protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A) - coding DNA reference sequence

(used for variant description)

(last modified March 31, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_014225.5 in the PPP2R1A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering PPP2R1A transcript NM_014225.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      aatcttggtcgctaggacacggctaacttccgctttcttccccctctcctaggct       c.-241

 .         .         .         .         .         .                g.5115
 caaactagtcaaatcttgttcactcgaccaatggcaaatcggaagtgggcgggacttcac       c.-181

 .         .         .         .         .         .                g.5175
 aagtccggaccaaagaaacgcgagcttagccctgggtagcgcggccaatggccgtggagc       c.-121

 .         .         .         .         .         .                g.5235
 agcccctgtaaactggctcgggcgcccccacgcccgcccttccttcttctcccagcattg       c.-61

 .         .         .         .         .         .                g.5295
 ccccccccacgtttcagcacagcgctggccgcagtctgacaggaaagggacggagccaag       c.-1

          .         .         .         .         .         .       g.5355
 ATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATAGACGAACTC       c.60
 M  A  A  A  D  G  D  D  S  L  Y  P  I  A  V  L  I  D  E  L         p.20

          .         | 02         .         .         .         .    g.17184
 CGCAATGAGGACGTTCAG | CTTCGCCTCAACAGCATCAAGAAGCTGTCCACCATCGCCTTG    c.120
 R  N  E  D  V  Q   | L  R  L  N  S  I  K  K  L  S  T  I  A  L      p.40

          .         .         .         .          | 03        .    g.21172
 GCCCTTGGGGTTGAAAGGACCCGAAGTGAGCTTCTGCCTTTCCTTACAG | ATACCATCTAT    c.180
 A  L  G  V  E  R  T  R  S  E  L  L  P  F  L  T  D |   T  I  Y      p.60

          .         .         .         .         .         .       g.21232
 GATGAAGATGAGGTCCTCCTGGCCCTGGCAGAACAGCTGGGAACCTTCACTACCCTGGTG       c.240
 D  E  D  E  V  L  L  A  L  A  E  Q  L  G  T  F  T  T  L  V         p.80

          .         .         . | 04       .         .         .    g.26488
 GGAGGCCCAGAGTACGTGCACTGCCTGCTG | CCACCGCTGGAGTCGCTGGCCACAGTGGAG    c.300
 G  G  P  E  Y  V  H  C  L  L   | P  P  L  E  S  L  A  T  V  E      p.100

          .         .         .         .         .         .       g.26548
 GAGACAGTGGTGCGGGACAAGGCAGTGGAGTCCTTACGGGCCATCTCACACGAGCACTCG       c.360
 E  T  V  V  R  D  K  A  V  E  S  L  R  A  I  S  H  E  H  S         p.120

          .         .         .         .         .         .       g.26608
 CCCTCTGACCTGGAGGCGCACTTTGTGCCGCTAGTGAAGCGGCTGGCGGGCGGCGACTGG       c.420
 P  S  D  L  E  A  H  F  V  P  L  V  K  R  L  A  G  G  D  W         p.140

          .         .         .         .         .         .       g.26668
 TTCACCTCCCGCACCTCGGCCTGCGGCCTCTTCTCCGTCTGCTACCCCCGAGTGTCCAGT       c.480
 F  T  S  R  T  S  A  C  G  L  F  S  V  C  Y  P  R  V  S  S         p.160

          .         .    | 05    .         .         .         .    g.27921
 GCTGTGAAGGCGGAACTTCGACA | GTACTTCCGGAACCTGTGCTCAGATGACACCCCCATG    c.540
 A  V  K  A  E  L  R  Q  |  Y  F  R  N  L  C  S  D  D  T  P  M      p.180

          .         .         .         .         .         .       g.27981
 GTGCGGCGGGCCGCAGCCTCCAAGCTGGGGGAGTTTGCCAAGGTGCTGGAGCTGGACAAC       c.600
 V  R  R  A  A  A  S  K  L  G  E  F  A  K  V  L  E  L  D  N         p.200

