protein phosphatase 3, catalytic subunit, alpha isozyme (PPP3CA) - coding DNA reference sequence

(used for variant description)

(last modified June 1, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000944.4 in the PPP3CA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering PPP3CA transcript NM_000944.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              aggagcggcgcgggg       c.-661

 .         .         .         .         .         .                g.5075
 aggcagaggcgagcgcgggcgatcgcggcggcgggacgtctccggcggccgcggcaccag       c.-601

 .         .         .         .         .         .                g.5135
 cggcggcgctctgtgtggagaagcaggggcagcggcagcagcaacagcggcagcggcagc       c.-541

 .         .         .         .         .         .                g.5195
 agcagcggcagcagcggcggccgcctctccgccgccggggacgccaaggtgcggctggtg       c.-481

 .         .         .         .         .         .                g.5255
 gcactgacatcggcggccctgcctctcctccctcgcccccggccttccccatgtgatcgg       c.-421

 .         .         .         .         .         .                g.5315
 tcttaatcctggccgtgtgtgcgcgcgtggggctccattccgcggtgctgggtctccgtg       c.-361

 .         .         .         .         .         .                g.5375
 ccggggtgggtgctcgtgtgtgcgcttctcctccccatcccccttcccccaagaataaaa       c.-301

 .         .         .         .         .         .                g.5435
 gaagaaccgggaggcgtgctcagaaaataaataaataaccaccacacacgcgcagcccgg       c.-241

 .         .         .         .         .         .                g.5495
 agcgagtcggcggggctggcggcagcggcggaggaggagtgaaggcggcggcggcggagg       c.-181

 .         .         .         .         .         .                g.5555
 agggacgcgcggaaaaggcagcaactttaaagccagctcagagcctagacctccagccga       c.-121

 .         .         .         .         .         .                g.5615
 gcggtttgcagcgcggcggcggcggcggcggcggcggcgttgagtgtctggcccgccggt       c.-61

 .         .         .         .         .         .                g.5675
 ccggtcggggtgtgcagtcggacggacgagcagcgcgtcgctgtcctccggcagctggag       c.-1

          .         .         .         .         .         | 02    g.156357
 ATGTCCGAGCCCAAGGCAATTGATCCCAAGTTGTCGACGACCGACAGGGTGGTGAAAG | CT    c.60
 M  S  E  P  K  A  I  D  P  K  L  S  T  T  D  R  V  V  K  A |       p.20

          .         .         .         .         .         .       g.156417
 GTTCCATTTCCTCCAAGTCACCGGCTTACAGCAAAAGAAGTGTTTGATAATGATGGAAAA       c.120
 V  P  F  P  P  S  H  R  L  T  A  K  E  V  F  D  N  D  G  K         p.40

          .         .         .         .         .         .       g.156477
 CCTCGTGTGGATATCTTAAAGGCGCATCTTATGAAGGAGGGAAGGCTGGAAGAGAGTGTT       c.180
 P  R  V  D  I  L  K  A  H  L  M  K  E  G  R  L  E  E  S  V         p.60

          .         .         .         .         .         .       g.156537
 GCATTGAGAATAATAACAGAGGGTGCATCAATTCTTCGACAGGAAAAAAATTTGCTGGAT       c.240
 A  L  R  I  I  T  E  G  A  S  I  L  R  Q  E  K  N  L  L  D         p.80

          .          | 03        .         .         .         .    g.243434
 ATTGATGCGCCAGTCACTG | TTTGTGGGGACATTCATGGACAATTCTTTGATTTGATGAAG    c.300
 I  D  A  P  V  T  V |   C  G  D  I  H  G  Q  F  F  D  L  M  K      p.100

          .         .         .         .         .         .       g.243494
 CTCTTTGAAGTCGGGGGATCTCCTGCCAACACTCGCTACCTCTTCTTAGGGGACTATGTT       c.360
 L  F  E  V  G  G  S  P  A  N  T  R  Y  L  F  L  G  D  Y  V         p.120

          .         .     | 04   .         .         .         .    g.252785
 GACAGAGGGTACTTCAGTATTGAA | TGTGTGCTGTATTTGTGGGCCTTGAAAATTCTCTAC    c.420
 D  R  G  Y  F  S  I  E   | C  V  L  Y  L  W  A  L  K  I  L  Y      p.140

