patatin-like phospholipase domain containing 7 (PNPLA7) - coding DNA reference sequence

(used for variant description)

(last modified December 7, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001098537.1 in the PNPLA7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering PNPLA7 transcript NM_001098537.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5037
                        gctgcccccatccccgccgcgctgggcctggctcctc       c.-301

 .         .         .         .         .         .                g.5097
 ttgacctgcttggatacgccccatctggctgctgttctgggttccgggacagccacgtga       c.-241

 .         .         .         .         .         .                g.5157
 gggctgtttacagagggaaggaggtggctcctagcagatgacagacacttctcaaaagac       c.-181

 .         .         .         .         .         .                g.5217
 agcttttcttcctggagaacagactttttcagcaggattttcctttcagtgaaacataat       c.-121

 .         .         .         .         .         .                g.5277
 ttgacttgaaaggaacccagggaaaagtgtccaggtgtgagcatgagcgggtagaggtgt       c.-61

 .         .         .         .         .         .                g.5337
 gcccttgtttgcttcaggctgtctgcttttcgcccctgactgttttttctgtttctggcc       c.-1

          .         .         . | 02       .         .         .    g.7905
 ATGGAGGAAGAGAAAGATGACAGCCCACAG | GCTGACTTCTGCCTGGGCACCGCCCTGCAC    c.60
 M  E  E  E  K  D  D  S  P  Q   | A  D  F  C  L  G  T  A  L  H      p.20

          .         .         .         .      | 03  .         .    g.8153
 TCTTGGGGACTGTGGTTCACGGAGGAAGGTTCACCGTCCACCATG | CTGACGGGGATTGCA    c.120
 S  W  G  L  W  F  T  E  E  G  S  P  S  T  M   | L  T  G  I  A      p.40

          .         .         .         .         .         .       g.8213
 GTTGGAGCCCTCCTGGCCCTGGCCTTGGTTGGTGTCCTCATCCTTTTCATGTTCAGAAGG       c.180
 V  G  A  L  L  A  L  A  L  V  G  V  L  I  L  F  M  F  R  R         p.60

          .    | 04    .         .         .         .         .    g.8672
 CTTAGACAATTTC | GACAAGCACAGCCCACTCCTCAGTACCGGTTCCGGAAGAGAGACAAA    c.240
 L  R  Q  F  R |   Q  A  Q  P  T  P  Q  Y  R  F  R  K  R  D  K      p.80

          .         .         .    | 05    .         .         .    g.11746
 GTGATGTTTTACGGCCGGAAGATCATGAGGAAG | GTGACCACACTCCCCAACACCCTTGTG    c.300
 V  M  F  Y  G  R  K  I  M  R  K   | V  T  T  L  P  N  T  L  V      p.100

          .         .         .         .         .         .       g.11806
 GAGAACACTGCCCTGCCCCGGCAGCGGGCCAGGAAGAGGACCAAGGTGCTGTCTTTGGCC       c.360
 E  N  T  A  L  P  R  Q  R  A  R  K  R  T  K  V  L  S  L  A         p.120

       | 06  .         .         .         .         .         .    g.12017
 AAGAG | GATTCTGCGTTTCAAGAAGGAATACCCGGCCCTGCAGCCCAAGGAGCCCCCGCCC    c.420
 K  R  |  I  L  R  F  K  K  E  Y  P  A  L  Q  P  K  E  P  P  P      p.140

          .         .         .         .         .         .       g.12077
 TCCCTGCTGGAGGCCGACCTCACGGAGTTTGACGTGAAGAATTCTCACCTGCCATCGGAA       c.480
 S  L  L  E  A  D  L  T  E  F  D  V  K  N  S  H  L  P  S  E         p.160

          .         .       | 07 .         .         .         .    g.12767
 GTTCTGTACATGCTGAAAAACGTTCG | GGTCCTGGGCCACTTTGAGAAGCCGCTGTTCCTG    c.540
 V  L  Y  M  L  K  N  V  R  |  V  L  G  H  F  E  K  P  L  F  L      p.180

