popeye domain containing 3 (POPDC3) - coding DNA reference sequence

(used for variant description)

(last modified August 26, 2025)

This file was created to facilitate the description of sequence variants on transcript NM_022361.4 in the POPDC3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering POPDC3 transcript NM_022361.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.5042
                   cacgctgcgcccggcgccgcagggtgggcggcgaggcactca       c.-361

 .         .         .         .         .         .                g.5102
 cgagggggacgctgagggcttccgcgcgggccacccgggtcaagcgcgctccgccgggaa       c.-301

 .         .         .         .         .         | 02             g.22834
 acttctgcgggcgccgggctgaagctccgggcagggctgggaaggaaag | gaaataccaaa    c.-241

 .         .         .         .         .         .                g.22894
 atatttgcagactggatccaaatcaggagcccagatgaacttaaagaagcgagcatggga       c.-181

 .         .         .         .         .         .                g.22954
 ttcttagtttttcaagatccgtacacacgaagcctttaatcagcatcaactccagtgtcc       c.-121

 .         .         .         .         .         .                g.23014
 gttttctctggttttgtgaagactgcacaaaactctcatgatggagaaccaaaggactta       c.-61

 .         .         .         .         .         .                g.23074
 gttacctgtttcagtgtcatctaaagtcaactgaaaagtgaagcaggcagtaatacagcc       c.-1

          .         .         .         .         .         .       g.23134
 ATGGAAAGAAATTCAAGTTTATGGAAGAACCTAATAGATGAACACCCAGTCTGCACAACC       c.60
 M  E  R  N  S  S  L  W  K  N  L  I  D  E  H  P  V  C  T  T         p.20

          .         .         .         .         .         .       g.23194
 TGGAAGCAAGAGGCCGAAGGAGCCATTTATCATCTTGCCAGTATTTTATTTGTAGTAGGT       c.120
 W  K  Q  E  A  E  G  A  I  Y  H  L  A  S  I  L  F  V  V  G         p.40

          .         .         .         .         .         .       g.23254
 TTCATGGGTGGCAGTGGATTCTTCGGGCTCCTTTATGTCTTCAGTTTGCTGGGGTTGGGT       c.180
 F  M  G  G  S  G  F  F  G  L  L  Y  V  F  S  L  L  G  L  G         p.60

          .         .         .         .         .         .       g.23314
 TTTCTCTGTTCTGCTGTCTGGGCTTGGGTAGATGTCTGTGCAGCTGACATATTTTCCTGG       c.240
 F  L  C  S  A  V  W  A  W  V  D  V  C  A  A  D  I  F  S  W         p.80

          .         .         .         .         .         .       g.23374
 AATTTTGTACTGTTTGTCATCTGCTTCATGCAATTTGTTCATATTGCATATCAAGTTCGC       c.300
 N  F  V  L  F  V  I  C  F  M  Q  F  V  H  I  A  Y  Q  V  R         p.100

          .         .         .         .         .         .       g.23434
 AGCATAACCTTTGCCCGAGAATTCCAAGTGTTGTACAGCTCCCTTTTCCAGCCCCTGGGG       c.360
 S  I  T  F  A  R  E  F  Q  V  L  Y  S  S  L  F  Q  P  L  G         p.120

          .         .         .         .         .         .       g.23494
 ATCTCTTTGCCTGTCTTCAGAACGATTGCTTTGAGCTCTGAAGTGGTTACTTTGGAAAAG       c.420
 I  S  L  P  V  F  R  T  I  A  L  S  S  E  V  V  T  L  E  K         p.140

          .         .         .         .         .         .       g.23554
 GAACACTGTTATGCCATGCAGGGGAAAACTTCCATTGATAAACTCTCCTTGCTTGTTTCA       c.480
 E  H  C  Y  A  M  Q  G  K  T  S  I  D  K  L  S  L  L  V  S         p.160

       | 03  .         .         .         .         .         .    g.25219
 GGAAG | GATCAGAGTGACAGTTGATGGCGAATTTCTGCATTACATTTTCCCCCTTCAGTTC    c.540
 G  R  |  I  R  V  T  V  D  G  E  F  L  H  Y  I  F  P  L  Q  F      p.180

          .         .         .         .         .     | 04   .    g.26238
 CTGGATTCTCCTGAGTGGGATTCACTGAGACCCACAGAGGAAGGCATTTTTCAG | GTAACC    c.600
 L  D  S  P  E  W  D  S  L  R  P  T  E  E  G  I  F  Q   | V  T      p.200

          .         .         .         .         .         .       g.26298
 CTCACTGCAGAAACTGATTGTCGATATGTGTCTTGGAGGAGAAAGAAATTATATCTGCTC       c.660
 L  T  A  E  T  D  C  R  Y  V  S  W  R  R  K  K  L  Y  L  L         p.220

          .         .         .         .         .         .       g.26358
 TTTGCTCAGCATCGCTACATCTCCCGCCTTTTTTCAGTGCTAATTGGCAGTGACATTGCA       c.720
 F  A  Q  H  R  Y  I  S  R  L  F  S  V  L  I  G  S  D  I  A         p.240

          .         .         .         .         .         .       g.26418
 GATAAACTCTATGCCTTGAATGACAGGGTATATATAGGAAAAAGATATCACTATGATATT       c.780
 D  K  L  Y  A  L  N  D  R  V  Y  I  G  K  R  Y  H  Y  D  I         p.260

          .         .         .         .         .         .       g.26478
 CGGCTACCCAACTTCTATCAAATGTCAACTCCAGAAATACGCAGATCACCCCTGACACAA       c.840
 R  L  P  N  F  Y  Q  M  S  T  P  E  I  R  R  S  P  L  T  Q         p.280

          .         .         .                                     g.26514
 CATTTTCAGAATTCCAGACGATACTGTGATAAATGA                               c.876
 H  F  Q  N  S  R  R  Y  C  D  K  X                                 p.291

          .         .         .         .         .         .       g.26574
 catcaaagtctgaaatttataagtataaaaaaagactctctcttcatcattccccagtga       c.*60

          .         .         .         .         .         .       g.26634
 aatagcaaaatacaaaaaaagagctccctaatgtttttataaatcaaattcagaagcgag       c.*120

          .         .         .         .         .         .       g.26694
 atgccattgccaactgttttattcctttcaacaactgcattgtgaataaactttacaaat       c.*180

          .         .         .         .         .         .       g.26754
 ttttcttgtatttctcattgttataattggggagggggtggataactatgggcagtttgc       c.*240

          .         .         .         .         .         .       g.26814
 ccttttctgcatcaaaactgggagaatgaaattccactttctcaattcttttctcacatt       c.*300

          .         .         .         .         .         .       g.26874
 tactcaaatgcattgtcttgccctatagactcaggagttgcttctcaagaaagagccagc       c.*360

          .         .         .         .         .         .       g.26934
 aagtattctcagcctgagggtgggttgctactgtccacataggcatttccggaattcact       c.*420

          .         .         .         .         .         .       g.26994
 tttttgctacaacctccagtgaaagcaattatttattttaaatgtgcagttacttgatgc       c.*480

          .         .         .         .         .         .       g.27054
 gactaaaaagtagaataaatgcaagagataataatatgtgaatcttgaagcctattttat       c.*540

          .         .         .                                     g.27084
 tgctacaaataaaataacatttaaaaagaa                                     c.*570

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Popeye domain containing 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.