patatin-like phospholipase domain containing 6 (PNPLA6) - coding DNA reference sequence

(used for variant description)

(last modified January 27, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_006702.4 in the PNPLA6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013374.1, covering PNPLA6 transcript NM_006702.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  agtgaataatttaaaggggccgtgcctgcggagccgggcggaa       c.-241

 .         .         .         .         .     | 02   .             g.5613
 cgctagcggtgttggcgcggagtggaccccggctgcggcccctgg | caatggcgccaccat    c.-181

 .         .         .         .         .         .                g.5673
 cggtcccggagtcccagtgatgctctgtgccatagagcccccataacttcactactacgt       c.-121

 .         .         .         .         .         .                g.5733
 gatagtaaatccccggcaaaaaccagcagcgccttgcaagcccacgccaccccaagcatc       c.-61

 .         .        | 03.         .         .         .             g.6399
 ccaggactcttctgaaac | gactccgggctaccagatcggccgtccagctggaatcaaccg    c.-1

          .         .        | 04.         .         .         .    g.6814
 ATGGAGGCTCCGCTGCAAACTGGAATG | GTGCTTGGCGTGATGATCGGGGCCGGAGTGGCG    c.60
 M  E  A  P  L  Q  T  G  M   | V  L  G  V  M  I  G  A  G  V  A      p.20

          .         .         .         .         .      | 05  .    g.7044
 GTGGTGGTCACGGCCGTGCTCATCCTCCTGGTGGTGCGGAGGCTGCGAGTGCCAA | AAACC    c.120
 V  V  V  T  A  V  L  I  L  L  V  V  R  R  L  R  V  P  K |   T      p.40

          .         .         .         .         .         .       g.7104
 CCAGCCCCGGATGGCCCCCGGTATCGGTTCCGGAAGAGGGACAAAGTGCTCTTCTATGGC       c.180
 P  A  P  D  G  P  R  Y  R  F  R  K  R  D  K  V  L  F  Y  G         p.60

          .         | 06         .         .         .         .    g.7339
 CGGAAGATTATGCGGAAG | GTGTCACAATCCACCTCCTCCCTCGTGGATACCTCTGTCTCC    c.240
 R  K  I  M  R  K   | V  S  Q  S  T  S  S  L  V  D  T  S  V  S      p.80

          .         .         .         .         .       | 07 .    g.10770
 GCCACCTCCCGGCCACGCATGAGGAAGAAACTGAAGATGCTCAACATTGCCAAGAA | GATC    c.300
 A  T  S  R  P  R  M  R  K  K  L  K  M  L  N  I  A  K  K  |  I      p.100

          .         .         .         .         .         .       g.10830
 CTGCGCATCCAGAAAGAGACGCCCACGCTGCAGCGGAAGGAGCCCCCGCCCGCAGTGCTA       c.360
 L  R  I  Q  K  E  T  P  T  L  Q  R  K  E  P  P  P  A  V  L         p.120

          .         .         .         .         .         .       g.10890
 GAAGCTGACCTGACCGAGGGCGACCTGGCTAACTCCCATCTGCCCTCTGAAGTGCTTTAT       c.420
 E  A  D  L  T  E  G  D  L  A  N  S  H  L  P  S  E  V  L  Y         p.140

          .        | 08.         .         .         .         .    g.11040
 ATGCTCAAGAACGTCCG | GGTGCTGGGCCACTTCGAGAAGCCACTCTTCCTGGAGCTCTGC    c.480
 M  L  K  N  V  R  |  V  L  G  H  F  E  K  P  L  F  L  E  L  C      p.160

          .         .         .         .         .         .       g.11100
 CGCCACATGGTCTTCCAGCGGCTGGGCCAGGGTGACTACGTCTTCCGGCCGGGCCAGCCA       c.540
 R  H  M  V  F  Q  R  L  G  Q  G  D  Y  V  F  R  P  G  Q  P         p.180

