protein kinase, cGMP-dependent, type II (PRKG2) - coding DNA reference sequence

(used for variant description)

(last modified September 29, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_006259.1 in the PRKG2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering PRKG2 transcript NM_006259.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               ggtccctgagcaaa       c.-1

          .         .         .         .         .         .       g.5074
 ATGGGAAATGGTTCAGTGAAACCTAAACATTCTAAGCACCCAGATGGACACTCTGGGAAC       c.60
 M  G  N  G  S  V  K  P  K  H  S  K  H  P  D  G  H  S  G  N         p.20

          .         .         .         .         .         .       g.5134
 CTCACCACTGATGCTCTGCGGAACAAGGTGACAGAGCTGGAGAGAGAGTTGAGGAGGAAG       c.120
 L  T  T  D  A  L  R  N  K  V  T  E  L  E  R  E  L  R  R  K         p.40

          .         .         .         .         .         .       g.5194
 GATGCTGAGATCCAGGAGCGGGAGTACCATTTGAAGGAGCTGCGGGAGCAGCTGTCGAAG       c.180
 D  A  E  I  Q  E  R  E  Y  H  L  K  E  L  R  E  Q  L  S  K         p.60

          .         .         .         .         .         .       g.5254
 CAGACTGTGGCCATTGCTGAACTCACAGAGGAGCTCCAGAACAAGTGCATCCAGCTGAAC       c.240
 Q  T  V  A  I  A  E  L  T  E  E  L  Q  N  K  C  I  Q  L  N         p.80

          .         .         .         .         .         .       g.5314
 AAGCTGCAGGATGTGGTGCATATGCAGGGAGGAAGCCCGCTTCAGGCCTCTCCAGATAAA       c.300
 K  L  Q  D  V  V  H  M  Q  G  G  S  P  L  Q  A  S  P  D  K         p.100

          .         .         .         .         .         .       g.5374
 GTGCCTCTTGAGGTCCACCGGAAGACCTCTGGATTGGTCTCTCTCCATAGCAGGAGGGGA       c.360
 V  P  L  E  V  H  R  K  T  S  G  L  V  S  L  H  S  R  R  G         p.120

          .         .         .         .         .         .       g.5434
 GCAAAGGCTGGCGTGTCTGCTGAGCCAACAACCCGGACCTATGACCTGAACAAACCCCCT       c.420
 A  K  A  G  V  S  A  E  P  T  T  R  T  Y  D  L  N  K  P  P         p.140

          .         .         .         .  | 02      .         .    g.35121
 GAATTTTCCTTTGAGAAAGCAAGAGTCAGAAAAGACTCCAG | TGAGAAGAAGCTCATTACA    c.480
 E  F  S  F  E  K  A  R  V  R  K  D  S  S  |  E  K  K  L  I  T      p.160

          .         .         .         .         .         .       g.35181
 GATGCCCTTAATAAAAATCAGTTTCTGAAAAGACTGGATCCTCAGCAGATCAAAGACATG       c.540
 D  A  L  N  K  N  Q  F  L  K  R  L  D  P  Q  Q  I  K  D  M         p.180

          .         .         .         .         .         .       g.35241
 GTGGAATGCATGTATGGGAGAAACTATCAGCAAGGGAGTTACATTATTAAGCAAGGAGAA       c.600
 V  E  C  M  Y  G  R  N  Y  Q  Q  G  S  Y  I  I  K  Q  G  E         p.200

          .         .         | 03         .         .         .    g.38289
 CCAGGAAACCATATCTTTGTGCTGGCAG | AGGGTCGACTAGAGGTGTTCCAAGGGGAGAAA    c.660
 P  G  N  H  I  F  V  L  A  E |   G  R  L  E  V  F  Q  G  E  K      p.220

          .         .         .         .         .         .       g.38349
 TTGCTGTCCTCCATCCCTATGTGGACCACATTTGGGGAGCTTGCCATTTTATACAATTGT       c.720
 L  L  S  S  I  P  M  W  T  T  F  G  E  L  A  I  L  Y  N  C         p.240

          .         .   | 04     .         .         .         .    g.40331
 ACAAGGACTGCCTCTGTGAAAG | CTATTACCAATGTTAAAACATGGGCACTAGATCGAGAG    c.780
 T  R  T  A  S  V  K  A |   I  T  N  V  K  T  W  A  L  D  R  E      p.260

          .         .         .         .         .         .       g.40391
 GTATTCCAGAATATAATGAGGAGGACAGCCCAAGCTAGAGATGAACAATACAGAAACTTC       c.840
 V  F  Q  N  I  M  R  R  T  A  Q  A  R  D  E  Q  Y  R  N  F         p.280

          | 05         .         .         .         .         .    g.42889
 CTCAGAAG | TGTATCCTTGCTGAAGAATTTACCTGAAGATAAATTAACCAAGATCATTGAC    c.900
 L  R  S  |  V  S  L  L  K  N  L  P  E  D  K  L  T  K  I  I  D      p.300

