protein phosphatase 2, regulatory subunit B', delta (PPP2R5D) - coding DNA reference sequence

(used for variant description)

(last modified November 17, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_006245.3 in the PPP2R5D gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_050636.1, covering PPP2R5D transcript NM_006245.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5059
  ggcgcctggttgtcaggcagttttgtaggagttcgggccaattggaggcgcaggcaccg       c.-121

 .         .         .         .         .         .                g.5119
 ctcgacccgggcgcagcgcgcaggcggtggcgaagagacgccgagcgggccgagtgcggc       c.-61

 .         .         .         .         .         .                g.5179
 cgagcaaagccggagccggagcggggccgcaggagacgggccgggtccggacgggccgag       c.-1

          .         .        | 02.         .         .         .    g.10145
 ATGCCCTATAAACTGAAAAAGGAGAAG | GAGCCCCCCAAGGTTGCCAAATGCACAGCCAAG    c.60
 M  P  Y  K  L  K  K  E  K   | E  P  P  K  V  A  K  C  T  A  K      p.20

          .         .         .         .      | 03  .         .    g.26979
 CCTAGCAGCTCGGGCAAGGATGGTGGAGGCGAGAACACTGAGGAG | GCCCAGCCGCAGCCC    c.120
 P  S  S  S  G  K  D  G  G  G  E  N  T  E  E   | A  Q  P  Q  P      p.40

          .         .         .         .         .         .       g.27039
 CAGCCCCAGCCCCAGCCCCAAGCCCAGTCTCAGCCACCGTCATCCAACAAGCGTCCCAGC       c.180
 Q  P  Q  P  Q  P  Q  A  Q  S  Q  P  P  S  S  N  K  R  P  S         p.60

          .         .         .         .         .         .       g.27099
 AATAGCACGCCGCCCCCCACGCAGCTCAGCAAAATCAAGTACTCAGGGGGGCCCCAGATT       c.240
 N  S  T  P  P  P  T  Q  L  S  K  I  K  Y  S  G  G  P  Q  I         p.80

          .         .         .         .         .         .       g.27159
 GTCAAGAAGGAGCGACGGCAAAGCTCCTCCCGCTTCAACCTCAGCAAGAATCGGGAGCTG       c.300
 V  K  K  E  R  R  Q  S  S  S  R  F  N  L  S  K  N  R  E  L         p.100

          .         .   | 04     .         .         .         .    g.27450
 CAGAAGCTTCCTGCCCTGAAAG | ATTCGCCAACCCAGGAGCGGGAGGAGCTGTTTATCCAG    c.360
 Q  K  L  P  A  L  K  D |   S  P  T  Q  E  R  E  E  L  F  I  Q      p.120

          .         .         .         .         .         .       g.27510
 AAGCTACGCCAGTGCTGTGTCCTCTTTGACTTCGTGTCAGACCCACTCAGTGACCTCAAA       c.420
 K  L  R  Q  C  C  V  L  F  D  F  V  S  D  P  L  S  D  L  K         p.140

          .         .         .         .         .         .       g.27570
 TTCAAGGAGGTGAAGCGGGCAGGACTCAACGAGATGGTGGAGTACATCACCCATAGCCGT       c.480
 F  K  E  V  K  R  A  G  L  N  E  M  V  E  Y  I  T  H  S  R         p.160

          .         .         .         .   | 05     .         .    g.27715
 GATGTTGTCACTGAGGCCATTTACCCTGAGGCTGTCACCATG | TTTTCAGTGAACCTCTTC    c.540
 D  V  V  T  E  A  I  Y  P  E  A  V  T  M   | F  S  V  N  L  F      p.180

          .         .         .         .         .         .       g.27775
 CGGACGCTGCCACCTTCATCGAATCCCACAGGGGCTGAGTTTGACCCAGAGGAAGATGAG       c.600
 R  T  L  P  P  S  S  N  P  T  G  A  E  F  D  P  E  E  D  E         p.200

          .         .         .    | 06    .         .         .    g.27942
 CCCACCCTGGAAGCTGCTTGGCCACATCTCCAG | CTCGTGTATGAGTTCTTCTTACGTTTC    c.660
 P  T  L  E  A  A  W  P  H  L  Q   | L  V  Y  E  F  F  L  R  F      p.220

