protein kinase D1 (PRKD1) - coding DNA reference sequence

(used for variant description)

(last modified May 22, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_002742.2 in the PRKD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000014.8, covering PRKD1 transcript NM_002742.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            c       c.-181

 .         .         .         .         .         .                g.5061
 cctcccctcccgatcctcatccccttgccctcccccagcccagggacttttccggaaagt       c.-121

 .         .         .         .         .         .                g.5121
 ttttattttccgtctgggctctcggagaaagaagctcctggctcagcggctgcaaaactt       c.-61

 .         .         .         .         .         .                g.5181
 tcctgctgccgcgccgccagcccccgccctccgctgcccggccctgcgccccgccgagcg       c.-1

          .         .         .         .         .         .       g.5241
 ATGAGCGCCCCTCCGGTCCTGCGGCCGCCCAGTCCGCTGCTGCCCGTGGCGGCGGCAGCT       c.60
 M  S  A  P  P  V  L  R  P  P  S  P  L  L  P  V  A  A  A  A         p.20

          .         .         .         .         .         .       g.5301
 GCCGCAGCGGCCGCCGCACTGGTCCCAGGGTCCGGGCCCGGGCCCGCGCCGTTCTTGGCT       c.120
 A  A  A  A  A  A  L  V  P  G  S  G  P  G  P  A  P  F  L  A         p.40

          .         .         .         .         .         .       g.5361
 CCTGTCGCGGCCCCGGTCGGGGGCATCTCGTTCCATCTGCAGATCGGCCTGAGCCGTGAG       c.180
 P  V  A  A  P  V  G  G  I  S  F  H  L  Q  I  G  L  S  R  E         p.60

          .         .         .         .         .         .       g.5421
 CCGGTGCTGCTGCTGCAGGACTCGTCCGGGGACTACAGCCTGGCGCACGTCCGCGAGATG       c.240
 P  V  L  L  L  Q  D  S  S  G  D  Y  S  L  A  H  V  R  E  M         p.80

          .         .     | 02   .         .         .         .    g.207055
 GCTTGCTCCATTGTCGACCAGAAG | TTCCCTGAATGTGGTTTCTACGGAATGTATGATAAG    c.300
 A  C  S  I  V  D  Q  K   | F  P  E  C  G  F  Y  G  M  Y  D  K      p.100

          .         .         .         .         .         .       g.207115
 ATCCTGCTTTTTCGCCATGACCCTACCTCTGAAAACATCCTTCAGCTGGTGAAAGCGGCC       c.360
 I  L  L  F  R  H  D  P  T  S  E  N  I  L  Q  L  V  K  A  A         p.120

          .         .         .         .    | 03    .         .    g.266502
 AGTGATATCCAGGAAGGCGATCTTATTGAAGTGGTCTTGTCAG | CTTCCGCCACCTTTGAA    c.420
 S  D  I  Q  E  G  D  L  I  E  V  V  L  S  A |   S  A  T  F  E      p.140

          .         .         .         .         .         .       g.266562
 GACTTTCAGATTCGTCCCCACGCTCTCTTTGTTCATTCATACAGAGCTCCAGCTTTCTGT       c.480
 D  F  Q  I  R  P  H  A  L  F  V  H  S  Y  R  A  P  A  F  C         p.160

          .         .         .         .         .      | 04  .    g.268839
 GATCACTGTGGAGAAATGCTGTGGGGGCTGGTACGTCAAGGTCTTAAATGTGAAG | GGTGT    c.540
 D  H  C  G  E  M  L  W  G  L  V  R  Q  G  L  K  C  E  G |   C      p.180

          .         .         .         .         .         .       g.268899
 GGTCTGAATTACCATAAGAGATGTGCATTTAAAATACCCAACAATTGCAGCGGTGTGAGG       c.600
 G  L  N  Y  H  K  R  C  A  F  K  I  P  N  N  C  S  G  V  R         p.200

          .         .         .         .         .         .       g.268959
 CGGAGAAGGCTCTCAAACGTTTCCCTCACTGGGGTCAGCACCATCCGCACATCATCTGCT       c.660
 R  R  R  L  S  N  V  S  L  T  G  V  S  T  I  R  T  S  S  A         p.220

