protein phosphatase 1, regulatory subunit 21 (PPP1R21) - coding DNA reference sequence

(used for variant description)

(last modified November 16, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_001135629.2 in the PPP1R21 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering PPP1R21 transcript NM_001135629.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        ccacc       c.-181

 .         .         .         .         .         .                g.5065
 ttcctcccaccccgggaacccggaagtggaggaggaggcgcggcggcggcggcggcggcg       c.-121

 .         .         .         .         .         .                g.5125
 gctgcggtggccaagcaggcagatactgcctgacccgttcccgggagcgtgtctgggttt       c.-61

 .         .         .         .         .         .                g.5185
 gggggcgggagacaggctgagccgcctgggcggcctggcctgtacggggcgggggaggcc       c.-1

          .         .         .         .         .        | 02.    g.15242
 ATGGCCTCGGCTGAGTTGCAGGGGAAGTACCAGAAGCTGGCTCAGGAGTACTCGAAG | CTT    c.60
 M  A  S  A  E  L  Q  G  K  Y  Q  K  L  A  Q  E  Y  S  K   | L      p.20

          .         .         .         .         .         .       g.15302
 CGGGCTCAGAATCAGGTTCTGAAAAAAGGTGTTGTGGATGAACAAGCAAATTCTGCAGCT       c.120
 R  A  Q  N  Q  V  L  K  K  G  V  V  D  E  Q  A  N  S  A  A         p.40

        | 03 .         .         .         .         .         .    g.18880
 TTAAAG | GAGCAACTGAAAATGAAGGATCAGTCATTGAGAAAACTACAACAGGAAATGGAC    c.180
 L  K   | E  Q  L  K  M  K  D  Q  S  L  R  K  L  Q  Q  E  M  D      p.60

          .         .         .         .         .         .       g.18940
 AGTTTGACATTTCGAAATCTGCAGCTTGCCAAGAGGGTAGAACTACTTCAAGATGAACTA       c.240
 S  L  T  F  R  N  L  Q  L  A  K  R  V  E  L  L  Q  D  E  L         p.80

          .         .         .    | 04    .         .         .    g.22384
 GCTCTAAGTGAACCACGAGGCAAGAAAAACAAG | AAAAGTGGAGAATCTTCTTCTCAGTTG    c.300
 A  L  S  E  P  R  G  K  K  N  K   | K  S  G  E  S  S  S  Q  L      p.100

          .         .         .         .         .         .       g.22444
 AGTCAAGAGCAGAAGAGTGTCTTTGATGAAGATCTGCAAAAGAAGATAGAAGAGAATGAA       c.360
 S  Q  E  Q  K  S  V  F  D  E  D  L  Q  K  K  I  E  E  N  E         p.120

          .      | 05  .         .         .         .         .    g.24030
 CGGTTGCATATACAA | TTTTTTGAAGCTGATGAGCAGCACAAGCATGTGGAAGCAGAGCTG    c.420
 R  L  H  I  Q   | F  F  E  A  D  E  Q  H  K  H  V  E  A  E  L      p.140

          .         .         .         .         .         .       g.24090
 AGGAGTCGACTGGCCACTCTGGAGACAGAAGCAGCCCAGCACCAAGCTGTGGTTGACGGT       c.480
 R  S  R  L  A  T  L  E  T  E  A  A  Q  H  Q  A  V  V  D  G         p.160

          .         .         .         .         .         .       g.24150
 CTCACCCGGAAGTACATGGAAACCATTGAGAAGCTGCAGAACGACAAGGCTAAACTAGAA       c.540
 L  T  R  K  Y  M  E  T  I  E  K  L  Q  N  D  K  A  K  L  E         p.180

  | 06       .         .         .         .         .          | 07 g.25370
  | GTGAAATCTCAGACTCTAGAAAAGGAAGCCAAGGAATGTCGACTTCGAACGGAAGAATG | T c.600
  | V  K  S  Q  T  L  E  K  E  A  K  E  C  R  L  R  T  E  E  C  |   p.200

          .         .         .         .         .         .       g.25430
 CAATTACAGTTAAAGACTCTTCATGAAGATTTGTCAGGTAGATTAGAGGAATCCTTATCA       c.660
 Q  L  Q  L  K  T  L  H  E  D  L  S  G  R  L  E  E  S  L  S         p.220

          .         .         .     | 08   .         .         .    g.29194
 ATCATCAATGAAAAAGTACCTTTTAATGATACAA | AATATAGTCAGTACAACGCTCTGAAC    c.720
 I  I  N  E  K  V  P  F  N  D  T  K |   Y  S  Q  Y  N  A  L  N      p.240

          .         .        | 09.         .         .         .    g.29757
 GTTCCACTCCACAATAGGAGACACCAG | CTGAAGATGCGAGATATTGCTGGGCAGGCCCTG    c.780
 V  P  L  H  N  R  R  H  Q   | L  K  M  R  D  I  A  G  Q  A  L      p.260

