PMS1 postmeiotic segregation increased 1 (S. cerevisiae) (PMS1) - coding DNA reference sequence

(used for variant description)

(last modified August 22, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000534.4 in the PMS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008648.1, covering PMS1 transcript NM_000534.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5049
            ggcaagacaacgaggatttgcgtagggggcgagcctctgaggccacttg       c.-481

 .         .         .         .         .         .                g.5109
 gctcttacggccacgcagggcgccgcagatgcagccggagcccgcttttccctctcagga       c.-421

 .         .         .         .         .         .                g.5169
 cgacccctaggccgccagcagttccctaccgacgaaggcgactgtacagcgtccaccgcg       c.-361

 .         .         .         .         .         .                g.5229
 ttcgtgcccacttacccgccgccccactccgggccgccggctcgcagcaggaccagcccg       c.-301

 .         .         .         .         .         .                g.5289
 gctgctacggccgcggatacacgccctcaggcccggcgctgcgcagcttgcggaagcttt       c.-241

 .         .         .         .         .         .                g.5349
 cccggacagactcgctgccagcggattggctgcgagcagcgccaatctcacgttgccccc       c.-181

 .         .         .         .         .         .                g.5409
 gggcgaggcgggactcagtgccgcgctctctgcacccgctctgccgcgcgcgtgcgtgct       c.-121

 .         .         .         .         .         .                g.5469
 gggtgcgggtgcgggtgcggggttgggcctgcgcatcgggtgagacgctggctgcttgcg       c.-61

 .         .         .         .          | 02        .             g.12725
 gctagtggatggtaattgcctgcctcgcgctagcaggaag | ctgctctgttaaaagcgaaa    c.-1

          .         .         .         .         .         .       g.12785
 ATGAAACAATTGCCTGCGGCAACAGTTCGACTCCTTTCAAGTTCTCAGATCATCACTTCG       c.60
 M  K  Q  L  P  A  A  T  V  R  L  L  S  S  S  Q  I  I  T  S         p.20

          .         .         .         .         .         .       g.12845
 GTGGTCAGTGTTGTAAAAGAGCTTATTGAAAACTCCTTGGATGCTGGTGCCACAAGCGTA       c.120
 V  V  S  V  V  K  E  L  I  E  N  S  L  D  A  G  A  T  S  V         p.40

          .   | 03     .         .         .         .         .    g.16732
 GATGTTAAACTG | GAGAACTATGGATTTGATAAAATTGAGGTGCGAGATAACGGGGAGGGT    c.180
 D  V  K  L   | E  N  Y  G  F  D  K  I  E  V  R  D  N  G  E  G      p.60

          .         .         .         .         .         .       g.16792
 ATCAAGGCTGTTGATGCACCTGTAATGGCAATGAAGTACTACACCTCAAAAATAAATAGT       c.240
 I  K  A  V  D  A  P  V  M  A  M  K  Y  Y  T  S  K  I  N  S         p.80

          .         .         .         .         .         .       g.16852
 CATGAAGATCTTGAAAATTTGACAACTTACGGTTTTCGTGGAGAAGCCTTGGGGTCAATT       c.300
 H  E  D  L  E  N  L  T  T  Y  G  F  R  G  E  A  L  G  S  I         p.100

          .      | 04  .         .         .         .         .    g.26612
 TGTTGTATAGCTGAG | GTTTTAATTACAACAAGAACGGCTGCTGATAATTTTAGCACCCAG    c.360
 C  C  I  A  E   | V  L  I  T  T  R  T  A  A  D  N  F  S  T  Q      p.120

          .         .         .         .         .         | 05    g.38934
 TATGTTTTAGATGGCAGTGGCCACATACTTTCTCAGAAACCTTCACATCTTGGTCAAG | GT    c.420
 Y  V  L  D  G  S  G  H  I  L  S  Q  K  P  S  H  L  G  Q  G |       p.140

          .         .         .         .         .         .       g.38994
 ACAACTGTAACTGCTTTAAGATTATTTAAGAATCTACCTGTAAGAAAGCAGTTTTACTCA       c.480
 T  T  V  T  A  L  R  L  F  K  N  L  P  V  R  K  Q  F  Y  S         p.160