          .         .         .         .         .        | 09.    g.11481
 GATGCCAGCATCTACGTGGTGCAGGACGGGCTGCTGGAGCTCTGTCTGCCAGGGCCT | GAC    c.600
 D  A  S  I  Y  V  V  Q  D  G  L  L  E  L  C  L  P  G  P   | D      p.200

          .         .         .         .         .         .       g.11541
 GGGAAGGAGTGTGTGGTGAAGGAAGTGGTTCCTGGGGACAGCGTCAACAGCCTTCTCAGC       c.660
 G  K  E  C  V  V  K  E  V  V  P  G  D  S  V  N  S  L  L  S         p.220

          .         | 10         .         .         .         .    g.11813
 ATCCTGGATGTCATCACC | GGTCACCAGCATCCCCAGCGGACCGTGTCTGCCCGGGCGGCC    c.720
 I  L  D  V  I  T   | G  H  Q  H  P  Q  R  T  V  S  A  R  A  A      p.240

          .         .         .         .         .         .       g.11873
 CGGGACTCCACGGTGCTGCGCCTGCCGGTGGAAGCATTCTCCGCGGTCTTCACCAAGTAC       c.780
 R  D  S  T  V  L  R  L  P  V  E  A  F  S  A  V  F  T  K  Y         p.260

          .         .        | 11.         .         .         .    g.12235
 CCGGAGAGCTTGGTGCGGGTCGTGCAG | ATCATCATGGTGCGGCTGCAGCGAGTCACCTTC    c.840
 P  E  S  L  V  R  V  V  Q   | I  I  M  V  R  L  Q  R  V  T  F      p.280

          .         .         .         .         | 12         .    g.12382
 CTGGCACTGCACAACTACCTGGGTCTGACCAATGAGCTCTTCAGCCAC | GAGATCCAGCCC    c.900
 L  A  L  H  N  Y  L  G  L  T  N  E  L  F  S  H   | E  I  Q  P      p.300

          .         .         .         .         .         .       g.12442
 CTGCGTCTGTTCCCCAGCCCCGGCCTCCCAACTCGCACCAGCCCTGTGCGGGGCTCCAAG       c.960
 L  R  L  F  P  S  P  G  L  P  T  R  T  S  P  V  R  G  S  K         p.320

          .         .         .         .         .         .       g.12502
 AGAATGGTCAGCACCTCAGCTACAGACGAGCCCAGGGAGACCCCAGGGCGGCCACCCGAT       c.1020
 R  M  V  S  T  S  A  T  D  E  P  R  E  T  P  G  R  P  P  D         p.340

          .         .         .  | 13      .         .         .    g.12861
 CCCACCGGGGCCCCGCTGCCTGGACCTACAG | GGGACCCTGTGAAGCCCACATCCCTGGAA    c.1080
 P  T  G  A  P  L  P  G  P  T  G |   D  P  V  K  P  T  S  L  E      p.360

          .         .         .         .         .      | 14  .    g.13414
 ACCCCCTCGGCCCCTCTGCTGAGCCGCTGCGTCTCCATGCCAGGGGACATCTCAG | GCTTG    c.1140
 T  P  S  A  P  L  L  S  R  C  V  S  M  P  G  D  I  S  G |   L      p.380

          .         .         .         .         .         .       g.13474
 CAGGGTGGCCCCCGCTCCGACTTCGACATGGCCTATGAGCGTGGCCGGATCTCCGTGTCC       c.1200
 Q  G  G  P  R  S  D  F  D  M  A  Y  E  R  G  R  I  S  V  S         p.400

          .         .         .         .      | 15  .         .    g.13624
 CTGCAGGAAGAGGCCTCCGGGGGGTCCCTGGCAGCCCCCGCTCGG | ACCCCCACTCAGGAG    c.1260
 L  Q  E  E  A  S  G  G  S  L  A  A  P  A  R   | T  P  T  Q  E      p.420

