protease, serine, 16 (thymus) (PRSS16) - coding DNA reference sequence

(used for variant description)

(last modified December 24, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_005865.3 in the PRSS16 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering PRSS16 transcript NM_005865.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              agagtcccgaacacc       c.-1

          .         .         .         .         .         .       g.5075
 ATGGCCGTCTGGCTTGCCCAGTGGCTGGGCCCTCTGCTCTTGGTTTCCCTCTGGGGACTC       c.60
 M  A  V  W  L  A  Q  W  L  G  P  L  L  L  V  S  L  W  G  L         p.20

          . | 02       .         .         .         .         .    g.5209
 TTGGCTCCAG | CCTCCCTTCTTAGGCGCCTGGGTGAGCACATTCAGCAGTTTCAGGAGAGC    c.120
 L  A  P  A |   S  L  L  R  R  L  G  E  H  I  Q  Q  F  Q  E  S      p.40

          .         .         .         .         .         .       g.5269
 TCTGCCCAGGGCCTGGGCCTGAGCCTGGGGCCAGGTGCTGCAGCCCTCCCAAAAGTGGGG       c.180
 S  A  Q  G  L  G  L  S  L  G  P  G  A  A  A  L  P  K  V  G         p.60

          .         .         .         .         .        | 03.    g.6127
 TGGCTGGAGCAACTGCTGGACCCCTTCAACGTGTCCGACAGACGATCCTTCCTACAG | CGT    c.240
 W  L  E  Q  L  L  D  P  F  N  V  S  D  R  R  S  F  L  Q   | R      p.80

          .         .         .         .         .         .       g.6187
 TACTGGGTGAATGACCAACATTGGGTTGGCCAGGATGGACCCATATTCCTGCATCTAGGG       c.300
 Y  W  V  N  D  Q  H  W  V  G  Q  D  G  P  I  F  L  H  L  G         p.100

          .         .         .        | 04.         .         .    g.6400
 GGTGAGGGCAGCCTTGGGCCTGGCTCAGTGATGAGAG | GCCATCCCGCAGCCTTGGCCCCA    c.360
 G  E  G  S  L  G  P  G  S  V  M  R  G |   H  P  A  A  L  A  P      p.120

          .         .         .         .         .         .       g.6460
 GCCTGGGGCGCCCTGGTGATAAGCCTGGAACACAGATTTTATGGCCTGAGTATACCTGCT       c.420
 A  W  G  A  L  V  I  S  L  E  H  R  F  Y  G  L  S  I  P  A         p.140

          .         .         .         .        | 05.         .    g.7973
 GGAGGCCTGGAAATGGCCCAGCTCCGCTTCTTGTCCAGCCGCCTTGC | GCTGGCTGATGTG    c.480
 G  G  L  E  M  A  Q  L  R  F  L  S  S  R  L  A  |  L  A  D  V      p.160

          .         .         .         .         .         .       g.8033
 GTCTCTGCCCGCCTGGCACTTTCCCGCCTCTTTAACATCTCCTCCTCCAGCCCCTGGATC       c.540
 V  S  A  R  L  A  L  S  R  L  F  N  I  S  S  S  S  P  W  I         p.180

          .         .         .         .         .  | 06      .    g.8328
 TGCTTCGGAGGCTCCTATGCCGGCTCCTTGGCCGCCTGGGCCCGGCTGAAG | TTCCCCCAT    c.600
 C  F  G  G  S  Y  A  G  S  L  A  A  W  A  R  L  K   | F  P  H      p.200

          .         .         .         .         .         .       g.8388
 CTCATTTTCGCGTCGGTCGCCTCCTCCGCCCCGGTGCGGGCCGTGCTGGATTTCTCCGAG       c.660
 L  I  F  A  S  V  A  S  S  A  P  V  R  A  V  L  D  F  S  E         p.220

           | 07        .         .         .         .        | 08. g.9030
 TATAATGAC | GTGGTATCCCGAAGCCTAATGAGCACCGCGATCGGCGGGTCCCTGGAG | TGC c.720
 Y  N  D   | V  V  S  R  S  L  M  S  T  A  I  G  G  S  L  E   | C   p.240

