patatin-like phospholipase domain containing 8 (PNPLA8) - coding DNA reference sequence

(used for variant description)

(last modified February 6, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_015723.3 in the PNPLA8 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_042172.1, covering PNPLA8 transcript NM_015723.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.6894
          gtcatgctctattgcgcatatctcggggcgggggaggaacggagattgaca       c.-481

 .         .         .         .         .         .                g.6954
 aggaggcagaggcctgagcgaggcggaaaatcctcaccccggcccgcgggtagacccaaa       c.-421

 .         .         .         .         .         .                g.7014
 cttctagcgcgtcacttccgctgggggcggagcggggcggggctgagtgggtggcgacct       c.-361

 .         .         .         .         .         .                g.7074
 agctgctgcgccagtgtttgtgttggaagctcagctgatgcaggccggttggagtggacg       c.-301

 .         .         .         .         .         .         | 02    g.11641
 tcattgccgggaacgagcgagtcgccgctgcagccctagtgactgcggcctgcatcccg | a    c.-241

 .         .         .         .         .     | 03   .             g.14875
 ttgtcttctcctccaaggtctacatgattacctgaagtttaataa | ttttgcctttctaga    c.-181

 .         .         .         .         .         .                g.14935
 gtgttatacagctggaatcatactgctatggtccgaatgtttgtgcctctcaaaattcat       c.-121

 .         .         .         .       | 04 .         .             g.17610
 gtggaaatcataaccgctaaagtgatggtattaagag | gtaagaccatgaattatggcatt    c.-61

 .         .         .         .         .         .                g.17670
 tcttaaatgaagcgttcaagaagtgagagaatgtcatagaaaataaatgatttttaagtt       c.-1

          .         .         .         .         .         .       g.17730
 ATGTCTATTAATCTGACTGTAGATATATATATTTACCTCCTTAGTAATGCAAGAAGTGTT       c.60
 M  S  I  N  L  T  V  D  I  Y  I  Y  L  L  S  N  A  R  S  V         p.20

          .         .         .         .         .         .       g.17790
 TGTGGGAAGCAGAGAAGCAAGCAACTGTATTTCTTGTTCTCACCTAAGCATTACTGGAGG       c.120
 C  G  K  Q  R  S  K  Q  L  Y  F  L  F  S  P  K  H  Y  W  R         p.40

          .         .         .         .         .         .       g.17850
 ATAAGCCACATCAGTCTACAAAGAGGTTTTCATACAAACATAATAAGATGTAAATGGACC       c.180
 I  S  H  I  S  L  Q  R  G  F  H  T  N  I  I  R  C  K  W  T         p.60

          .         .         .         .         .         .       g.17910
 AAAAGTGAAGCACATTCTTGCAGTAAGCACTGTTACTCTCCAAGCAACCATGGTTTACAT       c.240
 K  S  E  A  H  S  C  S  K  H  C  Y  S  P  S  N  H  G  L  H         p.80

          .         .         .         .         .         .       g.17970
 ATTGGGATTTTGAAACTTAGCACTTCTGCTCCCAAGGGACTTACAAAAGTGAACATTTGT       c.300
 I  G  I  L  K  L  S  T  S  A  P  K  G  L  T  K  V  N  I  C         p.100

          .         .         .         .         .         .       g.18030
 ATGTCCCGTATTAAAAGTACTTTGAACTCTGTTTCAAAGGCTGTTTTTGGCAATCAAAAT       c.360
 M  S  R  I  K  S  T  L  N  S  V  S  K  A  V  F  G  N  Q  N         p.120

          .         .         .         .         .         .       g.18090
 GAAATGATTTCACGTTTAGCTCAATTTAAGCCAAGTTCCCAAATTTTAAGAAAAGTATCG       c.420
 E  M  I  S  R  L  A  Q  F  K  P  S  S  Q  I  L  R  K  V  S         p.140

