POC1 centriolar protein homolog B (Chlamydomonas) (POC1B) - coding DNA reference sequence

(used for variant description)

(last modified December 6, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_172240.2 in the POC1B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering POC1B transcript NM_172240.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      atcgatc       c.-361

 .         .         .         .         .         .                g.5067
 acaggctcacaacgcccttccattcatcgctcttattccagtcctggttactaccccact       c.-301

 .         .         .         .         .         .                g.5127
 tcctgacatcaaaccagggagaacgcgagtgttagttaacatggcttggtgtgtggccac       c.-241

 .         .         .         .         .         .                g.5187
 agctgacccggcgcatacctcccgtcctctctttacagggctggcggtgtctcggggctc       c.-181

 .         .         .         .         .         .                g.5247
 ggctggccatgcctggagcgcggggtttgactgggccgccgttgttgtagtgaccgggag       c.-121

 .         .         .         .         .         .                g.5307
 gcgctgccgctctgggcagacggttccgggagccgcacggtcccctctccttccccatcc       c.-61

 .         .         .         .         .         .                g.5367
 tctcccctcccctctccgggttcccccacccacaggagccttgggccgaccactcccccg       c.-1

          .      | 02  .         .         .         .         .    g.6103
 ATGGCCTCAGCCACG | GAGGACCCCGTTCTGGAGCGTTATTTCAAAGGCCACAAAGCTGCG    c.60
 M  A  S  A  T   | E  D  P  V  L  E  R  Y  F  K  G  H  K  A  A      p.20

          .         .         .         . | 03       .         .    g.33940
 ATCACCTCCTTGGACCTCAGCCCCAACGGCAAGCAACTTG | CTACTGCTTCTTGGGATACC    c.120
 I  T  S  L  D  L  S  P  N  G  K  Q  L  A |   T  A  S  W  D  T      p.40

          .         .         .         .         .         .       g.34000
 TTTCTCATGCTATGGAATTTCAAGCCACATGCTAGAGCTTACAGATATGTGGGTCACAAG       c.180
 F  L  M  L  W  N  F  K  P  H  A  R  A  Y  R  Y  V  G  H  K         p.60

          .         .         .         .         .         .       g.34060
 GATGTTGTAACCAGCGTGCAGTTTTCTCCACATGGAAACTTATTGGCGTCTGCCTCACGA       c.240
 D  V  V  T  S  V  Q  F  S  P  H  G  N  L  L  A  S  A  S  R         p.80

          .         .         .   | 04     .         .         .    g.39175
 GACAGAACCGTGAGACTCTGGATTCCTGATAA | GAGAGGAAAATTCTCAGAATTTAAAGCT    c.300
 D  R  T  V  R  L  W  I  P  D  K  |  R  G  K  F  S  E  F  K  A      p.100

          .         .         .         .         .         .       g.39235
 CATACAGCTCCAGTTCGAAGTGTAGACTTTTCAGCTGATGGCCAGTTTCTAGCTACAGCT       c.360
 H  T  A  P  V  R  S  V  D  F  S  A  D  G  Q  F  L  A  T  A         p.120

          .         .         .         .         .         .       g.39295
 TCTGAAGACAAATCCATAAAAGTATGGAGCATGTATCGCCAGCGCTTCCTGTATTCCTTG       c.420
 S  E  D  K  S  I  K  V  W  S  M  Y  R  Q  R  F  L  Y  S  L         p.140

          .         .         .   | 05     .         .         .    g.59015
 TATCGACATACACACTGGGTACGCTGTGCCAA | ATTTTCACCCGATGGAAGACTAATTGTG    c.480
 Y  R  H  T  H  W  V  R  C  A  K  |  F  S  P  D  G  R  L  I  V      p.160

          .         .         .         .         .         .       g.59075
 TCATGTAGTGAGGATAAAACTATTAAAATTTGGGATACCACAAATAAGCAATGTGTTAAT       c.540
 S  C  S  E  D  K  T  I  K  I  W  D  T  T  N  K  Q  C  V  N         p.180

          .         . | 06       .         .         .         .    g.59573
 AACTTCTCAGATTCCGTTGG | ATTTGCAAATTTTGTGGACTTTAACCCTAGTGGTACATGC    c.600
 N  F  S  D  S  V  G  |  F  A  N  F  V  D  F  N  P  S  G  T  C      p.200