          .         .         .         .         .         .       g.29817
 GCTTTTGTTCAGGATCTTGTGACGGCTCTTCTAAACTTTCATACCTACACAGAACAGAGG       c.840
 A  F  V  Q  D  L  V  T  A  L  L  N  F  H  T  Y  T  E  Q  R         p.280

          .         .         .         .         .        | 10.    g.35321
 ATTCAAATTTTTCCTGTTGATTCTGCCATTGACACTATATCTCCATTGAATCAGAAG | TTC    c.900
 I  Q  I  F  P  V  D  S  A  I  D  T  I  S  P  L  N  Q  K   | F      p.300

          .         .         .         .         .         .       g.35381
 TCACAATACCTTCATGAAAATGCGTCCTATGTCCGCCCTCTTGAGGAAGGAATGCTTCAT       c.960
 S  Q  Y  L  H  E  N  A  S  Y  V  R  P  L  E  E  G  M  L  H         p.320

          .         .         .          | 11        .         .    g.35531
 TTATTTGAAAGTATCACTGAGGATACTGTGACTGTCTTG | GAGACAACTGTGAAATTGAAA    c.1020
 L  F  E  S  I  T  E  D  T  V  T  V  L   | E  T  T  V  K  L  K      p.340

          .         .         .         .         .         .       g.35591
 ACTTTTTCAGAACACTTAACCTCCTACATATGTTTTCTTAGGAAGATTCTTCCCTATCAG       c.1080
 T  F  S  E  H  L  T  S  Y  I  C  F  L  R  K  I  L  P  Y  Q         p.360

          | 12         .         .         .         .         .    g.38966
 TTAAAAAG | TTTAGAAGAAGAATGTGAATCCTCTCTTTGCACATCTGCGTTAAGAGCCAGG    c.1140
 L  K  S  |  L  E  E  E  C  E  S  S  L  C  T  S  A  L  R  A  R      p.380

          .         .         .         .         .         .       g.39026
 AATCTAGAGCTGTCCCAGGACATGAAAAAAATGACAGCTGTGTTTGAGAAGCTGCAGACT       c.1200
 N  L  E  L  S  Q  D  M  K  K  M  T  A  V  F  E  K  L  Q  T         p.400

          .         .      | 13  .         .         .         .    g.44190
 TACATAGCTCTTCTTGCCTTGCCAA | GTACAGAGCCAGATGGACTCCTTCGGACAAACTAC    c.1260
 Y  I  A  L  L  A  L  P  S |   T  E  P  D  G  L  L  R  T  N  Y      p.420

          .         .         .         .         .         | 14    g.50864
 AGTTCTGTGTTAACAAATGTTGGTGCTGCTCTGCATGGATTTCATGACGTTATGAAAG | AT    c.1320
 S  S  V  L  T  N  V  G  A  A  L  H  G  F  H  D  V  M  K  D |       p.440

          .         .         .         .         .         .       g.50924
 ATTTCCAAACATTATAGTCAAAAAGCTGCAATAGAGCATGAACTTCCAACAGCAACACAG       c.1380
 I  S  K  H  Y  S  Q  K  A  A  I  E  H  E  L  P  T  A  T  Q         p.460

          .         .         .         .         .         .       g.50984
 AAGCTGATAACAACTAATGACTGTATCCTGTCATCAGTAGTGGCATTAACAAATGGAGCA       c.1440
 K  L  I  T  T  N  D  C  I  L  S  S  V  V  A  L  T  N  G  A         p.480

        | 15 .         .         .         .         .         .    g.55303
 GGAAAG | ATTGCATCCTTCTTCAGCAACAATTTGGACTACTTCATTGCTTCACTGAGCTAT    c.1500
 G  K   | I  A  S  F  F  S  N  N  L  D  Y  F  I  A  S  L  S  Y      p.500

          .         .         .         .         .         .       g.55363
 GGACCTAAGGCAGCGAGTGGATTCATTAGTCCTCTTTCAGCTGAATGCATGCTACAGTAT       c.1560
 G  P  K  A  A  S  G  F  I  S  P  L  S  A  E  C  M  L  Q  Y         p.520

          .         .         .          | 16        .         .    g.59931
 AAGAAAAAAGCTGCTGCCTATATGAAGTCTTTGAGAAAG | CCCCTCTTGGAGTCTGTGCCT    c.1620
 K  K  K  A  A  A  Y  M  K  S  L  R  K   | P  L  L  E  S  V  P      p.540

          .         .         .         .         .         .       g.59991
 TATGAAGAAGCACTGGCAAACCGCCGCATCCTTCTCAGCTCTACTGAAAGTCGAGAAGGC       c.1680
 Y  E  E  A  L  A  N  R  R  I  L  L  S  S  T  E  S  R  E  G         p.560

          .   | 17     .         .         .         .         .    g.62772
 CTTGCACAGCAA | GTTCAACAGAGTTTGGAAAAGATTTCTAAACTGGAGCAGGAAAAAGAA    c.1740
 L  A  Q  Q   | V  Q  Q  S  L  E  K  I  S  K  L  E  Q  E  K  E      p.580