          .         .         .         .         .         .       g.18150
 GATAGTGGCTGGTTAAAACAGAAAAACATCAAACAAGCCATCAAATCTCTGAAAAAATAT       c.480
 D  S  G  W  L  K  Q  K  N  I  K  Q  A  I  K  S  L  K  K  Y         p.160

          .         .         .         .         .         .       g.18210
 AGTGACAAATCAGCAGAAAAGAGTCCTTTTCCAGAAGAGAAAAGTCACATTATAGACAAA       c.540
 S  D  K  S  A  E  K  S  P  F  P  E  E  K  S  H  I  I  D  K         p.180

          .         .         .         .         .         .       g.18270
 GAAGAAGATATAGGTAAACGCAGTCTTTTTCATTACACAAGTTCTATAACCACAAAATTT       c.600
 E  E  D  I  G  K  R  S  L  F  H  Y  T  S  S  I  T  T  K  F         p.200

          .         .         .         .         .         .       g.18330
 GGAGACTCATTCTACTTTTTATCAAATCATATTAATTCATATTTCAAACGTAAGGAAAAA       c.660
 G  D  S  F  Y  F  L  S  N  H  I  N  S  Y  F  K  R  K  E  K         p.220

          .         .         .         .         .         .       g.18390
 ATGTCTCAACAAAAGGAAAATGAACATTTCCGGGACAAATCAGAACTTGAAGATAAAAAG       c.720
 M  S  Q  Q  K  E  N  E  H  F  R  D  K  S  E  L  E  D  K  K         p.240

          .         .         .         .         .         .       g.18450
 GTAGAAGAGGGGAAATTAAGATCTCCAGATCCTGGCATCCTGGCTTATAAGCCAGGCTCA       c.780
 V  E  E  G  K  L  R  S  P  D  P  G  I  L  A  Y  K  P  G  S         p.260

          .         .         .         .         .         .       g.18510
 GAATCTGTACATACGGTGGACAAGCCTACAAGTCCTTCTGCGATACCTGATGTTCTTCAA       c.840
 E  S  V  H  T  V  D  K  P  T  S  P  S  A  I  P  D  V  L  Q         p.280

          .         .         .         .         .         .       g.18570
 GTTTCAACTAAACAAAGTATTGCTAACTTTCTTTCTCGTCCCACGGAAGGTGTACAAGCT       c.900
 V  S  T  K  Q  S  I  A  N  F  L  S  R  P  T  E  G  V  Q  A         p.300

          .         .         .         .         .         .       g.18630
 TTAGTAGGTGGTTATATTGGTGGACTTGTCCCCAAATTAAAGTATGATTCAAAGAGTCAG       c.960
 L  V  G  G  Y  I  G  G  L  V  P  K  L  K  Y  D  S  K  S  Q         p.320

          .         .         .         .         .         .       g.18690
 TCAGAAGAACAGGAAGAGCCTGCTAAAACTGATCAGGCTGTCAGCAAAGACAGAAATGCA       c.1020
 S  E  E  Q  E  E  P  A  K  T  D  Q  A  V  S  K  D  R  N  A         p.340

          .         .         .       | 05 .         .         .    g.18892
 GAGGAGAAAAAGCGTTTATCTCTTCAGCGAGAAAAG | ATTATCGCAAGGGTGAGTATTGAT    c.1080
 E  E  K  K  R  L  S  L  Q  R  E  K   | I  I  A  R  V  S  I  D      p.360

          .         .         .         .         .         .       g.18952
 AACAGGACCCGGGCATTAGTTCAGGCATTAAGAAGAACAACTGACCCAAAGCTCTGCATT       c.1140
 N  R  T  R  A  L  V  Q  A  L  R  R  T  T  D  P  K  L  C  I         p.380

