proline dehydrogenase (oxidase) 1 (PRODH) - coding DNA reference sequence

(used for variant description)

(last modified October 23, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_016335.4 in the PRODH gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008226.2, covering PRODH transcript NM_016335.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     ggtctcactctgttgctgtcttca       c.-181

 .         .         .         .         .         .                g.5084
 cggagagcaggagcagaggctttgagaagccagtgggccttggcctcagccctgccggca       c.-121

 .         .         .         .         .         .                g.5144
 gagggtccccaccatgcagctgaagtgccagggtgcttgtgaagtctaagcccttgtctg       c.-61

 .         .          | 02        .         .         .             g.5266
 gcatttgtcaggaatatagg | cgcacacttaagcggcccgggcgggtaccgccgtcccgcc    c.-1

          .         .         .         .         .         .       g.5326
 ATGGCTCTGAGGCGCGCCCTGCCCGCGCTGCGCCCCTGCATTCCCCGCTTCGTCCCGCTG       c.60
 M  A  L  R  R  A  L  P  A  L  R  P  C  I  P  R  F  V  P  L         p.20

          .         .         .         .         .         .       g.5386
 TCCACGGCGCCGGCCTCCCGCGAGCAGCCCGCAGCGGGCCCAGCGGCCGTGCCAGGAGGT       c.120
 S  T  A  P  A  S  R  E  Q  P  A  A  G  P  A  A  V  P  G  G         p.40

          .         .         .         .         .         .       g.5446
 GGGTCGGCCACGGCAGTGCGGCCGCCGGTGCCCGCCGTGGACTTCGGCAACGCGCAGGAG       c.180
 G  S  A  T  A  V  R  P  P  V  P  A  V  D  F  G  N  A  Q  E         p.60

          .         .         .         .         .         .       g.5506
 GCGTACCGCAGCCGGCGAACCTGGGAGCTGGCGCGGAGCCTGCTGGTGCTGCGCTTGTGC       c.240
 A  Y  R  S  R  R  T  W  E  L  A  R  S  L  L  V  L  R  L  C         p.80

          .         .         .    | 03    .         .         .    g.10382
 GCCTGGCCCGCGCTGCTGGCGCGCCACGAGCAG | CTGCTGTATGTTTCCAGGAAACTTCTA    c.300
 A  W  P  A  L  L  A  R  H  E  Q   | L  L  Y  V  S  R  K  L  L      p.100

          .         .         .         .         .         .       g.10442
 GGACAGAGGCTATTCAACAAGCTCATGAAGATGACCTTCTATGGGCATTTTGTAGCCGGG       c.360
 G  Q  R  L  F  N  K  L  M  K  M  T  F  Y  G  H  F  V  A  G         p.120

          .         .         .         .         .         .       g.10502
 GAGGACCAGGAGTCCATCCAGCCCCTGCTTCGGCACTACAGGGCCTTCGGTGTCAGCGCC       c.420
 E  D  Q  E  S  I  Q  P  L  L  R  H  Y  R  A  F  G  V  S  A         p.140

          .         .         .         .         .         .       g.10562
 ATCCTGGACTATGGAGTGGAGGAGGACCTGAGCCCCGAGGAGGCAGAGCACAAGGAGATG       c.480
 I  L  D  Y  G  V  E  E  D  L  S  P  E  E  A  E  H  K  E  M         p.160

    | 04     .         .         .        | 05.         .         . g.16376
 GA | GTCCTGCACCTCAGCTGCGGAGAGGGATGGCAGTG | GCACGAATAAGCGGGACAAGCAA c.540
 E  |  S  C  T  S  A  A  E  R  D  G  S  G |   T  N  K  R  D  K  Q   p.180

          .         .         .         .         .         .       g.16436
 TACCAGGCCCACCGGGCCTTCGGGGACCGCAGGAATGGTGTCATCAGTGCCCGCACCTAC       c.600
 Y  Q  A  H  R  A  F  G  D  R  R  N  G  V  I  S  A  R  T  Y         p.200