          .         .         .       | 05 .         .         .    g.293813
 GAACTCTCTACAAGTGCCCCTGATGAGCCCCTTCTG | CAAAAATCACCATCAGAGTCGTTT    c.720
 E  L  S  T  S  A  P  D  E  P  L  L   | Q  K  S  P  S  E  S  F      p.240

          .         .         .         .         .         .       g.293873
 ATTGGTCGAGAGAAGAGGTCAAATTCTCAATCATACATTGGACGACCAATTCACCTTGAC       c.780
 I  G  R  E  K  R  S  N  S  Q  S  Y  I  G  R  P  I  H  L  D         p.260

          .         .         .         .         .         .       g.293933
 AAGATTTTGATGTCTAAAGTTAAAGTGCCGCACACATTTGTCATCCACTCCTACACCCGG       c.840
 K  I  L  M  S  K  V  K  V  P  H  T  F  V  I  H  S  Y  T  R         p.280

          .         .         .         .         .         .       g.293993
 CCCACAGTGTGCCAGTACTGCAAGAAGCTTCTGAAGGGGCTTTTCAGGCAGGGCTTGCAG       c.900
 P  T  V  C  Q  Y  C  K  K  L  L  K  G  L  F  R  Q  G  L  Q         p.300

         | 06.         .         .         .         .         .    g.294180
 TGCAAAG | ATTGCAGATTCAACTGCCATAAACGTTGTGCACCGAAAGTACCAAACAACTGC    c.960
 C  K  D |   C  R  F  N  C  H  K  R  C  A  P  K  V  P  N  N  C      p.320

          .         .      | 07  .         .         .         .    g.296234
 CTTGGCGAAGTGACCATTAATGGAG | ATTTGCTTAGCCCTGGGGCAGAGTCTGATGTGGTC    c.1020
 L  G  E  V  T  I  N  G  D |   L  L  S  P  G  A  E  S  D  V  V      p.340

          .         .         .         .         .         .       g.296294
 ATGGAAGAAGGGAGTGATGACAATGATAGTGAAAGGAACAGTGGGCTCATGGATGATATG       c.1080
 M  E  E  G  S  D  D  N  D  S  E  R  N  S  G  L  M  D  D  M         p.360

          .         .         .         .         .         .       g.296354
 GAAGAAGCAATGGTCCAAGATGCAGAGATGGCAATGGCAGAGTGCCAGAACGACAGTGGC       c.1140
 E  E  A  M  V  Q  D  A  E  M  A  M  A  E  C  Q  N  D  S  G         p.380

          .         .         .         .         . | 08       .    g.298162
 GAGATGCAAGATCCAGACCCAGACCACGAGGACGCCAACAGAACCATCAG | TCCATCAACA    c.1200
 E  M  Q  D  P  D  P  D  H  E  D  A  N  R  T  I  S  |  P  S  T      p.400

          .         .         .         .         .         .       g.298222
 AGCAACAATATCCCACTCATGAGGGTAGTGCAGTCTGTCAAACACACGAAGAGGAAAAGC       c.1260
 S  N  N  I  P  L  M  R  V  V  Q  S  V  K  H  T  K  R  K  S         p.420

          .         .         .         .         .     | 09   .    g.299753
 AGCACAGTCATGAAAGAAGGATGGATGGTCCACTACACCAGCAAGGACACGCTG | CGGAAA    c.1320
 S  T  V  M  K  E  G  W  M  V  H  Y  T  S  K  D  T  L   | R  K      p.440

          .         .         .         .         .         .       g.299813
 CGGCACTATTGGAGATTGGATAGCAAATGTATTACCCTCTTTCAGAATGACACAGGAAGC       c.1380
 R  H  Y  W  R  L  D  S  K  C  I  T  L  F  Q  N  D  T  G  S         p.460

          .   | 10     .         .         .         .         .    g.301720
 AGGTACTACAAG | GAAATTCCTTTATCTGAAATTTTGTCTCTGGAACCAGTAAAAACTTCA    c.1440
 R  Y  Y  K   | E  I  P  L  S  E  I  L  S  L  E  P  V  K  T  S      p.480

          .         .         .         .         .         .       g.301780
 GCTTTAATTCCTAATGGGGCCAATCCTCATTGTTTCGAAATCACTACGGCAAATGTAGTG       c.1500
 A  L  I  P  N  G  A  N  P  H  C  F  E  I  T  T  A  N  V  V         p.500

