perforin 1 (pore forming protein) (PRF1) - coding DNA reference sequence

(used for variant description)

(last modified August 15, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_005041.4 in the PRF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009615.1, covering PRF1 transcript NM_005041.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              gaagtgatgtgagtg       c.-121

 .         .         .         .         .         .                g.5075
 gtggctggtgcaaggagccacagtgggctgcctggggggctgatgccaccattccaggag       c.-61

 .         .         .         .         .         .      | 02      g.6873
 cctcggtgaagagaggatatccatctgtgtagccgcttctctatacgggattccag | ctcc    c.-1

          .         .         .         .         .         .       g.6933
 ATGGCAGCCCGTCTGCTCCTCCTGGGCATCCTTCTCCTGCTGCTGCCCCTGCCCGTCCCT       c.60
 M  A  A  R  L  L  L  L  G  I  L  L  L  L  L  P  L  P  V  P         p.20

          .         .         .         .         .         .       g.6993
 GCCCCGTGCCACACAGCCGCACGCTCAGAGTGCAAGCGCAGCCACAAGTTCGTGCCTGGT       c.120
 A  P  C  H  T  A  A  R  S  E  C  K  R  S  H  K  F  V  P  G         p.40

          .         .         .         .         .         .       g.7053
 GCATGGCTGGCCGGGGAGGGTGTGGACGTGACCAGCCTCCGCCGCTCGGGCTCCTTCCCA       c.180
 A  W  L  A  G  E  G  V  D  V  T  S  L  R  R  S  G  S  F  P         p.60

          .         .         .         .         .         .       g.7113
 GTGGACACACAAAGGTTCCTGCGGCCCGACGGCACCTGCACCCTCTGTGAAAATGCCCTA       c.240
 V  D  T  Q  R  F  L  R  P  D  G  T  C  T  L  C  E  N  A  L         p.80

          .         .         .         .         .         .       g.7173
 CAGGAGGGCACCCTCCAGCGCCTGCCTCTGGCGCTCACCAACTGGCGGGCCCAGGGCTCT       c.300
 Q  E  G  T  L  Q  R  L  P  L  A  L  T  N  W  R  A  Q  G  S         p.100

          .         .         .         .         .         .       g.7233
 GGCTGCCAGCGCCATGTAACCAGGGCCAAAGTCAGCTCCACTGAAGCTGTGGCCCGGGAT       c.360
 G  C  Q  R  H  V  T  R  A  K  V  S  S  T  E  A  V  A  R  D         p.120

          .         .         .         .         .         .       g.7293
 GCGGCTCGTAGCATCCGCAACGACTGGAAGGTCGGGCTGGACGTGACTCCTAAGCCCACC       c.420
 A  A  R  S  I  R  N  D  W  K  V  G  L  D  V  T  P  K  P  T         p.140

          .         .         .         .         .         .       g.7353
 AGCAATGTGCATGTGTCTGTGGCCGGCTCACACTCACAGGCAGCCAACTTTGCAGCCCAG       c.480
 S  N  V  H  V  S  V  A  G  S  H  S  Q  A  A  N  F  A  A  Q         p.160

          .         .         .         .         .          | 03    g.8595
 AAGACCCACCAGGACCAGTACAGCTTCAGCACTGACACGGTGGAGTGCCGCTTCTACAG | T    c.540
 K  T  H  Q  D  Q  Y  S  F  S  T  D  T  V  E  C  R  F  Y  S  |      p.180

          .         .         .         .         .         .       g.8655
 TTCCATGTGGTACACACTCCCCCGCTGCACCCTGACTTCAAGAGGGCCCTCGGGGACCTG       c.600
 F  H  V  V  H  T  P  P  L  H  P  D  F  K  R  A  L  G  D  L         p.200

          .         .         .         .         .         .       g.8715
 CCCCACCACTTCAACGCCTCCACCCAGCCCGCCTACCTCAGGCTTATCTCCAACTACGGC       c.660
 P  H  H  F  N  A  S  T  Q  P  A  Y  L  R  L  I  S  N  Y  G         p.220

          .         .         .         .         .         .       g.8775
 ACCCACTTCATCCGGGCTGTGGAGCTGGGTGGCCGCATATCGGCCCTCACTGCCCTGCGC       c.720
 T  H  F  I  R  A  V  E  L  G  G  R  I  S  A  L  T  A  L  R         p.240

          .         .         .         .         .         .       g.8835
 ACCTGCGAGCTGGCCCTGGAAGGGCTCACGGACAACGAGGTGGAGGACTGCCTGACTGTC       c.780
 T  C  E  L  A  L  E  G  L  T  D  N  E  V  E  D  C  L  T  V         p.260

          .         .         .         .         .         .       g.8895
 GAGGCCCAGGTCAACATAGGCATCCACGGCAGCATCTCTGCCGAAGCCAAGGCCTGTGAG       c.840
 E  A  Q  V  N  I  G  I  H  G  S  I  S  A  E  A  K  A  C  E         p.280

          .         .         .         .         .         .       g.8955
 GAGAAGAAGAAGAAGCACAAGATGACGGCCTCCTTCCACCAAACCTACCGGGAGCGCCAC       c.900
 E  K  K  K  K  H  K  M  T  A  S  F  H  Q  T  Y  R  E  R  H         p.300

          .         .         .         .         .         .       g.9015
 TCGGAAGTGGTTGGCGGCCATCACACCTCCATTAACGACCTGCTGTTCGGGATCCAGGCC       c.960
 S  E  V  V  G  G  H  H  T  S  I  N  D  L  L  F  G  I  Q  A         p.320