          .         .         .         .         .  | 06      .    g.28162
 GTCAAGAGTGAGATCATCCCCATGTTCTCCAACCTGGCCTCTGACGAGCAG | GACTCGGTG    c.660
 V  K  S  E  I  I  P  M  F  S  N  L  A  S  D  E  Q   | D  S  V      p.220

          .         .         .         .         .         .       g.28222
 CGGCTGCTGGCGGTGGAGGCGTGCGTGAACATCGCCCAGCTTCTGCCCCAGGAGGATCTG       c.720
 R  L  L  A  V  E  A  C  V  N  I  A  Q  L  L  P  Q  E  D  L         p.240

          .         .         .         .         .         .       g.28282
 GAGGCCCTGGTGATGCCCACTCTGCGCCAGGCCGCTGAAGACAAGTCCTGGCGCGTCCGC       c.780
 E  A  L  V  M  P  T  L  R  Q  A  A  E  D  K  S  W  R  V  R         p.260

          .         .        | 07.         .         .         .    g.31010
 TACATGGTGGCTGACAAGTTCACAGAG | CTCCAGAAAGCAGTGGGGCCTGAGATCACCAAG    c.840
 Y  M  V  A  D  K  F  T  E   | L  Q  K  A  V  G  P  E  I  T  K      p.280

          .         .         .         .         .         .       g.31070
 ACAGACCTGGTCCCTGCCTTCCAGAACCTGATGAAAGACTGTGAGGCCGAGGTGAGGGCC       c.900
 T  D  L  V  P  A  F  Q  N  L  M  K  D  C  E  A  E  V  R  A         p.300

          .         .   | 08     .         .         .         .    g.31240
 GCAGCCTCCCACAAGGTCAAAG | AGTTCTGTGAAAACCTCTCAGCTGACTGTCGGGAGAAT    c.960
 A  A  S  H  K  V  K  E |   F  C  E  N  L  S  A  D  C  R  E  N      p.320

          .         .         .    | 09    .         .         .    g.31754
 GTGATCATGTCCCAGATCTTGCCCTGCATCAAG | GAGCTGGTGTCCGATGCCAACCAACAT    c.1020
 V  I  M  S  Q  I  L  P  C  I  K   | E  L  V  S  D  A  N  Q  H      p.340

          .         .         .         .         .         .       g.31814
 GTCAAGTCTGCCCTGGCCTCAGTCATCATGGGTCTCTCTCCCATCTTGGGCAAAGACAAC       c.1080
 V  K  S  A  L  A  S  V  I  M  G  L  S  P  I  L  G  K  D  N         p.360

          .         .         .         .         | 10         .    g.34901
 ACCATCGAGCACCTCTTGCCCCTCTTCCTGGCTCAGCTGAAGGATGAG | TGCCCTGAGGTA    c.1140
 T  I  E  H  L  L  P  L  F  L  A  Q  L  K  D  E   | C  P  E  V      p.380

          .         .         .         .         .         .       g.34961
 CGGCTGAACATCATCTCTAACCTGGACTGTGTGAACGAGGTGATTGGCATCCGGCAGCTG       c.1200
 R  L  N  I  I  S  N  L  D  C  V  N  E  V  I  G  I  R  Q  L         p.400

          .         .         .         .         .         .       g.35021
 TCCCAGTCCCTGCTCCCTGCCATTGTGGAGCTGGCTGAGGACGCCAAGTGGCGGGTGCGG       c.1260
 S  Q  S  L  L  P  A  I  V  E  L  A  E  D  A  K  W  R  V  R         p.420

          .         .         .         .   | 11     .         .    g.35405
 CTGGCCATCATTGAGTACATGCCCCTCCTGGCTGGACAGCTG | GGAGTGGAGTTCTTTGAT    c.1320
 L  A  I  I  E  Y  M  P  L  L  A  G  Q  L   | G  V  E  F  F  D      p.440

