peptidylprolyl isomerase (cyclophilin)-like 2 (PPIL2) - coding DNA reference sequence

(used for variant description)

(last modified July 20, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_014337.3 in the PPIL2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering PPIL2 transcript NM_014337.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5056
     gtttccggggcgcgccgcggaacccggaagtggtcacggaactcggctgcggctcc       c.-61

 .         .         .         .         .         .                g.5116
 atggtctgagttgtcagccgttgttttttcgtgctcgctagtcgccgccgccgctccgcc       c.-1

          .         .         .   | 02     .         .         .    g.8957
 ATGGGGAAGCGACAGCACCAAAAGGACAAAAT | GTACATTACCTGTGCTGAATACACTCAC    c.60
 M  G  K  R  Q  H  Q  K  D  K  M  |  Y  I  T  C  A  E  Y  T  H      p.20

          .         .   | 03     .         .         .         .    g.9620
 TTTTATGGTGGCAAGAAGCCAG | ATCTCCCACAAACAAATTTTCGTCGTTTACCTTTTGAC    c.120
 F  Y  G  G  K  K  P  D |   L  P  Q  T  N  F  R  R  L  P  F  D      p.40

          | 04         .         .         .         .         .    g.10065
 CACTGCAG | TCTCTCTCTGCAGCCCTTTGTCTACCCAGTCTGCACTCCCGATGGCATCGTC    c.180
 H  C  S  |  L  S  L  Q  P  F  V  Y  P  V  C  T  P  D  G  I  V      p.60

          .  | 05      .         .         .         .         .    g.11395
 TTTGACTTACT | GAACATTGTTCCATGGCTTAAGAAGTACGGGACCAACCCCAGCAATGGA    c.240
 F  D  L  L  |  N  I  V  P  W  L  K  K  Y  G  T  N  P  S  N  G      p.80

     | 06    .         .         .         .         .      | 07  . g.20320
 GAG | AAGCTGGACGGGAGGTCCCTGATCAAGCTGAACTTTTCCAAGAACAGTGAGG | GGAAG c.300
 E   | K  L  D  G  R  S  L  I  K  L  N  F  S  K  N  S  E  G |   K   p.100

          .         .         .         .         .         .       g.20380
 TACCACTGCCCAGTGCTGTTTACCGTGTTCACCAACAACACCCACATCGTGGCTGTGAGG       c.360
 Y  H  C  P  V  L  F  T  V  F  T  N  N  T  H  I  V  A  V  R         p.120

          .         .        | 08.         .         .         .    g.21486
 ACGACCGGCAACGTCTACGCCTATGAG | GCAGTGGAACAGCTAAATATCAAGGCCAAGAAC    c.420
 T  T  G  N  V  Y  A  Y  E   | A  V  E  Q  L  N  I  K  A  K  N      p.140

          .         .         .         .         .        | 09.    g.22201
 TTCCGGGACCTGCTGACCGACGAGCCCTTCTCCCGGCAGGACATCATCACCCTCCAG | GAC    c.480
 F  R  D  L  L  T  D  E  P  F  S  R  Q  D  I  I  T  L  Q   | D      p.160

          .         .         .         .         .         .       g.22261
 CCCACCAATTTGGACAAGTTCAATGTCTCTAACTTCTATCATGTGAAGAATAACATGAAA       c.540
 P  T  N  L  D  K  F  N  V  S  N  F  Y  H  V  K  N  N  M  K         p.180

          .    | 10    .         .         .         .         .    g.23816
 ATAATAGACCCAG | ATGAAGAGAAGGCCAAACAGGACCCGTCTTATTATCTGAAAAATACA    c.600
 I  I  D  P  D |   E  E  K  A  K  Q  D  P  S  Y  Y  L  K  N  T      p.200

