protein kinase, cGMP-dependent, type I (PRKG1) - coding DNA reference sequence

(used for variant description)

(last modified August 23, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_006258.3 in the PRKG1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering PRKG1 transcript NM_006258.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.88380
    aggaagctttggcactcgggaggcagcggcgactttggggaaagttgatcggagagg       c.-61

 .         .         .         .         .         .                g.88440
 ggaggaagcctcaagacgcggagcagcggcaggaaggagcccccggcagcccggaggagc       c.-1

          .         .         .         .         .         .       g.88500
 ATGGGCACCTTGCGGGATTTACAGTACGCGCTCCAGGAGAAGATCGAGGAGCTGAGGCAG       c.60
 M  G  T  L  R  D  L  Q  Y  A  L  Q  E  K  I  E  E  L  R  Q         p.20

          .         .         .         .         .         .       g.88560
 CGGGATGCTCTCATCGACGAGCTGGAGCTGGAGTTGGATCAGAAGGACGAACTGATCCAG       c.120
 R  D  A  L  I  D  E  L  E  L  E  L  D  Q  K  D  E  L  I  Q         p.40

          .         .         .         .         .         .       g.88620
 AAGCTGCAGAACGAGCTGGACAAGTACCGCTCGGTGATCCGACCAGCCACCCAGCAGGCG       c.180
 K  L  Q  N  E  L  D  K  Y  R  S  V  I  R  P  A  T  Q  Q  A         p.60

          .         .         .         .         .         .       g.88680
 CAGAAGCAGAGCGCGAGCACCTTGCAGGGCGAGCCGCGCACCAAGCGGCAGGCGATCTCC       c.240
 Q  K  Q  S  A  S  T  L  Q  G  E  P  R  T  K  R  Q  A  I  S         p.80

          .         .         .         .         .         .       g.88740
 GCCGAGCCCACCGCCTTCGACATCCAGGATCTCAGCCATGTGACCCTGCCCTTCTACCCC       c.300
 A  E  P  T  A  F  D  I  Q  D  L  S  H  V  T  L  P  F  Y  P         p.100

          .  | 02      .         .         .         .         .    g.167062
 AAGAGCCCACA | GTCCAAGGATCTTATAAAGGAAGCTATCCTTGACAATGACTTTATGAAG    c.360
 K  S  P  Q  |  S  K  D  L  I  K  E  A  I  L  D  N  D  F  M  K      p.120

          .         .         .         .         .         .       g.167122
 AACTTGGAGCTGTCGCAGATCCAGGAGATTGTGGATTGTATGTACCCGGTGGAGTATGGC       c.420
 N  L  E  L  S  Q  I  Q  E  I  V  D  C  M  Y  P  V  E  Y  G         p.140

          .         .         .         .         .         | 03    g.481574
 AAGGACAGTTGCATCATCAAAGAAGGAGACGTGGGGTCACTGGTGTATGTCATGGAAG | AT    c.480
 K  D  S  C  I  I  K  E  G  D  V  G  S  L  V  Y  V  M  E  D |       p.160

          .         .         .         .         .         .       g.481634
 GGTAAGGTTGAAGTTACAAAAGAAGGTGTGAAGTTGTGTACCATGGGTCCAGGAAAAGTG       c.540
 G  K  V  E  V  T  K  E  G  V  K  L  C  T  M  G  P  G  K  V         p.180

          .         .         .         .         .   | 04     .    g.818442
 TTTGGGGAATTGGCTATTCTTTACAACTGTACCCGGACAGCGACCGTCAAGA | CTCTTGTA    c.600
 F  G  E  L  A  I  L  Y  N  C  T  R  T  A  T  V  K  T |   L  V      p.200

          .         .         .         .         .         .       g.818502
 AATGTAAAACTCTGGGCCATTGATCGACAATGTTTTCAAACAATAATGATGAGGACAGGA       c.660
 N  V  K  L  W  A  I  D  R  Q  C  F  Q  T  I  M  M  R  T  G         p.220