          .         .         .         .         .         .       g.252845
 CCCAAAACACTGTTTTTACTTCGTGGAAATCATGAATGTAGACATCTAACAGAGTATTTC       c.480
 P  K  T  L  F  L  L  R  G  N  H  E  C  R  H  L  T  E  Y  F         p.160

          .       | 05 .         .         .         .         .    g.254003
 ACATTTAAACAAGAAT | GTAAAATAAAGTATTCAGAACGCGTATATGATGCCTGTATGGAT    c.540
 T  F  K  Q  E  C |   K  I  K  Y  S  E  R  V  Y  D  A  C  M  D      p.180

          .         .         .         .         .         .       g.254063
 GCCTTTGACTGCCTTCCCCTGGCTGCCCTGATGAACCAACAGTTCCTGTGTGTGCATGGT       c.600
 A  F  D  C  L  P  L  A  A  L  M  N  Q  Q  F  L  C  V  H  G         p.200

          .         .         .         .   | 06     .         .    g.258574
 GGTTTGTCTCCAGAGATTAACACTTTAGATGATATCAGAAAA | TTAGACCGATTCAAAGAA    c.660
 G  L  S  P  E  I  N  T  L  D  D  I  R  K   | L  D  R  F  K  E      p.220

          .         .         .         .         .         .       g.258634
 CCACCTGCATATGGACCTATGTGTGATATCCTGTGGTCAGACCCCCTGGAAGATTTTGGA       c.720
 P  P  A  Y  G  P  M  C  D  I  L  W  S  D  P  L  E  D  F  G         p.240

          .         .         .         .         .         .       g.258694
 AATGAGAAGACTCAGGAACATTTCACTCACAACACAGTCAGGGGGTGTTCATACTTCTAC       c.780
 N  E  K  T  Q  E  H  F  T  H  N  T  V  R  G  C  S  Y  F  Y         p.260

    | 07     .         .         .         .         .         .    g.269266
 AG | TTACCCGGCTGTATGTGAATTCTTACAGCACAATAACTTGTTATCTATACTCCGAGCC    c.840
 S  |  Y  P  A  V  C  E  F  L  Q  H  N  N  L  L  S  I  L  R  A      p.280

          .         . | 08       .         .         .         .    g.271885
 CACGAAGCCCAAGATGCAGG | GTACCGCATGTACAGGAAAAGCCAAACAACAGGCTTCCCT    c.900
 H  E  A  Q  D  A  G  |  Y  R  M  Y  R  K  S  Q  T  T  G  F  P      p.300

          .         .         .         .         .      | 09  .    g.289119
 TCTCTAATTACAATTTTTTCAGCACCAAATTACTTAGATGTATACAATAACAAAG | CTGCA    c.960
 S  L  I  T  I  F  S  A  P  N  Y  L  D  V  Y  N  N  K  A |   A      p.320

          .         .         .         .         .         .       g.289179
 GTATTGAAGTATGAGAACAATGTTATGAATATCAGGCAATTCAACTGTTCTCCTCATCCA       c.1020
 V  L  K  Y  E  N  N  V  M  N  I  R  Q  F  N  C  S  P  H  P         p.340

          .         .         .         .         .         .       g.289239
 TACTGGCTTCCAAATTTCATGGATGTTTTTACTTGGTCCCTTCCATTTGTTGGGGAAAAA       c.1080
 Y  W  L  P  N  F  M  D  V  F  T  W  S  L  P  F  V  G  E  K         p.360

   | 10      .         .         .         .         .         .    g.291369
 G | TGACTGAGATGCTGGTAAATGTCCTCAACATCTGCTCAGATGATGAACTAGGGTCAGAA    c.1140
 V |   T  E  M  L  V  N  V  L  N  I  C  S  D  D  E  L  G  S  E      p.380

          .       | 11 .         .         .         .         .    g.311949
 GAAGATGGATTTGATG | GTGCAACAGCTGCAGCCCGGAAAGAGGTGATAAGGAACAAGATC    c.1200
 E  D  G  F  D  G |   A  T  A  A  A  R  K  E  V  I  R  N  K  I      p.400

