protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) - coding DNA reference sequence

(used for variant description)

(last modified June 14, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_003620.3 in the PPM1D gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering PPM1D transcript NM_003620.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         ggggaagcgcagtgcgcaggcgcaactgcctggctctgctcgctccggcgct       c.-181

 .         .         .         .         .         .                g.5112
 ccggcccagctctcgcggacaagtccagacatcgcgcgcccccccttctccgggtccgcc       c.-121

 .         .         .         .         .         .                g.5172
 ccctcccccttctcggcgtcgtcgaagataaacaatagttggccggcgagcgcctagtgt       c.-61

 .         .         .         .         .         .                g.5232
 gtctcccgccgccggattcggcgggctgcgtgggaccggcgggatcccggccagccggcc       c.-1

          .         .         .         .         .         .       g.5292
 ATGGCGGGGCTGTACTCGCTGGGAGTGAGCGTCTTCTCCGACCAGGGCGGGAGGAAGTAC       c.60
 M  A  G  L  Y  S  L  G  V  S  V  F  S  D  Q  G  G  R  K  Y         p.20

          .         .         .         .         .         .       g.5352
 ATGGAGGACGTTACTCAAATCGTTGTGGAGCCCGAACCGACGGCTGAAGAAAAGCCCTCG       c.120
 M  E  D  V  T  Q  I  V  V  E  P  E  P  T  A  E  E  K  P  S         p.40

          .         .         .         .         .         .       g.5412
 CCGCGGCGGTCGCTGTCTCAGCCGTTGCCTCCGCGGCCGTCGCCGGCCGCCCTTCCCGGC       c.180
 P  R  R  S  L  S  Q  P  L  P  P  R  P  S  P  A  A  L  P  G         p.60

          .         .         .         .         .         .       g.5472
 GGCGAAGTCTCGGGGAAAGGCCCAGCGGTGGCAGCCCGAGAGGCTCGCGACCCTCTCCCG       c.240
 G  E  V  S  G  K  G  P  A  V  A  A  R  E  A  R  D  P  L  P         p.80

          .         .         .         .         .         .       g.5532
 GACGCCGGGGCCTCGCCGGCACCTAGCCGCTGCTGCCGCCGCCGTTCCTCCGTGGCCTTT       c.300
 D  A  G  A  S  P  A  P  S  R  C  C  R  R  R  S  S  V  A  F         p.100

          .         .         .         .         .         .       g.5592
 TTCGCCGTGTGCGACGGGCACGGCGGGCGGGAGGCGGCACAGTTTGCCCGGGAGCACTTG       c.360
 F  A  V  C  D  G  H  G  G  R  E  A  A  Q  F  A  R  E  H  L         p.120

          .         .         .         .         .         .       g.5652
 TGGGGTTTCATCAAGAAGCAGAAGGGTTTCACCTCGTCCGAGCCGGCTAAGGTTTGCGCT       c.420
 W  G  F  I  K  K  Q  K  G  F  T  S  S  E  P  A  K  V  C  A         p.140

          .         .         .         .         .   | 02     .    g.28346
 GCCATCCGCAAAGGCTTTCTCGCTTGTCACCTTGCCATGTGGAAGAAACTGG | CGGAATGG    c.480
 A  I  R  K  G  F  L  A  C  H  L  A  M  W  K  K  L  A |   E  W      p.160

          .         .         .         .         .         .       g.28406
 CCAAAGACTATGACGGGTCTTCCTAGCACATCAGGGACAACTGCCAGTGTGGTCATCATT       c.540
 P  K  T  M  T  G  L  P  S  T  S  G  T  T  A  S  V  V  I  I         p.180

          .         .         .         .         .         .       g.28466
 CGGGGCATGAAGATGTATGTAGCTCACGTAGGTGACTCAGGGGTGGTTCTTGGAATTCAG       c.600
 R  G  M  K  M  Y  V  A  H  V  G  D  S  G  V  V  L  G  I  Q         p.200

          .         .         .         .         .         .       g.28526
 GATGACCCGAAGGATGACTTTGTCAGAGCTGTGGAGGTGACACAGGACCATAAGCCAGAA       c.660
 D  D  P  K  D  D  F  V  R  A  V  E  V  T  Q  D  H  K  P  E         p.220

          .         .         .         .  | 03      .         .    g.38689
 CTTCCCAAGGAAAGAGAACGAATCGAAGGACTTGGTGGGAG | TGTAATGAACAAGTCTGGG    c.720
 L  P  K  E  R  E  R  I  E  G  L  G  G  S  |  V  M  N  K  S  G      p.240