          .         .         .         .         .         .       g.39054
 ACTGCAAAAAAATGTAAAGATGAAATAAAAAAGATCCAAGATCTCCTCATGAGCTTTGGT       c.540
 T  A  K  K  C  K  D  E  I  K  K  I  Q  D  L  L  M  S  F  G         p.180

          .         .         .         .   | 06     .         .    g.64897
 ATCCTTAAACCTGACTTAAGGATTGTCTTTGTACATAACAAG | GCAGTTATTTGGCAGAAA    c.600
 I  L  K  P  D  L  R  I  V  F  V  H  N  K   | A  V  I  W  Q  K      p.200

          .         .         .         .         .         .       g.64957
 AGCAGAGTATCAGATCACAAGATGGCTCTCATGTCAGTTCTGGGGACTGCTGTTATGAAC       c.660
 S  R  V  S  D  H  K  M  A  L  M  S  V  L  G  T  A  V  M  N         p.220

          .         .         .          | 07        .         .    g.73591
 AATATGGAATCCTTTCAGTACCACTCTGAAGAATCTCAG | ATTTATCTCAGTGGATTTCTT    c.720
 N  M  E  S  F  Q  Y  H  S  E  E  S  Q   | I  Y  L  S  G  F  L      p.240

          .         .         .         .         .         .       g.73651
 CCAAAGTGTGATGCAGACCACTCTTTCACTAGTCTTTCAACACCAGAAAGAAGTTTCATC       c.780
 P  K  C  D  A  D  H  S  F  T  S  L  S  T  P  E  R  S  F  I         p.260

          .         .         .         .   | 08     .         .    g.74872
 TTCATAAACAGTCGACCAGTACATCAAAAAGATATCTTAAAG | TTAATCCGACATCATTAC    c.840
 F  I  N  S  R  P  V  H  Q  K  D  I  L  K   | L  I  R  H  H  Y      p.280

          .         .         .         .         .         .       g.74932
 AATCTGAAATGCCTAAAGGAATCTACTCGTTTGTATCCTGTTTTCTTTCTGAAAATCGAT       c.900
 N  L  K  C  L  K  E  S  T  R  L  Y  P  V  F  F  L  K  I  D         p.300

          .         .         .         .         .         .       g.74992
 GTTCCTACAGCTGATGTTGATGTAAATTTAACACCAGATAAAAGCCAAGTATTATTACAA       c.960
 V  P  T  A  D  V  D  V  N  L  T  P  D  K  S  Q  V  L  L  Q         p.320

        | 09 .         .         .         .         .         .    g.75208
 AATAAG | GAATCTGTTTTAATTGCTCTTGAAAATCTGATGACGACTTGTTATGGACCATTA    c.1020
 N  K   | E  S  V  L  I  A  L  E  N  L  M  T  T  C  Y  G  P  L      p.340

          .         .         .         .         .         .       g.75268
 CCTAGTACAAATTCTTATGAAAATAATAAAACAGATGTTTCCGCAGCTGACATCGTTCTT       c.1080
 P  S  T  N  S  Y  E  N  N  K  T  D  V  S  A  A  D  I  V  L         p.360

          .         .         .         .         .         .       g.75328
 AGTAAAACAGCAGAAACAGATGTGCTTTTTAATAAAGTGGAATCATCTGGAAAGAATTAT       c.1140
 S  K  T  A  E  T  D  V  L  F  N  K  V  E  S  S  G  K  N  Y         p.380

          .         .         .         .         .         .       g.75388
 TCAAATGTTGATACTTCAGTCATTCCATTCCAAAATGATATGCATAATGATGAATCTGGA       c.1200
 S  N  V  D  T  S  V  I  P  F  Q  N  D  M  H  N  D  E  S  G         p.400

          .         .         .         .         .         .       g.75448
 AAAAACACTGATGATTGTTTAAATCACCAGATAAGTATTGGTGACTTTGGTTATGGTCAT       c.1260
 K  N  T  D  D  C  L  N  H  Q  I  S  I  G  D  F  G  Y  G  H         p.420

          .         .         .         .         .         .       g.75508
 TGTAGTAGTGAAATTTCTAACATTGATAAAAACACTAAGAATGCATTTCAGGACATTTCA       c.1320
 C  S  S  E  I  S  N  I  D  K  N  T  K  N  A  F  Q  D  I  S         p.440