          .         .         .         .         .         .       g.59633
 ATAGCTTCAGCAGGTTCTGATCAAACTGTGAAAGTCTGGGATGTAAGAGTGAACAAATTA       c.660
 I  A  S  A  G  S  D  Q  T  V  K  V  W  D  V  R  V  N  K  L         p.220

          .       | 07 .         .         .         .         .    g.60812
 CTACAGCATTACCAAG | TTCACAGCGGTGGAGTTAATTGCATATCATTCCATCCTTCGGGT    c.720
 L  Q  H  Y  Q  V |   H  S  G  G  V  N  C  I  S  F  H  P  S  G      p.240

          .         .         .         .         .         .       g.60872
 AACTATCTCATCACAGCTTCTTCAGATGGTACCCTTAAGATTCTGGACCTCTTAGAAGGA       c.780
 N  Y  L  I  T  A  S  S  D  G  T  L  K  I  L  D  L  L  E  G         p.260

          .         .         . | 08       .         .         .    g.63607
 AGGCTCATCTATACACTTCAAGGACATACG | GGACCTGTCTTTACTGTTTCATTTTCAAAA    c.840
 R  L  I  Y  T  L  Q  G  H  T   | G  P  V  F  T  V  S  F  S  K      p.280

          .         .         .          | 09        .         .    g.64361
 GGTGGAGAGCTATTTGCATCAGGAGGTGCAGACACACAG | GTCTTATTATGGAGGACTAAC    c.900
 G  G  E  L  F  A  S  G  G  A  D  T  Q   | V  L  L  W  R  T  N      p.300

          .         .         .         .         .         .       g.64421
 TTTGATGAATTGCATTGTAAAGGTCTTACCAAAAGAAATCTCAAAAGATTACATTTTGAT       c.960
 F  D  E  L  H  C  K  G  L  T  K  R  N  L  K  R  L  H  F  D         p.320

          .         .         .         .         .         .       g.64481
 TCACCACCACATCTTCTTGATATCTACCCAAGAACACCACATCCCCATGAGGAAAAAGTT       c.1020
 S  P  P  H  L  L  D  I  Y  P  R  T  P  H  P  H  E  E  K  V         p.340

          .   | 10     .         .         .         .         .    g.71592
 GAGACTGTAGAA | ATTAATCCAAAGCTTGAGGTAATCGATTTGCAGATCTCTACTCCCCCT    c.1080
 E  T  V  E   | I  N  P  K  L  E  V  I  D  L  Q  I  S  T  P  P      p.360

          .         .         .    | 11    .         .         .    g.105910
 GTTATGGATATCCTTTCTTTTGATTCTACCACA | ACAACAGAAACCAGTGGTAGGACTCTG    c.1140
 V  M  D  I  L  S  F  D  S  T  T   | T  T  E  T  S  G  R  T  L      p.380

          .         .         .         .         .         .       g.105970
 CCAGACAAGGGTGAAGAGGCCTGTGGATATTTCTTGAACCCTTCCTTAATGTCACCAGAA       c.1200
 P  D  K  G  E  E  A  C  G  Y  F  L  N  P  S  L  M  S  P  E         p.400

          .         .         .         .         .         .       g.106030
 TGTTTGCCAACAACCACGAAAAAGAAAACAGAAGACATGAGTGACCTCCCCTGTGAAAGT       c.1260
 C  L  P  T  T  T  K  K  K  T  E  D  M  S  D  L  P  C  E  S         p.420

          .         .         .         .         .         .       g.106090
 CAAAGGAGCATACCTCTCGCTGTGACTGATGCTTTAGAGCATATTATGGAACAACTCAAT       c.1320
 Q  R  S  I  P  L  A  V  T  D  A  L  E  H  I  M  E  Q  L  N         p.440

          .   | 12     .         .         .         .         .    g.110053
 GTTTTGACACAG | ACTGTTTCAATCTTGGAGCAGCGACTGACTTTGACAGAGGATAAGCTG    c.1380
 V  L  T  Q   | T  V  S  I  L  E  Q  R  L  T  L  T  E  D  K  L      p.460