          .         .         .         .         .         .       g.9075
 GGGCCCGAGCAGTACTCAGCCTGGGTAAACTCGCTGCCCGGCAGCCCTGGCCTGGTGGAC       c.1020
 G  P  E  Q  Y  S  A  W  V  N  S  L  P  G  S  P  G  L  V  D         p.340

          .         .         .         .         .         .       g.9135
 TACACCCTGGAACCCCTGCACGTGCTGCTGGACAGCCAGGACCCGCGGCGGGAGGCACTG       c.1080
 Y  T  L  E  P  L  H  V  L  L  D  S  Q  D  P  R  R  E  A  L         p.360

          .         .         .         .         .         .       g.9195
 AGGAGGGCCCTGAGTCAGTACCTGACGGACAGGGCTCGCTGGAGGGACTGCAGCCGGCCG       c.1140
 R  R  A  L  S  Q  Y  L  T  D  R  A  R  W  R  D  C  S  R  P         p.380

          .         .         .         .         .         .       g.9255
 TGCCCACCAGGGCGGCAGAAGAGCCCCCGAGACCCATGCCAGTGTGTGTGCCATGGCTCA       c.1200
 C  P  P  G  R  Q  K  S  P  R  D  P  C  Q  C  V  C  H  G  S         p.400

          .         .         .         .         .         .       g.9315
 GCGGTCACCACCCAGGACTGCTGCCCTCGGCAGAGGGGCCTGGCCCAGCTGGAGGTGACC       c.1260
 A  V  T  T  Q  D  C  C  P  R  Q  R  G  L  A  Q  L  E  V  T         p.420

          .         .         .         .         .         .       g.9375
 TTCATCCAAGCATGGGGCCTGTGGGGGGACTGGTTCACTGCCACGGATGCCTATGTGAAG       c.1320
 F  I  Q  A  W  G  L  W  G  D  W  F  T  A  T  D  A  Y  V  K         p.440

          .         .         .         .         .         .       g.9435
 CTCTTCTTTGGTGGCCAGGAGCTGAGGACGAGCACCGTGTGGGACAATAACAACCCCATC       c.1380
 L  F  F  G  G  Q  E  L  R  T  S  T  V  W  D  N  N  N  P  I         p.460

          .         .         .         .         .         .       g.9495
 TGGTCAGTGCGGCTGGATTTTGGGGATGTGCTCCTGGCCACAGGGGGGCCCCTGAGGTTG       c.1440
 W  S  V  R  L  D  F  G  D  V  L  L  A  T  G  G  P  L  R  L         p.480

          .         .         .         .         .         .       g.9555
 CAGGTCTGGGATCAGGACTCTGGCAGGGACGATGACCTCCTTGGCACCTGTGATCAGGCT       c.1500
 Q  V  W  D  Q  D  S  G  R  D  D  D  L  L  G  T  C  D  Q  A         p.500

          .         .         .         .         .         .       g.9615
 CCCAAGTCTGGTTCCCATGAGGTGAGATGCAACCTGAATCATGGCCACCTAAAATTCCGC       c.1560
 P  K  S  G  S  H  E  V  R  C  N  L  N  H  G  H  L  K  F  R         p.520

          .         .         .         .         .         .       g.9675
 TATCATGCCAGGTGCTTGCCCCACCTGGGAGGAGGCACCTGCCTGGACTATGTCCCCCAA       c.1620
 Y  H  A  R  C  L  P  H  L  G  G  G  T  C  L  D  Y  V  P  Q         p.540

          .         .         .         .                           g.9723
 ATGCTTCTGGGGGAGCCTCCAGGAAACCGGAGTGGGGCCGTGTGGTGA                   c.1668
 M  L  L  G  E  P  P  G  N  R  S  G  A  V  W  X                     p.555

          .         .         .         .         .         .       g.9783
 gaacagtgagcttggaaaggaccagtatgcttggactgaaggggttctcacagtgggagc       c.*60

          .         .         .         .         .         .       g.9843
 cagggctgtcttcgtattcccattagaccaagcttgtccaacccgaggcccgcatgcggc       c.*120

          .         .         .         .         .         .       g.9903
 ccaggatggctttgaatgcggcccaacgcaaattcgcaaactttcttaaaacattatgag       c.*180

          .         .         .         .         .         .       g.9963
 tttctttttgctattttttttttttttttagctcatcggctatcgttagtgctagtggat       c.*240

          .         .         .         .         .         .       g.10023
 tttacatgtggcccaacacaattcttcttccaacgtggcccagagaagccaaaagattgg       c.*300

          .         .         .         .         .         .       g.10083
 atacgcatcagacagatggaaaagggagattcagactgtttttcagggaggtggctgggt       c.*360

          .         .         .         .         .         .       g.10143
 ttacacgctaatcccgattcaccctgtccaaactgcctaagccctccgccattctcaagc       c.*420

          .         .         .         .         .         .       g.10203
 cctgcagtcacagctacacagatcacagcttcagccaggagctgggcagaaggccaagag       c.*480

          .         .         .         .         .         .       g.10263
 gctgttcccaccaggctgctcagggctggtcttttaggacccttcccttgagccctctat       c.*540

          .         .         .         .         .         .       g.10323
 ggtgtggcaaagccttcattgccttaactggagccccatcagctccagctgctctgtctt       c.*600

          .         .         .         .         .         .       g.10383
 ctttgcccacaatgctttgcccctgagacaaatggaggcctgtcctgacctgtctcacca       c.*660

          .         .         .         .                           g.10428
 tgtacatagcttgataaagggccaataaatatgatgttatggtga                      c.*705

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Perforin 1 (pore forming protein) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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