          .         .         .         .         .         .       g.13684
 CCTCGTGAGCAGCCGGCAGGCGCCTGTGAATACAGCTACTGTGAGGATGAGTCGGCCACT       c.1320
 P  R  E  Q  P  A  G  A  C  E  Y  S  Y  C  E  D  E  S  A  T         p.440

          .         .         .         .         .         .       g.13744
 GGTGGCTGCCCTTTCGGGCCCTACCAGGGCCGCCAGACCAGCAGCATCTTCGAGGCAGCA       c.1380
 G  G  C  P  F  G  P  Y  Q  G  R  Q  T  S  S  I  F  E  A  A         p.460

          .         .         .    | 16    .         .         .    g.13882
 AAGCAGGAGCTGGCCAAGCTGATGCGGATTGAG | GACCCCTCCCTCCTGAACAGCAGAGTC    c.1440
 K  Q  E  L  A  K  L  M  R  I  E   | D  P  S  L  L  N  S  R  V      p.480

          .         .         .         .         .  | 17      .    g.20764
 TTGCTGCACCACGCCAAAGCTGGCACCATCATTGCCCGCCAGGGAGACCAG | GACGTGAGC    c.1500
 L  L  H  H  A  K  A  G  T  I  I  A  R  Q  G  D  Q   | D  V  S      p.500

          .         .         .         .         .         .       g.20824
 CTGCACTTCGTGCTCTGGGGCTGCCTGCACGTGTACCAGCGCATGATCGACAAGGCGGAG       c.1560
 L  H  F  V  L  W  G  C  L  H  V  Y  Q  R  M  I  D  K  A  E         p.520

          .         .         .         .         .         .       g.20884
 GACGTGTGCCTGTTCGTAGCGCAGCCCGGGGAACTGGTGGGGCAGCTGGCGGTGCTCACT       c.1620
 D  V  C  L  F  V  A  Q  P  G  E  L  V  G  Q  L  A  V  L  T         p.540

          .         .         .         .         .         .       g.20944
 GGCGAACCTCTCATCTTCACACTGCGAGCCCAACGCGACTGCACCTTCCTGCGGATCTCC       c.1680
 G  E  P  L  I  F  T  L  R  A  Q  R  D  C  T  F  L  R  I  S         p.560

          .        | 18.         .         .         .         .    g.21189
 AAGTCCGACTTCTATGA | GATCATGCGCGCACAGCCCAGTGTGGTGCTGAGTGCGGCGCAC    c.1740
 K  S  D  F  Y  E  |  I  M  R  A  Q  P  S  V  V  L  S  A  A  H      p.580

          .         .         .         .         .         .       g.21249
 ACGGTGGCAGCCAGGATGTCGCCCTTCGTGCGCCAGATGGACTTCGCCATCGACTGGACT       c.1800
 T  V  A  A  R  M  S  P  F  V  R  Q  M  D  F  A  I  D  W  T         p.600

          .         .          | 19        .         .         .    g.21396
 GCAGTGGAGGCGGGACGCGCGCTGTACAG | GCAGGGCGACCGCTCCGACTGCACTTACATC    c.1860
 A  V  E  A  G  R  A  L  Y  R  |  Q  G  D  R  S  D  C  T  Y  I      p.620

          .         .         .         .         .         .       g.21456
 GTGCTCAATGGGCGGCTGCGTAGCGTGATCCAGCGAGGCAGTGGCAAGAAGGAGCTGGTG       c.1920
 V  L  N  G  R  L  R  S  V  I  Q  R  G  S  G  K  K  E  L  V         p.640

          .         .         .    | 20    .         .         .    g.21869
 GGCGAGTACGGCCGCGGCGACCTCATCGGCGTG | GTGGAGGCACTGACCCGGCAGCCGCGA    c.1980
 G  E  Y  G  R  G  D  L  I  G  V   | V  E  A  L  T  R  Q  P  R      p.660