          .         .         .         .         .         .       g.9090
 CGGGCGGCGGTGTCCGTCGCCTTCGCTGAAGTGGAGCGGCGGCTGCGCTCGGGTGGGGCG       c.780
 R  A  A  V  S  V  A  F  A  E  V  E  R  R  L  R  S  G  G  A         p.260

          .         .         .         .         .         .       g.9150
 GCTCAAGCAGCATTGCGGACGGAGCTGAGCGCTTGCGGGCCCCTGGGCCGCGCTGAAAAC       c.840
 A  Q  A  A  L  R  T  E  L  S  A  C  G  P  L  G  R  A  E  N         p.280

          .         .         .         .         .         .       g.9210
 CAGGCGGAGCTGTTGGGGGCGCTGCAGGCACTGGTGGGAGGTGTAGTGCAGTATGATGGG       c.900
 Q  A  E  L  L  G  A  L  Q  A  L  V  G  G  V  V  Q  Y  D  G         p.300

          .         .         .         .         .         .       g.9270
 CAGACGGGAGCGCCGCTAAGCGTGCGACAGCTCTGCGGACTTCTCCTCGGGGGCGGGGGC       c.960
 Q  T  G  A  P  L  S  V  R  Q  L  C  G  L  L  L  G  G  G  G         p.320

          .         .         .         .         | 09         .    g.10097
 AACCGCAGCCACTCCACGCCCTACTGCGGGCTTCGTCGGGCGGTGCAG | ATTGTCTTGCAC    c.1020
 N  R  S  H  S  T  P  Y  C  G  L  R  R  A  V  Q   | I  V  L  H      p.340

          .         .         .         .         .         .       g.10157
 AGCCTGGGCCAGAAGTGTTTAAGCTTTTCCCGAGCAGAGACAGTGGCACAGCTGAGGAGC       c.1080
 S  L  G  Q  K  C  L  S  F  S  R  A  E  T  V  A  Q  L  R  S         p.360

          .         .         .         .         .         .       g.10217
 ACAGAACCTCAACTGTCTGGTGTGGGTGACCGGCAGTGGTTGTATCAGACATGTACCGAG       c.1140
 T  E  P  Q  L  S  G  V  G  D  R  Q  W  L  Y  Q  T  C  T  E         p.380

          . | 10       .         .         .         .         .    g.12020
 TTCGGCTTCT | ATGTCACCTGTGAGAATCCCAGATGTCCTTTCTCCCAGCTCCCAGCACTG    c.1200
 F  G  F  Y |   V  T  C  E  N  P  R  C  P  F  S  Q  L  P  A  L      p.400

          .         .         .         .         .         .       g.12080
 CCCTCCCAGCTAGACCTATGTGAGCAGGTGTTTGGGCTCTCAGCCTTGTCAGTAGCCCAG       c.1260
 P  S  Q  L  D  L  C  E  Q  V  F  G  L  S  A  L  S  V  A  Q         p.420

          .         .         .         .         .         .       g.12140
 GCTGTGGCTCAGACGAACTCCTACTACGGTGGCCAGACCCCTGGGGCTAACAAAGTGCTG       c.1320
 A  V  A  Q  T  N  S  Y  Y  G  G  Q  T  P  G  A  N  K  V  L         p.440

          . | 11       .         .         .         .         .    g.12313
 TTTGTTAATG | GGGACACAGACCCCTGGCATGTGCTAAGTGTAACACAGGCTTTAGGATCC    c.1380
 F  V  N  G |   D  T  D  P  W  H  V  L  S  V  T  Q  A  L  G  S      p.460

          .         .         .         .         .         .       g.12373
 TCAGAATCAACTCTTCTTATCCGCACTGGCTCCCACTGCTTGGACATGGCACCTGAGAGG       c.1440
 S  E  S  T  L  L  I  R  T  G  S  H  C  L  D  M  A  P  E  R         p.480

