PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) (PRPF6) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_012469.3 in the PRPF6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029719.1, covering PRPF6 transcript NM_012469.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             gggcggggcgtgtgcggactgagcgctctgcttccggggcgcgggtga       c.-121

 .         .         .         .         .         .                g.5108
 cgcgacgacggcgacactttgctacggagtgcatcggacgtcgaagcctagagtctctgc       c.-61

 .         .         .         .         .         .                g.5168
 gtctttccctcttccgctgcctcattcctttccttcctagccttggtcgtcgccgccacc       c.-1

          .         .         .         .         .         .       g.5228
 ATGAACAAGAAGAAGAAACCGTTCCTAGGGATGCCCGCGCCCCTCGGCTACGTGCCGGGG       c.60
 M  N  K  K  K  K  P  F  L  G  M  P  A  P  L  G  Y  V  P  G         p.20

          .  | 02      .         .         .         .         .    g.7018
 CTGGGCCGGGG | CGCCACTGGCTTCACCACGCGGTCAGACATTGGGCCCGCCCGTGATGCA    c.120
 L  G  R  G  |  A  T  G  F  T  T  R  S  D  I  G  P  A  R  D  A      p.40

          .         .         .         .         .         .       g.7078
 AATGACCCTGTGGATGATCGCCATGCACCCCCAGGCAAGAGAACCGTTGGGGACCAGATG       c.180
 N  D  P  V  D  D  R  H  A  P  P  G  K  R  T  V  G  D  Q  M         p.60

          .         .         .         .         .         .       g.7138
 AAGAAAAATCAGGCTGCTGACGATGACGACGAGGATCTAAATGACACCAATTACGATGAG       c.240
 K  K  N  Q  A  A  D  D  D  D  E  D  L  N  D  T  N  Y  D  E         p.80

  | 03       .         .         .         .         .         .    g.8889
  | TTTAATGGCTATGCTGGGAGCCTCTTCTCAAGTGGACCCTACGAGAAAGATGATGAGGAA    c.300
  | F  N  G  Y  A  G  S  L  F  S  S  G  P  Y  E  K  D  D  E  E      p.100

          .         .         .         .         .          | 04    g.17330
 GCAGATGCTATCTATGCAGCCCTGGATAAAAGGATGGATGAAAGAAGAAAAGAAAGACG | G    c.360
 A  D  A  I  Y  A  A  L  D  K  R  M  D  E  R  R  K  E  R  R  |      p.120

          .         .         .         .         .         .       g.17390
 GAGCAAAGGGAGAAAGAAGAAATAGAGAAATATCGTATGGAACGCCCCAAAATCCAACAG       c.420
 E  Q  R  E  K  E  E  I  E  K  Y  R  M  E  R  P  K  I  Q  Q         p.140

          .         | 05         .         .         .         .    g.18880
 CAGTTCTCAGACCTCAAG | AGGAAGTTGGCAGAAGTCACAGAAGAAGAGTGGCTGAGCATC    c.480
 Q  F  S  D  L  K   | R  K  L  A  E  V  T  E  E  E  W  L  S  I      p.160

          .         .         .         .         .         .       g.18940
 CCCGAGGTTGGCGATGCCAGAAATAAACGTCAGCGGAACCCACGCTATGAGAAGCTGACC       c.540
 P  E  V  G  D  A  R  N  K  R  Q  R  N  P  R  Y  E  K  L  T         p.180

          .         .         .         .         .         .       g.19000
 CCTGTTCCTGACAGTTTCTTTGCCAAACATTTACAGACCGGAGAGAACCATACCTCAGTG       c.600
 P  V  P  D  S  F  F  A  K  H  L  Q  T  G  E  N  H  T  S  V         p.200

          .      | 06  .         .         .         .         .    g.19294
 GATCCCCGACAAACT | CAATTTGGAGGTCTTAACACACCCTATCCAGGTGGACTAAACACT    c.660
 D  P  R  Q  T   | Q  F  G  G  L  N  T  P  Y  P  G  G  L  N  T      p.220