          .         .         .         .         .         .       g.21929
 GCCACGACGGTGCACGCGGTGCGCGACACGGAGCTGGCCAAGCTTCCCGAGGGCACCTTG       c.2040
 A  T  T  V  H  A  V  R  D  T  E  L  A  K  L  P  E  G  T  L         p.680

          .         .        | 21.         .         .         .    g.22243
 GGTCACATCAAACGCCGGTACCCGCAG | GTCGTGACCCGCCTTATCCACCTACTGAGCCAG    c.2100
 G  H  I  K  R  R  Y  P  Q   | V  V  T  R  L  I  H  L  L  S  Q      p.700

          .         .         .         .    | 22    .         .    g.24737
 AAAATTCTAGGGAATTTGCAGCAGCTGCAAGGACCCTTCCCAG | CAGGCTCTGGGTTGGGT    c.2160
 K  I  L  G  N  L  Q  Q  L  Q  G  P  F  P  A |   G  S  G  L  G      p.720

          .         .         .         .         .         .       g.24797
 GTGCCCCCACACTCGGAACTCACCAACCCAGCCAGCAACCTGGCAACTGTGGCAATCCTG       c.2220
 V  P  P  H  S  E  L  T  N  P  A  S  N  L  A  T  V  A  I  L         p.740

          .         .         .         .         .         .       g.24857
 CCTGTGTGTGCTGAGGTCCCCATGGTGGCCTTCACGCTGGAGCTGCAGCACGCCCTGCAG       c.2280
 P  V  C  A  E  V  P  M  V  A  F  T  L  E  L  Q  H  A  L  Q         p.760

         | 23.         .         .         .         .         .    g.25110
 GCCATCG | GTCCGACGCTACTCCTTAACAGTGACATCATCCGGGCACGCCTGGGGGCCTCC    c.2340
 A  I  G |   P  T  L  L  L  N  S  D  I  I  R  A  R  L  G  A  S      p.780

          .  | 24      .         .         .         .         .    g.25452
 GCACTGGATAG | CATCCAAGAGTTCCGGCTGTCAGGGTGGCTGGCCCAGCAGGAGGATGCA    c.2400
 A  L  D  S  |  I  Q  E  F  R  L  S  G  W  L  A  Q  Q  E  D  A      p.800

          .         .         .         .         .         .       g.25512
 CACCGTATCGTACTCTACCAGACGGACGCCTCGCTGACGCCCTGGACCGTGCGCTGCCTG       c.2460
 H  R  I  V  L  Y  Q  T  D  A  S  L  T  P  W  T  V  R  C  L         p.820

          .         .         .         .         .         .       g.25572
 CGACAGGCCGACTGCATCCTCATTGTGGGCCTGGGGGACCAGGAGCCTACCCTCGGCCAG       c.2520
 R  Q  A  D  C  I  L  I  V  G  L  G  D  Q  E  P  T  L  G  Q         p.840

  | 25       .         .         .         .         .         .    g.25801
  | CTGGAGCAGATGCTGGAGAACACGGCTGTGCGCGCCCTTAAGCAGCTAGTCCTGCTCCAC    c.2580
  | L  E  Q  M  L  E  N  T  A  V  R  A  L  K  Q  L  V  L  L  H      p.860

          .         .         .         .         .         .       g.25861
 CGAGAGGAGGGCGCGGGCCCCACGCGCACCGTGGAGTGGCTAAATATGCGCAGCTGGTGC       c.2640
 R  E  E  G  A  G  P  T  R  T  V  E  W  L  N  M  R  S  W  C         p.880