          .         .         .         .         .         .       g.301840
 TATTATGTGGGAGAAAATGTGGTCAATCCTTCCAGCCCATCACCAAATAACAGTGTTCTC       c.1560
 Y  Y  V  G  E  N  V  V  N  P  S  S  P  S  P  N  N  S  V  L         p.520

          .         .         .         .         .         .       g.301900
 ACCAGTGGCGTTGGTGCAGATGTGGCCAGGATGTGGGAGATAGCCATCCAGCATGCCCTT       c.1620
 T  S  G  V  G  A  D  V  A  R  M  W  E  I  A  I  Q  H  A  L         p.540

          .         .         .         .         .   | 11     .    g.303608
 ATGCCCGTCATTCCCAAGGGCTCCTCCGTGGGTACAGGAACCAACTTGCACA | GAGATATC    c.1680
 M  P  V  I  P  K  G  S  S  V  G  T  G  T  N  L  H  R |   D  I      p.560

          .         .         .         .      | 12  .         .    g.306152
 TCTGTGAGTATTTCAGTATCAAATTGCCAGATTCAAGAAAATGTG | GACATCAGCACAGTA    c.1740
 S  V  S  I  S  V  S  N  C  Q  I  Q  E  N  V   | D  I  S  T  V      p.580

          .         .         .         .         .         | 13    g.308437
 TATCAGATTTTTCCTGATGAAGTACTGGGTTCTGGACAGTTTGGAATTGTTTATGGAG | GA    c.1800
 Y  Q  I  F  P  D  E  V  L  G  S  G  Q  F  G  I  V  Y  G  G |       p.600

          .         .         .         .         .         .       g.308497
 AAACATCGTAAAACAGGAAGAGATGTAGCTATTAAAATCATTGACAAATTACGATTTCCA       c.1860
 K  H  R  K  T  G  R  D  V  A  I  K  I  I  D  K  L  R  F  P         p.620

          .         .         .         .      | 14  .         .    g.332891
 ACAAAACAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTACAG | AACCTTCATCACCCT    c.1920
 T  K  Q  E  S  Q  L  R  N  E  V  A  I  L  Q   | N  L  H  H  P      p.640

          .         .         .         .         .         .       g.332951
 GGTGTTGTAAATTTGGAGTGTATGTTTGAGACGCCTGAAAGAGTGTTTGTTGTTATGGAA       c.1980
 G  V  V  N  L  E  C  M  F  E  T  P  E  R  V  F  V  V  M  E         p.660

          .         .         .         .         .         .       g.333011
 AAACTCCATGGAGACATGCTGGAAATGATCTTGTCAAGTGAAAAGGGCAGGTTGCCAGAG       c.2040
 K  L  H  G  D  M  L  E  M  I  L  S  S  E  K  G  R  L  P  E         p.680

          .         .        | 15.         .         .         .    g.333601
 CACATAACGAAGTTTTTAATTACTCAG | ATACTCGTGGCTTTGCGGCACCTTCATTTTAAA    c.2100
 H  I  T  K  F  L  I  T  Q   | I  L  V  A  L  R  H  L  H  F  K      p.700

          .         .         .         .         .         .       g.333661
 AATATCGTTCACTGTGACCTCAAACCAGAAAATGTGTTGCTAGCCTCAGCTGATCCTTTT       c.2160
 N  I  V  H  C  D  L  K  P  E  N  V  L  L  A  S  A  D  P  F         p.720

        | 16 .         .         .         .         .         .    g.334989
 CCTCAG | GTGAAACTTTGTGATTTTGGTTTTGCCCGGATCATTGGAGAGAAGTCTTTCCGG    c.2220
 P  Q   | V  K  L  C  D  F  G  F  A  R  I  I  G  E  K  S  F  R      p.740

          .         .         .         .         .         .       g.335049
 AGGTCAGTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTAC       c.2280
 R  S  V  V  G  T  P  A  Y  L  A  P  E  V  L  R  N  K  G  Y         p.760