          .         .         .         .         .         .       g.19012
 ACTAGGGTTGAAGAACTGACTTTTCATCTTCTAGAATTTCCTGAAGGAAAAGGAGTGGCT       c.1200
 T  R  V  E  E  L  T  F  H  L  L  E  F  P  E  G  K  G  V  A         p.400

        | 06 .         .         .         .         .         .    g.30573
 GTCAAG | GAAAGAATTATTCCATATTTATTACGACTGAGACAAATTAAGGATGAAACTCTT    c.1260
 V  K   | E  R  I  I  P  Y  L  L  R  L  R  Q  I  K  D  E  T  L      p.420

          .         .         .         .         .         .       g.30633
 CAGGCTGCAGTTAGAGAAATTTTGGCCCTAATTGGCTATGTGGATCCAGTGAAAGGGAGA       c.1320
 Q  A  A  V  R  E  I  L  A  L  I  G  Y  V  D  P  V  K  G  R         p.440

          .         .         .         | 07         .         .    g.35606
 GGAATCCGAATTCTCTCAATTGATGGTGGAGGAACAAG | GGGCGTGGTTGCTCTCCAGACC    c.1380
 G  I  R  I  L  S  I  D  G  G  G  T  R  |  G  V  V  A  L  Q  T      p.460

          .         .         .         .         .         .       g.35666
 CTACGAAAATTAGTTGAACTTACTCAGAAGCCAGTTCATCAGCTCTTTGATTACATTTGT       c.1440
 L  R  K  L  V  E  L  T  Q  K  P  V  H  Q  L  F  D  Y  I  C         p.480

          .    | 08    .         .         .         .         .    g.36453
 GGTGTAAGCACAG | GTGCCATATTAGCTTTCATGTTGGGGTTGTTTCATATGCCCTTGGAT    c.1500
 G  V  S  T  G |   A  I  L  A  F  M  L  G  L  F  H  M  P  L  D      p.500

          .         .         .         .         .         .       g.36513
 GAATGTGAGGAACTTTATCGAAAATTAGGATCAGATGTATTTTCACAAAATGTCATTGTT       c.1560
 E  C  E  E  L  Y  R  K  L  G  S  D  V  F  S  Q  N  V  I  V         p.520

          .         .         .         .         .         .       g.36573
 GGAACAGTAAAAATGAGTTGGAGCCATGCATTTTATGACAGTCAAACATGGGAAAACATT       c.1620
 G  T  V  K  M  S  W  S  H  A  F  Y  D  S  Q  T  W  E  N  I         p.540

       | 09  .         .         .         .         .         .    g.41749
 CTTAA | GGATAGGATGGGATCTGCACTGATGATTGAAACAGCAAGAAACCCCACATGTCCT    c.1680
 L  K  |  D  R  M  G  S  A  L  M  I  E  T  A  R  N  P  T  C  P      p.560

     | 10    .         .         .         .         .         .    g.45265
 AAG | GTAGCTGCTGTAAGTACCATAGTAAATAGAGGGATAACACCCAAAGCTTTTGTGTTC    c.1740
 K   | V  A  A  V  S  T  I  V  N  R  G  I  T  P  K  A  F  V  F      p.580

          .         .         .         .         .         .       g.45325
 AGAAACTATGGTCATTTTCCTGGAATCAACTCTCATTATTTGGGAGGCTGTCAGTATAAA       c.1800
 R  N  Y  G  H  F  P  G  I  N  S  H  Y  L  G  G  C  Q  Y  K         p.600

          .         .         .         .         .         .       g.45385
 ATGTGGCAGGCCATTAGAGCCTCATCTGCTGCTCCAGGCTACTTTGCAGAATATGCATTG       c.1860
 M  W  Q  A  I  R  A  S  S  A  A  P  G  Y  F  A  E  Y  A  L         p.620

          .         | 11         .         .         .         .    g.53824
 GGAAATGATCTTCATCAA | GATGGAGGTTTGCTTCTGAATAACCCTTCGGCATTAGCTATG    c.1920
 G  N  D  L  H  Q   | D  G  G  L  L  L  N  N  P  S  A  L  A  M      p.640