          .         .         .         | 05         .         .    g.921378
 CTCATCAAGCATACCGAGTATATGGAATTTTTAAAAAG | CGTTCCAACATTCCAGAGCCTT    c.720
 L  I  K  H  T  E  Y  M  E  F  L  K  S  |  V  P  T  F  Q  S  L      p.240

          .         .         .         .   | 06     .         .    g.1068351
 CCTGAAGAGATCCTCAGCAAGCTTGCTGATGTCCTTGAAGAG | ACCCACTATGAAAATGGA    c.780
 P  E  E  I  L  S  K  L  A  D  V  L  E  E   | T  H  Y  E  N  G      p.260

          .         .         .         .         .         .       g.1068411
 GAATATATTATCAGGCAAGGTGCAAGAGGGGACACCTTCTTTATCATCAGCAAAGGAACG       c.840
 E  Y  I  I  R  Q  G  A  R  G  D  T  F  F  I  I  S  K  G  T         p.280

  | 07       .         .         .         .         .         .    g.1076446
  | GTAAATGTCACTCGTGAAGACTCACCGAGTGAAGACCCAGTCTTTCTTAGAACTTTAGGA    c.900
  | V  N  V  T  R  E  D  S  P  S  E  D  P  V  F  L  R  T  L  G      p.300

          .         .         .      | 08  .         .         .    g.1147714
 AAAGGAGACTGGTTTGGAGAGAAAGCCTTGCAGGG | GGAAGATGTGAGAACAGCAAACGTA    c.960
 K  G  D  W  F  G  E  K  A  L  Q  G  |  E  D  V  R  T  A  N  V      p.320

          .         .         .         .  | 09      .         .    g.1175757
 ATTGCTGCAGAAGCTGTAACCTGCCTTGTGATTGACAGAGA | CTCTTTTAAACATTTGATT    c.1020
 I  A  A  E  A  V  T  C  L  V  I  D  R  D  |  S  F  K  H  L  I      p.340

          .         .         .         .         .       | 10 .    g.1265423
 GGAGGGCTGGATGATGTTTCTAATAAAGCATATGAAGATGCAGAAGCTAAAGCAAA | ATAT    c.1080
 G  G  L  D  D  V  S  N  K  A  Y  E  D  A  E  A  K  A  K  |  Y      p.360

          .         .         .         .         .         .       g.1265483
 GAAGCTGAAGCGGCTTTCTTCGCCAACCTGAAGCTGTCTGATTTCAACATCATTGATACC       c.1140
 E  A  E  A  A  F  F  A  N  L  K  L  S  D  F  N  I  I  D  T         p.380

          .         .         .    | 11    .         .         .    g.1285226
 CTTGGAGTTGGAGGTTTCGGACGAGTAGAACTG | GTCCAGTTGAAAAGTGAAGAATCCAAA    c.1200
 L  G  V  G  G  F  G  R  V  E  L   | V  Q  L  K  S  E  E  S  K      p.400

          .         .         .         .         .         .       g.1285286
 ACGTTTGCAATGAAGATTCTCAAGAAACGTCACATTGTGGACACAAGACAGCAGGAGCAC       c.1260
 T  F  A  M  K  I  L  K  K  R  H  I  V  D  T  R  Q  Q  E  H         p.420

          .         .         .         .         .    | 12    .    g.1286248
 ATCCGCTCAGAGAAGCAGATCATGCAGGGGGCTCATTCCGATTTCATAGTGAG | ACTGTAC    c.1320
 I  R  S  E  K  Q  I  M  Q  G  A  H  S  D  F  I  V  R  |  L  Y      p.440

          .         .         .         .         .         .       g.1286308
 AGAACATTTAAGGACAGCAAATATTTGTATATGTTGATGGAAGCTTGTCTAGGTGGAGAG       c.1380
 R  T  F  K  D  S  K  Y  L  Y  M  L  M  E  A  C  L  G  G  E         p.460