          .         .         .         .         .         .       g.16496
 TTCTACGCCAATGAGGCCAAGTGCGACAGCCACATGGAGACATTCTTGCGCTGCATCGAA       c.660
 F  Y  A  N  E  A  K  C  D  S  H  M  E  T  F  L  R  C  I  E         p.220

         | 06.         .         .         .         .         .    g.18427
 GCCTCAG | GTAGAGTCAGCGATGACGGCTTCATAGCCATTAAGCTCACAGCACTGGGGAGA    c.720
 A  S  G |   R  V  S  D  D  G  F  I  A  I  K  L  T  A  L  G  R      p.240

          .   | 07     .         .         .         .         .    g.18668
 CCCCAGTTTCTG | CTGCAGTTCTCAGAGGTGCTGGCCAAGTGGAGGTGCTTCTTTCACCAA    c.780
 P  Q  F  L   | L  Q  F  S  E  V  L  A  K  W  R  C  F  F  H  Q      p.260

          .         .         .         .         .         .       g.18728
 ATGGCTGTGGAGCAAGGGCAGGCGGGCCTGGCTGCCATGGACACCAAGCTGGAGGTGGCG       c.840
 M  A  V  E  Q  G  Q  A  G  L  A  A  M  D  T  K  L  E  V  A         p.280

           | 08        .         .         .         .         .    g.19200
 GTGCTGCAG | GAAAGTGTCGCAAAGTTGGGCATCGCATCCAGGGCTGAGATTGAGGACTGG    c.900
 V  L  Q   | E  S  V  A  K  L  G  I  A  S  R  A  E  I  E  D  W      p.300

          .         .          | 09        .         .         .    g.20161
 TTCACGGCAGAGACCCTGGGAGTGTCTGG | CACCATGGACCTGCTGGACTGGAGCAGCCTC    c.960
 F  T  A  E  T  L  G  V  S  G  |  T  M  D  L  L  D  W  S  S  L      p.320

          .         .         .         .         .  | 10      .    g.21764
 ATCGACAGCAGGACCAAGCTGTCCAAGCACTTGGTAGTCCCCAACGCACAG | ACAGGACAG    c.1020
 I  D  S  R  T  K  L  S  K  H  L  V  V  P  N  A  Q   | T  G  Q      p.340

          .         .         .         .         .         .       g.21824
 CTGGAGCCCCTGCTGTCCCGGTTCACTGAGGAGGAGGAGCTACAGATGACCAGGATGCTA       c.1080
 L  E  P  L  L  S  R  F  T  E  E  E  E  L  Q  M  T  R  M  L         p.360

          .         .     | 11   .         .         .         .    g.21992
 CAGCGGATGGATGTCCTGGCCAAG | AAAGCCACAGAGATGGGCGTGCGGCTGATGGTGGAT    c.1140
 Q  R  M  D  V  L  A  K   | K  A  T  E  M  G  V  R  L  M  V  D      p.380

          .         .         .         .         .         .       g.22052
 GCCGAGCAGACCTACTTCCAGCCGGCCATCAGCCGCCTGACGCTGGAGATGCAGCGGAAG       c.1200
 A  E  Q  T  Y  F  Q  P  A  I  S  R  L  T  L  E  M  Q  R  K         p.400

          .         .         .         .         .  | 12      .    g.23071
 TTCAATGTGGAGAAGCCGCTCATCTTCAACACATACCAGTGCTACCTCAAG | GATGCCTAT    c.1260
 F  N  V  E  K  P  L  I  F  N  T  Y  Q  C  Y  L  K   | D  A  Y      p.420

          .         .         .         .         .         .       g.23131
 GACAATGTGACCCTGGACGTGGAGCTGGCTCGCCGTGAGGGCTGGTGTTTTGGGGCCAAG       c.1320
 D  N  V  T  L  D  V  E  L  A  R  R  E  G  W  C  F  G  A  K         p.440