          .         .         .         .         .         .       g.53884
 CATGAGTGTAAATGTCTTTGGCCAGATGTGCCGTTAGAGTGCATAGTATCCCTGGGCACT       c.1980
 H  E  C  K  C  L  W  P  D  V  P  L  E  C  I  V  S  L  G  T         p.660

          .         .         .         .         .         .       g.53944
 GGACGTTATGAGAGTGATGTGAGAAACACGGTAACATACACAAGCTTGAAAACTAAACTT       c.2040
 G  R  Y  E  S  D  V  R  N  T  V  T  Y  T  S  L  K  T  K  L         p.680

          .         .         .     | 12   .         .         .    g.60512
 TCTAATGTTATCAACAGTGCTACAGATACAGAAG | AAGTCCATATAATGCTTGATGGCCTG    c.2100
 S  N  V  I  N  S  A  T  D  T  E  E |   V  H  I  M  L  D  G  L      p.700

          .         .         .         .         .         .       g.60572
 TTACCTCCTGACACCTATTTTAGATTCAATCCTGTAATGTGTGAAAACATACCTCTAGAT       c.2160
 L  P  P  D  T  Y  F  R  F  N  P  V  M  C  E  N  I  P  L  D         p.720

          .         .         .         .         .         .       g.60632
 GAAAGTCGAAATGAAAAGCTGGATCAGCTGCAGTTGGAAGGGTTGAAATACATAGAAAGA       c.2220
 E  S  R  N  E  K  L  D  Q  L  Q  L  E  G  L  K  Y  I  E  R         p.740

          .         .         .         .         .         .       g.60692
 AATGAACAAAAAATGAAAAAAGTTGCAAAAATATTAAGTCAAGAAAAAACAACTCTGCAG       c.2280
 N  E  Q  K  M  K  K  V  A  K  I  L  S  Q  E  K  T  T  L  Q         p.760

          .         .         .         .         .         .       g.60752
 AAAATTAATGATTGGATAAAATTAAAAACTGATATGTATGAAGGACTTCCATTCTTTTCA       c.2340
 K  I  N  D  W  I  K  L  K  T  D  M  Y  E  G  L  P  F  F  S         p.780

                                                                    g.60761
 AAATTGTGA                                                          c.2349
 K  L  X                                                            p.782

          .         .         .         .         .         .       g.60821
 tgagtatatgcttatgttctcataaatgaaggtctgtttagaagatcaaccacattcaat       c.*60

          .         .         .         .         .         .       g.60881
 aaggaattgtggggttcgacatgagttaactttgaaatacgtatgaattctggagaatcc       c.*120

          .         .         .         .         .         .       g.60941
 tgaaaaagacggtgcttcaaccagcttgcatagcacagagaatattcttggttacagaat       c.*180

          .         .         .         .         .         .       g.61001
 tcatatgggaactaggcttttaagatgttaataattagctaagctttagtaacccttact       c.*240

          .         .         .         .         .         .       g.61061
 gtgctagtagattttagtagatattggtgttatattgtttgatgtttgaaaatatattaa       c.*300

          .         .         .         .         .         .       g.61121
 tatatgtgccgaacaagaaaccgaaagctatattgtactgtgtatttttactttagtcct       c.*360

          .         .         .         .         .         .       g.61181
 cataatcatgttgaatttatgtgatcattgattttatttcatatggaaaagctaatttct       c.*420

          .         .         .         .         .         .       g.61241
 tcttaaatttacattacctaatattctcactagctatgttctccaatccacactgccttt       c.*480

          .         .         .         .         .         .       g.61301
 tattgtaatatcatctaaatagatgcagaaaaatggaattttctctattaaagtatttta       c.*540