          .         .         .         .         .         .       g.12827
 GAGCTTTGCAAACACATCGTCTTTGTGCAGCTGCAGGAAGGGGAGCACGTCTTCCAGCCC       c.600
 E  L  C  K  H  I  V  F  V  Q  L  Q  E  G  E  H  V  F  Q  P         p.200

          .         .         .         .         .         .       g.12887
 AGGGAGCCGGACCCCAGCATCTGTGTGGTGCAGGACGGGCGGCTGGAGGTCTGCATCCAG       c.660
 R  E  P  D  P  S  I  C  V  V  Q  D  G  R  L  E  V  C  I  Q         p.220

        | 08 .         .         .         .         .         .    g.14866
 GACACT | GACGGCACCGAGGTGGTGGTGAAAGAGGTTCTGGCGGGAGACAGCGTCCACAGC    c.720
 D  T   | D  G  T  E  V  V  V  K  E  V  L  A  G  D  S  V  H  S      p.240

          .         .        | 09.         .         .         .    g.32710
 CTGCTCAGCATCCTGGACATCATCACC | GGCCATGCTGCACCTTACAAAACGGTCTCCGTC    c.780
 L  L  S  I  L  D  I  I  T   | G  H  A  A  P  Y  K  T  V  S  V      p.260

          .         .         .         .         .         .       g.32770
 CGCGCGGCCATCCCGTCCACCATCCTCCGGCTTCCAGCTGCGGCTTTTCATGGAGTTTTT       c.840
 R  A  A  I  P  S  T  I  L  R  L  P  A  A  A  F  H  G  V  F         p.280

          .         .         .       | 10 .         .         .    g.33842
 GAGAAATATCCGGAAACTCTGGTGAGGGTGGTGCAG | ATCATCATGGTGCGGCTGCAGAGG    c.900
 E  K  Y  P  E  T  L  V  R  V  V  Q   | I  I  M  V  R  L  Q  R      p.300

          .         .         .         .         .        | 11.    g.35494
 GTGACCTTTCTGGCTCTGCACAACTACCTCGGCCTGACCACAGAGCTCTTCAACGCT | GAG    c.960
 V  T  F  L  A  L  H  N  Y  L  G  L  T  T  E  L  F  N  A   | E      p.320

          .         .         .         .         .         .       g.35554
 AGCCAGGCCATCCCTCTCGTGTCTGTAGCCAGTGTGGCTGCCGGGAAGGCCAAGAAGCAG       c.1020
 S  Q  A  I  P  L  V  S  V  A  S  V  A  A  G  K  A  K  K  Q         p.340

          .         .         .         .         .         .       g.35614
 GTGTTCTATGGCGAAGAAGAGCGGCTTAAAAAGCCACCGCGGCTCCAGGAGTCCTGTGAC       c.1080
 V  F  Y  G  E  E  E  R  L  K  K  P  P  R  L  Q  E  S  C  D         p.360

      | 12   .         .         .         .         .         .    g.40071
 TCAG | ATCACGGGGGCGGCCGCCCGGCAGCTGCTGGGCCCCTGCTGAAGAGGAGCCACTCC    c.1140
 S  D |   H  G  G  G  R  P  A  A  A  G  P  L  L  K  R  S  H  S      p.380

          .         .         .         .         .         .       g.40131
 GTCCCCGCGCCTTCCATTCGCAAACAGATCTTGGAGGAGCTGGAGAAGCCCGGGGCAGGT       c.1200
 V  P  A  P  S  I  R  K  Q  I  L  E  E  L  E  K  P  G  A  G         p.400

          .         .      | 13  .         .         .         .    g.49486
 GACCCTGACCCTTCGGCCCCACAAG | GGGGCCCAGGCAGTGCCACTTCTGATCTGGGGATG    c.1260
 D  P  D  P  S  A  P  Q  G |   G  P  G  S  A  T  S  D  L  G  M      p.420

