protein S (alpha) (PROS1) - coding DNA reference sequence

(used for variant description)

(last modified May 27, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000313.3 in the PROS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009813.1, covering PROS1 transcript NM_000313.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    tttggaaacgtcacactgtggaggaaaagcagcaactaggg       c.-301

 .         .         .         .         .         .                g.5101
 agctggtgaagaaggatgtctcagcagtgtttactaggcctccaacactagagcccatcc       c.-241

 .         .         .         .         .         .                g.5161
 cccagctccgaaaagcttcctggaaatgtccttgttatcacttcccctctcgggctgggc       c.-181

 .         .         .         .         .         .                g.5221
 gctgggagcgggcggtctcctccgcccccggctgttccgccgaggctcgctgggtcgctg       c.-121

 .         .         .         .         .         .                g.5281
 gcgccgccgcgcagcacggctcagaccgaggcgcacaggctcgcagctccgcggcgccta       c.-61

 .         .         .         .         .         .                g.5341
 gcgctccggtccccgccgcgacgcgccaccgtccctgccggcgcctccgcgcgcttcgaa       c.-1

          .         .         .         .         .         .       g.5401
 ATGAGGGTCCTGGGTGGGCGCTGCGGGGCGCTGCTGGCGTGTCTCCTCCTAGTGCTTCCC       c.60
 M  R  V  L  G  G  R  C  G  A  L  L  A  C  L  L  L  V  L  P         p.20

          .       | 02 .         .         .         .         .    g.51727
 GTCTCAGAGGCAAACT | TTTTGTCAAAGCAACAGGCTTCACAAGTCCTGGTTAGGAAGCGT    c.120
 V  S  E  A  N  F |   L  S  K  Q  Q  A  S  Q  V  L  V  R  K  R      p.40

          .         .         .         .         .         .       g.51787
 CGTGCAAATTCTTTACTTGAAGAAACCAAACAGGGTAATCTTGAAAGAGAATGCATCGAA       c.180
 R  A  N  S  L  L  E  E  T  K  Q  G  N  L  E  R  E  C  I  E         p.60

          .         .         .         .         .     | 03   .    g.54832
 GAACTGTGCAATAAAGAAGAAGCCAGGGAGGTCTTTGAAAATGACCCGGAAACG | GATTAT    c.240
 E  L  C  N  K  E  E  A  R  E  V  F  E  N  D  P  E  T   | D  Y      p.80

          .          | 04        .         .         .         .    g.68426
 TTTTATCCAAAATACTTAG | TTTGTCTTCGCTCTTTTCAAACTGGGTTATTCACTGCTGCA    c.300
 F  Y  P  K  Y  L  V |   C  L  R  S  F  Q  T  G  L  F  T  A  A      p.100

          .         .         .         .       | 05 .         .    g.72961
 CGTCAGTCAACTAATGCTTATCCTGACCTAAGAAGCTGTGTCAATG | CCATTCCAGACCAG    c.360
 R  Q  S  T  N  A  Y  P  D  L  R  S  C  V  N  A |   I  P  D  Q      p.120

          .         .         .         .         .         .       g.73021
 TGTAGTCCTCTGCCATGCAATGAAGATGGATATATGAGCTGCAAAGATGGAAAAGCTTCT       c.420
 C  S  P  L  P  C  N  E  D  G  Y  M  S  C  K  D  G  K  A  S         p.140

          .         .         .         .          | 06        .    g.73186
 TTTACTTGCACTTGTAAACCAGGTTGGCAAGGAGAAAAGTGTGAATTTG | ACATAAATGAA    c.480
 F  T  C  T  C  K  P  G  W  Q  G  E  K  C  E  F  D |   I  N  E      p.160

          .         .         .         .         .         .       g.73246
 TGCAAAGATCCCTCAAATATAAATGGAGGTTGCAGTCAAATTTGTGATAATACACCTGGA       c.540
 C  K  D  P  S  N  I  N  G  G  C  S  Q  I  C  D  N  T  P  G         p.180

          .         .         .         .         .         .       g.73306
 AGTTACCACTGTTCCTGTAAAAATGGTTTTGTTATGCTTTCAAATAAGAAAGATTGTAAA       c.600
 S  Y  H  C  S  C  K  N  G  F  V  M  L  S  N  K  K  D  C  K         p.200

   | 07      .         .         .         .         .         .    g.78220
 G | ATGTGGATGAATGCTCTTTGAAGCCAAGCATTTGTGGCACAGCTGTGTGCAAGAACATC    c.660
 D |   V  D  E  C  S  L  K  P  S  I  C  G  T  A  V  C  K  N  I      p.220

          .         .         .         .         .         .       g.78280
 CCAGGAGATTTTGAATGTGAATGCCCCGAAGGCTACAGATATAATCTCAAATCAAAGTCT       c.720
 P  G  D  F  E  C  E  C  P  E  G  Y  R  Y  N  L  K  S  K  S         p.240

         | 08.         .         .         .         .         .    g.80574
 TGTGAAG | ATATAGATGAATGCTCTGAGAACATGTGTGCTCAGCTTTGTGTCAATTACCCT    c.780
 C  E  D |   I  D  E  C  S  E  N  M  C  A  Q  L  C  V  N  Y  P      p.260