          .         .         .         .         .         .       g.23876
 AATGCCGAGACCCGAGAGACCCTGCAGGAGCTCTACAAGGAGTTCAAAGGGGACGAGATT       c.660
 N  A  E  T  R  E  T  L  Q  E  L  Y  K  E  F  K  G  D  E  I         p.220

          .         .         .         .         .     | 11   .    g.25505
 CTGGCAGCCACCATGAAGGCCCCGGAGAAGAAGAAAGTGGACAAGCTGAACGCT | GCCCAC    c.720
 L  A  A  T  M  K  A  P  E  K  K  K  V  D  K  L  N  A   | A  H      p.240

          .         .         .         .         .         .       g.25565
 TATTCCACAGGGAAGGTCAGCGCTTCCTTCACCTCCACCGCGATGGTCCCGGAGACCACA       c.780
 Y  S  T  G  K  V  S  A  S  F  T  S  T  A  M  V  P  E  T  T         p.260

          . | 12       .         .         .         .         .    g.25958
 CATGAAGCAG | CTGCCATCGACGAGGATGTGCTGCGCTACCAGTTTGTGAAGAAGAAGGGC    c.840
 H  E  A  A |   A  I  D  E  D  V  L  R  Y  Q  F  V  K  K  K  G      p.280

          .         .         .         .         .        | 13.    g.26662
 TACGTGCGGCTGCACACCAACAAGGGCGACCTCAACCTGGAGCTGCACTGCGACCTG | ACA    c.900
 Y  V  R  L  H  T  N  K  G  D  L  N  L  E  L  H  C  D  L   | T      p.300

          .         .         .         .         .         .       g.26722
 CCAAAAACCTGCGAAAACTTCATCAGGCTTTGCAAGAAGCATTATTACGATGGCACCATC       c.960
 P  K  T  C  E  N  F  I  R  L  C  K  K  H  Y  Y  D  G  T  I         p.320

          .         .        | 14.         .         .         .    g.27122
 TTCCACAGATCCATCCGGAACTTTGTG | ATCCAAGGGGGCGACCCCACAGGCACAGGCACG    c.1020
 F  H  R  S  I  R  N  F  V   | I  Q  G  G  D  P  T  G  T  G  T      p.340

   | 15      .         .         .         .         .         .    g.27807
 G | GTGGGGAGTCATACTGGGGGAAGCCCTTCAAAGACGAGTTCCGGCCCAACCTCTCGCAC    c.1080
 G |   G  E  S  Y  W  G  K  P  F  K  D  E  F  R  P  N  L  S  H      p.360

          .         .         .         .         .          | 16    g.32833
 ACGGGCCGCGGCATCCTCAGCATGGCCAACTCCGGGCCCAACAGCAACAGGTCTCAATT | C    c.1140
 T  G  R  G  I  L  S  M  A  N  S  G  P  N  S  N  R  S  Q  F  |      p.380

          .         .         .         .         .       | 17 .    g.33613
 TTCATCACGTTTCGCTCCTGTGCCTACCTGGACAAGAAGCATACCATCTTTGGACG | GGTT    c.1200
 F  I  T  F  R  S  C  A  Y  L  D  K  K  H  T  I  F  G  R  |  V      p.400

          .         .         .         .         .         .       g.33673
 GTTGGGGGCTTTGACGTACTGACAGCCATGGAGAATGTGGAGAGTGACCCCAAAACTGAC       c.1260
 V  G  G  F  D  V  L  T  A  M  E  N  V  E  S  D  P  K  T  D         p.420

           | 18        .         .         .         .         .    g.33822
 CGCCCTAAG | GAGGAGATCCGCATTGATGCCACTACAGTGTTCGTGGACCCCTATGAGGAG    c.1320
 R  P  K   | E  E  I  R  I  D  A  T  T  V  F  V  D  P  Y  E  E      p.440

          .   | 19     .         .         .         .         .    g.34001
 GCCGATGCCCAG | ATTGCGCAGGAGCGGAAGACACAGCTCAAGGTAGCCCCGGAGACCAAA    c.1380
 A  D  A  Q   | I  A  Q  E  R  K  T  Q  L  K  V  A  P  E  T  K      p.460

