palmitoyl-protein thioesterase 1 (PPT1) - coding DNA reference sequence

(used for variant description)

(last modified July 12, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_000310.3 in the PPT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering PPT1 transcript NM_000310.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         ttattttgattcaccgcagagggcggtctacgagagcgcagagccccactcg       c.-181

 .         .         .         .         .         .                g.5112
 gccagcggggtctggcgggggacctgtcgcgctgaaagctccagggtagggccgacgccc       c.-121

 .         .         .         .         .         .                g.5172
 atcaggctgggcatccgttcgggatgcgcaggttgcgatctgcaaccggcggcgccacgc       c.-61

 .         .         .         .         .         .                g.5232
 ccaggcgggcggagcgcggttcccggagtctcgcgcccgcggtcatgtgacacagcgaag       c.-1

          .         .         .         .         .         .       g.5292
 ATGGCGTCGCCCGGCTGCCTGTGGCTCTTGGCTGTGGCTCTCCTGCCATGGACCTGCGCT       c.60
 M  A  S  P  G  C  L  W  L  L  A  V  A  L  L  P  W  T  C  A         p.20

          .         .         .         .         .         .       g.5352
 TCTCGGGCGCTGCAGCATCTGGACCCGCCGGCGCCGCTGCCGTTGGTGATCTGGCATGGG       c.120
 S  R  A  L  Q  H  L  D  P  P  A  P  L  P  L  V  I  W  H  G         p.40

      | 02   .         .         .         .         .         .    g.10019
 ATGG | GAGACAGCTGTTGCAATCCCTTAAGCATGGGTGCTATTAAAAAAATGGTGGAGAAG    c.180
 M  G |   D  S  C  C  N  P  L  S  M  G  A  I  K  K  M  V  E  K      p.60

          .         .         .         .         .     | 03   .    g.10304
 AAAATACCTGGAATTTACGTCTTATCTTTAGAGATTGGGAAGACCCTGATGGAG | GACGTG    c.240
 K  I  P  G  I  Y  V  L  S  L  E  I  G  K  T  L  M  E   | D  V      p.80

          .         .         .         .         .         .       g.10364
 GAGAACAGCTTCTTCTTGAATGTCAATTCCCAAGTAACAACAGTGTGTCAGGCACTTGCT       c.300
 E  N  S  F  F  L  N  V  N  S  Q  V  T  T  V  C  Q  A  L  A         p.100

          .         .         .         .         .         .       g.10424
 AAGGATCCTAAATTGCAGCAAGGCTACAATGCTATGGGATTCTCCCAGGGAGGCCAATTT       c.360
 K  D  P  K  L  Q  Q  G  Y  N  A  M  G  F  S  Q  G  G  Q  F         p.120

    | 04     .         .         .         .         .         .    g.11129
 CT | GAGGGCAGTGGCTCAGAGATGCCCTTCACCTCCCATGATCAATCTGATCTCGGTTGGG    c.420
 L  |  R  A  V  A  Q  R  C  P  S  P  P  M  I  N  L  I  S  V  G      p.140

          .    | 05    .         .         .         .         .    g.13005
 GGACAACATCAAG | GTGTTTTTGGACTCCCTCGATGCCCAGGAGAGAGCTCTCACATCTGT    c.480
 G  Q  H  Q  G |   V  F  G  L  P  R  C  P  G  E  S  S  H  I  C      p.160

          .         .         .         .         .       | 06 .    g.21987
 GACTTCATCCGAAAAACACTGAATGCTGGGGCGTACTCCAAAGTTGTTCAGGAACG | CCTC    c.540
 D  F  I  R  K  T  L  N  A  G  A  Y  S  K  V  V  Q  E  R  |  L      p.180

          .         .         .         .         .         .       g.22047
 GTGCAAGCCGAATACTGGCATGACCCCATAAAGGAGGATGTGTATCGCAACCACAGCATC       c.600
 V  Q  A  E  Y  W  H  D  P  I  K  E  D  V  Y  R  N  H  S  I         p.200

          .         .        | 07.         .         .         .    g.23845
 TTCTTGGCAGATATAAATCAGGAGCGG | GGTATCAATGAGTCCTACAAGAAAAACCTGATG    c.660
 F  L  A  D  I  N  Q  E  R   | G  I  N  E  S  Y  K  K  N  L  M      p.220

          .         .         .         .         .         .       g.23905
 GCCCTGAAGAAGTTTGTGATGGTGAAATTCCTCAATGATTCCATTGTGGACCCTGTAGAT       c.720
 A  L  K  K  F  V  M  V  K  F  L  N  D  S  I  V  D  P  V  D         p.240

        | 08 .         .         .         .         .         .    g.25611
 TCGGAG | TGGTTTGGATTTTACAGAAGTGGCCAAGCCAAGGAAACCATTCCCTTACAGGAG    c.780
 S  E   | W  F  G  F  Y  R  S  G  Q  A  K  E  T  I  P  L  Q  E      p.260

