         .         .         .         .        | 13.    g.90519
 GACTGGAGTAAGGTTAATAAACCTCCATACCCGAAACTGGGAGCCAACATGAAAAAG | CTA    c.1380
 D  W  S  K  V  N  K  P  P  Y  P  K  L  G  A  N  M  K  K   | L      p.460

          .         .         .         .         .         .       g.90579
 GAAAACTGCAACTATGCTGTTGAATTAGGGAAGCATCCTGCTAAATTCTCCCTGGTTGGC       c.1440
 E  N  C  N  Y  A  V  E  L  G  K  H  P  A  K  F  S  L  V  G         p.480

          .         .         .         .         .         .       g.90639
 ATTGGAGGGCAAGACCTGAATGATGGGAACCAAACCCTGACTTTAGCTTTAGTCTGGCAG       c.1500
 I  G  G  Q  D  L  N  D  G  N  Q  T  L  T  L  A  L  V  W  Q         p.500

          .  | 14      .         .         .         .         .    g.91713
 CTGATGAGAAG | ATATACCCTCAATGTCCTGGAAGATCTTGGAGATGGTCAGAAAGCCAAT    c.1560
 L  M  R  R  |  Y  T  L  N  V  L  E  D  L  G  D  G  Q  K  A  N      p.520

          .         .         .         .         .         .       g.91773
 GACGACATCATTGTGAACTGGGTGAACAGAACGTTGAGTGAAGCTGGAAAATCAACTTCC       c.1620
 D  D  I  I  V  N  W  V  N  R  T  L  S  E  A  G  K  S  T  S         p.540

          .      | 15  .         .         .         .         .    g.92052
 ATTCAGAGTTTTAAG | GACAAGACGATCAGCTCCAGTTTGGCAGTTGTGGATTTAATTGAT    c.1680
 I  Q  S  F  K   | D  K  T  I  S  S  S  L  A  V  V  D  L  I  D      p.560

          .         .         .         .         .         .       g.92112
 GCCATCCAGCCAGGCTGTATAAACTATGACCTTGTGAAGAGTGGCAATCTAACAGAAGAT       c.1740
 A  I  Q  P  G  C  I  N  Y  D  L  V  K  S  G  N  L  T  E  D         p.580

          .         . | 16       .         .         .         .    g.93583
 GACAAGCACAATAATGCCAA | GTATGCAGTGTCAATGGCTAGAAGAATCGGAGCCAGAGTG    c.1800
 D  K  H  N  N  A  K  |  Y  A  V  S  M  A  R  R  I  G  A  R  V      p.600

          .         .         .         .         .         .       g.93643
 TATGCTCTCCCTGAAGACCTTGTGGAAGTAAAGCCCAAGATGGTCATGACTGTGTTTGCA       c.1860
 Y  A  L  P  E  D  L  V  E  V  K  P  K  M  V  M  T  V  F  A         p.620

          .         .         .                                     g.93676
 TGTTTGATGGGCAGGGGAATGAAGAGAGTGTAA                                  c.1893
 C  L  M  G  R  G  M  K  R  V  X                                    p.630

          .         .         .         .         .         .       g.93736
 aataaccaatctgaataaaacagccatgctcccaggtgcatgattcgcaggtcagctatt       c.*60

          .         .         .         .         .         .       g.93796
 tccaggtgaagtgcttatggcttaaggaactcttggccattcaaaggacttttcattttg       c.*120

          .         .         .         .         .         .       g.93856
 attaacaggactagcttatcatgagagccctcaggggaaagggtttaagaaaaacaactc       c.*180

          .         .         .         .         .         .       g.93916
 ctctttcccatagtcagagttgaatttgtcaggcacgcctgaaatgtgctcatagccaaa       c.*240

          .         .         .         .         .         .       g.93976
 acattttactctctcctcctagaatgctgcccttgacatttcccattgctgtatgttatt       c.*300

          .         .         .         .         .         .       g.94036
 tcttgctctgttatcttttgccctcttagaatgtccctctcttgggacttgcttagatga       c.*360

          .         .         .         .         .         .       g.94096
 tgggatatgaatattattagacagtaattttgctttccatccagtatgctagttcttatt       c.*420

          .         .         .         .         .         .       g.94156
 cgagaactatggtcagagcgtatttggatatgagtatcctttgcttatctttgtagtact       c.*480

          .         .         .         .         .         .       g.94216
 gaaaatttgccgaagtaactggctgtgcagaatgtaatagaagcttttcttattctttta       c.*540

          .         .         .         .         .         .       g.94276
 ttcttaagatcagtatctttttacagtattctttctacatgatccttttttgtacattta       c.*600

          .         .         .         .         .         .       g.94336
 agaatattttgattatattaaacaagactgctgattttgctactttttttaaggggtctt       c.*660

          .         .         .         .         .         .       g.94396
 caagtaagtaaaacatacatcgtagctagaagaaaaatgtaccttaaatttgcatcttcc       c.*720

          .         .         .         .         .         .       g.94456
 ctctcatacccaagctgtaaacaattgaaatattttgtcttaaatcacttggttcaatac       c.*780

          .         .         .         .         .         .       g.94516
 atgcttatttgttttaaaacctgtatcatcaaactctctctctaaatttaaaatgctgtt       c.*840

          .         .         .         .         .         .       g.94576
 gaatatgatacttttgaggagagagtgtgctcagaacttagacgggatttggtaggccaa       c.*900

          .         .         .         .         .         .       g.94636
 gtatgctaagtgtacaatatattttttaattttacacctgaaacaaagaaatgtggtcac       c.*960

          .         .         .         .         .         .       g.94696
 taaaaataaaagtatatatgtaggaattaatgtactcttgctttgtcaagctgtttgcta       c.*1020

          .         .         .         .         .         .       g.94756
 tagtttccaaggtattatgttactctaactctgaaaagtgatgtaatctggtagcaatgt       c.*1080

          .         .         .         .         .         .       g.94816
 agtagttcaaataaaggcatttacataataattagtctgttcttcatgcttttgtctctt       c.*1140

          .         .         .         .         .         .       g.94876
 aggaagtatgccaatgtttgtcaggatttttttctttttgtttttctgatgtattctgta       c.*1200

          .         .         .         .         .         .       g.94936
 aaatggtgtttgttaaatttgagttttgggagctgaattagaggtactgaattaaggaca       c.*1260

          .         .         .         .                           g.94976
 gtacaaatgaagtaaaaaggttttctccaatttaccaaaa                           c.*1300

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Plastin 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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