          .   | 06     .         .         .         .         .    g.56388
 TGCTTGGAAGTG | GAATACTATGACAAAGGAGATTACATCATTAGAGAGGGCGAGGAAGGA    c.960
 C  L  E  V   | E  Y  Y  D  K  G  D  Y  I  I  R  E  G  E  E  G      p.320

          .         .         . | 07       .         .         .    g.58037
 AGTACCTTTTTCATTTTGGCAAAAGGAAAG | GTAAAAGTAACACAGAGCACAGAAGGCCAT    c.1020
 S  T  F  F  I  L  A  K  G  K   | V  K  V  T  Q  S  T  E  G  H      p.340

          .         .         .         .         .         .       g.58097
 GATCAACCACAGCTGATAAAAACACTGCAGAAAGGAGAATACTTTGGAGAAAAAGCTCTT       c.1080
 D  Q  P  Q  L  I  K  T  L  Q  K  G  E  Y  F  G  E  K  A  L         p.360

       | 08  .         .         .         .         .         .    g.61164
 ATCAG | TGATGATGTCAGGTCAGCTAACATTATTGCTGAAGAAAATGATGTTGCATGCCTG    c.1140
 I  S  |  D  D  V  R  S  A  N  I  I  A  E  E  N  D  V  A  C  L      p.380

          .     | 09   .         .         .         .         .    g.65777
 GTTATAGATCGAGA | AACATTCAACCAAACTGTCGGTACATTTGAAGAGCTGCAAAAATAC    c.1200
 V  I  D  R  E  |  T  F  N  Q  T  V  G  T  F  E  E  L  Q  K  Y      p.400

          .         .         .         .         .    | 10    .    g.67121
 CTTGAAGGATATGTGGCAAACCTGAACCGTGATGATGAAAAAAGACATGCGAA | GCGGTCC    c.1260
 L  E  G  Y  V  A  N  L  N  R  D  D  E  K  R  H  A  K  |  R  S      p.420

          .         .         .         .         .         .       g.67181
 ATGTCTAACTGGAAGCTGTCCAAAGCACTCTCTCTGGAAATGATTCAGCTGAAGGAGAAG       c.1320
 M  S  N  W  K  L  S  K  A  L  S  L  E  M  I  Q  L  K  E  K         p.440

          .         .         .         .         .         .       g.67241
 GTGGCCAGATTTTCCTCATCATCCCCATTCCAGAACCTTGAGATTATTGCAACACTGGGC       c.1380
 V  A  R  F  S  S  S  S  P  F  Q  N  L  E  I  I  A  T  L  G         p.460

          .         .        | 11.         .         .         .    g.69425
 GTTGGTGGGTTCGGAAGAGTTGAGCTT | GTTAAAGTAAAAAATGAGAATGTTGCTTTTGCT    c.1440
 V  G  G  F  G  R  V  E  L   | V  K  V  K  N  E  N  V  A  F  A      p.480

          .         .         .         .         .         .       g.69485
 ATGAAGTGTATAAGGAAGAAGCACATAGTTGACACCAAGCAGCAGGAGCATGTCTACTCA       c.1500
 M  K  C  I  R  K  K  H  I  V  D  T  K  Q  Q  E  H  V  Y  S         p.500

          .         .         .         .     | 12   .         .    g.72595
 GAGAAGAGGATCCTAGAGGAGCTGTGCTCTCCATTCATTGTGAA | ATTATATCGTACTTTC    c.1560
 E  K  R  I  L  E  E  L  C  S  P  F  I  V  K  |  L  Y  R  T  F      p.520

          .         .         .         .         .         .       g.72655
 AAGGACAATAAGTATGTATACATGCTTCTGGAGGCCTGCTTAGGTGGGGAGCTCTGGAGT       c.1620
 K  D  N  K  Y  V  Y  M  L  L  E  A  C  L  G  G  E  L  W  S         p.540

          .     | 13   .         .         .         .         .    g.74811
 ATATTAAGGGACAG | AGGCAGCTTTGATGAACCCACCTCCAAATTCTGCGTTGCTTGTGTG    c.1680
 I  L  R  D  R  |  G  S  F  D  E  P  T  S  K  F  C  V  A  C  V      p.560

          .         .         .         .         .         .       g.74871
 ACAGAAGCATTTGATTACCTGCATCGACTAGGTATTATCTACAGAGACTTGAAACCAGAA       c.1740
 T  E  A  F  D  Y  L  H  R  L  G  I  I  Y  R  D  L  K  P  E         p.580

          .         .         .       | 14 .         .         .    g.99474
 AACTTAATTCTAGATGCTGAGGGTTACCTTAAATTG | GTTGACTTTGGATTTGCGAAGAAA    c.1800
 N  L  I  L  D  A  E  G  Y  L  K  L   | V  D  F  G  F  A  K  K      p.600

          .         .         .         .         .         .       g.99534
 ATAGGGTCTGGACAGAAAACATGGACATTCTGTGGGACTCCAGAATATGTAGCTCCTGAA       c.1860
 I  G  S  G  Q  K  T  W  T  F  C  G  T  P  E  Y  V  A  P  E         p.620