          .         .         .         .  | 12      .         .    g.320126
 CGAGCAATAGGCAAAATGGCCAGAGTGTTCTCAGTGCTCAG | AGAAGAGAGTGAGAGTGTG    c.1260
 R  A  I  G  K  M  A  R  V  F  S  V  L  R  |  E  E  S  E  S  V      p.420

          .         .         .         .         .         .       g.320186
 CTGACGCTGAAAGGCTTGACCCCAACTGGCATGCTCCCCAGCGGAGTACTTTCTGGAGGG       c.1320
 L  T  L  K  G  L  T  P  T  G  M  L  P  S  G  V  L  S  G  G         p.440

          .          | 13        .         .          | 14        . g.326421
 AAGCAAACCCTGCAAAGCG | CTACTGTTGAGGCTATTGAGGCTGATGAAG | CTATCAAAGGA c.1380
 K  Q  T  L  Q  S  A |   T  V  E  A  I  E  A  D  E  A |   I  K  G   p.460

          .         .         .         .         .         .       g.326481
 TTTTCACCACAACATAAGATCACTAGCTTCGAGGAAGCCAAGGGCTTAGACCGAATTAAT       c.1440
 F  S  P  Q  H  K  I  T  S  F  E  E  A  K  G  L  D  R  I  N         p.480

          .         .         .         .         .         .       g.326541
 GAGAGGATGCCGCCTCGCAGAGATGCCATGCCCTCTGACGCCAACCTTAACTCCATCAAC       c.1500
 E  R  M  P  P  R  R  D  A  M  P  S  D  A  N  L  N  S  I  N         p.500

          .         .         .         .         .         .       g.326601
 AAGGCTCTCACCTCAGAGACTAACGGCACGGACAGCAATGGCAGTAATAGCAGCAATATT       c.1560
 K  A  L  T  S  E  T  N  G  T  D  S  N  G  S  N  S  S  N  I         p.520

                                                                    g.326607
 CAGTGA                                                             c.1566
 Q  X                                                               p.521

          .         .         .         .         .         .       g.326667
 ccacttcctgttcactttttttttttttttttttttttttttttgagctgcggggcatga       c.*60

          .         .         .         .         .         .       g.326727
 tggggattgctgcatatcagcagttggatgttcttgcctctgacagtagcttatttgctc       c.*120

          .         .         .         .         .         .       g.326787
 tgggggccaggaattggattcagtttacactatcattaaaaaagagggagagagataata       c.*180

          .         .         .         .         .         .       g.326847
 aactatattttggtggggatggtgattaaacacctcttttgggtatgccttttaaaaatg       c.*240

          .         .         .         .         .         .       g.326907
 cttatagagaaaaaaaattttaaaaagaaagctaatgctagtatatactgcaatgttagg       c.*300

          .         .         .         .         .         .       g.326967
 ggaatgaacatgttttcctactgcattggggacttctagataggttaatgaaaggccttt       c.*360

          .         .         .         .         .         .       g.327027
 tattctgttactggacatgaaaactttgtctaatttcttactctattgtacgtttacagt       c.*420

          .         .         .         .         .         .       g.327087
 cgcagcactaaaaatggatgacatcaaacatttttaacaaaatgatgtacaaactaagga       c.*480

          .         .         .         .         .         .       g.327147
 ctatttattgataatgttttgctactcttgtcagacaatggctataaactgaattaggca       c.*540

          .         .         .         .         .         .       g.327207
 gtcttaaaaaaaaaaaaaaacagaaaaagaaaaaaaagaacgttgcaaatttgttaaaat       c.*600

          .         .         .         .         .         .       g.327267
 gccaaaaaggacagtttaattttgtacagattatgcttacctcaggtttctttagtgtgc       c.*660

          .         .         .         .         .         .       g.327327
 ttgaatgcccttctttccatataacacttatcttcttcttaattcggcaatggaatatct       c.*720

          .         .         .         .         .         .       g.327387
 tttaagttttaaaaaaactggaataattatatctatcttttttgccgtttatatttaggg       c.*780

          .         .         .         .         .         .       g.327447
 gtttttgttgataaaatcaagtcttggttgtggcttgctgaattaaatatttatgagtgg       c.*840

          .         .         .         .         .         .       g.327507
 tgcatttttaagtatagtgaacaagacaccatattaagtacagtgataaagcatctatat       c.*900

