protein-O-mannose kinase (POMK) - coding DNA reference sequence

(used for variant description)

(last modified March 21, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_032237.4 in the POMK gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.11, covering POMK transcript NM_032237.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5027
                                  agtaggcccagtgcgtgctggcccggg       c.-241

 .         .         .         . | 02       .         .             g.9047
 gtggcaggagccgcagaggcttgggctgcag | aaaaaggatcctgtttgctgtgtaatcct    c.-181

 .         .         .         .         .         .                g.9107
 gagaatggactgcaagagaggaaaaactgggcgtctgcttgggaatctattgtggaaacc       c.-121

 .   | 03     .         .         .         .         .             g.14056
 cag | ggtgtttcccgaccagtccctgggcgccaactagagtatggactgaccaggtacctg    c.-61

 .         .         .         .         | 04         .             g.15043
 gatggagacctgagctggagaaggagatgcgcttgggag | gaaattgcagaggccgtcaac    c.-1

          .         .         .         .         .         .       g.15103
 ATGGAAAAGCAGCCCCAGAACAGCAGGAGAGGCCTCGCCCCCCGAGAGGTGCCGCCAGCT       c.60
 M  E  K  Q  P  Q  N  S  R  R  G  L  A  P  R  E  V  P  P  A         p.20

          .         .         .         .         .         .       g.15163
 GTTGGGCTGCTGCTGATCATGGCCCTGATGAATACTCTGCTCTACCTCTGCCTCGACCAC       c.120
 V  G  L  L  L  I  M  A  L  M  N  T  L  L  Y  L  C  L  D  H         p.40

          .         .         .         .         .         .       g.15223
 TTCTTCATCGCTCCTCGACAATCCACTGTGGACCCCACACACTGTCCCTATGGTCACTTC       c.180
 F  F  I  A  P  R  Q  S  T  V  D  P  T  H  C  P  Y  G  H  F         p.60

          .         .         .         .         .         .       g.15283
 AGGATAGGACAGATGAAAAACTGCTCACCTTGGCTGTCCTGCGAGGAGCTGAGAACAGAA       c.240
 R  I  G  Q  M  K  N  C  S  P  W  L  S  C  E  E  L  R  T  E         p.80

          .         .         .         .   | 05     .         .    g.33619
 GTGAGACAGCTGAAGCGTGTTGGGGAAGGAGCTGTAAAGAGA | GTCTTTCTGTCTGAGTGG    c.300
 V  R  Q  L  K  R  V  G  E  G  A  V  K  R   | V  F  L  S  E  W      p.100

          .         .         .         .         .         .       g.33679
 AAGGAGCACAAAGTTGCACTCTCACAGCTCACCAGCCTGGAGATGAAAGATGATTTCCTC       c.360
 K  E  H  K  V  A  L  S  Q  L  T  S  L  E  M  K  D  D  F  L         p.120

          .         .         .         .         .         .       g.33739
 CATGGACTGCAGATGCTGAAATCTCTCCAAGGCACACATGTTGTCACGCTGCTTGGCTAT       c.420
 H  G  L  Q  M  L  K  S  L  Q  G  T  H  V  V  T  L  L  G  Y         p.140

          .         .         .         .         .         .       g.33799
 TGTGAGGATGACAACACTATGCTTACTGAATATCACCCTCTAGGTTCCTTGAGTAACCTG       c.480
 C  E  D  D  N  T  M  L  T  E  Y  H  P  L  G  S  L  S  N  L         p.160

          .         .         .         .         .         .       g.33859
 GAAGAAACACTAAACCTTTCAAAGTACCAAAATGTGAACACGTGGCAGCACAGGCTGGAG       c.540
 E  E  T  L  N  L  S  K  Y  Q  N  V  N  T  W  Q  H  R  L  E         p.180

          .         .         .         .         .         .       g.33919
 CTGGCCATGGACTATGTCAGCATCATTAATTACCTGCACCACAGCCCTGTGGGCACACGG       c.600
 L  A  M  D  Y  V  S  I  I  N  Y  L  H  H  S  P  V  G  T  R         p.200

          .         .         .         .         .         .       g.33979
 GTCATGTGCGACTCCAACGACCTGCCGAAGACACTGTCCCAGTATCTGCTAACAAGCAAC       c.660
 V  M  C  D  S  N  D  L  P  K  T  L  S  Q  Y  L  L  T  S  N         p.220

          .         .         .         .         .         .       g.34039
 TTCAGCATTTTGGCAAATGACTTGGACGCCTTACCCCTGGTGAACCACAGCTCCGGGATG       c.720
 F  S  I  L  A  N  D  L  D  A  L  P  L  V  N  H  S  S  G  M         p.240

          .         .         .         .         .         .       g.34099
 CTGGTGAAGTGCGGCCACAGGGAGCTGCATGGGGATTTCGTGGCTCCAGAGCAACTGTGG       c.780
 L  V  K  C  G  H  R  E  L  H  G  D  F  V  A  P  E  Q  L  W         p.260

          .         .         .         .         .         .       g.34159
 CCCTATGGAGAGGACGTGCCTTTCCACGATGATCTCATGCCCTCATATGATGAGAAGATT       c.840
 P  Y  G  E  D  V  P  F  H  D  D  L  M  P  S  Y  D  E  K  I         p.280

          .         .         .         .         .         .       g.34219
 GACATTTGGAAGATCCCAGACATCTCCAGTTTCCTTCTGGGGCACATTGAAGGGAGTGAT       c.900
 D  I  W  K  I  P  D  I  S  S  F  L  L  G  H  I  E  G  S  D         p.300

          .         .         .         .         .         .       g.34279
 ATGGTCCGATTCCATTTGTTTGATATTCACAAAGCATGCAAGAGCCAGACTCCCTCAGAA       c.960
 M  V  R  F  H  L  F  D  I  H  K  A  C  K  S  Q  T  P  S  E         p.320

          .         .         .         .         .         .       g.34339
 AGACCCACTGCCCAGGACGTTCTGGAGACCTACCAGAAGGTCTTGGATACACTTAGAGAT       c.1020
 R  P  T  A  Q  D  V  L  E  T  Y  Q  K  V  L  D  T  L  R  D         p.340

          .         .         .                                     g.34372
 GCCATGATGTCTCAGGCAAGAGAGATGCTGTGA                                  c.1053
 A  M  M  S  Q  A  R  E  M  L  X                                    p.350

          .         .         .         .         .         .       g.34432
 aaaccagtccagccaatgaaggtgggattgaagggctgaatggaagttacagcattctac       c.*60

          .         .         .         .         .         .       g.34492
 tctgatggtggagttttttgcctgagtttcgtgttttattgttttttttatggcttagcc       c.*120

          .         .         .         .         .         .       g.34552
 atgtggttcgttgtccacatccacatgtacgtttgtatgtagtccacattggttgttaga       c.*180

          .         .         .         .         .         .       g.34612
 tttttttttttttctttgagatgcggtcttgctctgttgctgaggctggagtgcagtgat       c.*240

          .         .         .         .         .         .       g.34672
 gtgatcttggctcactgcagcctctgcctcccaggttcaagcaattctcccacctcagcc       c.*300

                                                                    g.34675
 tcc                                                                c.*303

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein-O-mannose kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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