peroxisome proliferator-activated receptor gamma (PPARG) - coding DNA reference sequence

(used for variant description)

(last modified July 12, 2024)

This file was created to facilitate the description of sequence variants on transcript NM_138711.3 in the PPARG gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering PPARG transcript NM_138711.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.6121
                           ttggtggaaggtgggtgtgtagtcgtggtacttt       c.-241

 .         .         .         .         .         .                g.6181
 acgcctcggtgtttagggaggagcctaaggtaaggagtcagaaacggggagtaaccgagc       c.-181

 .         .         .         .         .         .                g.6241
 tgcggcttttatataaggtcagtggtaggtaaggaaggggccttaacctctgctggtgac       c.-121

 .         .         .         .         .    | 02    .             g.29546
 cagaagcctgcatttctgcattctgcttaattccctttccttag | atttgaaagaagccaa    c.-61

 .         .         .         .         .         .        | 03    g.96856
 cactaaaccacaaatatacaacaaggccattttctcaaacgagagtcagcctttaacg | aa    c.-1

          .         .         .         .         .         .       g.96916
 ATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGTG       c.60
 M  T  M  V  D  T  E  M  P  F  W  P  T  N  F  G  I  S  S  V         p.20

          .         .         .         .         .         .       g.96976
 GATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGTT       c.120
 D  L  S  V  M  E  D  H  S  H  S  F  D  I  K  P  F  T  T  V         p.40

          .         .         .         .         .         .       g.97036
 GACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCCA       c.180
 D  F  S  S  I  S  T  P  H  Y  E  D  I  P  F  T  R  T  D  P         p.60

          .         .         .         .       | 04 .         .    g.98486
 GTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAA | GTGCAATCAAAGTG    c.240
 V  V  A  D  Y  K  Y  D  L  K  L  Q  E  Y  Q  S |   A  I  K  V      p.80

          .         .         .         .         .         .       g.98546
 GAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGAA       c.300
 E  P  A  S  P  P  Y  Y  S  E  K  T  Q  L  Y  N  K  P  H  E         p.100

          .         .         .         .         .         .       g.98606
 GAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGGA       c.360
 E  P  S  N  S  L  M  A  I  E  C  R  V  C  G  D  K  A  S  G         p.120

          .         .         .       | 05 .         .         .    g.109788
 TTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAG | GGTTTCTTCCGGAGAACAATCAGA    c.420
 F  H  Y  G  V  H  A  C  E  G  C  K   | G  F  F  R  R  T  I  R      p.140

          .         .         .         .         .         .       g.109848
 TTGAAGCTTATCTATGACAGATGTGATCTTAACTGTCGGATCCACAAAAAAAGTAGAAAT       c.480
 L  K  L  I  Y  D  R  C  D  L  N  C  R  I  H  K  K  S  R  N         p.160

          .         .         .         .         .      | 06  .    g.123037
 AAATGTCAGTACTGTCGGTTTCAGAAATGCCTTGCAGTGGGGATGTCTCATAATG | CCATC    c.540
 K  C  Q  Y  C  R  F  Q  K  C  L  A  V  G  M  S  H  N  A |   I      p.180

          .         .         .         .         .         .       g.123097
 AGGTTTGGGCGGATGCCACAGGCCGAGAAGGAGAAGCTGTTGGCGGAGATCTCCAGTGAT       c.600
 R  F  G  R  M  P  Q  A  E  K  E  K  L  L  A  E  I  S  S  D         p.200

          .         .         .         .         .         .       g.123157
 ATCGACCAGCTGAATCCAGAGTCCGCTGACCTCCGGGCCCTGGCAAAACATTTGTATGAC       c.660
 I  D  Q  L  N  P  E  S  A  D  L  R  A  L  A  K  H  L  Y  D         p.220

          .         .         .         .         .         .       g.123217
 TCATACATAAAGTCCTTCCCGCTGACCAAAGCAAAGGCGAGGGCGATCTTGACAGGAAAG       c.720
 S  Y  I  K  S  F  P  L  T  K  A  K  A  R  A  I  L  T  G  K         p.240