          .         .         .         .         .         .       g.75568
 ATGAGTAATGTATCATGGGAGAACTCTCAGACGGAATATAGTAAAACTTGTTTTATAAGT       c.1380
 M  S  N  V  S  W  E  N  S  Q  T  E  Y  S  K  T  C  F  I  S         p.460

          .         .         .         .         .         .       g.75628
 TCCGTTAAGCACACCCAGTCAGAAAATGGCAATAAAGACCATATAGATGAGAGTGGGGAA       c.1440
 S  V  K  H  T  Q  S  E  N  G  N  K  D  H  I  D  E  S  G  E         p.480

          .         .         .         .         .         .       g.75688
 AATGAGGAAGAAGCAGGTCTTGAAAACTCTTCGGAAATTTCTGCAGATGAGTGGAGCAGG       c.1500
 N  E  E  E  A  G  L  E  N  S  S  E  I  S  A  D  E  W  S  R         p.500

          .         .         .         .         .         .       g.75748
 GGAAATATACTTAAAAATTCAGTGGGAGAGAATATTGAACCTGTGAAAATTTTAGTGCCT       c.1560
 G  N  I  L  K  N  S  V  G  E  N  I  E  P  V  K  I  L  V  P         p.520

          .         .         .         .         .         .       g.75808
 GAAAAAAGTTTACCATGTAAAGTAAGTAATAATAATTATCCAATCCCTGAACAAATGAAT       c.1620
 E  K  S  L  P  C  K  V  S  N  N  N  Y  P  I  P  E  Q  M  N         p.540

          .         .         .         .         .         .       g.75868
 CTTAATGAAGATTCATGTAACAAAAAATCAAATGTAATAGATAATAAATCTGGAAAAGTT       c.1680
 L  N  E  D  S  C  N  K  K  S  N  V  I  D  N  K  S  G  K  V         p.560

          .         .         .         .         .         .       g.75928
 ACAGCTTATGATTTACTTAGCAATCGAGTAATCAAGAAACCCATGTCAGCAAGTGCTCTT       c.1740
 T  A  Y  D  L  L  S  N  R  V  I  K  K  P  M  S  A  S  A  L         p.580

          .         .         .         .         .         .       g.75988
 TTTGTTCAAGATCATCGTCCTCAGTTTCTCATAGAAAATCCTAAGACTAGTTTAGAGGAT       c.1800
 F  V  Q  D  H  R  P  Q  F  L  I  E  N  P  K  T  S  L  E  D         p.600

          .         .         .         .         .       | 10 .    g.84662
 GCAACACTACAAATTGAAGAACTGTGGAAGACATTGAGTGAAGAGGAAAAACTGAA | ATAT    c.1860
 A  T  L  Q  I  E  E  L  W  K  T  L  S  E  E  E  K  L  K  |  Y      p.620

          .         .         .         .         .         .       g.84722
 GAAGAGAAGGCTACTAAAGACTTGGAACGATACAATAGTCAAATGAAGAGAGCCATTGAA       c.1920
 E  E  K  A  T  K  D  L  E  R  Y  N  S  Q  M  K  R  A  I  E         p.640

          .         .         .         .         .         .       g.84782
 CAGGAGTCACAAATGTCACTAAAAGATGGCAGAAAAAAGATAAAACCCACCAGCGCATGG       c.1980
 Q  E  S  Q  M  S  L  K  D  G  R  K  K  I  K  P  T  S  A  W         p.660

          .         .         .         .         .         .       g.84842
 AATTTGGCCCAGAAGCACAAGTTAAAAACCTCATTATCTAATCAACCAAAACTTGATGAA       c.2040
 N  L  A  Q  K  H  K  L  K  T  S  L  S  N  Q  P  K  L  D  E         p.680

          .         .         .         .         .         .       g.84902
 CTCCTTCAGTCCCAAATTGAAAAAAGAAGGAGTCAAAATATTAAAATGGTACAGATCCCC       c.2100
 L  L  Q  S  Q  I  E  K  R  R  S  Q  N  I  K  M  V  Q  I  P         p.700