          .         .         .         .         .         .       g.19354
 CCATACCCAGGTGGAATGACGCCAGGACTGATGACACCTGGCACAGGTGAGCTGGACATG       c.720
 P  Y  P  G  G  M  T  P  G  L  M  T  P  G  T  G  E  L  D  M         p.240

          .         .         .         .         .  | 07      .    g.22976
 AGGAAGATTGGCCAAGCGAGGAACACTCTGATGGACATGAGGCTGAGCCAG | GTGTCTGAC    c.780
 R  K  I  G  Q  A  R  N  T  L  M  D  M  R  L  S  Q   | V  S  D      p.260

          .         .         .         .         .         .       g.23036
 TCCGTGAGTGGACAGACCGTCGTTGACCCCAAAGGCTACCTGACGGATTTAAATTCCATG       c.840
 S  V  S  G  Q  T  V  V  D  P  K  G  Y  L  T  D  L  N  S  M         p.280

          .         .       | 08 .         .         .         .    g.23559
 ATCCCGACACACGGAGGAGACATCAA | TGATATCAAGAAGGCGCGACTGCTCCTCAAGTCT    c.900
 I  P  T  H  G  G  D  I  N  |  D  I  K  K  A  R  L  L  L  K  S      p.300

          .         .         .         .         .         .       g.23619
 GTTCGGGAGACGAACCCTCATCACCCGCCAGCCTGGATTGCATCAGCCCGCCTGGAAGAA       c.960
 V  R  E  T  N  P  H  H  P  P  A  W  I  A  S  A  R  L  E  E         p.320

          .         .         .         .         .         .       g.23679
 GTCACTGGGAAGCTACAAGTAGCTCGGAACCTTATCATGAAGGGGACGGAGATGTGCCCC       c.1020
 V  T  G  K  L  Q  V  A  R  N  L  I  M  K  G  T  E  M  C  P         p.340

     | 09    .         .         .         .         .         .    g.25056
 AAG | AGTGAAGATGTCTGGCTGGAAGCAGCCAGGTTGCAGCCTGGGGACACAGCCAAGGCC    c.1080
 K   | S  E  D  V  W  L  E  A  A  R  L  Q  P  G  D  T  A  K  A      p.360

          .         .         .         .         .         .       g.25116
 GTGGTAGCCCAAGCTGTCCGTCATCTCCCACAGTCTGTCAGGATTTACATCAGAGCCGCA       c.1140
 V  V  A  Q  A  V  R  H  L  P  Q  S  V  R  I  Y  I  R  A  A         p.380

          .         .         .         .       | 10 .         .    g.34136
 GAGCTGGAAACGGACATTCGTGCAAAGAAGCGGGTTCTTCGGAAAG | CCCTCGAGCATGTT    c.1200
 E  L  E  T  D  I  R  A  K  K  R  V  L  R  K  A |   L  E  H  V      p.400

          .         .         .         .         .         .       g.34196
 CCAAACTCGGTTCGCTTGTGGAAAGCAGCCGTTGAGCTGGAAGAACCTGAAGATGCTAGA       c.1260
 P  N  S  V  R  L  W  K  A  A  V  E  L  E  E  P  E  D  A  R         p.420

          .         .         .         .      | 11  .         .    g.35222
 ATCATGCTGAGCCGAGCTGTGGAGTGCTGCCCCACCAGCGTGGAG | CTCTGGCTTGCTCTG    c.1320
 I  M  L  S  R  A  V  E  C  C  P  T  S  V  E   | L  W  L  A  L      p.440

          .         .         .         .         .         .       g.35282
 GCAAGGCTGGAGACCTATGAAAATGCCCGCAAGGTCTTGAACAAGGCGCGGGAGAACATT       c.1380
 A  R  L  E  T  Y  E  N  A  R  K  V  L  N  K  A  R  E  N  I         p.460