          .         .         .         .         .         .       g.49546
 GCATGTGACCGTGCCAGGGTCTTCCTGCACTCGGACGAGCACCCCGGGAGCTCCGTGGCC       c.1320
 A  C  D  R  A  R  V  F  L  H  S  D  E  H  P  G  S  S  V  A         p.440

        | 14 .         .         .         .         .         .    g.49828
 AGCAAG | TCCAGGAAAAGCGTGATGGTTGCAGAGATACCCTCCACGGTCTCCCAGCACTCA    c.1380
 S  K   | S  R  K  S  V  M  V  A  E  I  P  S  T  V  S  Q  H  S      p.460

          .         .         .         .         .         .       g.49888
 GAGAGTCACACGGATGAGACCCTGGCCAGCAGGAAGTCGGATGCCATCTTCAGAGCTGCC       c.1440
 E  S  H  T  D  E  T  L  A  S  R  K  S  D  A  I  F  R  A  A         p.480

          .         .         .    | 15    .         .         .    g.53834
 AAGAAGGACCTGCTCACCCTGATGAAGCTGGAA | GACTCATCTCTGTTGGATGGCCGGGTG    c.1500
 K  K  D  L  L  T  L  M  K  L  E   | D  S  S  L  L  D  G  R  V      p.500

          .         .         .         .         .  | 16      .    g.54647
 GCGCTTCTGCACGTTCCTGCAGGCACGGTGGTGTCAAGGCAGGGAGACCAG | GACGCCAGC    c.1560
 A  L  L  H  V  P  A  G  T  V  V  S  R  Q  G  D  Q   | D  A  S      p.520

          .         .         .         .         .         .       g.54707
 ATCCTGTTCGTGGTCTCGGGGCTGCTGCACGTGTACCAGCGGAAGATCGGCAGCCAGGAG       c.1620
 I  L  F  V  V  S  G  L  L  H  V  Y  Q  R  K  I  G  S  Q  E         p.540

          .         .         .         .         .         .       g.54767
 GACACCTGCTTGTTCCTCACGCGCCCCGGGGAGATGGTGGGCCAGCTGGCCGTGCTCACC       c.1680
 D  T  C  L  F  L  T  R  P  G  E  M  V  G  Q  L  A  V  L  T         p.560

          .         .         .         .         .         .       g.54827
 GGGGAGCCTCTCATCTTCACCGTCAAGGCCAACAGGGACTGCAGCTTCCTGTCCATCTCC       c.1740
 G  E  P  L  I  F  T  V  K  A  N  R  D  C  S  F  L  S  I  S         p.580

          .        | 17.         .         .         .         .    g.57332
 AAGGCCCACTTCTATGA | AATCATGCGGAAGCAGCCGACCGTCGTCCTGGGTGTGGCGCAC    c.1800
 K  A  H  F  Y  E  |  I  M  R  K  Q  P  T  V  V  L  G  V  A  H      p.600

          .         .         .         .         .         .       g.57392
 ACTGTGGTGAAGAGGATGTCGTCCTTCGTGCGGCAAATCGACTTTGCCCTGGACTGGGTG       c.1860
 T  V  V  K  R  M  S  S  F  V  R  Q  I  D  F  A  L  D  W  V         p.620

          .         .          | 18        .         .         .    g.58255
 GAGGTGGAGGCCGGGCGAGCAATATACAG | GCAGGGGGACAAGTCCGACTGCACGTACATC    c.1920
 E  V  E  A  G  R  A  I  Y  R  |  Q  G  D  K  S  D  C  T  Y  I      p.640

          .         .         .         .         .         .       g.58315
 ATGCTCAGCGGCCGGCTGCGCTCTGTGATCCGGAAGGATGATGGGAAGAAGCGCCTGGCC       c.1980
 M  L  S  G  R  L  R  S  V  I  R  K  D  D  G  K  K  R  L  A         p.660

          .         .         .    | 19    .         .         .    g.60415
 GGGGAGTACGGCCGAGGAGACCTCGTCGGCGTG | GTGGAGACACTGACCCACCAGGCCCGG    c.2040
 G  E  Y  G  R  G  D  L  V  G  V   | V  E  T  L  T  H  Q  A  R      p.680

