PR domain containing 13 (PRDM13) - coding DNA reference sequence

(used for variant description)

(last modified January 28, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_021620.3 in the PRDM13 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering PRDM13 transcript NM_021620.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5021
                                        ccatgtgaccctctcgggtgg       c.-241

 .         .         .         .         .         .                g.5081
 gactctgcagctgcttcgcagcgcaactctctcaccaaactccgcgcccttgcgctagcg       c.-181

 .         .         .         .         .         .                g.5141
 gtgccaaaaggctcccgccccgattgaaaaggcgcagtgcatgcccgcccgcgtcactcc       c.-121

 .         .         .         .         .         .                g.5201
 gcgggcggaggacgcacgtcggggcgcggctctctggctagcgcgcagctccagctctgt       c.-61

 .         .         .         .         .         .                g.5261
 cactcgcgcccttccaaggacctggagcacccgagcgcctgcctggtggcggcggcaaca       c.-1

          .         .         .         .         .         .       g.5321
 ATGCACGGAGCCGCCAGAGCGCCAGCCACCAGCGTGAGTGCCGACTGCTGCATCCCGGCC       c.60
 M  H  G  A  A  R  A  P  A  T  S  V  S  A  D  C  C  I  P  A         p.20

          .         .         .         .         .         .       g.5381
 GGCTTGCGCCTCGGACCGGTGCCTGGTACCTTCAAGCTGGGCAAGTACCTGTCAGACCGC       c.120
 G  L  R  L  G  P  V  P  G  T  F  K  L  G  K  Y  L  S  D  R         p.40

          .         .     | 02   .         .         .         .    g.7003
 AGGGAGCCCGGGCCTAAGAAAAAG | GTGCGCATGGTGAGAGGGGAGCTGGTGGACGAGTCG    c.180
 R  E  P  G  P  K  K  K   | V  R  M  V  R  G  E  L  V  D  E  S      p.60

          .         .         .         .         .         .       g.7063
 GGGGGCTCCCCTCTGGAGTGGATAGGGTTAATCCGGGCAGCCAGAAACTCCCAGGAACAG       c.240
 G  G  S  P  L  E  W  I  G  L  I  R  A  A  R  N  S  Q  E  Q         p.80

          .         .         .       | 03 .         .         .    g.7437
 ACTCTGGAAGCTATTGCAGACTTACCCGGAGGACAG | ATCTTCTACCGAGCATTGCGAGAC    c.300
 T  L  E  A  I  A  D  L  P  G  G  Q   | I  F  Y  R  A  L  R  D      p.100

          .         .         .         .         .         .       g.7497
 GTCCAGCCAGGGGAGGAGCTGACAGTGTGGTATTCTAACTCCTTGGCTCAGTGGTTCGAC       c.360
 V  Q  P  G  E  E  L  T  V  W  Y  S  N  S  L  A  Q  W  F  D         p.120

          .         .         .        | 04.         .         .    g.11282
 ATCCCCACCACAGCGACTCCGACTCACGACGAGAAAG | GGGAGGAGCGCTACATCTGCTGG    c.420
 I  P  T  T  A  T  P  T  H  D  E  K  G |   E  E  R  Y  I  C  W      p.140

          .         .         .         .         .         .       g.11342
 TACTGCTGGAGGACGTTTAGATACCCCAACAGCCTTAAGGCACACCTGCGTTTCCACTGC       c.480
 Y  C  W  R  T  F  R  Y  P  N  S  L  K  A  H  L  R  F  H  C         p.160

          .         .         .         .         .         .       g.11402
 GTGTTCAGCGGCGGTGGAGGCGGCGCCTTCCTGCACCACGAACACGCGGCTCGCCAAGGC       c.540
 V  F  S  G  G  G  G  G  A  F  L  H  H  E  H  A  A  R  Q  G         p.180

          .         .         .         .         .         .       g.11462
 GCCGTCCCAGCGGCTGATGGCCTCGGTCTCTCCCCAAAACCCCCGGCGCCCGATTTCGCC       c.600
 A  V  P  A  A  D  G  L  G  L  S  P  K  P  P  A  P  D  F  A         p.200

          .         .         .         .         .         .       g.11522
 GCGCCTTCCCAGGCAGGAACTTTGCGACCCCACCCCCTGGGCCCGCCACCAGTTCAGGCC       c.660
 A  P  S  Q  A  G  T  L  R  P  H  P  L  G  P  P  P  V  Q  A         p.220

          .         .         .         .         .         .       g.11582
 TGCGGTGCGCGGGAGGGCATCAAGCGCGAGGCCTCTTCCGCGCCCTCGGCCACCTCGCCG       c.720
 C  G  A  R  E  G  I  K  R  E  A  S  S  A  P  S  A  T  S  P         p.240