          .         .    | 13    .         .         .         .    g.1294675
 CTCTGGACCATTCTCAGGGATAG | AGGTTCGTTTGAAGATTCTACAACCAGATTTTACACA    c.1440
 L  W  T  I  L  R  D  R  |  G  S  F  E  D  S  T  T  R  F  Y  T      p.480

          .         .         .         .         .         .       g.1294735
 GCATGTGTGGTAGAAGCTTTTGCCTATCTGCATTCCAAAGGAATCATTTACAGGGACCTC       c.1500
 A  C  V  V  E  A  F  A  Y  L  H  S  K  G  I  I  Y  R  D  L         p.500

          .         .         .         .      | 14  .         .    g.1296017
 AAGCCAGAAAATCTCATCCTAGATCACCGAGGTTATGCCAAACTG | GTTGATTTTGGCTTT    c.1560
 K  P  E  N  L  I  L  D  H  R  G  Y  A  K  L   | V  D  F  G  F      p.520

          .         .         .         .         .         .       g.1296077
 GCAAAGAAAATAGGATTTGGAAAGAAAACATGGACTTTTTGTGGGACTCCAGAGTATGTA       c.1620
 A  K  K  I  G  F  G  K  K  T  W  T  F  C  G  T  P  E  Y  V         p.540

          .         .         .         .         .         .       g.1296137
 GCCCCAGAGATCATCCTGAACAAAGGCCATGACATTTCAGCCGACTACTGGTCACTGGGA       c.1680
 A  P  E  I  I  L  N  K  G  H  D  I  S  A  D  Y  W  S  L  G         p.560

          .         .          | 15        .         .         .    g.1302606
 ATCCTAATGTATGAACTCCTGACTGGCAG | CCCACCTTTCTCAGGCCCAGATCCTATGAAA    c.1740
 I  L  M  Y  E  L  L  T  G  S  |  P  P  F  S  G  P  D  P  M  K      p.580

          .         .         .         .         .         .       g.1302666
 ACCTATAACATCATATTGAGGGGGATTGACATGATAGAATTTCCAAAGAAGATTGCCAAA       c.1800
 T  Y  N  I  I  L  R  G  I  D  M  I  E  F  P  K  K  I  A  K         p.600

          .         .         .   | 16     .         .         .    g.1302808
 AATGCTGCTAATTTAATTAAAAAACTATGCAG | GGACAATCCATCAGAAAGATTAGGGAAT    c.1860
 N  A  A  N  L  I  K  K  L  C  R  |  D  N  P  S  E  R  L  G  N      p.620

          .         .         .      | 17  .         .         .    g.1304098
 TTGAAAAATGGAGTAAAAGACATTCAAAAGCACAA | ATGGTTTGAGGGCTTTAACTGGGAA    c.1920
 L  K  N  G  V  K  D  I  Q  K  H  K  |  W  F  E  G  F  N  W  E      p.640

          .         .         .         .   | 18     .         .    g.1307669
 GGCTTAAGAAAAGGTACCTTGACACCTCCTATAATACCAAGT | GTTGCATCACCCACAGAC    c.1980
 G  L  R  K  G  T  L  T  P  P  I  I  P  S   | V  A  S  P  T  D      p.660

          .         .         .         .         .         .       g.1307729
 ACAAGTAATTTTGACAGTTTCCCTGAGGACAACGATGAACCACCACCTGATGACAACTCA       c.2040
 T  S  N  F  D  S  F  P  E  D  N  D  E  P  P  P  D  D  N  S         p.680

          .         .                                               g.1307750
 GGATGGGATATAGACTTCTAA                                              c.2061
 G  W  D  I  D  F  X                                                p.686

          .         .         .         .         .         .       g.1307810
 tgtatttctcttacctgcttctgccttgctgaagacagctttttctgagacacagctgcc       c.*60

          .         .         .         .         .         .       g.1307870
 agcaaacctgagggaaagagagaagattagtgctcggggtcaccatgatgcctttgatcg       c.*120

