proteasome (prosome, macropain) 26S subunit, ATPase, 3 (PSMC3) - coding DNA reference sequence

(used for variant description)

(last modified June 24, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_002804.4 in the PSMC3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering PSMC3 transcript NM_002804.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               gtggccaggggttg       c.-181

 .         .         .         .         .         .                g.5074
 gtctttggaatcggagaggcagattcgctgctccgcagcacggccggagctggtcgggtc       c.-121

 .         .         .         .         .         .                g.5134
 aagagtcgggatttgtggggagaggttttccactggtcaagagaaggctttaagaaagac       c.-61

 .         .         .         .         .         .                g.5194
 ggtattaatctcccgttgcggctcccgcctggtcccatcttctgcccgctcctccaggaa       c.-1

          .         .         .         .         .         .       g.5254
 ATGAATCTGCTGCCGAATATTGAGAGTCCAGTGACTCGGCAGGAGAAGATGGCGACCGTG       c.60
 M  N  L  L  P  N  I  E  S  P  V  T  R  Q  E  K  M  A  T  V         p.20

          .      | 02  .         .         .         .         .    g.5568
 TGGGATGAGGCCGAG | CAAGATGGAATTGGGGAGGAGGTGCTCAAGATGTCCACGGAGGAG    c.120
 W  D  E  A  E   | Q  D  G  I  G  E  E  V  L  K  M  S  T  E  E      p.40

          .         .         .          | 03        .         .    g.6248
 ATCATCCAGCGCACACGGCTGCTGGACAGTGAGATCAAG | ATCATGAAGAGTGAAGTGTTG    c.180
 I  I  Q  R  T  R  L  L  D  S  E  I  K   | I  M  K  S  E  V  L      p.60

          .         .         .         .         .         .       g.6308
 AGAGTCACCCATGAGCTCCAAGCCATGAAGGACAAGATAAAAGAGAACAGTGAGAAAATC       c.240
 R  V  T  H  E  L  Q  A  M  K  D  K  I  K  E  N  S  E  K  I         p.80

          .         .         .         .      | 04  .         .    g.6777
 AAAGTGAACAAGACCCTGCCGTACCTTGTCTCCAACGTCATCGAG | CTCCTGGATGTTGAT    c.300
 K  V  N  K  T  L  P  Y  L  V  S  N  V  I  E   | L  L  D  V  D      p.100

          .         .         .         .         .         .       g.6837
 CCTAATGACCAAGAGGAGGATGGTGCCAATATTGACCTGGACTCCCAGAGGAAGGGCAAG       c.360
 P  N  D  Q  E  E  D  G  A  N  I  D  L  D  S  Q  R  K  G  K         p.120

          .         .         . | 05       .         .         .    g.7012
 TGTGCTGTGATCAAAACCTCTACACGACAG | ACGTACTTCCTTCCTGTGATTGGGTTGGTG    c.420
 C  A  V  I  K  T  S  T  R  Q   | T  Y  F  L  P  V  I  G  L  V      p.140

          .         .         .    | 06    .         .         .    g.7317
 GATGCTGAAAAGCTAAAGCCAGGAGACCTGGTG | GGTGTGAACAAAGACTCCTATCTGATC    c.480
 D  A  E  K  L  K  P  G  D  L  V   | G  V  N  K  D  S  Y  L  I      p.160

          .         .         .         .         .         .       g.7377
 CTGGAGACGCTGCCCACAGAGTATGACTCGCGGGTGAAGGCCATGGAGGTAGACGAGAGG       c.540
 L  E  T  L  P  T  E  Y  D  S  R  V  K  A  M  E  V  D  E  R         p.180

          .         .         .         .         .  | 07      .    g.8509
 CCCACGGAGCAATACAGTGACATTGGGGGTTTGGACAAGCAGATCCAGGAG | CTGGTGGAG    c.600
 P  T  E  Q  Y  S  D  I  G  G  L  D  K  Q  I  Q  E   | L  V  E      p.200

