prokineticin receptor 2 (PROKR2) - coding DNA reference sequence

(used for variant description)

(last modified October 21, 2016)

This file was created to facilitate the description of sequence variants on transcript NM_144773.2 in the PROKR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008132.1, covering PROKR2 transcript NM_144773.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGGCAGCCCAGAATGGAAACACCAGTTTCACACCCAACTTTAATCCACCCCAAGACCAT       c.60
 M  A  A  Q  N  G  N  T  S  F  T  P  N  F  N  P  P  Q  D  H         p.20

          .         .         .         .         .         .       g.120
 GCCTCCTCCCTCTCCTTTAACTTCAGTTATGGTGATTATGACCTCCCTATGGATGAGGAT       c.120
 A  S  S  L  S  F  N  F  S  Y  G  D  Y  D  L  P  M  D  E  D         p.40

          .         .         .         .         .         .       g.180
 GAGGACATGACCAAGACCCGGACCTTCTTCGCAGCCAAGATCGTCATTGGCATTGCACTG       c.180
 E  D  M  T  K  T  R  T  F  F  A  A  K  I  V  I  G  I  A  L         p.60

          .         .         .         .         .         .       g.240
 GCAGGCATCATGCTGGTCTGCGGCATCGGTAACTTTGTCTTTATCGCTGCCCTCACCCGC       c.240
 A  G  I  M  L  V  C  G  I  G  N  F  V  F  I  A  A  L  T  R         p.80

          .         .         .         .         .         .       g.300
 TATAAGAAGTTGCGCAACCTCACCAATCTGCTCATTGCCAACCTGGCCATCTCCGACTTC       c.300
 Y  K  K  L  R  N  L  T  N  L  L  I  A  N  L  A  I  S  D  F         p.100

          .         .         .         .         .         .       g.360
 CTGGTGGCCATCATCTGCTGCCCCTTCGAGATGGACTACTACGTGGTACGGCAGCTCTCC       c.360
 L  V  A  I  I  C  C  P  F  E  M  D  Y  Y  V  V  R  Q  L  S         p.120

          .         .         .         .         .         .       g.420
 TGGGAGCATGGCCACGTGCTCTGTGCCTCCGTCAACTACCTGCGCACCGTCTCCCTCTAC       c.420
 W  E  H  G  H  V  L  C  A  S  V  N  Y  L  R  T  V  S  L  Y         p.140

          .         .         .         | 02         .         .    g.11655
 GTCTCCACCAATGCCTTGCTGGCCATTGCCATTGACAG | ATATCTCGCCATCGTTCACCCC    c.480
 V  S  T  N  A  L  L  A  I  A  I  D  R  |  Y  L  A  I  V  H  P      p.160

          .         .         .         .         .         .       g.11715
 TTGAAACCACGGATGAATTATCAAACGGCCTCCTTCCTGATCGCCTTGGTCTGGATGGTG       c.540
 L  K  P  R  M  N  Y  Q  T  A  S  F  L  I  A  L  V  W  M  V         p.180

          .         .         .         .         .         .       g.11775
 TCCATTCTCATTGCCATCCCATCGGCTTACTTTGCAACAGAAACGGTCCTCTTTATTGTC       c.600
 S  I  L  I  A  I  P  S  A  Y  F  A  T  E  T  V  L  F  I  V         p.200

          .         .         .         .         .         .       g.11835
 AAGAGCCAGGAGAAGATCTTCTGTGGCCAGATCTGGCCTGTGGATCAGCAGCTCTACTAC       c.660
 K  S  Q  E  K  I  F  C  G  Q  I  W  P  V  D  Q  Q  L  Y  Y         p.220

          .         .         .         .         .         .       g.11895
 AAGTCCTACTTCCTCTTCATCTTTGGTGTCGAGTTCGTGGGCCCTGTGGTCACCATGACC       c.720
 K  S  Y  F  L  F  I  F  G  V  E  F  V  G  P  V  V  T  M  T         p.240

          .         .         .         .         .         .       g.11955
 CTGTGCTATGCCAGGATCTCCCGGGAGCTCTGGTTCAAGGCAGTCCCTGGGTTCCAGACG       c.780
 L  C  Y  A  R  I  S  R  E  L  W  F  K  A  V  P  G  F  Q  T         p.260

          .         .         .         .         .         .       g.12015
 GAGCAGATTCGCAAGCGGCTGCGCTGCCGCAGGAAGACGGTCCTGGTGCTCATGTGCATT       c.840
 E  Q  I  R  K  R  L  R  C  R  R  K  T  V  L  V  L  M  C  I         p.280

          .         .         .         .         .         .       g.12075
 CTCACGGCCTATGTGCTGTGCTGGGCACCCTTCTACGGTTTCACCATCGTTCGTGACTTC       c.900
 L  T  A  Y  V  L  C  W  A  P  F  Y  G  F  T  I  V  R  D  F         p.300

          .         .         .         .         .         .       g.12135
 TTCCCCACTGTGTTCGTGAAGGAAAAGCACTACCTCACTGCCTTCTACGTGGTCGAGTGC       c.960
 F  P  T  V  F  V  K  E  K  H  Y  L  T  A  F  Y  V  V  E  C         p.320

          .         .         .         .         .         .       g.12195
 ATCGCCATGAGCAACAGCATGATCAACACCGTGTGCTTCGTGACGGTCAAGAACAACACC       c.1020
 I  A  M  S  N  S  M  I  N  T  V  C  F  V  T  V  K  N  N  T         p.340

          .         .         .         .         .         .       g.12255
 ATGAAGTACTTCAAGAAGATGATGCTGCTGCACTGGCGTCCCTCCCAGCGGGGGAGCAAG       c.1080
 M  K  Y  F  K  K  M  M  L  L  H  W  R  P  S  Q  R  G  S  K         p.360

          .         .         .         .         .         .       g.12315
 TCCAGTGCTGACCTTGACCTCAGAACCAACGGGGTGCCCACCACAGAAGAGGTGGACTGT       c.1140
 S  S  A  D  L  D  L  R  T  N  G  V  P  T  T  E  E  V  D  C         p.380

          .                                                         g.12330
 ATCAGGCTGAAGTGA                                                    c.1155
 I  R  L  K  X                                                      p.384

 

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Prokineticin receptor 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.