protection of telomeres 1 (POT1) - coding DNA reference sequence

(used for variant description)

(last modified October 14, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_015450.2 in the POT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029232.1, covering POT1 transcript NM_015450.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            g       c.-601

 .         .         .         .         .         .                g.5061
 tcagtatttcgccaaacctccaggcgccatcagtgtgtgaaccgttacgcagctggtcca       c.-541

 .         .         .         .         .         .                g.5121
 ccgcgggcggagaacaagcgactatgcccagggatcctgcacgcatgcgtggagctgaac       c.-481

 .         .         .         .         .         .                g.5181
 cgtcagcgtgcgtgtgacgtcacctgcgcgcccgcctaaactcttcctagggttctttct       c.-421

 .         | 02         .         .         .         .             g.6035
 agagtacgg | cagcaagttgtcagattccctagttgaatttgctttggacatcagtgtgaa    c.-361

 .         .         .         .         .         .                g.6095
 gcagaactgatatgccacttgaattaataaaggaagtcaatggggtgcctgaagttcagc       c.-301

 .         .         .         .         .         .                g.6155
 cgctgagtaaattacataaagtagatttcggatccctacagccaggttacaattatagca       c.-241

 .         .    | 03    .         .         .         .             g.19383
 agaaatatattcag | ggaaaactttcacttatctcttctttaacttatcgtggaaataaaa    c.-181

 .         .         .       | 04 .         .         .             g.36642
 cagctgttttgcagattggactacaag | gacaccattgcagtggctagatttattgttttt    c.-121

 .         .         .         .         .         .                g.36702
 ttagcttcttcatctacaagcagagatggtaaaccttgcatatttttgaaagcatttgaa       c.-61

 .         .         . | 05       .         .         .             g.37810
 gacctcaaatcaactgtttat | gtttatgtcaaatctttaagagatttttctacagaatca    c.-1

           | 06        .         .         .         .         .    g.42654
 ATGTCTTTG | GTTCCAGCAACAAATTATATATATACACCCCTGAATCAACTTAAGGGTGGT    c.60
 M  S  L   | V  P  A  T  N  Y  I  Y  T  P  L  N  Q  L  K  G  G      p.20

          .         .         .         .         .         .       g.42714
 ACAATTGTCAATGTCTATGGTGTTGTGAAGTTCTTTAAGCCCCCATATCTAAGCAAAGGA       c.120
 T  I  V  N  V  Y  G  V  V  K  F  F  K  P  P  Y  L  S  K  G         p.40

      | 07   .         .         .         .         .         .    g.63998
 ACTG | ATTATTGCTCAGTTGTAACTATTGTGGACCAGACAAATGTAAAACTAACTTGCCTG    c.180
 T  D |   Y  C  S  V  V  T  I  V  D  Q  T  N  V  K  L  T  C  L      p.60

          .         .         .         .         .         .       g.64058
 CTCTTTAGTGGAAACTATGAAGCCCTTCCAATAATTTATAAAAATGGAGATATTGTTCGC       c.240
 L  F  S  G  N  Y  E  A  L  P  I  I  Y  K  N  G  D  I  V  R         p.80

          .      | 08  .         .         .         .         .    g.71388
 TTTCACAGGCTGAAG | ATTCAAGTATATAAAAAGGAGACTCAGGGTATCACCAGCTCTGGC    c.300
 F  H  R  L  K   | I  Q  V  Y  K  K  E  T  Q  G  I  T  S  S  G      p.100

          .         .         .         .         .         .       g.71448
 TTTGCATCTTTGACGTTTGAGGGAACTTTGGGAGCCCCTATCATACCTCGCACTTCAAGC       c.360
 F  A  S  L  T  F  E  G  T  L  G  A  P  I  I  P  R  T  S  S         p.120

          .         .         .         .         .         .       g.71508
 AAGTATTTTAACTTCACTACTGAGGACCACAAAATGGTAGAAGCCTTACGTGTTTGGGCA       c.420
 K  Y  F  N  F  T  T  E  D  H  K  M  V  E  A  L  R  V  W  A         p.140