          .         .         .         .         .         .       g.23191
 CTGGTGCGGGGCGCATACCTGGCCCAGGAGCGAGCCCGTGCGGCAGAGATCGGCTATGAG       c.1380
 L  V  R  G  A  Y  L  A  Q  E  R  A  R  A  A  E  I  G  Y  E         p.460

          .         .         .         .        | 13.         .    g.24578
 GACCCCATCAACCCCACGTACGAGGCCACCAACGCCATGTACCACAG | GTGCCTGGACTAC    c.1440
 D  P  I  N  P  T  Y  E  A  T  N  A  M  Y  H  R  |  C  L  D  Y      p.480

          .         .         .         .         .         .       g.24638
 GTGTTGGAGGAGCTGAAGCACAACGCCAAGGCCAAGGTGATGGTGGCCTCCCACAATGAG       c.1500
 V  L  E  E  L  K  H  N  A  K  A  K  V  M  V  A  S  H  N  E         p.500

          .         .       | 14 .         .         .         .    g.28061
 GACACAGTGCGCTTTGCACTGCGCAG | GATGGAGGAGCTGGGCCTGCATCCTGCTGACCAC    c.1560
 D  T  V  R  F  A  L  R  R  |  M  E  E  L  G  L  H  P  A  D  H      p.520

          .         .         .         .         .      | 15  .    g.28196
 CAGGTGTACTTTGGACAGCTGCTAGGCATGTGTGACCAGATCAGCTTCCCGCTGG | GCCAG    c.1620
 Q  V  Y  F  G  Q  L  L  G  M  C  D  Q  I  S  F  P  L  G |   Q      p.540

          .         .         .         .         .         .       g.28256
 GCCGGCTACCCCGTGTACAAGTACGTGCCCTATGGCCCCGTGATGGAGGTGCTGCCCTAC       c.1680
 A  G  Y  P  V  Y  K  Y  V  P  Y  G  P  V  M  E  V  L  P  Y         p.560

          .         .         .         .         .         .       g.28316
 TTGTCCCGCCGTGCCCTGGAGAACAGCAGCCTCATGAAGGGCACCCATCGGGAGCGGCAG       c.1740
 L  S  R  R  A  L  E  N  S  S  L  M  K  G  T  H  R  E  R  Q         p.580

          .         .         .         .         .         .       g.28376
 CTGCTGTGGCTGGAGCTCTTGAGGCGGCTCCGAACTGGCAACCTCTTCCATCGCCCTGCC       c.1800
 L  L  W  L  E  L  L  R  R  L  R  T  G  N  L  F  H  R  P  A         p.600

                                                                    g.28379
 TAG                                                                c.1803
 X                                                                  p.600

          .         .         .         .         .         .       g.28439
 cacccgccagcacacccttagcctccagcaccccccgcccccgcccaggccatcaccaca       c.*60

          .         .         .         .         .         .       g.28499
 gctgcagccaaccccatcctcacacagattcaccttttttcaccccacacttgcagagct       c.*120

          .         .         .         .         .         .       g.28559
 gctggaggtgaggtcaggtgcctcccagccctgcccagagtatgggcactcaggtgtggg       c.*180

          .         .         .         .         .         .       g.28619
 ccgaacctgatacctgcctgggacagccactggaaacttttgggaactctcctcgaatgt       c.*240

          .         .         .         .         .         .       g.28679
 gtgggcccaaggcccccacctctgtgacccccatgtccttggacctagaggattgtccac       c.*300

          .         .         .         .         .         .       g.28739
 cttctgccaaggccagcccacacagcccgagccccttggggagcagtggccgggctgggg       c.*360

          .         .         .         .                           g.28780
 aggcctgcctggtcaataaaccactgttcctgcagctgaga                          c.*401

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Proline dehydrogenase (oxidase) 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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