          .         .         .         .         .         .       g.28002
 CTTGAGTCTCCTGATTTCCAGCCAAACATAGCCAAGAAGTACATCGACCAGAAGTTTGTA       c.720
 L  E  S  P  D  F  Q  P  N  I  A  K  K  Y  I  D  Q  K  F  V         p.240

        | 07 .         .         .         .         .         .    g.28490
 CTTGCT | CTCCTAGACCTATTTGACAGTGAGGATCCTCGAGAGCGGGACTTCCTCAAGACC    c.780
 L  A   | L  L  D  L  F  D  S  E  D  P  R  E  R  D  F  L  K  T      p.260

          .         .         .         .         .         .       g.28550
 ATTTTGCATCGCATCTATGGCAAGTTTTTGGGGCTCCGGGCTTATATCCGTAGGCAGATC       c.840
 I  L  H  R  I  Y  G  K  F  L  G  L  R  A  Y  I  R  R  Q  I         p.280

          .        | 08.         .         .         .         .    g.28745
 AACCACATCTTCTACAG | GTTCATCTACGAGACGGAGCATCACAACGGGATTGCTGAGCTC    c.900
 N  H  I  F  Y  R  |  F  I  Y  E  T  E  H  H  N  G  I  A  E  L      p.300

          .        | 09.         .         .         .         .    g.28911
 CTGGAGATCCTGGGCAG | CATCATCAATGGCTTTGCCCTGCCCCTTAAAGAAGAGCACAAG    c.960
 L  E  I  L  G  S  |  I  I  N  G  F  A  L  P  L  K  E  E  H  K      p.320

          .         .         .         .         .         .       g.28971
 ATGTTCCTCATCCGTGTCCTACTTCCCCTTCACAAGGTCAAGTCCCTGAGTGTCTACCAC       c.1020
 M  F  L  I  R  V  L  L  P  L  H  K  V  K  S  L  S  V  Y  H         p.340

        | 10 .         .         .         .         .         .    g.29248
 CCTCAG | CTGGCATACTGTGTGGTACAATTCCTGGAGAAGGAGAGCAGTCTGACTGAGCCG    c.1080
 P  Q   | L  A  Y  C  V  V  Q  F  L  E  K  E  S  S  L  T  E  P      p.360

  | 11       .         .         .         .         .         .    g.29618
  | GTAATTGTGGGACTTCTCAAGTTTTGGCCCAAGACCCACAGCCCCAAGGAGGTGATGTTC    c.1140
  | V  I  V  G  L  L  K  F  W  P  K  T  H  S  P  K  E  V  M  F      p.380

          .         .         .         .         .         .       g.29678
 TTGAATGAGCTGGAGGAGATTCTGGACGTCATTGAACCTTCTGAGTTCAGCAAAGTGATG       c.1200
 L  N  E  L  E  E  I  L  D  V  I  E  P  S  E  F  S  K  V  M         p.400

          .         .         .         .         .  | 12      .    g.29832
 GAACCCCTCTTCCGCCAGCTGGCCAAGTGTGTCTCTAGCCCCCATTTCCAG | GTGGCAGAG    c.1260
 E  P  L  F  R  Q  L  A  K  C  V  S  S  P  H  F  Q   | V  A  E      p.420

          .         .         .         .         .         .       g.29892
 CGTGCTCTCTATTACTGGAACAATGAGTACATCATGAGCCTGATAAGTGACAATGCTGCC       c.1320
 R  A  L  Y  Y  W  N  N  E  Y  I  M  S  L  I  S  D  N  A  A         p.440

          .         .         .         .         .          | 13    g.30970
 CGAGTCCTCCCCATCATGTTCCCTGCACTCTACAGGAACTCCAAGAGCCACTGGAACAA | G    c.1380
 R  V  L  P  I  M  F  P  A  L  Y  R  N  S  K  S  H  W  N  K  |      p.460

          .         .         .         .         .         .       g.31030
 ACAATCCATGGACTGATCTATAATGCCCTGAAGTTGTTTATGGAAATGAATCAGAAGCTG       c.1440
 T  I  H  G  L  I  Y  N  A  L  K  L  F  M  E  M  N  Q  K  L         p.480

          .         .         .         .  | 14      .         .    g.31184
 TTTGATGACTGCACACAACAATACAAGGCAGAGAAGCAGAA | GGGCCGGTTCCGAATGAAG    c.1500
 F  D  D  C  T  Q  Q  Y  K  A  E  K  Q  K  |  G  R  F  R  M  K      p.500