          .         .         .         .         .         .       g.38749
 GTGAATCGTGTAGTTTGGAAACGACCTCGACTCACTCACAATGGACCTGTTAGAAGGAGC       c.780
 V  N  R  V  V  W  K  R  P  R  L  T  H  N  G  P  V  R  R  S         p.260

          .         .         .         .       | 04 .         .    g.52723
 ACAGTTATTGACCAGATTCCTTTTCTGGCAGTAGCAAGAGCACTTG | GTGATTTGTGGAGC    c.840
 T  V  I  D  Q  I  P  F  L  A  V  A  R  A  L  G |   D  L  W  S      p.280

          .         .         .         .         .         .       g.52783
 TATGATTTCTTCAGTGGTGAATTTGTGGTGTCACCTGAACCAGACACAAGTGTCCACACT       c.900
 Y  D  F  F  S  G  E  F  V  V  S  P  E  P  D  T  S  V  H  T         p.300

          .         .         .         .         .         .       g.52843
 CTTGACCCTCAGAAGCACAAGTATATTATATTGGGGAGTGATGGACTTTGGAATATGATT       c.960
 L  D  P  Q  K  H  K  Y  I  I  L  G  S  D  G  L  W  N  M  I         p.320

          .         .         .         .         .        | 05.    g.61419
 CCACCACAAGATGCCATCTCAATGTGCCAGGACCAAGAGGAGAAAAAATACCTGATG | GGT    c.1020
 P  P  Q  D  A  I  S  M  C  Q  D  Q  E  E  K  K  Y  L  M   | G      p.340

          .         .         .         .         .         .       g.61479
 GAGCATGGACAATCTTGTGCCAAAATGCTTGTGAATCGAGCATTGGGCCGCTGGAGGCAG       c.1080
 E  H  G  Q  S  C  A  K  M  L  V  N  R  A  L  G  R  W  R  Q         p.360

          .         .         .         .         .         .       g.61539
 CGTATGCTCCGAGCAGATAACACTAGTGCCATAGTAATCTGCATCTCTCCAGAAGTGGAC       c.1140
 R  M  L  R  A  D  N  T  S  A  I  V  I  C  I  S  P  E  V  D         p.380

          .         .         .         .         .         .       g.61599
 AATCAGGGAAACTTTACCAATGAAGATGAGTTATACCTGAACCTGACTGACAGCCCTTCC       c.1200
 N  Q  G  N  F  T  N  E  D  E  L  Y  L  N  L  T  D  S  P  S         p.400

          .         .         .         .         .         .       g.61659
 TATAATAGTCAAGAAACCTGTGTGATGACTCCTTCCCCATGTTCTACACCACCAGTCAAG       c.1260
 Y  N  S  Q  E  T  C  V  M  T  P  S  P  C  S  T  P  P  V  K         p.420

  | 06       .         .         .         .         .         .    g.67872
  | TCACTGGAGGAGGATCCATGGCCAAGGGTGAATTCTAAGGACCATATACCTGCCCTGGTT    c.1320
  | S  L  E  E  D  P  W  P  R  V  N  S  K  D  H  I  P  A  L  V      p.440

          .         .         .         .         .         .       g.67932
 CGTAGCAATGCCTTCTCAGAGAATTTTTTAGAGGTTTCAGCTGAGATAGCTCGAGAGAAT       c.1380
 R  S  N  A  F  S  E  N  F  L  E  V  S  A  E  I  A  R  E  N         p.460

          .         .         .         .         .         .       g.67992
 GTCCAAGGTGTAGTCATACCCTCAAAAGATCCAGAACCACTTGAAGAAAATTGCGCTAAA       c.1440
 V  Q  G  V  V  I  P  S  K  D  P  E  P  L  E  E  N  C  A  K         p.480

          .         .         .         .         .         .       g.68052
 GCCCTGACTTTAAGGATACATGATTCTTTGAATAATAGCCTTCCAATTGGCCTTGTGCCT       c.1500
 A  L  T  L  R  I  H  D  S  L  N  N  S  L  P  I  G  L  V  P         p.500

          .         .         .         .         .         .       g.68112
 ACTAATTCAACAAACACTGTCATGGACCAAAAAAATTTGAAGATGTCAACTCCTGGCCAA       c.1560
 T  N  S  T  N  T  V  M  D  Q  K  N  L  K  M  S  T  P  G  Q         p.520