          .      | 07  .         .         .         .         .    g.133899
 ACAACAGACAAATCA | CCATTCGTTATCTATGACATGAATTCCTTAATGATGGGAGAAGAT    c.780
 T  T  D  K  S   | P  F  V  I  Y  D  M  N  S  L  M  M  G  E  D      p.260

          .         .         .         .         .         .       g.133959
 AAAATCAAGTTCAAACACATCACCCCCCTGCAGGAGCAGAGCAAAGAGGTGGCCATCCGC       c.840
 K  I  K  F  K  H  I  T  P  L  Q  E  Q  S  K  E  V  A  I  R         p.280

          .         .         .         .         .         .       g.134019
 ATCTTTCAGGGCTGCCAGTTTCGCTCCGTGGAGGCTGTGCAGGAGATCACAGAGTATGCC       c.900
 I  F  Q  G  C  Q  F  R  S  V  E  A  V  Q  E  I  T  E  Y  A         p.300

          .         .         .         .         .         .       g.134079
 AAAAGCATTCCTGGTTTTGTAAATCTTGACTTGAACGACCAAGTAACTCTCCTCAAATAT       c.960
 K  S  I  P  G  F  V  N  L  D  L  N  D  Q  V  T  L  L  K  Y         p.320

          .         .         .         .         .         .       g.134139
 GGAGTCCACGAGATCATTTACACAATGCTGGCCTCCTTGATGAATAAAGATGGGGTTCTC       c.1020
 G  V  H  E  I  I  Y  T  M  L  A  S  L  M  N  K  D  G  V  L         p.340

          .         .         .         .         .         .       g.134199
 ATATCCGAGGGCCAAGGCTTCATGACAAGGGAGTTTCTAAAGAGCCTGCGAAAGCCTTTT       c.1080
 I  S  E  G  Q  G  F  M  T  R  E  F  L  K  S  L  R  K  P  F         p.360

          .         .         .         .         .         .       g.134259
 GGTGACTTTATGGAGCCCAAGTTTGAGTTTGCTGTGAAGTTCAATGCACTGGAATTAGAT       c.1140
 G  D  F  M  E  P  K  F  E  F  A  V  K  F  N  A  L  E  L  D         p.380

          .         .         .         .       | 08 .         .    g.151062
 GACAGCGACTTGGCAATATTTATTGCTGTCATTATTCTCAGTGGAG | ACCGCCCAGGTTTG    c.1200
 D  S  D  L  A  I  F  I  A  V  I  I  L  S  G  D |   R  P  G  L      p.400

          .         .         .         .         .         .       g.151122
 CTGAATGTGAAGCCCATTGAAGACATTCAAGACAACCTGCTACAAGCCCTGGAGCTCCAG       c.1260
 L  N  V  K  P  I  E  D  I  Q  D  N  L  L  Q  A  L  E  L  Q         p.420

          .         .         .         .         .         .       g.151182
 CTGAAGCTGAACCACCCTGAGTCCTCACAGCTGTTTGCCAAGCTGCTCCAGAAAATGACA       c.1320
 L  K  L  N  H  P  E  S  S  Q  L  F  A  K  L  L  Q  K  M  T         p.440

          .         .         .         .         .         .       g.151242
 GACCTCAGACAGATTGTCACGGAACACGTGCAGCTACTGCAGGTGATCAAGAAGACGGAG       c.1380
 D  L  R  Q  I  V  T  E  H  V  Q  L  L  Q  V  I  K  K  T  E         p.460

          .         .         .         .         .                 g.151296
 ACAGACATGAGTCTTCACCCGCTCCTGCAGGAGATCTACAAGGACTTGTACTAG             c.1434
 T  D  M  S  L  H  P  L  L  Q  E  I  Y  K  D  L  Y  X               p.477

          .         .         .         .         .         .       g.151356
 cagagagtcctgagccactgccaacatttcccttcttccagttgcactattctgagggaa       c.*60

          .         .         .         .         .         .       g.151416
 aatctgacacctaagaaatttactgtgaaaaagcattttaaaaagaaaaggttttagaat       c.*120

          .         .         .         .         .         .       g.151476
 atgatctattttatgcatattgtttataaagacacatttacaatttacttttaatattaa       c.*180

          .         .         .                                     g.151507
 aaattaccatattatgaaattgctgatagta                                    c.*211

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Peroxisome proliferator-activated receptor gamma protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.