          .         .         .         .         .         .       g.99594
 GTCATTCTCAACAAGGGACATGACTTCAGTGTGGATTTCTGGTCACTGGGAATTCTAGTG       c.1920
 V  I  L  N  K  G  H  D  F  S  V  D  F  W  S  L  G  I  L  V         p.640

          .         . | 15       .         .         .         .    g.104166
 TATGAGCTCCTAACGGGCAA | CCCACCCTTTTCTGGGGTTGACCAAATGATGACCTACAAT    c.1980
 Y  E  L  L  T  G  N  |  P  P  F  S  G  V  D  Q  M  M  T  Y  N      p.660

          .         .         .         .         .         .       g.104226
 TTGATTCTCAAAGGAATTGAAAAAATGGATTTTCCCAGGAAGATAACACGACGACCTGAG       c.2040
 L  I  L  K  G  I  E  K  M  D  F  P  R  K  I  T  R  R  P  E         p.680

          .         .    | 16    .         .         .         .    g.105666
 GATTTGATTCGGAGGCTTTGCAG | GCAAAATCCAACAGAAAGGCTGGGAAATCTGAAGAAT    c.2100
 D  L  I  R  R  L  C  R  |  Q  N  P  T  E  R  L  G  N  L  K  N      p.700

          .         .       | 17 .         .         .         .    g.117643
 GGAATAAATGACATTAAGAAACACAG | GTGGTTAAATGGTTTTAATTGGGAGGGACTGAAA    c.2160
 G  I  N  D  I  K  K  H  R  |  W  L  N  G  F  N  W  E  G  L  K      p.720

          .         .         .    | 18    .         .         .    g.120285
 GCACGGAGCCTTCCATCACCTTTGCAAAGAGAG | CTCAAGGGACCCATAGATCACAGCTAC    c.2220
 A  R  S  L  P  S  P  L  Q  R  E   | L  K  G  P  I  D  H  S  Y      p.740

          .         .         .         .         .         .       g.120345
 TTTGACAAATATCCTCCTGAAAAGGGAATGCCTCCAGATGAGCTATCAGGCTGGGATAAA       c.2280
 F  D  K  Y  P  P  E  K  G  M  P  P  D  E  L  S  G  W  D  K         p.760

                                                                    g.120354
 GACTTCTGA                                                          c.2289
 D  F  X                                                            p.762

          .         .         .         .         .         .       g.120414
 cagaagaaaagttgattactgcctgtactctacagaagaggacctcaaggatcaataatc       c.*60

          .         .         .         .         .         .       g.120474
 caacacattattttcttttcagagtattataatatctttggaagaccattagggaaaaga       c.*120

          .         .         .         .         .         .       g.120534
 aattcctgcacaatgggaagaggagaatggtgtggatatggttctgagttatagtgtctt       c.*180

          .         .         .         .         .         .       g.120594
 atttagatgctgtgaattattgatgtattacattatttgcttttctcaactgctagaggc       c.*240

          .         .         .         .         .         .       g.120654
 taccccattttcctttccacaatcagagccatttttgttaaagtggcagttttttctgca       c.*300

          .         .         .         .         .         .       g.120714
 atctattgttccattccaatcatatccttctcgtttgagtactactaacgtttaaaaagg       c.*360

          .         .         .         .         .         .       g.120774
 gtcttgcccttgaataactaagtcatacaaatagaaggaaaaacaatggtgaattttgga       c.*420

          .         .         .         .         .         .       g.120834
 gagctccccagctctcagcaacttcatataagcatggtggtatcttaaaatggtggtttg       c.*480

          .         .         .         .         .         .       g.120894
 cagaaaccatggtagccaacagaacctcctgactttcacctgcttttaacctgaaaatat       c.*540

          .         .         .         .         .         .       g.120954
 attaatacgcctctgacatgagtccagggagaggcaagattgagcaatagtcagtggcac       c.*600

          .         .         .         .         .         .       g.121014
 catttcctaaagtaactgaatcaatcaatccagtcaggtaattattttctattggggaac       c.*660

          .         .         .         .         .         .       g.121074
 ttagaaaaaaaagtaaagcaagaaatattttctctcctttatgatcagtgataccttaga       c.*720

          .         .         .         .         .         .       g.121134
 gacttttcgaaagtccttgttaaagatagttacaatgtgtggttaaatgatgctaaaata       c.*780

          .         .         .         .         .         .       g.121194
 ttttcacaaccagagtagaaaacgtgctggaacaaaattgcgaaggcttttgcctcccag       c.*840

          .         .         .         .         .         .       g.121254
 taaatagaaaggaaaatatattctagtaggtaagactgctgactctttgaaaatctgagg       c.*900

          .         .         .         .         .         .       g.121314
 tattttgaaaaattctgtgatagttgctattaataaaccaaaattgtatagaatcatcgt       c.*960

          .         .         .         .         .         .       g.121374
 taatttttaatataaatcccattgacaaatgttgatgcactgtagtcactgctgagttaa       c.*1020

                                                                    g.121379
 tagcg                                                              c.*1025

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein kinase, cGMP-dependent, type II protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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