          .         .         .         .         .         .       g.335109
 AATCGCTCTCTAGACATGTGGTCTGTTGGGGTCATCATCTATGTAAGCCTAAGCGGCACA       c.2340
 N  R  S  L  D  M  W  S  V  G  V  I  I  Y  V  S  L  S  G  T         p.780

          .         .         .         .         .         .       g.335169
 TTCCCATTTAATGAAGATGAAGACATACACGACCAAATTCAGAATGCAGCTTTCATGTAT       c.2400
 F  P  F  N  E  D  E  D  I  H  D  Q  I  Q  N  A  A  F  M  Y         p.800

          .         .         .     | 17   .         .         .    g.354359
 CCACCAAATCCCTGGAAGGAAATATCTCATGAAG | CCATTGATCTTATCAACAATTTGCTG    c.2460
 P  P  N  P  W  K  E  I  S  H  E  A |   I  D  L  I  N  N  L  L      p.820

          .         .         .         .         .         .       g.354419
 CAAGTAAAAATGAGAAAGCGCTACAGTGTGGATAAGACCTTGAGCCACCCTTGGCTACAG       c.2520
 Q  V  K  M  R  K  R  Y  S  V  D  K  T  L  S  H  P  W  L  Q         p.840

  | 18       .         .         .         .         .         .    g.355297
  | GACTATCAGACCTGGTTAGATTTGCGAGAGCTGGAATGCAAAATCGGGGAGCGCTACATC    c.2580
  | D  Y  Q  T  W  L  D  L  R  E  L  E  C  K  I  G  E  R  Y  I      p.860

          .         .         .         .         .         .       g.355357
 ACCCATGAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTAC       c.2640
 T  H  E  S  D  D  L  R  W  E  K  Y  A  G  E  Q  G  L  Q  Y         p.880

          .         .         .         .         .         .       g.355417
 CCCACACACCTGATCAATCCAAGTGCTAGCCACAGTGACACTCCTGAGACTGAAGAAACA       c.2700
 P  T  H  L  I  N  P  S  A  S  H  S  D  T  P  E  T  E  E  T         p.900

          .         .         .                                     g.355456
 GAAATGAAAGCCCTCGGTGAGCGTGTCAGCATCCTCTGA                            c.2739
 E  M  K  A  L  G  E  R  V  S  I  L  X                              p.912

          .         .         .         .         .         .       g.355516
 gttccatctcctataatctgtcaaaacactgtggaactaataaatacatacggtcaggtt       c.*60

          .         .         .         .         .         .       g.355576
 taacatttgccttgcagaactgccattattttctgtcagatgagaacaaagctgttaaac       c.*120

          .         .         .         .         .         .       g.355636
 tgttagcactgttgatgtatctgagttgccaagacaaatcaacagaagcatttgtatttt       c.*180

          .         .         .         .         .         .       g.355696
 gtgtgaccaactgtgttgtattaacaaaagttccctgaaacacgaaacttgttattgtga       c.*240

          .         .         .         .         .         .       g.355756
 atgattcatgttatatttaatgcattaaacctgtctccactgtgcctttgcaaatcagtg       c.*300

          .         .         .         .         .         .       g.355816
 tttttcttactggagcttcattttggtaagagacagaatgtatctgtgaagtagttctgt       c.*360

          .         .         .         .         .         .       g.355876
 ttggtgtgtcccattggtgttgtcattgtaaacaaactcttgaagagtcgattatttcca       c.*420

          .         .         .         .         .         .       g.355936
 gtgttctatgaacaactccaaaacccatgtgggaaaaaaatgaatgaggagggtagggaa       c.*480

          .         .         .         .         .         .       g.355996
 taaaatcctaagacacaaatgcatgaacaagttttaatgtatagttttgaatcctttgcc       c.*540

          .         .         .         .         .         .       g.356056
 tgcctggtgtgcctcagtatatttaaactcaagacaatgcacctagctgtgcaagaccta       c.*600

          .         .         .         .         .         .       g.356116
 gtgctcttaagcctaaatgccttagaaatgtaaactgccatatataacagatacatttcc       c.*660

          .         .         .         .         .         .       g.356176
 ctctttcttataatactctgttgtactatggaaaatcagctgctcagcaacctttcacct       c.*720

          .         .         .                                     g.356215
 ttgtgtatttttcaataataaaaaatattcttgtcaaaa                            c.*759

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein kinase D1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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