          .         .         .         .         .         .       g.11642
 ACCCCAGGCAAGTGGGGGCAGCCCAAGAAGGGCAAGGAGCAGCTGGACCGTGCCCTGGAC       c.780
 T  P  G  K  W  G  Q  P  K  K  G  K  E  Q  L  D  R  A  L  D         p.260

          .         .         .         .         .         .       g.11702
 ATGAGCGGAGCCGCCCGAGGACAAGGGCACTTCCTCGGCATCGTGGGCGGCTCCTCGGCG       c.840
 M  S  G  A  A  R  G  Q  G  H  F  L  G  I  V  G  G  S  S  A         p.280

          .         .         .         .         .         .       g.11762
 GGGGTCGGCAGCCTGGCTTTCTACCCCGGCGTGCGCTCAGCTTTCAAGCCCGCCGGCCTA       c.900
 G  V  G  S  L  A  F  Y  P  G  V  R  S  A  F  K  P  A  G  L         p.300

          .         .         .         .         .         .       g.11822
 GCGAGGGCGGCGGCGGCCGCTCACGGCGACCCCTACCGGGAGGAGAGCAGCAGCAAGCAA       c.960
 A  R  A  A  A  A  A  H  G  D  P  Y  R  E  E  S  S  S  K  Q         p.320

          .         .         .         .         .         .       g.11882
 GGAGCCGGCCTCGCTTTGGGCAGGCTGCTGGGCGGGGGCCGGGCGTGCGGGCGCCCCGGG       c.1020
 G  A  G  L  A  L  G  R  L  L  G  G  G  R  A  C  G  R  P  G         p.340

          .         .         .         .         .         .       g.11942
 AGCGGGGAGAACTCGGCGGCGGGCGGCGCGGGTCACCACCATCACCACCACGCGCACCAC       c.1080
 S  G  E  N  S  A  A  G  G  A  G  H  H  H  H  H  H  A  H  H         p.360

          .         .         .         .         .         .       g.12002
 CACCACCATCCCAAGTGCCTGCTCGCTGGGGACCCGCCGCCGCCGCCGCCGCCTGGCCTG       c.1140
 H  H  H  P  K  C  L  L  A  G  D  P  P  P  P  P  P  P  G  L         p.380

          .         .         .         .         .         .       g.12062
 CCCTGCTCTGGGGCCCTGCGCGGCTTCCCTCTGCTCTCCGTCCCCCCGGAAGAGGCGTCC       c.1200
 P  C  S  G  A  L  R  G  F  P  L  L  S  V  P  P  E  E  A  S         p.400

          .         .         .         .         .         .       g.12122
 GCCTTCAAGCACGTGGAGCGCGCCCCGCCCGCAGCCGCCGCGCTGCCAGGAGCGCGTTAT       c.1260
 A  F  K  H  V  E  R  A  P  P  A  A  A  A  L  P  G  A  R  Y         p.420

          .         .         .         .         .         .       g.12182
 GCGCAGCTGCCCCCTGCGCCGGGGTTGCCCCTCGAGCGCTGCGCGCTGCCGCCCCTCGAC       c.1320
 A  Q  L  P  P  A  P  G  L  P  L  E  R  C  A  L  P  P  L  D         p.440

          .         .         .         .         .         .       g.12242
 CCGGGCGGTCTCAAAGCCTATCCGGGTGGTGAGTGCAGCCACCTGCCCGCCGTCATGCCG       c.1380
 P  G  G  L  K  A  Y  P  G  G  E  C  S  H  L  P  A  V  M  P         p.460

          .         .         .         .         .         .       g.12302
 GCCTTTACAGTCTACAACGGGGAGCTGCTCTACGGCTCACCGGCCACCACCGCTTATTAC       c.1440
 A  F  T  V  Y  N  G  E  L  L  Y  G  S  P  A  T  T  A  Y  Y         p.480

          .         .         .         .         .         .       g.12362
 CCGCTCAAATTGCACTTCGGCGGGCTGCTGAAGTATCCGGAGTCCATCTCCTACTTCAGC       c.1500
 P  L  K  L  H  F  G  G  L  L  K  Y  P  E  S  I  S  Y  F  S         p.500

          .         .         .         .         .         .       g.12422
 GGGCCTGCAGCGGCCGCCCTAAGCCCCGCCGAGCTGGGGTCGCTGGCCAGCATCGACCGA       c.1560
 G  P  A  A  A  A  L  S  P  A  E  L  G  S  L  A  S  I  D  R         p.520

          .         .         .         .         .         .       g.12482
 GAGATCGCCATGCACAATCAGCAGCTGTCCGAGATGGCTGCCGGGAAGGGTCGCGGACGC       c.1620
 E  I  A  M  H  N  Q  Q  L  S  E  M  A  A  G  K  G  R  G  R         p.540

