protein arginine methyltransferase 10 (putative) (PRMT10) - coding DNA reference sequence

(used for variant description)

(last modified December 8, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_138364.2 in the PRMT10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering PRMT10 transcript NM_138364.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       ggcgagttcacccgcggcggag       c.-121

 .         .         .         .         .         .                g.5082
 ggtaactttgctgtgctgttttttgagcagttgtctggtccctggaagtgtagcatcgag       c.-61

 .         .         .         .         .         .                g.5142
 agagttttctaattacgtttacaaaatatcttccctttggccatacaagtggtgactgcc       c.-1

          .         .         .         .         .         .       g.5202
 ATGTCGAACTCGCGGCCCAGGTCCCGCCGAGACGCCGGGGGTGGCGCTGGGGCAGCCGGC       c.60
 M  S  N  S  R  P  R  S  R  R  D  A  G  G  G  A  G  A  A  G         p.20

          .         .         .         .         .         .       g.5262
 CGGGACGAGCTGGTGTCGCGGTCCTTGCAGAGCGCAGAGCACTGTCTGGGCGTCCAGGAC       c.120
 R  D  E  L  V  S  R  S  L  Q  S  A  E  H  C  L  G  V  Q  D         p.40

          .         .         .         .         .         .       g.5322
 TTCGGCACTGCCTATGCCCACTACCTCCTCGTGCTCAGCCTGGCGCCGGAGCTGAAACAC       c.180
 F  G  T  A  Y  A  H  Y  L  L  V  L  S  L  A  P  E  L  K  H         p.60

           | 02        .         .         .         .         .    g.8709
 GACGTGAAG | GAAACTTTTCAGTACACACTTTTCAGATGGGCTGAAGAGCTTGATGCTCTC    c.240
 D  V  K   | E  T  F  Q  Y  T  L  F  R  W  A  E  E  L  D  A  L      p.80

          .         .         .         .         .         .       g.8769
 AGTCGGATACAAGACTTACTTGGTTGCTATGAGCAGGCCTTGGAACTGTTTCCTGATGAT       c.300
 S  R  I  Q  D  L  L  G  C  Y  E  Q  A  L  E  L  F  P  D  D         p.100

          .         .         .         | 03         .         .    g.15277
 GAAGTGATTTGCAATAGTATGGGGGAGCATCTCTTCAG | AATGGGCTTTAGGGATGAAGCA    c.360
 E  V  I  C  N  S  M  G  E  H  L  F  R  |  M  G  F  R  D  E  A      p.120

          .         .         .         .         .         .       g.15337
 GCTGGGTATTTTCATAAAGCAGTGAAGCTAAACCCTGATTTCAGTGATGCAAAGGAGAAT       c.420
 A  G  Y  F  H  K  A  V  K  L  N  P  D  F  S  D  A  K  E  N         p.140

          .         .         .         .         .         .       g.15397
 TTTTATCGTGTTGCAAACTGGTTGGTGGAACGCTGGCACTTTATCATGCTTAATGACACC       c.480
 F  Y  R  V  A  N  W  L  V  E  R  W  H  F  I  M  L  N  D  T         p.160

          .         .         .         .         .         .       g.15457
 AAGAGGAATACAATTTATAATGCAGCAATCCAAAAGGCAGTTTGTTTGGGGTCCAAAAGT       c.540
 K  R  N  T  I  Y  N  A  A  I  Q  K  A  V  C  L  G  S  K  S         p.180

          .         .         .      | 04  .         .         .    g.16028
 GTTTTGGACATTGGAGCAGGAACTGGAATACTAAG | CATGTTTGCTAAAAAAGCTGGAGCA    c.600
 V  L  D  I  G  A  G  T  G  I  L  S  |  M  F  A  K  K  A  G  A      p.200

          .         .         .         .         .         .       g.16088
 CATTCCGTGTATGCCTGTGAGTTATCCAAGACCATGTATGAACTTGCCTGTGATGTCGTG       c.660
 H  S  V  Y  A  C  E  L  S  K  T  M  Y  E  L  A  C  D  V  V         p.220

          .         .         .         .         .         .       g.16148
 GCAGCAAACAAGATGGAAGCAGGGATCAAACTCTTACATACGAAGTCACTTGACATAGAG       c.720
 A  A  N  K  M  E  A  G  I  K  L  L  H  T  K  S  L  D  I  E         p.240

          .         .    | 05    .         .         .         .    g.18423
 ATTCCAAAACATATTCCCGAAAG | AGTGTCCCTAGTTGTAACAGAAACTGTCGATGCAGGT    c.780
 I  P  K  H  I  P  E  R  |  V  S  L  V  V  T  E  T  V  D  A  G      p.260