          .         .         .         .         .                 g.110110
 AAAGACTGCCTTGAAAATCAGCAAAAGCTTTTCAGTGCTGTCCAACAGAAAAGCTGA          c.1437
 K  D  C  L  E  N  Q  Q  K  L  F  S  A  V  Q  Q  K  S  X            p.478

          .         .         .         .         .         .       g.110170
 ataaaaaattcattttcatttgttgggcagaggcccaataaatgaacaaatgtacataca       c.*60

          .         .         .         .         .         .       g.110230
 ctcaggaaggtagtacaagatactccatacaacacaaccatgtgctatttatcatggcat       c.*120

          .         .         .         .         .         .       g.110290
 ttcttaaaagggtgagcaacagaacaaaaggcagaaaaggcatacctaaggactaattta       c.*180

          .         .         .         .         .         .       g.110350
 aacacatatcaatgtgaaggactaatttaaattactatcatttatgattgcagtaataaa       c.*240

          .         .         .         .         .         .       g.110410
 gtgataagcattcaagcaactctgtattttccccatattattttaaatgtccattttcat       c.*300

          .         .         .         .         .         .       g.110470
 ttataggccaaatcctgccaggaaagtaaccagatctctggatttcactgttaagtcatt       c.*360

          .         .         .         .         .         .       g.110530
 tcagattgaccatattcagacagtcatggggtgaaataattcacttacctccaaaatagc       c.*420

          .         .         .         .         .         .       g.110590
 atcctatatgccaataatgagttattgatctgactagttgtatgtctttctgttcaaaat       c.*480

          .         .         .         .         .         .       g.110650
 agaaattatcctttcttactaatgccttgaaagaatgaacaaataaaaattcccagacca       c.*540

          .         .         .         .         .         .       g.110710
 cagaatttccacagcaagaatacacttattttaattaacaatagcacagatatagcatag       c.*600

          .         .         .         .         .         .       g.110770
 ggcagtgggttttttagttaatttatggcgtactttgtttatccattggccaacctgaag       c.*660

          .         .         .         .         .         .       g.110830
 gaaatgaaactcacctatctttctatcacagatgaatgtgctagatgaatgatttgggtt       c.*720

          .         .         .         .         .         .       g.110890
 gtatctgatcatggttcacaaaaattatgttagtgtgttttcagtatgctaaaaagtcag       c.*780

          .         .         .         .         .         .       g.110950
 agtgatacaaaagtgatatttaaaaatatacacacatgtatgtacacatgcttcagaaat       c.*840

          .         .         .         .         .         .       g.111010
 attgttgcttagggtgatttgggcagctaaatagtaagtactttttaaaatttttgcatc       c.*900

          .         .         .         .         .         .       g.111070
 atcatcttcctatttaatgaattgtgatttaaaacaaaatgaaaataagccaggtattct       c.*960

          .         .         .         .         .         .       g.111130
 aaaagatcctggatacaaattaagaattttgctttattttaaaccaaattgagattaaat       c.*1020

          .         .         .         .         .         .       g.111190
 tgaagaaaagcaagcaaattaatttcagcttgattatcaacctgtatcaagaacaaaaat       c.*1080

          .         .         .         .         .         .       g.111250
 gggaggaggtgtccacatttatggtgtgtataggtaacatggggaaaatgctattctgtg       c.*1140

          .         .         .         .         .         .       g.111310
 ttttggaaaagaagaaatagtgccgtcctatttatttctatatttagaaatttttctcaa       c.*1200

          .         .         .         .         .         .       g.111370
 agaaatttcaattgtatctatgagatgggtttctaagtatcttattgtgtgttataagtg       c.*1260

          .         .         .         .         .         .       g.111430
 ccttttaatatcatactaagtgtgagcttctggacattttcaagagcttacaaaaactaa       c.*1320

          .         .         .         .         .         .       g.111490
 gtggcattgtatttttataaccccattgagaagactaagtaagaaatgaaatgtcctatc       c.*1380

          .         .         .         .         .                 g.111545
 aattttattttgtcatgcttcaaacaataaagacatttctgctttaaaagaaaaa            c.*1435

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The POC1 centriolar protein homolog B (Chlamydomonas) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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