          .         .         .         .         .         .       g.34061
 GTGAAGAGCAGCCAGCCCCAGGCAGGGAGCCAGGGCCCCCAGACCTTCCGCCAGGGCGTG       c.1440
 V  K  S  S  Q  P  Q  A  G  S  Q  G  P  Q  T  F  R  Q  G  V         p.480

          .         .       | 20 .         .         .         .    g.34444
 GGCAAGTACATCAACCCAGCAGCCAC | GAAGCGAGCAGCAGAGGAAGAGCCCTCAACCAGT    c.1500
 G  K  Y  I  N  P  A  A  T  |  K  R  A  A  E  E  E  P  S  T  S      p.500

          .         .         .         .         .         .       g.34504
 GCCACTGTCCCCATGTCCAAGAAGAAGCCCAGTCGGGGTTTTGGGGACTTCAGCTCCTGG       c.1560
 A  T  V  P  M  S  K  K  K  P  S  R  G  F  G  D  F  S  S  W         p.520

                                                                    g.34507
 TAG                                                                c.1563
 X                                                                  p.520

          .         .         .         .         .         .       g.34567
 cagcaggttggccgctgtggaccttggtggggttgcagggctgggggcccatgtccacat       c.*60

          .         .         .         .         .         .       g.34627
 ctccatttccagcctttctagcctgccctctgctgccagccaataaattgcttgcctgct       c.*120

          .         .         .         .         .         .       g.34687
 gcctgcatcccctttcctggcccctgggagcccacagccttcccatcccttaacctgttg       c.*180

          .         .         .         .         .         .       g.34747
 ccaagggccttggccctgtttccaggacctggcccagccagagcccactgctgggacctt       c.*240

          .         .         .         .         .         .       g.34807
 caagcacaaggcctgccctacacccaggctggtgcctcaggcctcccctctagtaggcag       c.*300

          .         .         .         .         .         .       g.34867
 gccaggttagtgaggaaggactgtgtctccagattgtggtttcctctttaagacagggtc       c.*360

          .         .         .         .         .         .       g.34927
 ttgctctgttgcccaggctccagtgcagtggtgtgatcatggctcactgcagcctcgacc       c.*420

          .         .         .         .         .         .       g.34987
 tcctgggctcaagcaatcctcctgcctcagcctcgcaagtagctgggactacagccgtgc       c.*480

          .         .         .         .         .         .       g.35047
 accactacatccagctgtatatgtctggttttcttacccctacttctgtcatcttctcag       c.*540

          .         .         .         .         .         .       g.35107
 ggacagcctatttatacaaccagtgtggtcccctgaccaacgccattacctgggacaagt       c.*600

          .         .         .         .         .         .       g.35167
 tttcagaccccagacttactgagcctaagcctctgcagggtgggcttctcggtctgtttt       c.*660

          .         .         .         .         .         .       g.35227
 gacaaaacttcaggggcttctgaaggctggtgttggacggcagcattgagtttcctgccg       c.*720

          .         .         .         .         .         .       g.35287
 tgccctgcctgagctctcagggccctgctcacctgctctggctgtgaaccacctgggctt       c.*780

          .         .         .         .         .         .       g.35347
 catctcaagcctgcctggcgtctctgtgcccctgtgagaatcttgaggggacccacactg       c.*840

          .         .         .         .         .         .       g.35407
 ggttgaggccagtgtctcctgctgtgagaacaagtggatgtccctctccccgccctcctg       c.*900

          .         .         .         .         .         .       g.35467
 ctgaagtggccttgctgctctcaggcccggccactgggctccaagactctgctcctcctg       c.*960

          .         .         .         .         .         .       g.35527
 tcagtcactgactctgatggccttgggccagctgcatcagcagcccttaaagaaagaccc       c.*1020