          .         .         .         .         .         .       g.68172
 ATGAAAGCCCAAGAAATTGAAAGAACCCCTCCAACAAACTTTAAAAGGACATTAGAAGAG       c.1620
 M  K  A  Q  E  I  E  R  T  P  P  T  N  F  K  R  T  L  E  E         p.540

          .         .         .         .         .         .       g.68232
 TCCAATTCTGGCCCCCTGATGAAGAAGCATAGACGAAATGGCTTAAGTCGAAGTAGTGGT       c.1680
 S  N  S  G  P  L  M  K  K  H  R  R  N  G  L  S  R  S  S  G         p.560

          .         .         .         .         .         .       g.68292
 GCTCAGCCTGCAAGTCTCCCCACAACCTCACAGCGAAAGAACTCTGTTAAACTCACCATG       c.1740
 A  Q  P  A  S  L  P  T  T  S  Q  R  K  N  S  V  K  L  T  M         p.580

          .         .         .         .         .         .       g.68352
 CGACGCAGACTTAGGGGCCAGAAGAAAATTGGAAATCCTTTACTTCATCAACACAGGAAA       c.1800
 R  R  R  L  R  G  Q  K  K  I  G  N  P  L  L  H  Q  H  R  K         p.600

          .                                                         g.68370
 ACTGTTTGTGTTTGCTGA                                                 c.1818
 T  V  C  V  C  X                                                   p.605

          .         .         .         .         .         .       g.68430
 aatgcatctgggaaatgaggtttttccaaacttaggatataagagggctttttaaatttg       c.*60

          .         .         .         .         .         .       g.68490
 gtgccgatgttgaactttttttaaggggagaaaattaaaagaaatatacagtttgacttt       c.*120

          .         .         .         .         .         .       g.68550
 ttggaattcagcagttttatcctggccttgtacttgcttgtattgtaaatgtggattttg       c.*180

          .         .         .         .         .         .       g.68610
 tagatgttagggtataagttgctgtaaaatttgtgtaaatttgtatccacacaaattcag       c.*240

          .         .         .         .         .         .       g.68670
 tctctgaatacacagtattcagagtctctgatacacagtaattgtgacaatagggctaaa       c.*300

          .         .         .         .         .         .       g.68730
 tgtttaaagaaatcaaaagaatctattagattttagaaaaacatttaaactttttaaaat       c.*360

          .         .         .         .         .         .       g.68790
 acttattaaaaaatttgtataagccacttgtcttgaaaactgtgcaactttttaaagtaa       c.*420

          .         .         .         .         .         .       g.68850
 attattaagcagactggaaaagtgatgtattttcatagtgacctgtgtttcacttaatgt       c.*480

          .         .         .         .         .         .       g.68910
 ttcttagagccaagtgtcttttaaacattattttttatttctgatttcataattcagaac       c.*540

          .         .         .         .         .         .       g.68970
 taaatttttcatagaagtgttgagccatgctacagttagtcttgtcccaattaaaatact       c.*600

          .         .         .         .         .         .       g.69030
 atgcagtatctcttacatcagtagcatttttctaaaaccttagtcatcagatatgcttac       c.*660

          .         .         .         .         .         .       g.69090
 taaatcttcagcatagaaggaagtgtgtttgcctaaaacaatctaaaacaattcccttct       c.*720

          .         .         .         .         .         .       g.69150
 ttttcatcccagaccaatggcattattaggtcttaaagtagttactcccttctcgtgttt       c.*780

          .         .         .         .         .         .       g.69210
 gcttaaaatatgtgaagttttccttgctatttcaataacagatggtgctgctaattccca       c.*840

          .         .         .         .         .         .       g.69270
 acatttcttaaattattttatatcatacagttttcattgattatatgggtatatattcat       c.*900

          .         .         .         .         .         .       g.69330
 ctaataaatcagtgaactgttcctcatgttgctgaatttgtagttgttggtttattttaa       c.*960

          .         .         .         .         .         .       g.69390
 tggtatgtacaagttgagtatcccttatccaaaatgcttgggaccagaagtgtttcagat       c.*1020

          .         .         .         .         .         .       g.69450
 tttttaaaattttggaatatttgctttatactgagcttttgagtgttcccaatctgaaat       c.*1080