          .         .         .         .         .         .       g.25921
 TCGGGGCACCTGCACCTGCGCTGTCCGCGCCGCCTCTTTTCGCGCCGCAGCCCTGCCAAG       c.2700
 S  G  H  L  H  L  R  C  P  R  R  L  F  S  R  R  S  P  A  K         p.900

     | 26    .         .         .         .         .         .    g.26154
 CTG | CATGAGCTCTACGAGAAGGTTTTCTCCAGGCGCGCGGACCGGCACAGCGACTTCTCC    c.2760
 L   | H  E  L  Y  E  K  V  F  S  R  R  A  D  R  H  S  D  F  S      p.920

          .         .         .         .         .         .       g.26214
 CGCTTGGCGAGGGTGCTCACGGGGAACACCATTGCCCTTGTGCTAGGCGGGGGCGGGGCC       c.2820
 R  L  A  R  V  L  T  G  N  T  I  A  L  V  L  G  G  G  G  A         p.940

    | 27     .         .         .         .         .         .    g.26513
 AG | GGGCTGCTCGCACATCGGAGTACTAAAGGCATTAGAGGAGGCGGGGGTCCCCGTGGAC    c.2880
 R  |  G  C  S  H  I  G  V  L  K  A  L  E  E  A  G  V  P  V  D      p.960

          .         .         .         .         .         .       g.26573
 CTGGTGGGCGGCACGTCCATTGGCTCTTTCATCGGAGCGTTGTACGCGGAGGAGCGCAGC       c.2940
 L  V  G  G  T  S  I  G  S  F  I  G  A  L  Y  A  E  E  R  S         p.980

          .         .         .          | 28        .         .    g.27322
 GCCAGCCGCACGAAGCAGCGGGCCCGGGAGTGGGCCAAG | AGCATGACTTCGGTGCTGGAA    c.3000
 A  S  R  T  K  Q  R  A  R  E  W  A  K   | S  M  T  S  V  L  E      p.1000

          .         .         .         .         .         .       g.27382
 CCTGTGTTGGACCTCACGTACCCAGTCACCTCCATGTTCACTGGGTCTGCCTTTAACCGC       c.3060
 P  V  L  D  L  T  Y  P  V  T  S  M  F  T  G  S  A  F  N  R         p.1020

          .         .         .       | 29 .         .         .    g.27527
 AGCATCCATCGGGTCTTCCAGGATAAGCAGATTGAG | GACCTGTGGCTGCCTTACTTCAAC    c.3120
 S  I  H  R  V  F  Q  D  K  Q  I  E   | D  L  W  L  P  Y  F  N      p.1040

          .         .         .         .       | 30 .         .    g.28030
 GTGACCACAGATATCACCGCCTCAGCCATGCGAGTCCACAAAGATG | GCTCCCTGTGGCGG    c.3180
 V  T  T  D  I  T  A  S  A  M  R  V  H  K  D  G |   S  L  W  R      p.1060

          .         .         .         .         .         .       g.28090
 TACGTGCGCGCCAGCATGACGCTGTCGGGCTACCTGCCCCCGCTGTGCGACCCCAAGGAC       c.3240
 Y  V  R  A  S  M  T  L  S  G  Y  L  P  P  L  C  D  P  K  D         p.1080

          .         .         .         .    | 31    .         .    g.29715
 GGGCACCTACTCATGGATGGCGGCTACATCAACAATCTGCCAG | CGGACATCGCCCGCAGC    c.3300
 G  H  L  L  M  D  G  G  Y  I  N  N  L  P  A |   D  I  A  R  S      p.1100

          .         .         .         .         .         .       g.29775
 ATGGGTGCCAAAACGGTCATCGCCATTGACGTGGGGAGCCAGGATGAGACGGACCTCAGC       c.3360
 M  G  A  K  T  V  I  A  I  D  V  G  S  Q  D  E  T  D  L  S         p.1120

          .         .         .         .         .         .       g.29835
 ACCTACGGGGACAGCCTGTCCGGCTGGTGGCTGCTGTGGAAGCGGCTGAATCCCTGGGCT       c.3420
 T  Y  G  D  S  L  S  G  W  W  L  L  W  K  R  L  N  P  W  A         p.1140