          .         .         .         .         .         .       g.327567
 tctgtaaaaaaaaaaaaaatctgcctatgcatgttttttaagaaaaaaaaaatggctgta       c.*960

          .         .         .         .         .         .       g.327627
 tcggcctgtatgggactgtaatgcgcttagtggtctgacatatactggaaatgtatgtat       c.*1020

          .         .         .         .         .         .       g.327687
 actggcgtactttatattctctaaaatgcttaatgcctttgaaattttgtaatcaaaaaa       c.*1080

          .         .         .         .         .         .       g.327747
 aagctttgaaaaaatctaaaggggagagtattctttaaagtttttaacataagcttgtca       c.*1140

          .         .         .         .         .         .       g.327807
 atgcacatgtagatggttagcatgtttagcaaaccttgtgaaattataataagtttgtag       c.*1200

          .         .         .         .         .         .       g.327867
 ttacatgtgaaactctaaatgcatggcaactgttaatgtcataacagtttagttattttg       c.*1260

          .         .         .         .         .         .       g.327927
 ttctgttctgtcatgtgccacaaaatatgtacttttttcacttttttccctttgtatatc       c.*1320

          .         .         .         .         .         .       g.327987
 agttacgggttacaactggttcattctgaaaacaacaacaacaaaagtccattcatattt       c.*1380

          .         .         .         .         .         .       g.328047
 tttaacaattgtataagtgcccaagtaattcactacagcctaaagccttgcctttgtaat       c.*1440

          .         .         .         .         .         .       g.328107
 ttgacttctgacatgttggcaatcaaagcatgcacttgtaacaatgaaaaagaaaaagca       c.*1500

          .         .         .         .         .         .       g.328167
 ttttatattactactcaataaaatgtgcatgaacttacagaattctcatccttccactga       c.*1560

          .         .         .         .         .         .       g.328227
 gtccgctgaagggatttatgtgcacaaccaccatgtgtcttctaggtgctggcccaccac       c.*1620

          .         .         .         .         .         .       g.328287
 cacacatcacaggctgatttccacaggcttcttcctaggggcctcgtgatctgaggggtg       c.*1680

          .         .         .         .         .         .       g.328347
 gtgcctacttccactgtaagaaagaatcttggtggatttgtgtctcaaatcagataagag       c.*1740

          .         .         .         .         .         .       g.328407
 aagcctgtttaaagagcagatgccatcttctggcttcctcaaggagccagttaaaaaacc       c.*1800

          .         .         .         .         .         .       g.328467
 agagcattcctttttattgaaaaataaaattaatttgttatcaggttgtttcagttgtat       c.*1860

          .         .         .         .         .         .       g.328527
 tggatgccctatctatctgctaaagcaaaaagtactaggctactaagtgcattttcatca       c.*1920

          .         .         .         .         .         .       g.328587
 cagaaaagagttgcatttgtattaacaagaaatttgtatacccacgcttcagctactatc       c.*1980

          .         .         .         .         .         .       g.328647
 taatcatcacccgaagatttaagatacaccaaatttcagtttgtttgtaacattgttcat       c.*2040

          .         .         .         .         .         .       g.328707
 ctttagtgcactttgttttatataataaagtatgcctgttatattaaataataagaatat       c.*2100

          .         .         .         .         .         .       g.328767
 ggcaattagcgatatagcatacccaaacaaagatgttctcgatacagtctggcaaagact       c.*2160

          .         .         .         .         .         .       g.328827
 atcccaaggttattttaatgaattcagacattttttcctgtggatatttctccatcctaa       c.*2220

          .         .         .         .         .         .       g.328887
 aaaaagtggcaaccaaggaaaatatttagatgcaacttactagagtgatgatgtgaaaga       c.*2280

          .         .         .         .         .         .       g.328947
 aatggtgattctggtatcatggtgtttattttctttcttataactgcagagaaaatatcc       c.*2340

          .         .         .         .         .         .       g.329007
 tgactaaaaaaaattcatttttttggattcctttcttttacaaattgtgctgaggcaact       c.*2400

          .         .         .                                     g.329042
 atggcatagaaataaacatttgacattaaaataag                                c.*2435

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein phosphatase 3, catalytic subunit, alpha isozyme protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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