          .         .         .         .         .     | 15   .    g.31388
 GAAAGGGAAGAGATGTGGCAAAAAATCGAGGAGCTGGCCCGGCTTAATCCCCAG | TATCCC    c.1560
 E  R  E  E  M  W  Q  K  I  E  E  L  A  R  L  N  P  Q   | Y  P      p.520

          .         .         .         .         .         .       g.31448
 ATGTTCCGAGCCCCTCCACCACTGCCCCCTGTGTACTCGATGGAGACAGAGACCCCCACA       c.1620
 M  F  R  A  P  P  P  L  P  P  V  Y  S  M  E  T  E  T  P  T         p.540

          .         .         .         .         .  | 16      .    g.31659
 GCTGAGGACATCCAGCTTCTGAAGAGGACTGTGGAGACTGAGGCTGTTCAG | ATGCTAAAA    c.1680
 A  E  D  I  Q  L  L  K  R  T  V  E  T  E  A  V  Q   | M  L  K      p.560

          .         .         .         .         .         .       g.31719
 GACATCAAGAAGGAGAAAGTGCTGCTGCGGAGGAAGTCGGAGCTGCCCCAGGACGTGTAC       c.1740
 D  I  K  K  E  K  V  L  L  R  R  K  S  E  L  P  Q  D  V  Y         p.580

          .         .         .         .         .         .       g.31779
 ACCATCAAGGCACTGGAGGCGCACAAGCGGGCGGAAGAGTTCCTAACTGCCAGCCAGGAG       c.1800
 T  I  K  A  L  E  A  H  K  R  A  E  E  F  L  T  A  S  Q  E         p.600

                                                                    g.31788
 GCTCTCTGA                                                          c.1809
 A  L  X                                                            p.602

          .         .         .         .         .         .       g.31848
 cccctcacgttcctaccacagggccacagcccacacagccctgggacactgccctggccc       c.*60

          .         .         .         .         .         .       g.31908
 tccatactctgctccctactggctgtcttgggggaaggcagcgcctctctagctactcaa       c.*120

          .         .         .         .         .         .       g.31968
 gggagggggatgtgggcacttgaagcagggacacccacagaatggtccctcttctcccca       c.*180

          .         .         .         .         .         .       g.32028
 aaaggtgttcatgcctccctgtggctagtacaggctgagcactaagatgcttagtgctca       c.*240

          .         .         .         .         .         .       g.32088
 gacaacctggggatgcctgtcccctacctgctcctcacccacagctacctgaggctgctc       c.*300

          .         .         .         .         .         .       g.32148
 tgagaagtacacacaggaatacatacgctcctctattcttcccttcatcctcatttgaac       c.*360

          .         .         .         .         .         .       g.32208
 gccaggtatctcccctcctctctctcccctgcagaggcatgtagggaacagcaggagatt       c.*420

          .         .         .         .         .         .       g.32268
 attctcaccaaagttatgtcaagccccattggtcccagagtagctgaagggaagccaacc       c.*480

          .         .         .         .         .         .       g.32328
 cccctgcagcacaaataggccccccagtcccagccgtgtgctggcagatagggttgtatt       c.*540

          .         .         .         .         .         .       g.32388
 atttcttcttaccccatgcctgaccaagggaggtcaaaaggagaaaagtataggctgtgg       c.*600

          .         .         .         .         .         .       g.32448
 acaataactgatgaatatagggcccagatggaccaagtggggccggggagggatgaataa       c.*660

          .         .         .         .         .         .       g.32508
 acaccctaccccgtgccctgtctttggtgagcagcagccctggggtcacagacatggaag       c.*720

          .         .         .         .         .         .       g.32568
 ggaccaccctggggctgactgcttttctgtgctgttggttcccaaaactagaaagaagga       c.*780

          .         .         .         .         .         .       g.32628
 agcagggagcggtgccccaagcatggctcctgccaacacctatttatttccttgtttgtg       c.*840

          .         .         .         .         .         .       g.32688
 ctatgctgggcaggccttctcttgtcccttataggtaccttggaggggccaggggctgag       c.*900

          .         .         .         .         .         .       g.32748
 gaaggccggacccaggttccaggggcgcaggcagtgcggcttttggctgtgtacataggg       c.*960

          .         .         .         .         .         .       g.32808
 tgctttattctccacagagtgatacatgctaaggtgggttgggcttggaccgatgtcccc       c.*1020

          .         .         .                                     g.32847
 atatgtacagaactgaataaagtgggtctctgagaagtc                            c.*1059

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein phosphatase 2, regulatory subunit B', delta protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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