          .         .         .         .         .         .       g.71568
 TCTACTCATATGTCACCGTCTTGGACATTACTAAAATTGTGTGATGTTCAGCCAATGCAG       c.480
 S  T  H  M  S  P  S  W  T  L  L  K  L  C  D  V  Q  P  M  Q         p.160

          .         .         .         .         .         .       g.71628
 TATTTTGACCTGACTTGTCAGCTCTTGGGCAAAGCAGAAGTGGACGGAGCATCATTTCTT       c.540
 Y  F  D  L  T  C  Q  L  L  G  K  A  E  V  D  G  A  S  F  L         p.180

        | 09 .         .         .         .         .         .    g.75925
 CTAAAG | GTATGGGATGGCACCAGGACACCATTTCCATCTTGGAGAGTCTTAATACAAGAC    c.600
 L  K   | V  W  D  G  T  R  T  P  F  P  S  W  R  V  L  I  Q  D      p.200

          .         .         .         .         .         .       g.75985
 CTTGTTCTTGAAGGTGATTTAAGTCACATCCATCGGCTACAAAATCTGACAATAGACATT       c.660
 L  V  L  E  G  D  L  S  H  I  H  R  L  Q  N  L  T  I  D  I         p.220

          .         .         .         .   | 10     .         .    g.81863
 TTAGTCTACGATAACCATGTTCATGTGGCAAGATCTCTGAAG | GTTGGAAGCTTTCTTAGA    c.720
 L  V  Y  D  N  H  V  H  V  A  R  S  L  K   | V  G  S  F  L  R      p.240

          .         .         .         .         .         .       g.81923
 ATCTATAGCCTTCATACCAAACTTCAATCAATGAATTCAGAGAATCAGACAATGTTAAGT       c.780
 I  Y  S  L  H  T  K  L  Q  S  M  N  S  E  N  Q  T  M  L  S         p.260

          .         .         .         .         .         .       g.81983
 TTAGAGTTTCATCTTCATGGAGGTACCAGTTACGGTCGGGGAATCAGGGTCTTGCCAGAA       c.840
 L  E  F  H  L  H  G  G  T  S  Y  G  R  G  I  R  V  L  P  E         p.280

          .         .          | 11        .         .         .    g.83063
 AGTAACTCTGATGTGGATCAACTGAAAAA | GGATTTAGAATCTGCAAATTTGACAGCCAAT    c.900
 S  N  S  D  V  D  Q  L  K  K  |  D  L  E  S  A  N  L  T  A  N      p.300

          .         .         .         .          | 12        .    g.87996
 CAGCATTCAGATGTTATCTGTCAATCAGAACCTGACGACAGCTTTCCAA | GCTCTGGATCA    c.960
 Q  H  S  D  V  I  C  Q  S  E  P  D  D  S  F  P  S |   S  G  S      p.320

          .         .         .         .       | 13 .         .    g.92034
 GTATCATTATACGAGGTAGAAAGATGTCAACAGCTATCTGCTACAA | TACTTACAGATCAT    c.1020
 V  S  L  Y  E  V  E  R  C  Q  Q  L  S  A  T  I |   L  T  D  H      p.340

          .         .         .         .         .         .       g.92094
 CAGTATTTGGAGAGGACACCACTATGTGCCATTTTGAAACAAAAAGCTCCTCAACAATAC       c.1080
 Q  Y  L  E  R  T  P  L  C  A  I  L  K  Q  K  A  P  Q  Q  Y         p.360

          .         .         .         .         .         .       g.92154
 CGCATCCGAGCAAAATTGAGGTCATATAAGCCCAGAAGACTATTTCAGTCTGTTAAACTT       c.1140
 R  I  R  A  K  L  R  S  Y  K  P  R  R  L  F  Q  S  V  K  L         p.380

          .         .    | 14    .         .         .         .    g.93842
 CATTGCCCTAAATGTCATTTGCT | GCAAGAAGTTCCACATGAGGGCGATTTGGATATAATT    c.1200
 H  C  P  K  C  H  L  L  |  Q  E  V  P  H  E  G  D  L  D  I  I      p.400