          .         .         .         .         .         .       g.12542
 CTGGACTCGGGGACGTTGCCACCGGCCGTCGCGGCGGCGGGAGGCACCGGGGGCGGCGGC       c.1680
 L  D  S  G  T  L  P  P  A  V  A  A  A  G  G  T  G  G  G  G         p.560

          .         .         .         .         .         .       g.12602
 AGCGGAGGCAGCGGCGCAGGTAAGCCCAAGACCGGCCACCTGTGCCTCTACTGTGGCAAG       c.1740
 S  G  G  S  G  A  G  K  P  K  T  G  H  L  C  L  Y  C  G  K         p.580

          .         .         .         .         .         .       g.12662
 CTGTACTCGCGCAAGTATGGGCTCAAGATCCACATGCGGACGCACACGGGCTACAAGCCA       c.1800
 L  Y  S  R  K  Y  G  L  K  I  H  M  R  T  H  T  G  Y  K  P         p.600

          .         .         .         .         .         .       g.12722
 CTCAAGTGCAAAGTCTGTCTGCGGCCCTTCGGCGACCCCAGCAATCTCAACAAGCACATC       c.1860
 L  K  C  K  V  C  L  R  P  F  G  D  P  S  N  L  N  K  H  I         p.620

          .         .         .         .         .         .       g.12782
 CGGCTGCACGCCGAGGGCAATACGCCCTACCGCTGCGAGTTCTGCGGCAAGGTACTTGTG       c.1920
 R  L  H  A  E  G  N  T  P  Y  R  C  E  F  C  G  K  V  L  V         p.640

          .         .         .         .         .         .       g.12842
 CGCCGCCGGGACCTGGAGCGACATGTCAAGTCCCGCCACCCTGGCCAGAGTCTGCTCGCC       c.1980
 R  R  R  D  L  E  R  H  V  K  S  R  H  P  G  Q  S  L  L  A         p.660

          .         .         .         .         .         .       g.12902
 AAAGCGGGCGACGGCCCGGGTGCCGAGCCCGGCTATCCCCCGGAGCCTGGGGATCCCAAG       c.2040
 K  A  G  D  G  P  G  A  E  P  G  Y  P  P  E  P  G  D  P  K         p.680

          .         .         .         .         .         .       g.12962
 AGCGACGACAGTGACGTGGACGTCTGCTTCACAGACGACCAGAGCGACCCCGAGGTTGGG       c.2100
 S  D  D  S  D  V  D  V  C  F  T  D  D  Q  S  D  P  E  V  G         p.700

          .         .                                               g.12986
 GGCGGCGGGGAGCGCGACTTGTAA                                           c.2124
 G  G  G  E  R  D  L  X                                             p.707

          .         .         .         .         .         .       g.13046
 cgagtcttcccgggaaggggcggggtgaggacagagaggagtcgagggtttattctcgca       c.*60

          .         .         .         .         .         .       g.13106
 gtagaggaactcctggtggtgggaagagggacccaatggacaaaaccgtttttgtttttg       c.*120

          .         .         .         .         .         .       g.13166
 agagggcgccagatttgaaacagtgagaggtcccacatctggtgctgaaactcagagcaa       c.*180

          .         .         .         .         .         .       g.13226
 cagttcagaggtggcgtaaatctggccacctggagagctcgagtgccaccagtacctccg       c.*240

          .         .         .         .         .         .       g.13286
 caccccgggcctctggacttcttggatgagctcaccctgaaccgcccaggcggtctgctc       c.*300

          .         .         .         .         .         .       g.13346
 ttggtgttcagaatcacatcaatgcgaacgtcacagcgccttcgagggcgcagattttaa       c.*360

          .         .         .         .         .         .       g.13406
 ctgccacgtatttttaagttgtacttttctgtggaggaaattgtgccttttgaaacgacg       c.*420

          .         .         .         .         .         .       g.13466
 ttttgtgtgtgtatttcacgttagcatttcattgcataggcaaaacactagtcacaattg       c.*480

          .         .         .         .         .         .       g.13526
 ggtagatgtgacatccatatacttgtttacattttatctgttctcatgtcaaagactact       c.*540

          .         .         .         .         .         .       g.13586
 ccttgccccattgaatatatagtggtagcaggtgtacaaattggtcaagttgcaattatt       c.*600

          .         .         .         .         .         .       g.13646
 tatgagaaaataatgataaatgtaaaatatctaaagcatgaatctaagagcacgcaatat       c.*660

          .         .         .         .         .         .       g.13706
 ataattttaaagaaaatattctatttggtagaatacaaatgtggtgtgtgttgttttata       c.*720

          .         .         .         .         .         .       g.13766
 atgactgctgtacagtgggtatagtattttggttttggttccagattgtgcaatctttaa       c.*780

          .         .         .                                     g.13805
 gaaaaataaagatacaaacgagagttttgttcacttagt                            c.*819

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The PR domain containing 13 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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