          .         .         .         .         .         .       g.80634
 GGAGGTTACACTTGCTATTGTGATGGGAAGAAAGGATTCAAACTTGCCCAAGATCAGAAG       c.840
 G  G  Y  T  C  Y  C  D  G  K  K  G  F  K  L  A  Q  D  Q  K         p.280

           | 09        .         .         .         .         .    g.82450
 AGTTGTGAG | GTTGTTTCAGTGTGCCTTCCCTTGAACCTTGACACAAAGTATGAATTACTT    c.900
 S  C  E   | V  V  S  V  C  L  P  L  N  L  D  T  K  Y  E  L  L      p.300

          .         .         .         .         .         .       g.82510
 TACTTGGCGGAGCAGTTTGCAGGGGTTGTTTTATATTTAAAATTTCGTTTGCCAGAAATC       c.960
 Y  L  A  E  Q  F  A  G  V  V  L  Y  L  K  F  R  L  P  E  I         p.320

       | 10  .         .         .         .         .         .    g.86023
 AGCAG | ATTTTCAGCAGAATTTGATTTCCGGACATATGATTCAGAAGGCGTGATACTGTAC    c.1020
 S  R  |  F  S  A  E  F  D  F  R  T  Y  D  S  E  G  V  I  L  Y      p.340

          .         .         .         .         .         .       g.86083
 GCAGAATCTATCGATCACTCAGCGTGGCTCCTGATTGCACTTCGTGGTGGAAAGATTGAA       c.1080
 A  E  S  I  D  H  S  A  W  L  L  I  A  L  R  G  G  K  I  E         p.360

          .         .         .         .         .         .       g.86143
 GTTCAGCTTAAGAATGAACATACATCCAAAATCACAACTGGAGGTGATGTTATTAATAAT       c.1140
 V  Q  L  K  N  E  H  T  S  K  I  T  T  G  G  D  V  I  N  N         p.380

          .      | 11  .         .         .         .         .    g.92632
 GGTCTATGGAATATG | GTGTCTGTGGAAGAATTAGAACATAGTATTAGCATTAAAATAGCT    c.1200
 G  L  W  N  M   | V  S  V  E  E  L  E  H  S  I  S  I  K  I  A      p.400

          .         .         .         .         .         .       g.92692
 AAAGAAGCTGTGATGGATATAAATAAACCTGGACCCCTTTTTAAGCCGGAAAATGGATTG       c.1260
 K  E  A  V  M  D  I  N  K  P  G  P  L  F  K  P  E  N  G  L         p.420

          .         .         .         .         .         .       g.92752
 CTGGAAACCAAAGTATACTTTGCAGGATTCCCTCGGAAAGTGGAAAGTGAACTCATTAAA       c.1320
 L  E  T  K  V  Y  F  A  G  F  P  R  K  V  E  S  E  L  I  K         p.440

     | 12    .         .         .         .         .         .    g.94251
 CCG | ATTAACCCTCGTCTAGATGGATGTATACGAAGCTGGAATTTGATGAAGCAAGGAGCT    c.1380
 P   | I  N  P  R  L  D  G  C  I  R  S  W  N  L  M  K  Q  G  A      p.460

          .         .         .         .         .         .       g.94311
 TCTGGAATAAAGGAAATTATTCAAGAAAAACAAAATAAGCATTGCCTGGTTACTGTGGAG       c.1440
 S  G  I  K  E  I  I  Q  E  K  Q  N  K  H  C  L  V  T  V  E         p.480

          .         .         .         .         .   | 13     .    g.99784
 AAGGGCTCCTACTATCCTGGTTCTGGAATTGCTCAATTTCACATAGATTATA | ATAATGTA    c.1500
 K  G  S  Y  Y  P  G  S  G  I  A  Q  F  H  I  D  Y  N |   N  V      p.500

          .         .         .         .         .         .       g.99844
 TCCAGTGCTGAGGGTTGGCATGTAAATGTGACCTTGAATATTCGTCCATCCACGGGCACT       c.1560
 S  S  A  E  G  W  H  V  N  V  T  L  N  I  R  P  S  T  G  T         p.520

          .         .         .         .         .         .       g.99904
 GGTGTTATGCTTGCCTTGGTTTCTGGTAACAACACAGTGCCCTTTGCTGTGTCCTTGGTG       c.1620
 G  V  M  L  A  L  V  S  G  N  N  T  V  P  F  A  V  S  L  V         p.540

          .         .     | 14   .         .         .         .    g.101935
 GACTCCACCTCTGAAAAATCACAG | GATATTCTGTTATCTGTTGAAAATACTGTAATATAT    c.1680
 D  S  T  S  E  K  S  Q   | D  I  L  L  S  V  E  N  T  V  I  Y      p.560