          .         .         .         .         .         .       g.35342
 CCTACAGACCGACATATCTGGATCACGGCTGCTAAGCTGGAGGAAGCCAATGGGAACACG       c.1440
 P  T  D  R  H  I  W  I  T  A  A  K  L  E  E  A  N  G  N  T         p.480

          .         .         .         .         .         .       g.35402
 CAGATGGTGGAGAAGATCATCGACCGAGCCATCACCTCGCTGCGGGCCAACGGTGTGGAG       c.1500
 Q  M  V  E  K  I  I  D  R  A  I  T  S  L  R  A  N  G  V  E         p.500

          .         .     | 12   .         .         .         .    g.40681
 ATCAACCGTGAGCAGTGGATCCAG | GATGCCGAGGAATGTGACAGGGCTGGGAGTGTGGCC    c.1560
 I  N  R  E  Q  W  I  Q   | D  A  E  E  C  D  R  A  G  S  V  A      p.520

          .         .         .         .         .         .       g.40741
 ACCTGCCAGGCCGTCATGCGTGCCGTGATTGGGATTGGGATTGAGGAGGAAGATCGGAAG       c.1620
 T  C  Q  A  V  M  R  A  V  I  G  I  G  I  E  E  E  D  R  K         p.540

          .         .        | 13.         .         .         .    g.46712
 CATACCTGGATGGAGGATGCTGACAGT | TGTGTAGCCCACAATGCCCTGGAGTGTGCACGA    c.1680
 H  T  W  M  E  D  A  D  S   | C  V  A  H  N  A  L  E  C  A  R      p.560

          .         .         .         .         .         .       g.46772
 GCCATCTACGCCTACGCCCTGCAGGTGTTCCCCAGCAAGAAGAGTGTGTGGCTGCGCGCC       c.1740
 A  I  Y  A  Y  A  L  Q  V  F  P  S  K  K  S  V  W  L  R  A         p.580

          .         .          | 14        .         .         .    g.48508
 GCGTACTTCGAGAAGAACCATGGCACTCG | GGAGTCCCTGGAAGCACTCCTGCAGAGGGCT    c.1800
 A  Y  F  E  K  N  H  G  T  R  |  E  S  L  E  A  L  L  Q  R  A      p.600

          .         .         .         .         .         .       g.48568
 GTGGCCCACTGCCCCAAAGCAGAGGTGCTGTGGCTCATGGGCGCCAAGTCCAAGTGGCTG       c.1860
 V  A  H  C  P  K  A  E  V  L  W  L  M  G  A  K  S  K  W  L         p.620

          .         .         .         .         | 15         .    g.49873
 GCAGGGGATGTGCCTGCAGCAAGGAGCATCCTGGCCCTGGCCTTCCAG | GCCAACCCCAAC    c.1920
 A  G  D  V  P  A  A  R  S  I  L  A  L  A  F  Q   | A  N  P  N      p.640

          .         .         .         .         .         .       g.49933
 AGTGAGGAGATCTGGCTGGCAGCCGTGAAGCTGGAGTCCGAGAATGATGAGTACGAGCGG       c.1980
 S  E  E  I  W  L  A  A  V  K  L  E  S  E  N  D  E  Y  E  R         p.660

          .         .         .         .         | 16         .    g.50916
 GCCCGGAGGCTGCTGGCCAAGGCGCGGAGCAGTGCCCCCACCGCCCGG | GTGTTCATGAAG    c.2040
 A  R  R  L  L  A  K  A  R  S  S  A  P  T  A  R   | V  F  M  K      p.680

          .         .         .         .         .         .       g.50976
 TCTGTGAAGCTGGAGTGGGTGCAAGACAACATCAGGGCAGCCCAAGATCTGTGCGAGGAG       c.2100
 S  V  K  L  E  W  V  Q  D  N  I  R  A  A  Q  D  L  C  E  E         p.700

          .         .         .         .         .         .       g.51036
 GCCCTGCGGCACTATGAGGACTTCCCCAAGCTGTGGATGATGAAGGGGCAGATCGAGGAG       c.2160
 A  L  R  H  Y  E  D  F  P  K  L  W  M  M  K  G  Q  I  E  E         p.720