          .         .         .         .         .         .       g.29895
 GACAAGGTAAAGGTTCCAGACATGGCTGAAATCCAGTCCCGCCTGGCCTACGTGTCCTGT       c.3480
 D  K  V  K  V  P  D  M  A  E  I  Q  S  R  L  A  Y  V  S  C         p.1160

          .         .         .         .         .         .       g.29955
 GTGCGGCAGCTAGAGGTTGTCAAGTCCAGCTCCTACTGCGAGTACCTGCGCCCGCCCATC       c.3540
 V  R  Q  L  E  V  V  K  S  S  S  Y  C  E  Y  L  R  P  P  I         p.1180

          .         .         .         .      | 32  .         .    g.31511
 GACTGCTTCAAGACCATGGACTTTGGGAAGTTCGACCAGATCTAT | GATGTGGGCTACCAG    c.3600
 D  C  F  K  T  M  D  F  G  K  F  D  Q  I  Y   | D  V  G  Y  Q      p.1200

          .         .         .         .         .         .       g.31571
 TACGGGAAGGCGGTGTTTGGAGGCTGGAGCCGTGGCAACGTCATTGAGAAAATGCTCACA       c.3660
 Y  G  K  A  V  F  G  G  W  S  R  G  N  V  I  E  K  M  L  T         p.1220

          .         .         .         .   | 33     .         .    g.31880
 GACCGGCGGTCTACAGACCTTAATGAGAGCCGCCGTGCAGAC | GTGCTTGCCTTCCCAAGC    c.3720
 D  R  R  S  T  D  L  N  E  S  R  R  A  D   | V  L  A  F  P  S      p.1240

          .         .         .         .         .         .       g.31940
 TCTGGCTTCACTGACTTGGCAGAGATTGTGTCCCGGATTGAGCCCCCCACGAGCTATGTC       c.3780
 S  G  F  T  D  L  A  E  I  V  S  R  I  E  P  P  T  S  Y  V         p.1260

          .          | 34        .         .         .         .    g.32097
 TCTGATGGCTGTGCTGACG | GAGAGGAGTCAGATTGTCTGACAGAGTATGAGGAGGACGCC    c.3840
 S  D  G  C  A  D  G |   E  E  S  D  C  L  T  E  Y  E  E  D  A      p.1280

          .         .         .         .         .         .       g.32157
 GGACCCGACTGCTCGAGGGATGAAGGGGGGTCCCCCGAGGGCGCAAGCCCCAGCACTGCC       c.3900
 G  P  D  C  S  R  D  E  G  G  S  P  E  G  A  S  P  S  T  A         p.1300

           | 35        .         .         .         .         .    g.32387
 TCCGAGATG | GAGGAGGAGAAGTCGATTCTCCGGCAACGACGCTGTCTGCCCCAGGAGCCG    c.3960
 S  E  M   | E  E  E  K  S  I  L  R  Q  R  R  C  L  P  Q  E  P      p.1320

          .         .                                               g.32411
 CCCGGCTCAGCCACAGATGCCTGA                                           c.3984
 P  G  S  A  T  D  A  X                                             p.1327

          .         .         .         .         .         .       g.32471
 ggacctcgacaggggtcaccccctccctcccacccctggactgggctgggggtggccccg       c.*60

          .         .         .         .         .         .       g.32531
 tgggggtagctcactccccctcctgctgctatgcctgtgacccccgcggcccacacactg       c.*120

          .         .         .         .         .         .       g.32591
 gactgacctgccctgagcggggatgcagtgttgcactgatgacttgaccagcccctcccc       c.*180

          .         .                                               g.32616
 caataaactcgcctcttggaaatgg                                          c.*205

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Patatin-like phospholipase domain containing 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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