          .         .         .         .         .         .       g.61361
 catttgacataaaaaagaaccagatacagttttctattcagatatgtttattttaacatt       c.*600

          .         .         .         .         .         .       g.61421
 gtttggttaaaaaaggtgaagttccagtcaaccactttttacccctgaaatttcaagata       c.*660

          .         .         .         .         .         .       g.61481
 atgctatattaacttttccagatctaacactagcttattcttccctgttataaaatggtt       c.*720

          .         .         .         .         .         .       g.61541
 tgaacttactgaggagatattcctatcattaacaaaaataaactatttaaataatctgtt       c.*780

          .         .         .         .         .         .       g.61601
 gttaaaaggctaatgtcattttaaaattaatttttgttcataatgtagctcccctttagc       c.*840

          .         .         .         .         .         .       g.61661
 ctttgaatacacctggcagcagtatgcttaaaaataagaagttagttgcctggcgcagta       c.*900

          .         .         .         .         .         .       g.61721
 gctcacacctgtaatcccagcactttgggaggccgaggcaggcagatcacctgacgtcag       c.*960

          .         .         .         .         .         .       g.61781
 gagtccaagaccagcctggccaacacggtgaaacctcgtctctaataaaaatacaaacat       c.*1020

          .         .         .         .         .         .       g.61841
 tagcccggcatggtggtgcacacctatagtcccagctactcgggaggctaaggcaggaga       c.*1080

          .         .         .         .         .         .       g.61901
 atggcttgaacctgagagacggaggttgcagtgagccaaatagcgccagtgcactccagc       c.*1140

          .         .         .         .         .         .       g.61961
 ctaggcgacacagcgagactccatctcaaaaaaaaaaaaaaaaaaaagaagaagttaggc       c.*1200

          .         .         .         .         .         .       g.62021
 ttgttttaccttattaactcctttgaactgtctggatttcatggaagttggtaagatgca       c.*1260

          .         .         .         .         .         .       g.62081
 cttacatggaacattgttcatgccaaacaaactcatctttattgtatctatttgtcacat       c.*1320

          .         .         .         .         .         .       g.62141
 aaatccttacatggaatgttttgatttcttaagaaaaatgaaacaaaggttagcgcccct       c.*1380

          .         .         .         .         .         .       g.62201
 tgttttagacatacaaactaaagctagaccctgttgcccagatagtcatattgcttcttt       c.*1440

          .         .         .         .         .         .       g.62261
 gcaatatcaattcacagaggctgtgagatgtggttcaaagagtggagtcgagagtctgga       c.*1500

          .         .         .         .         .         .       g.62321
 tgctaatcctgcctttgctgcaagaacccttctgtttgttaccttgaggaaggcaaatgt       c.*1560

          .         .         .         .         .         .       g.62381
 ctgtaggctttgcatatctcatttgtaaaatgaggaaaggtagctgtaaaattttctaac       c.*1620

          .         .         .         .         .         .       g.62441
 atccgaattatataaactttagacatagtataaaataggaaactaccaatgatttctaaa       c.*1680

          .         .         .         .         .         .       g.62501
 gataatatagttctttcagaccacaaataatacataataacatgcaactaagaacaactt       c.*1740

          .         .         .         .         .         .       g.62561
 gtaaatgcaagaaaaaaacaaataattggaaatcagaatatttctgggaattcttcgtaa       c.*1800

          .         .         .         .         .         .       g.62621
 taaagcaaatttcaagcacaataaagtaatatttatgcatatttacatatttgcacctca       c.*1860

          .         .         .         .         .         .       g.62681
 tcataaggtcactctagtcctaaactgatgtagttcatctgttttacagctgaagttaag       c.*1920

          .         .         .         .         .                 g.62740
 tatgtcccttatttgtgcttggcttatttctttcttaaataatacattacacaagtgaa        c.*1979

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Patatin-like phospholipase domain containing 8 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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