          .         .         .         .         .         .       g.1307930
 atgctgctccagtaactacagtggcattaggacttaccgcttagatgacaatagtgctct       c.*180

          .         .         .         .         .         .       g.1307990
 ttacatgttttctgtttgaacctaaaatagcagttgacatggtggtcctgaagcaaagcc       c.*240

          .         .         .         .         .         .       g.1308050
 tttcaccagtaaaagatgttttctattgttgcaatgaccttgctttgctctgattataat       c.*300

          .         .         .         .         .         .       g.1308110
 ttgaaagactgtaggaaacacttcaatgtagtataagagtctgtaccttgctggaatatt       c.*360

          .         .         .         .         .         .       g.1308170
 caagaagatgaaagaataatatattgggtacaatagattactatggtacagaaactgggc       c.*420

          .         .         .         .         .         .       g.1308230
 tattccctttcttcaagtgaaggctgtgggatctattactgcaggccggtgtatatacca       c.*480

          .         .         .         .         .         .       g.1308290
 tacaaaagaggaccacacatctgttggtcacagagttcatgtcacaccagtgctagaagt       c.*540

          .         .         .         .         .         .       g.1308350
 ttcatgattttatttcccagcagtgctgatgacaagactgaatgttaccttttctttctg       c.*600

          .         .         .         .         .         .       g.1308410
 acagattttaaaaattgatatgataaaagcacaactgctatagattctgctgagacctct       c.*660

          .         .         .         .         .         .       g.1308470
 catagtaggtatatatgagttttcacagaagactgaaaaataatgcatgatatttgtttg       c.*720

          .         .         .         .         .         .       g.1308530
 ttttttttgataaattggcatgacagagtggggaaaaaaagcaattcacaaaaccatttc       c.*780

          .         .         .         .         .         .       g.1308590
 atattttttaaaatattgtgcttaaagatggtcctggaagtaaatgactagcagccaatt       c.*840

          .         .         .         .         .         .       g.1308650
 ggttttacttaacataccctcaaactgaggcttaaagtattcccttttataaaaataaat       c.*900

          .         .         .         .         .         .       g.1308710
 gcttggggtagggtggagtggggagggattaaaacccatccaaaaaataaataaaaacta       c.*960

          .         .         .         .         .         .       g.1308770
 tataggtgctatgtatatctttcatctgtaaatgtcagtgtctgaacagacaacacaaat       c.*1020

          .         .         .         .         .         .       g.1308830
 tcaaatcattatacgtgtagccagaaactcaagcattttcactaaagttattaaaccaaa       c.*1080

          .         .         .         .         .         .       g.1308890
 ctcctgtccaatttcacttatacaacatagtcagtctagagttgagagacaaaggtaatt       c.*1140

          .         .         .         .         .         .       g.1308950
 ataaacctatttgaactagcttcttgtcttaggcctgaaccaaaaaacaacaaacaaaca       c.*1200

          .         .         .         .         .         .       g.1309010
 aaaaacaagaatgaaaaacagaaataaaagaagtagaaaagacaaagaaagaaagcccaa       c.*1260

          .         .         .         .         .         .       g.1309070
 agtcaaagttgttaatatttacaggtttaccagatctggaacattacttatttgaggtca       c.*1320

          .         .         .         .         .         .       g.1309130
 gagaacaaaacaagaacctggccaggtgttgattaccttttagtgaataagctgagtcca       c.*1380

          .         .         .         .         .         .       g.1309190
 tatacttgtctaactaagaaagcagtacagaggaaaacaggaacctgatttttttaaaat       c.*1440

          .         .         .         .         .         .       g.1309250
 aaattttaaataaaatagaattactacaattctgcaatttcatactacctaaaaaagact       c.*1500

          .         .         .         .         .         .       g.1309310
 agatttgaaaatgtcaagctgatttactttattcacatggagaaaagaatccacaaatta       c.*1560