          .         .         .       | 12 .         .         .    g.12548
 CCCTCAGACTCCCCCAGCCTCCGCCTAGGGCGCCAG | AACATCTTCCAGCAGCTACAGACC    c.1500
 P  S  D  S  P  S  L  R  L  G  R  Q   | N  I  F  Q  Q  L  Q  T      p.500

          .         .         .         .                           g.12593
 TGGCTCAAGCTGGCAAAGGAGAGCCAGATTAAGGGTGAAGTCTGA                      c.1545
 W  L  K  L  A  K  E  S  Q  I  K  G  E  V  X                        p.514

          .         .         .         .         .         .       g.12653
 atctcataccctttccactccctgcatggtcacctcagtcctggacatacttgttcactg       c.*60

          .         .         .         .         .         .       g.12713
 aacaaaagaaagcagcttgttttgaaagaagaaactcccaggaattggaattcagcacct       c.*120

          .         .         .         .         .         .       g.12773
 gttccgcacgtaattggcatgtgtctgcaaacatccttattcccaacttaaagtgcttta       c.*180

          .         .         .         .         .         .       g.12833
 ttgcagagagttatggaaatataagtggatgattattctcattgtaaatattggtatttt       c.*240

          .         .         .         .         .         .       g.12893
 gaatgttaaatgtcaaacaaatgtgacttatgctggtgccctcgccctgctgatcagatt       c.*300

          .         .         .         .         .         .       g.12953
 ctggttcaaattctgccactccagctcctgggttaggggctttgctgtaagtttcttttt       c.*360

          .         .         .         .         .         .       g.13013
 ctggactttagatcctgaacctgtccttgcttctcagtttctctcactgtacccctttcc       c.*420

          .         .         .         .         .         .       g.13073
 ctcagtctcttcctctctctttcccctgtcactatttgtctttctaatctccttctgttt       c.*480

          .         .         .         .         .         .       g.13133
 ctctgaatatcttcatttctatctctgtgtttctgtctatttctctgtttatctttctgt       c.*540

          .         .         .         .         .         .       g.13193
 ccttcaatctgtgtttttgtttctggctctccgtcagtgtctttttctctcctctctctc       c.*600

          .         .         .         .         .         .       g.13253
 ttgctctgccatggctatttccactgctctatttctgactctcatttttggtctctgtgt       c.*660

          .         .         .         .         .         .       g.13313
 gtctcctagtcactttctttctcactctgtctctgtctctatttctgtctctcctctgct       c.*720

          .         .         .         .         .         .       g.13373
 gtgtcctcaatctctctgtctccctgaggctctatttctgtctctcctctgctgtgtcct       c.*780

          .         .         .         .         .         .       g.13433
 caatctctctgtctccctgaggctctatttctgtctctgatgctcttcttctgtgtctct       c.*840

          .         .         .         .         .         .       g.13493
 atttctcttcctgtcacttaatcttttccttctctatctctcttatttagtcttccttcc       c.*900

          .         .         .         .         .         .       g.13553
 acacccttcactcaccatcttttcccacaatcaaatatcactccctggtacttccagctt       c.*960

          .         .         .         .         .         .       g.13613
 ccaactctagggattcatgattctggtggagattccttcttccagggcctgggaggatag       c.*1020

          .         .         .         .         .         .       g.13673
 ggctaatcccaagggtgcctgcttaggctatgttagctgtgacaggaacctgccatagat       c.*1080

          .         .         .         .         .         .       g.13733
 ttgcactgttctttcctaaagatcaattattttcagcaataaatacttctcagctttttg       c.*1140

          .         .         .         .         .         .       g.13793
 tatgtctttgtatgcacagagatggtagttttagagttttatccagtttcatatttcctt       c.*1200

          .         .         .         .         .         .       g.13853
 gtgggtaagaggcaacctcctcatgctgtcataccaaagtcaatctccactacactttag       c.*1260

          .         .         .         .                           g.13898
 ttctgcctgttcttgatctttatataaatggaaacttgcagtata                      c.*1305

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protease, serine, 16 (thymus) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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