          .         .         .         .         .         .       g.35587
 ctccctcaacccccatttttctgttaaatgtgcccctggctggctttttcttcgtcttca       c.*1080

          .         .         .         .         .         .       g.35647
 gcccaggccagtggtcagtgttctcatgtcatggactctccttgcctgacacttgcctct       c.*1140

          .         .         .         .         .         .       g.35707
 tgggctccctgttgccctcaggccaccccccacttctagttcttcacactaagccctaac       c.*1200

          .         .         .         .         .         .       g.35767
 ttaggccttgttcttggttttctcatttttgttgccccaaatcttgaacctgtcagcaac       c.*1260

          .         .         .         .         .         .       g.35827
 ttgcaggctgtacctctgcccttccttttctcatcaatcactgatgctgaagctgcaggc       c.*1320

          .         .         .         .         .         .       g.35887
 ctgagccctttgtctccctggatgctgggtggcgcctcatctgcatctctgcctcacccc       c.*1380

          .         .         .         .         .         .       g.35947
 atccactgccacaggctgcctgatgaccactagaggtatgtctgcccctcgtcaccctgc       c.*1440

          .         .         .         .         .         .       g.36007
 tgcacaccaatctgtggcccttcatcatgctaagaacaagaactgcgccatggctggctc       c.*1500

          .         .         .         .         .         .       g.36067
 cttctcttctccagcccatccctctgcagcctgtcatccctgtctgtgaccattggtcgg       c.*1560

          .         .         .         .         .         .       g.36127
 gcccctgggctctagagtgacttttgacgccctccatccctcccgccaggcactgtcctc       c.*1620

          .         .         .         .         .         .       g.36187
 cgcaaggcctggtgcagccctggcagtaactggcttgtaagaggctcagacaccaagctg       c.*1680

          .         .         .         .         .         .       g.36247
 ggcctgcagaggaggggcacagtaggacacagtgactgcccaggtgtccacacacctgta       c.*1740

          .         .         .         .         .         .       g.36307
 ggcctctgagccagcgtccagggtacaggtgcgggtggtggggatgaaggcctgaccagg       c.*1800

          .         .         .         .         .         .       g.36367
 gagggagaagcaggtttggagaggaccctgtgcccaccctgacagacaccctggctggcc       c.*1860

          .         .         .         .         .         .       g.36427
 ctgactgactgtattctctggccacattcaagtcccccattggtgggggcagagaagtag       c.*1920

          .         .         .         .         .         .       g.36487
 gaccaggccatccttggctccagagctcgaagaccccaagacagccctctgctctcagcg       c.*1980

          .         .         .         .         .         .       g.36547
 gcgccacagagagcctgggctcagccttctgcatcaggacatggcctcgtccactgaggg       c.*2040

          .         .         .         .         .         .       g.36607
 cacgatttaaacatttgacatcagaagctttatttgtaaacctcacacagataaggacca       c.*2100

          .         .         .         .         .         .       g.36667
 agggctggcggtgtggccagaggacaggggaagctgaaggccccgtgcttgagctcggca       c.*2160

          .         .         .         .         .         .       g.36727
 gtcctgctccttgcagtgaagccaccatgggtgaccgtccagcctcacccggtggcctgc       c.*2220

          .         .         .         .         .         .       g.36787
 acagtgagggaagggcttcagggccatctgctcccagggcaggggacaggccaccaagga       c.*2280

          .         .         .         .         .         .       g.36847
 cctttggcaaatgaaggtttacatttctgtagtttgtttgttttagagcttaatttgtag       c.*2340

          .         .         .         .         .         .       g.36907
 ttttttagctattaaaaccatttgaatttttaacgacctgatgagggcatcaggtaaatt       c.*2400

          .         .                                               g.36930
 aaaggattttgggaagattctta                                            c.*2423

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Peptidylprolyl isomerase (cyclophilin)-like 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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