          .         .         .         .      | 17  .         .    g.51540
 CAGAAGGAGATGATGGAGAAGGCGCGGGAAGCCTATAACCAGGGG | TTGAAGAAGTGTCCC    c.2220
 Q  K  E  M  M  E  K  A  R  E  A  Y  N  Q  G   | L  K  K  C  P      p.740

          .         .         .         .         .         .       g.51600
 CACTCCACACCCCTGTGGCTTTTGCTCTCTCGGCTGGAGGAGAAGATTGGGCAGCTTACT       c.2280
 H  S  T  P  L  W  L  L  L  S  R  L  E  E  K  I  G  Q  L  T         p.760

          .         .         .         .         .          | 18    g.52401
 CGAGCACGGGCCATTTTGGAAAAGTCTCGTCTGAAGAACCCAAAGAACCCTGGGCTGTG | G    c.2340
 R  A  R  A  I  L  E  K  S  R  L  K  N  P  K  N  P  G  L  W  |      p.780

          .         .         .         .         .         .       g.52461
 TTGGAGTCCGTGCGGCTGGAGTACCGTGCGGGGCTGAAGAACATCGCAAATACACTCATG       c.2400
 L  E  S  V  R  L  E  Y  R  A  G  L  K  N  I  A  N  T  L  M         p.800

          .         .         .  | 19      .         .         .    g.53328
 GCCAAGGCGCTGCAGGAGTGCCCCAACTCCG | GTATCCTGTGGTCTGAGGCCATCTTCCTC    c.2460
 A  K  A  L  Q  E  C  P  N  S  G |   I  L  W  S  E  A  I  F  L      p.820

          .         .         .         .         .         .       g.53388
 GAGGCAAGGCCCCAGAGGAGGACCAAGAGCGTGGATGCCCTGAAGAAGTGTGAGCATGAC       c.2520
 E  A  R  P  Q  R  R  T  K  S  V  D  A  L  K  K  C  E  H  D         p.840

          .         .       | 20 .         .         .         .    g.55874
 CCCCATGTGCTCCTGGCCGTGGCCAA | GCTGTTTTGGAGTCAGCGGAAGATCACCAAGGCC    c.2580
 P  H  V  L  L  A  V  A  K  |  L  F  W  S  Q  R  K  I  T  K  A      p.860

          .         .         .         .         .         .       g.55934
 AGGGAGTGGTTCCACCGCACTGTGAAGATTGACTCGGACCTGGGGGATGCCTGGGCCTTC       c.2640
 R  E  W  F  H  R  T  V  K  I  D  S  D  L  G  D  A  W  A  F         p.880

          .         .         .    | 21    .         .         .    g.56790
 TTCTACAAGTTTGAGCTGCAGCATGGCACTGAG | GAGCAGCAGGAGGAGGTGAGGAAGCGC    c.2700
 F  Y  K  F  E  L  Q  H  G  T  E   | E  Q  Q  E  E  V  R  K  R      p.900

          .         .         .         .         .         .       g.56850
 TGTGAGAGTGCAGAGCCTCGGCATGGGGAGCTGTGGTGCGCCGTGTCCAAGGACATCGCC       c.2760
 C  E  S  A  E  P  R  H  G  E  L  W  C  A  V  S  K  D  I  A         p.920

          .         .         .         .         .         .       g.56910
 AACTGGCAGAAGAAGATCGGGGACATCCTTAGGCTGGTGGCCGGCCGCATCAAGAACACC       c.2820
 N  W  Q  K  K  I  G  D  I  L  R  L  V  A  G  R  I  K  N  T         p.940

                                                                    g.56916
 TTCTGA                                                             c.2826
 F  X                                                               p.941

          .         .         .         .         .         .       g.56976
 ttgagcggttgccatggccggtctccgtggggcagggttgggccgcatgtggaagggctc       c.*60

          .         .         .         .                           g.57023
 tgagctgtgtcctccttcattaaaagtttttatgtctcgtgtcagaa                    c.*107

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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