          .         .         .         .         .         .       g.84962
 TTTTCTATGAAAAACTTAAAAATAAATTTTAAGAAACAAAACAAAGTTGACTTAGAAGAG       c.2160
 F  S  M  K  N  L  K  I  N  F  K  K  Q  N  K  V  D  L  E  E         p.720

          .         .         .         .         .         .       g.85022
 AAGGATGAACCTTGCTTGATCCACAATCTCAGGTTTCCTGATGCATGGCTAATGACATCC       c.2220
 K  D  E  P  C  L  I  H  N  L  R  F  P  D  A  W  L  M  T  S         p.740

          .         .         .         .         .         .       g.85082
 AAAACAGAGGTAATGTTATTAAATCCATATAGAGTAGAAGAAGCCCTGCTATTTAAAAGA       c.2280
 K  T  E  V  M  L  L  N  P  Y  R  V  E  E  A  L  L  F  K  R         p.760

          .         .         .         .         .         .       g.85142
 CTTCTTGAGAATCATAAACTTCCTGCAGAGCCACTGGAAAAGCCAATTATGTTAACAGAG       c.2340
 L  L  E  N  H  K  L  P  A  E  P  L  E  K  P  I  M  L  T  E         p.780

    | 11     .         .         .         .         .         .    g.88772
 AG | TCTTTTTAATGGATCTCATTATTTAGACGTTTTATATAAAATGACAGCAGATGACCAA    c.2400
 S  |  L  F  N  G  S  H  Y  L  D  V  L  Y  K  M  T  A  D  D  Q      p.800

          .         .         .         .         .         .       g.88832
 AGATACAGTGGATCAACTTACCTGTCTGATCCTCGTCTTACAGCGAATGGTTTCAAGATA       c.2460
 R  Y  S  G  S  T  Y  L  S  D  P  R  L  T  A  N  G  F  K  I         p.820

          .    | 12    .         .         .         .         .    g.94458
 AAATTGATACCAG | GAGTTTCAATTACTGAAAATTACTTGGAAATAGAAGGAATGGCTAAT    c.2520
 K  L  I  P  G |   V  S  I  T  E  N  Y  L  E  I  E  G  M  A  N      p.840

          .         .         .         .         .         .       g.94518
 TGTCTCCCATTCTATGGAGTAGCAGATTTAAAAGAAATTCTTAATGCTATATTAAACAGA       c.2580
 C  L  P  F  Y  G  V  A  D  L  K  E  I  L  N  A  I  L  N  R         p.860

          .         .         .         .         .     | 13   .    g.98193
 AATGCAAAGGAAGTTTATGAATGTAGACCTCGCAAAGTGATAAGTTATTTAGAG | GGAGAA    c.2640
 N  A  K  E  V  Y  E  C  R  P  R  K  V  I  S  Y  L  E   | G  E      p.880

          .         .         .         .         .         .       g.98253
 GCAGTGCGTCTATCCAGACAATTACCCATGTACTTATCAAAAGAGGACATCCAAGACATT       c.2700
 A  V  R  L  S  R  Q  L  P  M  Y  L  S  K  E  D  I  Q  D  I         p.900

          .         .         .         .         .         .       g.98313
 ATCTACAGAATGAAGCACCAGTTTGGAAATGAAATTAAAGAGTGTGTTCATGGTCGCCCA       c.2760
 I  Y  R  M  K  H  Q  F  G  N  E  I  K  E  C  V  H  G  R  P         p.920

          .         .         .                                     g.98352
 TTTTTTCATCATTTAACCTATCTTCCAGAAACTACATGA                            c.2799
 F  F  H  H  L  T  Y  L  P  E  T  T  X                              p.932

          .         .         .         .         .         .       g.98412
 ttaaatatgtttaagaagattagttaccattgaaattggttctgtcataaaacagcatga       c.*60

          .         .         .         .         .         .       g.98472
 gtctggttttaaattatctttgtattatgtgtcacatggttattttttaaatgaggattc       c.*120

          .         .         .         .         .         .       g.98532
 actgacttgtttttatattgaaaaaagttccacgtattgtagaaaacgtaaataaactaa       c.*180

          .                                                         g.98545
 tatagactattca                                                      c.*193

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The PMS1 postmeiotic segregation increased 1 (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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