          .         .         .         .         .         .       g.1309370
 aactgagtccttcactggcatgccagttgactattattagctgtcataagtaactcagcc       c.*1620

          .         .         .         .         .         .       g.1309430
 atttggaagcatttcctggacaaaattacattatacctgtgaagaaaaatatagaagctt       c.*1680

          .         .         .         .         .         .       g.1309490
 tcaagctgtcattctgttttggccctgtgtgaatttggtatattaaattgacgcttgctt       c.*1740

          .         .         .         .         .         .       g.1309550
 tttttttcagtagagttttctttttaatcaatcaaacgcctacatttctggaagaaaaag       c.*1800

          .         .         .         .         .         .       g.1309610
 tccaattagatcattacaccttaactaagaaggcaaatcttataaattttgcttgaattg       c.*1860

          .         .         .         .         .         .       g.1309670
 ttcttactcaaaactaccttagaatatggtatcttatgaaaatataatattcttaaaatt       c.*1920

          .         .         .         .         .         .       g.1309730
 ttggaggataaaatgaaaagggtataaacttcaattagaactttaatcctaaaatattgt       c.*1980

          .         .         .         .         .         .       g.1309790
 tattcttgtatttttggagttttccgtcccttacaatttctccaaattggtctattcccc       c.*2040

          .         .         .         .         .         .       g.1309850
 aagatatccactgttttctacagattttagaatataaaattaaacatatcaacctaaaat       c.*2100

          .         .         .         .         .         .       g.1309910
 ctagctatgaatgttatttcaagagttttatatttttaattggctttttaaaaatatgta       c.*2160

          .         .         .         .         .         .       g.1309970
 attccaatattatagtgaatgttcagtaacttttgttgaaagataatgtggtttaggctt       c.*2220

          .         .         .         .         .         .       g.1310030
 gctaaagaaaggcttgctagaatactaaatttaccttgttatttggaaagagaatctgct       c.*2280

          .         .         .         .         .         .       g.1310090
 cctataacgttttaaaaatccccaaagtcccagagattagcacttgctatggattttgga       c.*2340

          .         .         .         .         .         .       g.1310150
 actatggttcaagtctaagacaaccaatatgaataagttcaatggagaaggaagaagtag       c.*2400

          .         .         .         .         .         .       g.1310210
 cattcagcacaagaaactgtagattgtttctcccacttgttactgcatctttgttcattt       c.*2460

          .         .         .         .         .         .       g.1310270
 cacccatagcattgcatttgatgtctgaagtaattaccacaaaataaaggtaaactacat       c.*2520

          .         .         .         .         .         .       g.1310330
 cttccaagatgtaccaacagaaaacattcgtctaattttgtcaacattgaatttttagga       c.*2580

          .         .         .         .         .         .       g.1310390
 tttaaatcttgtcttaatgaagactctagggctaaaattcatggtcagttccataaaatg       c.*2640

          .         .         .         .         .         .       g.1310450
 catctcactttatttctgaatttttcacaacccctctattttcttacattaaagaacatc       c.*2700

          .         .         .         .         .         .       g.1310510
 tggataagttagaatagtgccaacttgtttgatttgttatatgattttcttgttaatgtg       c.*2760

          .         .         .         .         .         .       g.1310570
 ttgagtatgggaaataagggctttctgtgtgtcttgactcacaggaaaactgaaactgcc       c.*2820

          .         .         .         .         .         .       g.1310630
 aagggaagcaacattaaaacaactgggatagattgaatacatttgaaaaaataatttctg       c.*2880

          .         .         .         .         .         .       g.1310690
 gaaaaacgctatacatgctttttatgtttatatcttctttcttattaagacatgaatcag       c.*2940

          .         .         .         .         .         .       g.1310750
 atccatgtggcattcaaaacaaatttattttggttatattctttacaagtcataattttt       c.*3000

          .         .         .         .         .         .       g.1310810
 acctaaaattgtggaatatgcatgtgaattacacatgtgtagtaataaactcaactattg       c.*3060