          .         .         .         .         .         .       g.93902
 TTTCAGGATGGTGCAACTAAAACCCCAGATGTCAAGCTACAAAATACATCATTATATGAT       c.1260
 F  Q  D  G  A  T  K  T  P  D  V  K  L  Q  N  T  S  L  Y  D         p.420

          .         .         .         .         .         .       g.93962
 TCAAAAATCTGGACCACTAAAAATCAAAAAGGACGAAAAGTAGCAGTTCATTTTGTGAAA       c.1320
 S  K  I  W  T  T  K  N  Q  K  G  R  K  V  A  V  H  F  V  K         p.440

          .         .         .         .          | 15        .    g.99580
 AATAATGGTATTCTCCCGCTTTCAAATGAATGTCTACTTTTGATAGAAG | GAGGTACACTC    c.1380
 N  N  G  I  L  P  L  S  N  E  C  L  L  L  I  E  G |   G  T  L      p.460

          .         .         .         .         .         .       g.99640
 AGTGAAATTTGCAAACTCTCGAACAAGTTTAATAGTGTAATTCCTGTGAGATCTGGCCAC       c.1440
 S  E  I  C  K  L  S  N  K  F  N  S  V  I  P  V  R  S  G  H         p.480

          .         .         .         .         .         .       g.99700
 GAAGACCTGGAACTTTTGGACCTTTCAGCACCATTTCTTATACAAGGAACAATACATCAC       c.1500
 E  D  L  E  L  L  D  L  S  A  P  F  L  I  Q  G  T  I  H  H         p.500

       | 16  .         .         .         .         .         .    g.105696
 TATGG | ATGTAAACAGTGTTCTAGTTTGAGATCCATACAAAATCTAAATTCCCTGGTTGAT    c.1560
 Y  G  |  C  K  Q  C  S  S  L  R  S  I  Q  N  L  N  S  L  V  D      p.520

          .         .         .     | 17   .         .         .    g.107704
 AAAACATCGTGGATTCCTTCTTCTGTGGCAGAAG | CACTGGGTATTGTACCCCTCCAATAT    c.1620
 K  T  S  W  I  P  S  S  V  A  E  A |   L  G  I  V  P  L  Q  Y      p.540

          .         .         .         .         .         .       g.107764
 GTGTTTGTTATGACCTTTACACTTGATGATGGAACAGGAGTACTAGAAGCCTATCTCATG       c.1680
 V  F  V  M  T  F  T  L  D  D  G  T  G  V  L  E  A  Y  L  M         p.560

        | 18 .         .         .         .         .         .    g.109680
 GATTCT | GACAAATTCTTCCAGATTCCAGCATCAGAAGTTCTGATGGATGATGACCTTCAG    c.1740
 D  S   | D  K  F  F  Q  I  P  A  S  E  V  L  M  D  D  D  L  Q      p.580

          .         .         .         .         .   | 19     .    g.110917
 AAAAGTGTGGATATGATCATGGATATGTTTTGTCCTCCAGGAATAAAAATTG | ATGCATAT    c.1800
 K  S  V  D  M  I  M  D  M  F  C  P  P  G  I  K  I  D |   A  Y      p.600

          .         .         .         .         .         .       g.110977
 CCGTGGTTGGAATGCTTCATCAAGTCATACAATGTCACAAATGGAACAGATAATCAAATT       c.1860
 P  W  L  E  C  F  I  K  S  Y  N  V  T  N  G  T  D  N  Q  I         p.620

          .         .         .         .                           g.111022
 TGCTATCAGATTTTTGACACCACAGTTGCAGAAGATGTAATCTAA                      c.1905
 C  Y  Q  I  F  D  T  T  V  A  E  D  V  I  X                        p.634

          .         .         .         .         .         .       g.111082
 tattgccatccaatttagcatacataaaatgttgccactcaccttccctgtttgagcttc       c.*60