          .         .         .         .    | 12    .         .    g.36194
 GAGAAACTTAACTCCTTGTGCATGGCCTGGCTTGTGGATCATG | TATATGCCATCCGCGAG    c.1380
 E  K  L  N  S  L  C  M  A  W  L  V  D  H  V |   Y  A  I  R  E      p.460

          .         .         .         .         .         .       g.36254
 GCAGCCACCAGCAACCTGAAGAAGCTAGTGGAAAAGTTTGGGAAGGAGTGGGCCCATGCC       c.1440
 A  A  T  S  N  L  K  K  L  V  E  K  F  G  K  E  W  A  H  A         p.480

          .         .         .         .         .         .       g.36314
 ACAATCATCCCCAAGGTCTTGGCCATGTCCGGAGACCCCAACTACCTGCACCGCATGACT       c.1500
 T  I  I  P  K  V  L  A  M  S  G  D  P  N  Y  L  H  R  M  T         p.500

          .         | 13         .         .         .         .    g.37339
 ACGCTCTTCTGCATCAAT | GTGCTGTCTGAGGTCTGTGGGCAGGACATCACCACCAAGCAC    c.1560
 T  L  F  C  I  N   | V  L  S  E  V  C  G  Q  D  I  T  T  K  H      p.520

          .         .         .         .         .         .       g.37399
 ATGCTACCCACGGTTCTGCGCATGGCTGGGGACCCGGTTGCCAATGTCCGCTTCAATGTG       c.1620
 M  L  P  T  V  L  R  M  A  G  D  P  V  A  N  V  R  F  N  V         p.540

          .         .         .         .  | 14      .         .    g.40934
 GCCAAGTCTCTGCAGAAGATAGGGCCCATCCTGGACAACAG | CACCTTGCAGAGTGAAGTC    c.1680
 A  K  S  L  Q  K  I  G  P  I  L  D  N  S  |  T  L  Q  S  E  V      p.560

          .         .         .         .         .         .       g.40994
 AAGCCCATCCTAGAGAAGCTGACCCAGGACCAGGATGTGGACGTCAAATACTTTGCCCAG       c.1740
 K  P  I  L  E  K  L  T  Q  D  Q  D  V  D  V  K  Y  F  A  Q         p.580

          .    | 15    .         .                                  g.41210
 GAGGCTCTGACTG | TTCTGTCTCTCGCCTGA                                  c.1770
 E  A  L  T  V |   L  S  L  A  X                                    p.589

          .         .         .         .         .         .       g.41270
 tgctggaagaggagcaaacactggcctctggtgtccaccctccaacccccacaagtccct       c.*60

          .         .         .         .         .         .       g.41330
 ctttggggagacactggggggcctttggctgtcactccctgtgcatggtctgaccccagg       c.*120

          .         .         .         .         .         .       g.41390
 ccccttcccccagcacggttcctcctctccccagcctgggaagatgtctcactgtccacc       c.*180

          .         .         .         .         .         .       g.41450
 tcccaacgggctaggggagcacggggttggacaggacagtgaccttgggaggaaggggct       c.*240

          .         .         .         .         .         .       g.41510
 actccgcccacgtcagggagagatgtgagcatcccgggtcactggatcctgctgctgtaa       c.*300

          .         .         .         .         .         .       g.41570
 tgggaacccctcccccatttacttctccacctcccgtcctccccatcattggtttttttt       c.*360

          .         .         .         .         .         .       g.41630
 tgtgtgtcaactgtgccgtttttattttattccttttattttcccccttttcacagagaa       c.*420

          .         .                                               g.41654
 ataaaggtctagaagtagttggtc                                           c.*444

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein phosphatase 2, regulatory subunit A, alpha protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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