          .         .         .         .         .         .       g.1310870
 aatttttcctgtttcatttctaaatgactgaactgatggtaaacaaatttaatgaagtca       c.*3120

          .         .         .         .         .         .       g.1310930
 gctaccatgttgaaaataaggatattagaactgatttcatacaatagaggtgatctgtgc       c.*3180

          .         .         .         .         .         .       g.1310990
 attatccataacaacgttttctttcactataggaccacagacaaatatttatgtaaatag       c.*3240

          .         .         .         .         .         .       g.1311050
 gtatttttgtgtgatattttgtggtacatataactttttttagtgtttcacagcattatt       c.*3300

          .         .         .         .         .         .       g.1311110
 atttcattttatttgtattgaataatgtttttaggtccaagtagacttgaattaatgtca       c.*3360

          .         .         .         .         .         .       g.1311170
 taattgtcagtattattgaaaattatgtcaactgtactgttattcatctgtcccatagtt       c.*3420

          .         .         .         .         .         .       g.1311230
 tagaacatgacctggctatctggcattgttgcaagtgccttaaattcatggcatcctatt       c.*3480

          .         .         .         .         .         .       g.1311290
 aaaaaaacaaatttggtgttatgctgcatgacaaagacaaacacacctcaaaatgttgtc       c.*3540

          .         .         .         .         .         .       g.1311350
 ctttcttagcttgctgcgttttacagttctttctgctaacaatttataagcctttattat       c.*3600

          .         .         .         .         .         .       g.1311410
 ataatattgatgaattacagaaatgatgaagttgttctcttatttctgttaaatgtacca       c.*3660

          .         .         .         .         .         .       g.1311470
 gagctgtgtatctgttaatgagatacagcgtcatttctgtgaaatgtataaatgtatgtg       c.*3720

          .         .         .         .         .         .       g.1311530
 caggtcaaattaatatatgacattctatcagtctgtatacaggtattcctgttttgctaa       c.*3780

          .         .         .         .         .         .       g.1311590
 gctgtgcagattctgtaaaaataaattagtgcagtcaagttctaacatatctcattttat       c.*3840

          .         .         .         .         .         .       g.1311650
 agactccattgacaatggtccaaccgaaaagaaaaattggaaatgactgctaaccagacc       c.*3900

          .         .         .         .         .         .       g.1311710
 tcgttatgaaaccaatgatgaaaaagtcacttggtgcacctctcaacaaaacaggatgct       c.*3960

          .         .         .         .         .         .       g.1311770
 ttttccgagttcttgtatatgcaaatcatttacgaggcaagttttcaacagacctagaaa       c.*4020

          .         .         .         .         .         .       g.1311830
 gcaaaacattgaaagtgtgttgttagccctcctctctgcccctgaatcaacagacagagc       c.*4080

          .         .         .         .         .         .       g.1311890
 tctgggaccttggcaatgactcagaggttggggctttctgagtaaagggacatttcttta       c.*4140

          .         .         .         .         .         .       g.1311950
 agcatcatctatcaaatttatttcaatgtatgatgtttttacaactggtcagttcttttg       c.*4200

          .         .         .         .         .         .       g.1312010
 tattcttacagctatggttatttgattgtcctcttacaatttgttctacatgaaagagtt       c.*4260

          .         .         .         .         .         .       g.1312070
 ctttgttagtcagaatgcaacaaactgtcatcaaatggtcattgaccacttgcactcttt       c.*4320

          .         .         .         .         .         .       g.1312130
 tgatgtagattaaaaactttttcataaatttacctgctttgatttgctctgtatttttcc       c.*4380

          .         .         .         .         .         .       g.1312190
 tgcagctgtaattgctgagtgcctgttgtatactttatagagttgaaataaaaaaataat       c.*4440

          .                                                         g.1312200
 tacttttgaa                                                         c.*4450

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein kinase, cGMP-dependent, type I protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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