          .         .         .         .         .         .       g.101995
 CGGATACAGGCCCTAAGTCTATGTTCCGATCAACAATCTCATCTGGAATTTAGAGTCAAC       c.1740
 R  I  Q  A  L  S  L  C  S  D  Q  Q  S  H  L  E  F  R  V  N         p.580

          .         .         .         .         .         .       g.102055
 AGAAACAATCTGGAGTTGTCGACACCACTTAAAATAGAAACCATCTCCCATGAAGACCTT       c.1800
 R  N  N  L  E  L  S  T  P  L  K  I  E  T  I  S  H  E  D  L         p.600

          .         .         .         .         .         .       g.102115
 CAAAGACAACTTGCCGTCTTGGACAAAGCAATGAAAGCAAAAGTGGCCACATACCTGGGT       c.1860
 Q  R  Q  L  A  V  L  D  K  A  M  K  A  K  V  A  T  Y  L  G         p.620

          . | 15       .         .         .         .         .    g.104735
 GGCCTTCCAG | ATGTTCCATTCAGTGCCACACCAGTGAATGCCTTTTATAATGGCTGCATG    c.1920
 G  L  P  D |   V  P  F  S  A  T  P  V  N  A  F  Y  N  G  C  M      p.640

          .         .         .         .         .         .       g.104795
 GAAGTGAATATTAATGGTGTACAGTTGGATCTGGATGAAGCCATTTCTAAACATAATGAT       c.1980
 E  V  N  I  N  G  V  Q  L  D  L  D  E  A  I  S  K  H  N  D         p.660

          .         .         .         .         .                 g.104846
 ATTAGAGCTCACTCATGTCCATCAGTTTGGAAAAAGACAAAGAATTCTTAA                c.2031
 I  R  A  H  S  C  P  S  V  W  K  K  T  K  N  S  X                  p.676

          .         .         .         .         .         .       g.104906
 ggcatcttttctctgcttataataccttttccttgtgtgtaattatacttatgtttcaat       c.*60

          .         .         .         .         .         .       g.104966
 aacagctgaagggttttatttacaatgtgcagtctttgattattttgtggtcctttcctg       c.*120

          .         .         .         .         .         .       g.105026
 ggatttttaaaaggtcctttgtcaaggaaaaaaattctgttgtgatataaatcacagtaa       c.*180

          .         .         .         .         .         .       g.105086
 agaaattcttacttctcttgctatctaagaatagtgaaaaataacaattttaaatttgaa       c.*240

          .         .         .         .         .         .       g.105146
 tttttttcctacaaatgacagtttcaatttttgtttgtaaaactaaattttaattttatc       c.*300

          .         .         .         .         .         .       g.105206
 atcatgaactagtgtctaaatacctatgtttttttcagaaagcaaggaagtaaactcaaa       c.*360

          .         .         .         .         .         .       g.105266
 caaaagtgcgtgtaattaaatactattaatcataggcagatactattttgtttatgtttt       c.*420

          .         .         .         .         .         .       g.105326
 tgtttttttcctgatgaaggcagaagagatggtggtctattaaatatgaattgaatggag       c.*480

          .         .         .         .         .         .       g.105386
 ggtcctaatgccttatttcaaaacaattcctcagggggaacagctttggcttcatctttc       c.*540

          .         .         .         .         .         .       g.105446
 tcttgtgtggcttcacatttaaaccagtatctttattgaattagaaaacaagtgggacat       c.*600

          .         .         .         .         .         .       g.105506
 attttcctgagagcagcacaggaatcttcttcttggcagctgcagtctgtcaggatgaga       c.*660

          .         .         .         .         .         .       g.105566
 tatcagattaggttggataggtggggaaatctgaagtgggtacattttttaaattttgct       c.*720

          .         .         .         .         .         .       g.105626
 gtgtgggtcacacaaggtctacattacaaaagacagaattcagggatggaaaggagaatg       c.*780

          .         .         .         .         .         .       g.105686
 aacaaatgtgggagttcatagttttccttgaatccaacttttaattaccagagtaagttg       c.*840

          .         .         .         .         .         .       g.105746
 ccaaaatgtgattgttgaagtacaaaaggaactatgaaaaccagaacaaattttaacaaa       c.*900

          .         .         .         .         .         .       g.105806
 aggacaaccacagagggatatagtgaatatcgtatcattgtaatcaaagaagtaaggagg       c.*960

          .         .         .         .         .         .       g.105866
 taagattgccacgtgcctgctggtactgtgatgcatttcaagtggcagttttatcacgtt       c.*1020

          .         .         .         .         .         .       g.105926
 tgaatctaccattcatagccagatgtgtatcagatgtttcactgacagtttttaacaata       c.*1080

          .         .         .         .         .         .       g.105986
 aattcttttcactgtattttatatcacttataataaatcggtgtataattttaaaatgca       c.*1140

          .         .         .         .         .         .       g.106046
 tgtgaatatctttattatatcaactgtttgaataaaacaaaattacataatagacattta       c.*1200

                                                                    g.106054
 actcttca                                                           c.*1208

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein S (alpha) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21
©2004-2018 Leiden University Medical Center