          .         .         .         .         .         .       g.60475
 GCGACCACGGTGCATGCCGTTCGGGACTCAGAATTGGCCAAGCTGCCGGCAGGAGCCCTC       c.2100
 A  T  T  V  H  A  V  R  D  S  E  L  A  K  L  P  A  G  A  L         p.700

          .         .        | 20.         .         .         .    g.62485
 ACGTCCATCAAGCGCAGGTACCCACAG | GTGGTGACTCGGCTGATTCATCTCTTGGGTGAG    c.2160
 T  S  I  K  R  R  Y  P  Q   | V  V  T  R  L  I  H  L  L  G  E      p.720

          .         .         .        | 21.         .         .    g.70821
 AAGATCCTGGGCAGCCTCCAGCAGGGACCTGTGACAG | GCCACCAGCTTGGGCTCCCCACG    c.2220
 K  I  L  G  S  L  Q  Q  G  P  V  T  G |   H  Q  L  G  L  P  T      p.740

          .         .         .         .         .         .       g.70881
 GAGGGCAGCAAGTGGGACTTGGGGAACCCGGCTGTCAACCTGTCCACGGTGGCAGTGATG       c.2280
 E  G  S  K  W  D  L  G  N  P  A  V  N  L  S  T  V  A  V  M         p.760

          .         .         .         .         .         .       g.70941
 CCCGTGTCAGAGGAAGTGCCCCTCACCGCCTTCGCCCTGGAGCTGGAGCATGCCCTCAGC       c.2340
 P  V  S  E  E  V  P  L  T  A  F  A  L  E  L  E  H  A  L  S         p.780

         | 22.         .         .         .         .         .    g.74564
 GCCATCG | GCCCGACCCTGCTGCTGACTAGTGACAACATAAAACGGCGCCTTGGCTCCGCT    c.2400
 A  I  G |   P  T  L  L  L  T  S  D  N  I  K  R  R  L  G  S  A      p.800

          .  | 23      .         .         .         .         .    g.75103
 GCCCTGGACAG | TGTTCACGAGTACCGGCTGTCCAGCTGGCTGGGGCAGCAGGAGGACACC    c.2460
 A  L  D  S  |  V  H  E  Y  R  L  S  S  W  L  G  Q  Q  E  D  T      p.820

          .         .         .         .         .         .       g.75163
 CACAGGATCGTGCTCTACCAGGTAGATGGCACGCTCACACCCTGGACCCAGCGCTGCGTG       c.2520
 H  R  I  V  L  Y  Q  V  D  G  T  L  T  P  W  T  Q  R  C  V         p.840

          .         .         .         .         .         .       g.75223
 CGCCAGGCCGACTGCATCCTCATCGTGGGCCTGGGTGACCAGGAGCCCACAGTGGGCGAG       c.2580
 R  Q  A  D  C  I  L  I  V  G  L  G  D  Q  E  P  T  V  G  E         p.860

  | 24       .         .         .         .         .         .    g.76356
  | CTGGAGCGGATGCTGGAGAGCACAGCTGTGCGTGCCCAGAAGCAGCTGATCCTGCTGCAC    c.2640
  | L  E  R  M  L  E  S  T  A  V  R  A  Q  K  Q  L  I  L  L  H      p.880

          .         .         .         .         .         .       g.76416
 AGGGAGGAGGGCCCGGCGCCAGCGCGCACCGTGGAGTGGCTCAACATGCGGAGCTGGTGC       c.2700
 R  E  E  G  P  A  P  A  R  T  V  E  W  L  N  M  R  S  W  C         p.900

          .         .         .         .         .         .       g.76476
 TCCGGCCACCTGCACCTCTGCTGCCCGCGCCGCGTCTTCTCCAGGAGGAGCCTGCCCAAG       c.2760
 S  G  H  L  H  L  C  C  P  R  R  V  F  S  R  R  S  L  P  K         p.920

     | 25    .         .         .         .         .         .    g.77439
 CTG | GTGGAGATGTACAAGCATGTCTTCCAGCGGCCCCCGGACCGACACTCAGACTTCTCC    c.2820
 L   | V  E  M  Y  K  H  V  F  Q  R  P  P  D  R  H  S  D  F  S      p.940