          .         .         .         .         .         .       g.18483
 TTATTTGGAGAAGGAATTGTGGAGAGTTTGATTCATGCATGGGAGCATTTACTTTTACAG       c.840
 L  F  G  E  G  I  V  E  S  L  I  H  A  W  E  H  L  L  L  Q         p.280

        | 06 .         .         .         .         .         .    g.20538
 CCAAAG | ACCAAAGGTGAAAGTGCTAATTGTGAAAAGTATGGGAAAGTTATACCAGCAAGT    c.900
 P  K   | T  K  G  E  S  A  N  C  E  K  Y  G  K  V  I  P  A  S      p.300

          .         .         .         .         .    | 07    .    g.28098
 GCTGTTATATTTGGGATGGCAGTAGAATGTGCAGAGATAAGAAGACATCATAG | AGTGGGT    c.960
 A  V  I  F  G  M  A  V  E  C  A  E  I  R  R  H  H  R  |  V  G      p.320

          .         .         .         .         .         .       g.28158
 ATTAAGGACATTGCTGGTATCCATTTGCCAACAAATGTGAAATTTCAGAGTCCGGCTTAT       c.1020
 I  K  D  I  A  G  I  H  L  P  T  N  V  K  F  Q  S  P  A  Y         p.340

          .         .         .         .         .         .       g.28218
 TCTTCTGTAGATACTGAAGAAACAATTGAACCTTATACAACTGAAAAGATGAGTCGAGTT       c.1080
 S  S  V  D  T  E  E  T  I  E  P  Y  T  T  E  K  M  S  R  V         p.360

          .         .         .         .         .         .       g.28278
 CCTGGAGGATATTTGGCTTTGACAGAGTGCTTTGAAATTATGACAGTAGATTTCAACAAC       c.1140
 P  G  G  Y  L  A  L  T  E  C  F  E  I  M  T  V  D  F  N  N         p.380

        | 08 .         .         .         .         .         .    g.31208
 CTTCAG | GAATTAAAAAGTCTTGCAACTAAAAAGCCTGATAAGATTGGTATTCCTGTTATT    c.1200
 L  Q   | E  L  K  S  L  A  T  K  K  P  D  K  I  G  I  P  V  I      p.400

          .         .         .         .         .         .       g.31268
 AAAGAAGGCATACTAGATGCTATTATGGTTTGGTTTGTGCTCCAGCTTGATGATGAACAT       c.1260
 K  E  G  I  L  D  A  I  M  V  W  F  V  L  Q  L  D  D  E  H         p.420

          .         .         .         .         .         .       g.31328
 AGTTTATCCACAAGTCCTAGTGAGGAAACATGTTGGGAACAGGCTGTCTACCCCGTACAG       c.1320
 S  L  S  T  S  P  S  E  E  T  C  W  E  Q  A  V  Y  P  V  Q         p.440

          . | 09       .         .         .         .         .    g.34613
 GACCTTGCAG | ACTACTGGATAAAGCCTGGAGACCATGTGATGATGGAAGTATCTTGTCAA    c.1380
 D  L  A  D |   Y  W  I  K  P  G  D  H  V  M  M  E  V  S  C  Q      p.460

          .         .         .         .         .         .       g.34673
 GACTGTTACTTAAGAATCCAGAGTATTAGTGTCTTGGGTTTGGAATGTGAAATGGATGTT       c.1440
 D  C  Y  L  R  I  Q  S  I  S  V  L  G  L  E  C  E  M  D  V         p.480

          .         .         .         .         .         .       g.34733
 GCAAAAAGTTTTACCCAGAATAAAGACTTGTTATCGTTAGGAAATGAGGCTGAACTTTGT       c.1500
 A  K  S  F  T  Q  N  K  D  L  L  S  L  G  N  E  A  E  L  C         p.500

          .         .         .         .         .         .       g.34793
 AGTGCCCTCGCTAACCTTCAGACCAGTAAACCAGATGCTGTAGAGCAGACATGTATATTG       c.1560
 S  A  L  A  N  L  Q  T  S  K  P  D  A  V  E  Q  T  C  I  L         p.520

          .         .         .         .         .         .       g.34853
 GAATCTACAGAAATTGCTTTGCTTAACAACATCCCATATCATGAAGGCTTTAAAATGGCA       c.1620
 E  S  T  E  I  A  L  L  N  N  I  P  Y  H  E  G  F  K  M  A         p.540

          .         .         .         .         .         .       g.34913
 ATGAGCAAAGTTTTGTCTTCACTGACTCCAGAGAAACTGTATCAGACCATGGATACTCAC       c.1680
 M  S  K  V  L  S  S  L  T  P  E  K  L  Y  Q  T  M  D  T  H         p.560

          .         .         .         .         .         .       g.34973
 TGTCAGAATGAGATGAGCTCTGGAACTGGACAGAGTAATACTGTACAGAACATCCTTGAA       c.1740
 C  Q  N  E  M  S  S  G  T  G  Q  S  N  T  V  Q  N  I  L  E         p.580