          .         .         .         .         .         .       g.69510
 tcaaaatgctctaatgagcatttcctttgagcatcatgcctgctctgaaaaagtttctga       c.*1140

          .         .         .         .         .         .       g.69570
 ttctggagcattttggattttggattttcagattagggatgcttaacctggattaacatt       c.*1200

          .         .         .         .         .         .       g.69630
 ctgttgtgccatgatcatgctttacagtgagtgtattttatttatttattattttgtttg       c.*1260

          .         .         .         .         .         .       g.69690
 tttgtttgagatggagtctcactctgtcatccaggctagagtgcagtggcgtgatctcgg       c.*1320

          .         .         .         .         .         .       g.69750
 ctgactgcaacctctgcctcccgggttcaagtgattctcctgcctcaatctctctcccca       c.*1380

          .         .         .         .         .         .       g.69810
 gaagctgggattacaggtgtgtgccaccacacccggctaatttttttttttttttttgag       c.*1440

          .         .         .         .         .         .       g.69870
 atggagtctagctctgtcatccaggctggagtgcagtggtgtgatctcggctccctgcaa       c.*1500

          .         .         .         .         .         .       g.69930
 cctctgccttctgggttcctgcgattctcctgcctcagcctcctgagtagctgagattac       c.*1560

          .         .         .         .         .         .       g.69990
 aggcacgcgccactgtgcccagccaatttttgtatttttagtagagatggggtttcacat       c.*1620

          .         .         .         .         .         .       g.70050
 gtcagtcatgctggtcttgatctcctgacctcgtgatccacccgcctcgacctcccaaag       c.*1680

          .         .         .         .         .         .       g.70110
 tactgggattacaggcgtgagccaccgcatccggcctgagttttatgctttcaatgtatt       c.*1740

          .         .         .         .         .         .       g.70170
 tcttacatttcagttcaagtgattttcatgtctcagcctcctgagtagctggaactacag       c.*1800

          .         .         .         .         .         .       g.70230
 gtgcgtgccaccatgcctggctaagttttgtatttttagtagagatgggttttcatcatg       c.*1860

          .         .         .         .         .         .       g.70290
 ttggccaagatggtcttgatctcttgacctcatgatccaccagcctaggcctcccaaagt       c.*1920

          .         .         .         .         .         .       g.70350
 gctgggattacaggtgtgagccaccgtgcccagccaactatgccattatttaaccatgtc       c.*1980

          .         .         .         .         .         .       g.70410
 cacacattctggttattttcaatattttgcagaagataattcttgatcggtgtgtcttat       c.*2040

          .         .         .         .         .         .       g.70470
 gccacaaggattaaaatatgtattcattgctacaaaacaatatctcgaaatttagcagtt       c.*2100

          .         .         .         .         .         .       g.70530
 taaaacaacaaatattatctccagtttctgagcctcagaaatctgagagtggtttagctg       c.*2160

          .         .         .         .         .         .       g.70590
 ggtgatagtctcgtggttttggtcaagctaccaaccagggctacaatctttcgaaggtgt       c.*2220

          .         .         .         .         .         .       g.70650
 cattggggctagaagatctgcttcccgcaagactcacagctgttggcaggagacctcagt       c.*2280

          .         .         .         .         .         .       g.70710
 ttgttgccacatgttcccctccagagggcctctcacaacatggcagttatttgtccccag       c.*2340

          .         .         .         .         .         .       g.70770
 agcaagcaacaccggagggcaaggaagaagccatgatgttttttgtaacctagcctctga       c.*2400

          .         .         .         .         .         .       g.70830
 aagtgtcataccaattctgtattttgttggtcacacagaccaagtcaactacaacgtggg       c.*2460

          .         .         .         .         .         .       g.70890
 agactcctacacaaggcatgaattctaggaggtgggcatttttaagtgtcatctggaagg       c.*2520

          .         .         .         .         .         .       g.70950
 aggctgtcacaacctggaagttaaaagcattgatattctgaaatacagcgtgtataacat       c.*2580

          .         .         .         .         .         .       g.71010
 tgttttagtagggtgtgcaatagttatgttttggtaatagcattaatgaacaatgttatt       c.*2640

          .         .         .         .         .         .       g.71070
 ttcatcttccagacatctggaagattgctctagtggagtaaaacatcttaatgtattttg       c.*2700

          .         .                                               g.71098
 tccctaaataaactatctcactaacaaa                                       c.*2728

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein phosphatase, Mg2+/Mn2+ dependent, 1D protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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