          .         .         .         .         .         .       g.77499
 CGCCTGGCGAGGGTGCTGACGGGCAACGCCATTGCCCTGGTGCTTGGGGGAGGGGGAGCA       c.2880
 R  L  A  R  V  L  T  G  N  A  I  A  L  V  L  G  G  G  G  A         p.960

    | 26     .         .         .         .         .         .    g.88119
 AG | AGGCTGTGCCCAGGTGGGCGTTCTCAAGGCCTTGGCGGAGTGCGGCATCCCTGTGGAC    c.2940
 R  |  G  C  A  Q  V  G  V  L  K  A  L  A  E  C  G  I  P  V  D      p.980

          .         .         .         .         .         .       g.88179
 ATGGTGGGAGGCACGTCCATCGGGGCCTTCGTGGGTGCCCTGTACTCTGAGGAGCGGAAC       c.3000
 M  V  G  G  T  S  I  G  A  F  V  G  A  L  Y  S  E  E  R  N         p.1000

          .         .         .          | 27        .         .    g.91099
 TACAGCCAGATGCGGATCCGGGCCAAGCAGTGGGCCGAG | GGCATGACGTCCTTGATGAAG    c.3060
 Y  S  Q  M  R  I  R  A  K  Q  W  A  E   | G  M  T  S  L  M  K      p.1020

          .         .         .         .         .         .       g.91159
 GCCGCGCTGGACCTCACCTACCCCATCACGTCCATGTTCTCCGGAGCCGGCTTCAACAGC       c.3120
 A  A  L  D  L  T  Y  P  I  T  S  M  F  S  G  A  G  F  N  S         p.1040

          .         .         .       | 28 .         .         .    g.91363
 AGCATCTTCAGCGTCTTCAAGGACCAGCAGATCGAG | GACCTGTGGATTCCTTATTTCGCC    c.3180
 S  I  F  S  V  F  K  D  Q  Q  I  E   | D  L  W  I  P  Y  F  A      p.1060

          .         .         .         .       | 29 .         .    g.92017
 ATCACCACCGACATCACAGCCTCGGCCATGCGGGTCCACACCGACG | GCTCCCTGTGGTGG    c.3240
 I  T  T  D  I  T  A  S  A  M  R  V  H  T  D  G |   S  L  W  W      p.1080

          .         .         .         .         .         .       g.92077
 TACGTGCGTGCCAGCATGTCCCTGTCCGGTTACATGCCCCCTCTCTGTGACCCGAAGGAC       c.3300
 Y  V  R  A  S  M  S  L  S  G  Y  M  P  P  L  C  D  P  K  D         p.1100

          .         .         .         .    | 30    .         .    g.92718
 GGACACCTGCTGATGGACGGGGGCTACATCAACAACCTCCCAG | CGGATGTGGCCCGGTCC    c.3360
 G  H  L  L  M  D  G  G  Y  I  N  N  L  P  A |   D  V  A  R  S      p.1120

          .         .         .         .         .         .       g.92778
 ATGGGGGCAAAAGTGGTGATCGCCATTGACGTGGGCAGCCGAGATGAGACGGACCTCACC       c.3420
 M  G  A  K  V  V  I  A  I  D  V  G  S  R  D  E  T  D  L  T         p.1140

          .         .         .         .         .         .       g.92838
 AACTATGGGGATGCGCTGTCTGGGTGGTGGCTGCTGTGGAAACGCTGGAACCCCTTGGCC       c.3480
 N  Y  G  D  A  L  S  G  W  W  L  L  W  K  R  W  N  P  L  A         p.1160

          .   | 31     .         .         .         .         .    g.93251
 ACGAAAGTCAAG | GTGTTGAACATGGCAGAGATTCAGACGCGCCTGGCCTACGTGTGTTGC    c.3540
 T  K  V  K   | V  L  N  M  A  E  I  Q  T  R  L  A  Y  V  C  C      p.1180