          .         .         .         .         .         .       g.8569
 GCCATTGTCTTGCCAATGAACCACAAGGAGAAGTTTGAGAACTTGGGGATCCAACCTCCA       c.660
 A  I  V  L  P  M  N  H  K  E  K  F  E  N  L  G  I  Q  P  P         p.220

          .         .         .         .         .         .       g.8629
 AAAGGGGTGCTGATGTATGGGCCCCCAGGGACGGGGAAGACCCTCCTGGCCCGGGCCTGT       c.720
 K  G  V  L  M  Y  G  P  P  G  T  G  K  T  L  L  A  R  A  C         p.240

          .      | 08  .         .         .         .         .    g.8796
 GCCGCACAGACTAAG | GCCACCTTCCTAAAGCTGGCTGGCCCCCAGCTGGTGCAGATGTTC    c.780
 A  A  Q  T  K   | A  T  F  L  K  L  A  G  P  Q  L  V  Q  M  F      p.260

          .         .         .         .         .         .       g.8856
 ATTGGAGATGGTGCCAAGCTAGTCCGGGATGCCTTTGCCCTGGCCAAGGAGAAAGCGCCC       c.840
 I  G  D  G  A  K  L  V  R  D  A  F  A  L  A  K  E  K  A  P         p.280

          .         .         .         .     | 09   .         .    g.10762
 TCTATCATCTTCATTGATGAGTTGGATGCCATCGGCACCAAGCG | CTTTGACAGTGAGAAG    c.900
 S  I  I  F  I  D  E  L  D  A  I  G  T  K  R  |  F  D  S  E  K      p.300

          .         .         .         .         .         .       g.10822
 GCTGGGGACCGGGAGGTGCAGAGGACAATGCTGGAGCTTCTGAACCAGCTGGATGGCTTC       c.960
 A  G  D  R  E  V  Q  R  T  M  L  E  L  L  N  Q  L  D  G  F         p.320

          .         .  | 10      .         .         .         .    g.11103
 CAGCCCAACACCCAAGTTAAG | GTAATTGCAGCCACAAACAGGGTGGACATCCTGGACCCC    c.1020
 Q  P  N  T  Q  V  K   | V  I  A  A  T  N  R  V  D  I  L  D  P      p.340

          .         .         .         .         .         .       g.11163
 GCCCTCCTCCGCTCGGGCCGCCTTGACCGCAAGATAGAGTTCCCGATGCCCAATGAGGAG       c.1080
 A  L  L  R  S  G  R  L  D  R  K  I  E  F  P  M  P  N  E  E         p.360

          .         .         .         .        | 11.         .    g.12289
 GCCCGGGCCAGAATCATGCAGATCCACTCCCGAAAGATGAATGTCAG | TCCTGACGTGAAC    c.1140
 A  R  A  R  I  M  Q  I  H  S  R  K  M  N  V  S  |  P  D  V  N      p.380

          .         .         .         .         .         .       g.12349
 TACGAGGAGCTGGCCCGCTGCACAGATGACTTCAATGGGGCCCAGTGCAAGGCTGTGTGT       c.1200
 Y  E  E  L  A  R  C  T  D  D  F  N  G  A  Q  C  K  A  V  C         p.400

           | 12        .         .         .         .         .    g.12579
 GTGGAGGCG | GGCATGATCGCACTGCGCAGGGGTGCCACGGAGCTCACCCACGAGGACTAC    c.1260
 V  E  A   | G  M  I  A  L  R  R  G  A  T  E  L  T  H  E  D  Y      p.420

          .         .         .         .         .         .       g.12639
 ATGGAAGGCATCCTGGAGGTGCAGGCCAAGAAGAAAGCCAACCTACAATACTACGCCTAG       c.1320
 M  E  G  I  L  E  V  Q  A  K  K  K  A  N  L  Q  Y  Y  A  X         p.439

          .         .         .         .         .         .       g.12699
 ggcacacaggccagccccagtctcacggctgaagtgcgcaataaaagatggtttagggtc       c.*60

                                                                    g.12705
 cctgcc                                                             c.*66

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Proteasome (prosome, macropain) 26S subunit, ATPase, 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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