          .         | 09         .         .         .         .    g.28329
 ACCTCCCTGTACACACAG | GACCGCCTGGGGCTAAAGGAAATGGACAATGCAGGACAGCTA    c.840
 T  S  L  Y  T  Q   | D  R  L  G  L  K  E  M  D  N  A  G  Q  L      p.280

          .         .         .         .         .         .       g.28389
 GTGTTTCTGGCTACAGAAGGGGACCATCTTCAGTTGTCTGAAGAATGGTTTTATGCCCAC       c.900
 V  F  L  A  T  E  G  D  H  L  Q  L  S  E  E  W  F  Y  A  H         p.300

          .         .                                               g.28410
 ATCATACCATTCCTTGGATGA                                              c.921
 I  I  P  F  L  G  X                                                p.306

          .         .         .         .         .         .       g.28470
 aacccgtatagttcacaatagagctcagggagcccctaactcttccaaaccacatgggag       c.*60

          .         .         .         .         .         .       g.28530
 acagtttccttcatgcccaagcctgagctcagatccagcttgcaactaatccttctatca       c.*120

          .         .         .         .         .         .       g.28590
 tctaacatgccctacttggaaagatctaagatctgaatcttatcctttgccatcttctgt       c.*180

          .         .         .         .         .         .       g.28650
 taccatatggtgttgaatgcaagtttaattaccatggagattgttttacaaacttttgat       c.*240

          .         .         .         .         .         .       g.28710
 gtggtcaagttcagttttagaaaagggagtctgttccagatcagtgccagaactgtgccc       c.*300

          .         .         .         .         .         .       g.28770
 aggcccaaaggagacaactaactaaagtagtgagatagattctaagggcaaacatttttc       c.*360

          .         .         .         .         .         .       g.28830
 caagtcttgccatatttcaagcaaagaggtgcccaggcctgaggtactcacataaatgct       c.*420

          .         .         .         .         .         .       g.28890
 ttgttttgctggtgatttaaccagtgcttggaaaaatcttgcttggctatttctgcatca       c.*480

          .         .         .         .         .         .       g.28950
 tttcttaaggctgccttcctctctcagtacgttgccctctgtgctatcatcttatcatca       c.*540

          .         .         .         .         .         .       g.29010
 attattagacaaatcccactggcctacagtcttgcttctgcagcacccactttgtctcct       c.*600

          .         .         .         .         .         .       g.29070
 caggtagtgatgaattagttgctgtcacaaaaggagggaagtagcacccaaattaagttg       c.*660

          .         .         .         .         .         .       g.29130
 cttaagagaggaaatgtacatcttgtataacttagggagcgaagaaaatgtaggcgcgaa       c.*720

          .         .         .         .         .         .       g.29190
 agtgaaaagtgaggcagctagttcttcctattccattctcgaccaacctgccctttctta       c.*780

          .         .         .         .         .         .       g.29250
 atatgactagtggtcttgatgctagagtcaacttactctgttgctggctttagcagagaa       c.*840

          .         .         .         .         .         .       g.29310
 taggaggaaccatatgaaaaagatcaggctttctgacttccatccccaaaacacatttac       c.*900

          .         .         .         .         .         .       g.29370
 cagcatactccaaactgtttctgatgtgttccatgagaaaaggattgtttgctcaaaaag       c.*960

          .         .         .         .         .         .       g.29430
 cttggaaaatactacacactccctttctccttctggagatcaacccacattagagtgtct       c.*1020

          .         .         .         .         .         .       g.29490
 aaggactcctgagaattcctgttacagtaaacaaaactaacgtaatctaccatttcctac       c.*1080

          .         .         .         .         .         .       g.29550
 actatttgagcatggaaatcatagtccccactctgtgaaaacttaacgctttttggaaga       c.*1140

          .         .         .         .         .         .       g.29610
 catttctgtagcatgtcagtttggagaaatgatgagctacgccttgatgaaagaaccgtg       c.*1200

          .         .         .         .         .         .       g.29670
 ttggtgctgctaagtttagccattatggtttttcctttctctctcttaagccttattctt       c.*1260

          .         .         .         .         .         .       g.29730
 caactaaaagatgaggattaagagcaagaagttgggggggatgtgaaaataattttatga       c.*1320

          .         .         .                                     g.29761
 ggttgtctaaaataaagagtagtttcttatc                                    c.*1351

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Palmitoyl-protein thioesterase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 06
©2004-2013 Leiden University Medical Center