          .         .         .         .         .         .       g.93311
 GTGCGGCAGCTGGAGGTGGTGAAGAGCAGTGACTACTGCGAGTACCTGCGCCCCCCCATC       c.3600
 V  R  Q  L  E  V  V  K  S  S  D  Y  C  E  Y  L  R  P  P  I         p.1200

          .         .         .         .      | 32  .         .    g.93508
 GACAGCTACAGCACCCTGGACTTCGGCAAGTTCAACGAGATCTGC | GAAGTGGGCTACCAG    c.3660
 D  S  Y  S  T  L  D  F  G  K  F  N  E  I  C   | E  V  G  Y  Q      p.1220

          .         .         .         .         .         .       g.93568
 CACGGGCGCACGGTGTTTGACATCTGGGGCCGCAGCGGCGTGCTGGAGAAGATGCTCCGC       c.3720
 H  G  R  T  V  F  D  I  W  G  R  S  G  V  L  E  K  M  L  R         p.1240

          .         .         .       | 33 .         .         .    g.93938
 GACCAGCAGGGGCCGAGCAAGAAGCCCGCGAGTGCG | GTCCTCACCTGTCCCAACGCCTCC    c.3780
 D  Q  Q  G  P  S  K  K  P  A  S  A   | V  L  T  C  P  N  A  S      p.1260

          .         .         .         .         .         .       g.93998
 TTCACGGACCTTGCCGAAATTGTGTCTCGCATTGAGCCCGCCAAGCCCGCCATGGTGGAT       c.3840
 F  T  D  L  A  E  I  V  S  R  I  E  P  A  K  P  A  M  V  D         p.1280

   | 34      .         .         .         .         .         .    g.94856
 G | ACGAATCTGACTACCAGACGGAGTACGAGGAGGAGCTGCTGGACGTCCCCAGGGATGCA    c.3900
 D |   E  S  D  Y  Q  T  E  Y  E  E  E  L  L  D  V  P  R  D  A      p.1300

          .         .         .         .      | 35  .         .    g.95073
 TACGCAGACTTCCAGAGCACCTCAGCCCAGCAGGGCTCAGACTTG | GAGGACGAGTCCTCA    c.3960
 Y  A  D  F  Q  S  T  S  A  Q  Q  G  S  D  L   | E  D  E  S  S      p.1320

          .         .         .         .         .         .       g.95133
 CTGCGGCATCGACACCCCAGTCTGGCTTTCCCAAAACTGTCTGAGGGCTCCTCTGACCAG       c.4020
 L  R  H  R  H  P  S  L  A  F  P  K  L  S  E  G  S  S  D  Q         p.1340

                                                                    g.95142
 GACGGGTAG                                                          c.4029
 D  G  X                                                            p.1342

          .         .         .         .         .         .       g.95202
 aggcctctgctaaagagcccggatgcagcgtcttccgtgggactgtccccaaggctgagg       c.*60

          .         .         .         .         .         .       g.95262
 ctcctgccaagtcctaggggcctctgtacctgccctgctggaagccctgacttccccggg       c.*120

          .         .         .         .         .         .       g.95322
 gccccaggctgtgttagggttctctgggcctcttctttgtaccagcagccctgcatacag       c.*180

          .         .         .         .         .         .       g.95382
 ggccctgtgagcccccctgcagtcctgtgaggcccctgaagctctgtgaggcccctgaag       c.*240

          .         .         .         .         .         .       g.95442
 ctctgtgaaccccctgcagccctgtgaggccccccgaagccctgtgaggccccccgaagc       c.*300

          .         .         .         .         .         .       g.95502
 cctgtgaaccacctgctgccctgtgaggcccccaaagccctgtgaactgcctgctgtcct       c.*360

          .         .         .         .         .         .       g.95562
 gtgaactgcctgctgccctgtgaggtgtgggagccctgatgctgccgtgtgatgtttcaa       c.*420

          .         .                                               g.95582
 taaaggtggatctcactgtt                                               c.*440

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Patatin-like phospholipase domain containing 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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