          .         .         .         .         .         .       g.62832
 CATTGGATGTTGGAAGCACAATTAGCCAAAATCAAGCTAGAGAAAGAAAACCAGCGAATT       c.1800
 H  W  M  L  E  A  Q  L  A  K  I  K  L  E  K  E  N  Q  R  I         p.600

          .         .         .         .         .         .       g.62892
 GCAGATAAGCTGAAGAATACAGGTAGTGCCCAGCTGGTTGGGCTGGCCCAGGAAAATGCT       c.1860
 A  D  K  L  K  N  T  G  S  A  Q  L  V  G  L  A  Q  E  N  A         p.620

          .         .         .         .         .         .       g.62952
 GCTGTGTCAAATACTGCTGGCCAGGATGAAGCCACAGCTAAGGCTGTGTTGGAGCCCATT       c.1920
 A  V  S  N  T  A  G  Q  D  E  A  T  A  K  A  V  L  E  P  I         p.640

          .      | 18  .         .         .         | 19         . g.71512
 CAGAGCACCAGTCTA | ATTGGGACTTTAACCAGGACATCTGACAGTGAG | GTTCCAGATGTG c.1980
 Q  S  T  S  L   | I  G  T  L  T  R  T  S  D  S  E   | V  P  D  V   p.660

          .         .         .         .         .         .       g.71572
 GAATCTCGTGAAGACTTAATTAAAAATCACTACATGGCAAGGATAGTGGAACTTACGTCT       c.2040
 E  S  R  E  D  L  I  K  N  H  Y  M  A  R  I  V  E  L  T  S         p.680

          .         .         .         .      | 20  .         .    g.74261
 CAGTTGCAGCTGGCTGACAGTAAGTCAGTGCATTTTTATGCCGAG | TGCCGAGCACTGTCT    c.2100
 Q  L  Q  L  A  D  S  K  S  V  H  F  Y  A  E   | C  R  A  L  S      p.700

          .         .         .         .         .         .       g.74321
 AAAAGACTGGCCTTGGCTGAAAAGTCTAAGGAAGCATTGACAGAAGAAATGAAACTTGCC       c.2160
 K  R  L  A  L  A  E  K  S  K  E  A  L  T  E  E  M  K  L  A         p.720

          .         .     | 21   .         .         .         .    g.75607
 AGTCAGAACATCAGCAGACTTCAG | GATGAGCTGACAACTACCAAGAGGAGTTACGAGGAT    c.2220
 S  Q  N  I  S  R  L  Q   | D  E  L  T  T  T  K  R  S  Y  E  D      p.740

          .         .         .         .         .         .       g.75667
 CAGTTAAGTATGATGAGTGACCACCTGTGCAGCATGAATGAGACATTATCTAAACAGAGA       c.2280
 Q  L  S  M  M  S  D  H  L  C  S  M  N  E  T  L  S  K  Q  R         p.760

          .         .         .    | 22    .         .         .    g.78973
 GAAGAGATTGACACACTAAAGATGTCCAGTAAG | GGGAATTCTAAAAAGAACAAGAGTCGA    c.2340
 E  E  I  D  T  L  K  M  S  S  K   | G  N  S  K  K  N  K  S  R      p.780

                                                                    g.78976
 TAG                                                                c.2343
 X                                                                  p.780

          .         .         .         .         .         .       g.79036
 ttttgaaatagctggttggcgactgttctttccagacctgctcctgctgcacagagccgc       c.*60

          .         .         .         .         .         .       g.79096
 agggctgagaccacgtccatgctggctgccttcaggaagctaaagtattgttggacctag       c.*120

          .         .         .         .         .         .       g.79156
 taaactagtcagtgttggaaacggccttgaaatatttaaaacatatttgtaaccagtgag       c.*180

          .         .         .         .         .         .       g.79216
 gcaaatacagaagttgatgtcggcagtaaatggaaaacaatacgtatgtcatggatattg       c.*240

          .         .         .         .         .         .       g.79276
 taggtttccttatgctgtttttactgtgcactttttaaaattaggttttaatttcagtat       c.*300

          .         .         .         .         .         .       g.79336
 gtaagaacaaatattttgtatactttcaaactcaattatatggtaatcgatttggtatct       c.*360

          .         .         .         .         .         .       g.79396
 atggaatagatatatgtttctggaaaaaaatgcttaaattgtcaaactgtcattacttct       c.*420

          .         .         .         .         .         .       g.79456
 tattatagttgaaggcattctccagattctttttaaaagatttgttcatatttctctctc       c.*480

          .         .         .         .         .         .       g.79516
 tctctctctctctctctctctcttctttctctctgagggagagggagccctccaaacttc       c.*540

          .         .         .         .         .         .       g.79576
 agatcctgtgggtttagtatcattatcttcagctctttgataccctgtgttagagtaata       c.*600

          .         .         .         .                           g.79624
 gctaaaggaagttcatgtcaataaattcatacttatatcacactttca                   c.*648

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein phosphatase 1, regulatory subunit 21 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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