          .         .         .         .         .         .       g.35033
 CCTTTCTACGTGTTAGATGTGTCCGAAGGCTTCTCTGTTCTGCCTGTTATTGCTGGCACA       c.1800
 P  F  Y  V  L  D  V  S  E  G  F  S  V  L  P  V  I  A  G  T         p.600

          .         .         .         .         .         .       g.35093
 CTTGGGCAGGTTAAACCATACAGTTCTGTGGAGAAAGACCAGCATCGTATTGCTCTGGAC       c.1860
 L  G  Q  V  K  P  Y  S  S  V  E  K  D  Q  H  R  I  A  L  D         p.620

          .         .         .         .         .         .       g.35153
 CTCATATCTGAAGCCAATCACTTTCCTAAAGAAACACTTGAGTTTTGGCTGAGACATGTG       c.1920
 L  I  S  E  A  N  H  F  P  K  E  T  L  E  F  W  L  R  H  V         p.640

          .         .         .         .         .         .       g.35213
 GAGGATGAATCTGCTATGTTACAAAGGCCAAAATCAGACAAGTTATGGAGCATAATTATA       c.1980
 E  D  E  S  A  M  L  Q  R  P  K  S  D  K  L  W  S  I  I  I         p.660

          .         .         .         .         .         .       g.35273
 TTGGATGTCATTGAGCCATCTGGGCTCATTCAGCAGGAAATAATGGAAAAAGCTGCAATA       c.2040
 L  D  V  I  E  P  S  G  L  I  Q  Q  E  I  M  E  K  A  A  I         p.680

       | 10  .         .         .         .         .         .    g.46244
 TCCAG | GTGTTTACTACAATCTGGAGGCAAGATCTTTCCTCAGTATGTGCTGATGTTTGGG    c.2100
 S  R  |  C  L  L  Q  S  G  G  K  I  F  P  Q  Y  V  L  M  F  G      p.700

          .         .         .         .         .         .       g.46304
 TTGCTTGTGGAATCACAGACACTCCTAGAGGAGAATGCTGTTCAAGGAACAGAACGTACT       c.2160
 L  L  V  E  S  Q  T  L  L  E  E  N  A  V  Q  G  T  E  R  T         p.720

          .         .         .          | 11        .         .    g.50068
 CTTGGATTAAATATAGCACCTTTTATTAACCAGTTTCAG | GTACCTATACGTGTATTTTTG    c.2220
 L  G  L  N  I  A  P  F  I  N  Q  F  Q   | V  P  I  R  V  F  L      p.740

          .         .         .         .         .         .       g.50128
 GACCTATCCTCATTGCCCTGTATACCTTTAAGCAAGCCAGTGGAACTCTTAAGACTAGAT       c.2280
 D  L  S  S  L  P  C  I  P  L  S  K  P  V  E  L  L  R  L  D         p.760

          .         .         .         .   | 12     .         .    g.50400
 TTAATGACTCCGTATTTGAACACCTCTAACAGAGAAGTAAAG | GTATACGTTTGTAAATCT    c.2340
 L  M  T  P  Y  L  N  T  S  N  R  E  V  K   | V  Y  V  C  K  S      p.780

          .         .         .         .         .         .       g.50460
 GGAAGACTGACTGCTATTCCATTTTGGTATCATATGTACCTTGATGAAGAGATTAGGTTG       c.2400
 G  R  L  T  A  I  P  F  W  Y  H  M  Y  L  D  E  E  I  R  L         p.800

          .         .         .         .         .         .       g.50520
 GATACTTCAAGTGAAGCCTCCCACTGGAAACAAGCTGCAGTTGTTTTAGATAATCCCATC       c.2460
 D  T  S  S  E  A  S  H  W  K  Q  A  A  V  V  L  D  N  P  I         p.820

          .         .         .         .         .         .       g.50580
 CAGGTTGAAATGGGAGAGGAACTTGTACTCAGCATTCAGCATCACAAAAGCAATGTCAGC       c.2520
 Q  V  E  M  G  E  E  L  V  L  S  I  Q  H  H  K  S  N  V  S         p.840

          .                                                         g.50598
 ATCACAGTAAAGCAATGA                                                 c.2538
 I  T  V  K  Q  X                                                   p.845

          .         .         .         .         .         .       g.50658
 agagcagttttccaatgaaaactgtgtaaatagagcatcaacaagtacaaaattcttgtc       c.*60

          .         .         .         .         .         .       g.50718
 ttaattagtgggggtatataaaaattccttgtaatggtcaaatattttttaaaattgaca       c.*120

          .         .         .                                     g.50748
 ttaataaagcatattttaaaagattctaaa                                     c.*150

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein arginine methyltransferase 10 (putative) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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