          .         .         .         .         .         .       g.111142
 ttttcctgacctgagttttgtatcagcaatgttgatgatgttagcatgggtatgggatta       c.*120

          .         .         .         .         .         .       g.111202
 gaaaatgtccttaccttaaatctcttggcttttactgggtgcaaggtaaataatggctat       c.*180

          .         .         .         .         .         .       g.111262
 ggattttgttttgctttctgttttgcttttgtacaaagagacctgcttaaacaagtactg       c.*240

          .         .         .         .         .         .       g.111322
 ctgagataagtgtctgatcaagctacagtgtactttaagtagaaatggcaaagttgcttt       c.*300

          .         .         .         .         .         .       g.111382
 gttggggtgctgatactgatgattttaggataaattcatttctttaaacttgtaatacat       c.*360

          .         .         .         .         .         .       g.111442
 ggttttattgcttgtttctctccaggatagtagagatttctctatttcacctcaacctaa       c.*420

          .         .         .         .         .         .       g.111502
 taaaagtggtcagatttataatgttaatgacttaatattatccttttctaatagtctcat       c.*480

          .         .         .         .         .         .       g.111562
 gtaaaatatgccgctattacaacttacaactaattgaatgagatgttaacttagtaaaat       c.*540

          .         .         .         .         .         .       g.111622
 agtttgatttttacctgacagtgtttgtcaaatttaaaatcatgaatattcaattttata       c.*600

          .         .         .         .         .         .       g.111682
 caaacatttatatatatatatatagatttgtgtatgttatttgccaaagacagatataaa       c.*660

          .         .         .         .         .         .       g.111742
 ttacctggtttaatattagtgaagaataaataagtgcacacatttcaactgtttcattta       c.*720

          .         .         .         .         .         .       g.111802
 tttgccctaagttgagctgaaaaatgatatgaggcaaagaatcgaaataggtgtggcaat       c.*780

          .         .         .         .         .         .       g.111862
 gcagcagatgtttagggctgtctacatcccaggtactgtgctaagcactaaacatgtatt       c.*840

          .         .         .         .         .         .       g.111922
 tgatcctcacagcaacctatttttccgataagaaatctgaggcttgattgataagctgac       c.*900

          .         .         .         .         .         .       g.111982
 ttgactaagttcacacagtttgtaaaagctagagtctgtgccttaattcacataatctct       c.*960

          .         .         .         .         .         .       g.112042
 attcagagcctgtactgttaaccactcaaggattctggaacagaagctaacagttttctg       c.*1020

          .         .         .         .         .         .       g.112102
 caacgagtctttgacttaaacatctgaaataacattggaaatagattataagaggagtca       c.*1080

          .         .         .         .         .         .       g.112162
 gtgtgtttttctatagtttcaaaatacttttaacatcttattgtcaaaaagattggataa       c.*1140

          .         .         .         .         .         .       g.112222
 ctgactttctttgctcataataactctaaattctagttcctgagtacattaacacatctt       c.*1200

          .         .         .         .         .         .       g.112282
 ctttacctaactaccaatgtcccccatcatcgacttatcagcttgtttgagacaatgaga       c.*1260

          .         .         .         .         .         .       g.112342
 aagactgattttattttcaagaatatagactcttggttcaaaacattttcaggaaaaata       c.*1320

          .         .         .         .         .         .       g.112402
 ttttaaaaccctacagttgaacaggtgtgtttccgtgttgatgatgtgctcaggatacaa       c.*1380

          .         .         .         .         .         .       g.112462
 aggtgaaataaacattttttctgccttcaggaagccctcaatctagaagagtagaggtcc       c.*1440

          .         .         .         .         .         .       g.112522
 aaaggtgccatatgttcacactgtgagcctgcaagatctccacgttaacaaaggaaaact       c.*1500

          .         .         .         .         .         .       g.112582
 cttcctatgaatcttcatgatgataggccatgtctcttcttatttttgttttaaataaac       c.*1560

          .                                                         g.112598
 atccaccttatcatga                                                   c.*1576

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protection of telomeres 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 17
©2004-2016 Leiden University Medical Center