pentatricopeptide repeat domain 1 (PTCD1) - coding DNA reference sequence

(used for variant description)

(last modified February 13, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_015545.3 in the PTCD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering PTCD1 transcript NM_015545.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5054
       ctcgccagaaacctgaaaccagccgcgtgagtcggcgacgcggattgcgcctgc       c.-121

 .         .         .         .         .         .                g.5114
 gcgcttggggagagggggacccgaggaagagactggttcgccgcggggaccgggcagggc       c.-61

 .         .         .         .    | 02    .         .             g.8597
 tccccgtcggagtgcactgcgccggacacttcaa | gccctggagggacaggaaagccagaa    c.-1

          .         .         .         .         .         .       g.8657
 ATGGACTTCGTGAGACTCGCTCGACTGTTCGCCAGGGCCCGCCCCATGGGACTGTTCATC       c.60
 M  D  F  V  R  L  A  R  L  F  A  R  A  R  P  M  G  L  F  I         p.20

          .         .         .         .         .         .       g.8717
 CTGCAACACCTGGACCCCTGTAGAGCCAGGTGGGCAGGAGGCAGGGAGGGGCTGATGCGG       c.120
 L  Q  H  L  D  P  C  R  A  R  W  A  G  G  R  E  G  L  M  R         p.40

          .         .         .         .         .         .       g.8777
 CCAATGTGGGCGCCCTTCAGCAGCTCCTCCTCTCAGCTGCCCCTCGGCCAGGAGCGTCAG       c.180
 P  M  W  A  P  F  S  S  S  S  S  Q  L  P  L  G  Q  E  R  Q         p.60

          .         .         .         .         .         .       g.8837
 GAAAACACGGGCAGCCTGGGCTCTGACCCGAGCCACTCCAACTCCACGGCCACGCAGGAA       c.240
 E  N  T  G  S  L  G  S  D  P  S  H  S  N  S  T  A  T  Q  E         p.80

          .         .         .         .         .         .       g.8897
 GAAGACGAGGAGGAGGAGGAGAGTTTTGGGACCCTCTCTGACAAATACTCCTCCCGGAGA       c.300
 E  D  E  E  E  E  E  S  F  G  T  L  S  D  K  Y  S  S  R  R         p.100

          .         .         .         .         .         .       g.8957
 CTATTCCGCAAATCCGCAGCCCAGTTCCATAACCTGCGGTTTGGGGAACGGAGAGATGAG       c.360
 L  F  R  K  S  A  A  Q  F  H  N  L  R  F  G  E  R  R  D  E         p.120

          .         .         .         .         .         .       g.9017
 CAAATGGAACCGGAGCCCAAATTATGGCGAGGCCGGAGAAACACCCCGTACTGGTACTTC       c.420
 Q  M  E  P  E  P  K  L  W  R  G  R  R  N  T  P  Y  W  Y  F         p.140

          .         .         .    | 03    .         .         .    g.10448
 TTGCAGTGCAAACACCTGATCAAGGAAGGGAAG | CTGGTTGAAGCCCTGGACCTGTTTGAG    c.480
 L  Q  C  K  H  L  I  K  E  G  K   | L  V  E  A  L  D  L  F  E      p.160

          .         .         .         .         .         .       g.10508
 AGGCAGATGCTGAAGGAGGAGCGATTGCAGCCCATGGAGAGCAACTACACGGTGCTGATT       c.540
 R  Q  M  L  K  E  E  R  L  Q  P  M  E  S  N  Y  T  V  L  I         p.180

          .         .         .         .         .     | 04   .    g.14039
 GGGGGCTGCGGGCGGGTTGGCTACCTGAAGAAGGCCTTCAACCTCTACAACCAG | ATGAAA    c.600
 G  G  C  G  R  V  G  Y  L  K  K  A  F  N  L  Y  N  Q   | M  K      p.200

          .         .         .         .         .         .       g.14099
 AAGCGGGACCTGGAGCCCTCGGACGCCACCTACACGGCCCTGTTCAACGTCTGTGCCGAG       c.660
 K  R  D  L  E  P  S  D  A  T  Y  T  A  L  F  N  V  C  A  E         p.220

          .         .         .         .         .         .       g.14159
 TCCCCCTGGAAGGACTCAGCTCTACAGAGCGCCCTGAAGCTCCGGCAGCAGCTGCAGGCC       c.720
 S  P  W  K  D  S  A  L  Q  S  A  L  K  L  R  Q  Q  L  Q  A         p.240

          .         .         .         .         .         .       g.14219
 AAAAACTTCGAGCTCAACTTGAAAACATACCACGCGCTGCTGAAGATGGCTGCCAAGTGC       c.780
 K  N  F  E  L  N  L  K  T  Y  H  A  L  L  K  M  A  A  K  C         p.260

          .         .         .    | 05    .         .         .    g.14662
 GCAGACCTTAGGATGTGCCTCGATGTGTTCAAG | GAAATCATCCACAAAGGGCACGTGGTC    c.840
 A  D  L  R  M  C  L  D  V  F  K   | E  I  I  H  K  G  H  V  V      p.280

          .         .         .         .         .         .       g.14722
 ACAGAGGAGACCTTCAGTTTCCTGCTCATGGGCTGCATCCAAGACAAGAAGACAGGCTTC       c.900
 T  E  E  T  F  S  F  L  L  M  G  C  I  Q  D  K  K  T  G  F         p.300

          .      | 06  .         .         .         .         .    g.18268
 CGGTACGCCCTCCAG | GTGTGGCGGCTGATGCTGAGTCTAGGGCTACAGCCGAGCCGGGAC    c.960
 R  Y  A  L  Q   | V  W  R  L  M  L  S  L  G  L  Q  P  S  R  D      p.320

          .         .         .         .         .         .       g.18328
 AGCTACAACCTGCTGTTGGTGGCAGCTCGGGACTGTGGCCTAGGGGACCCCCAGGTGGCC       c.1020
 S  Y  N  L  L  L  V  A  A  R  D  C  G  L  G  D  P  Q  V  A         p.340

          .         .         .         .         .         .       g.18388
 TCAGAGCTGCTTCTGAAGCCCAGGGAGGAGGCGACTGTGCTTCAGCCCCCAGTGAGCAGG       c.1080
 S  E  L  L  L  K  P  R  E  E  A  T  V  L  Q  P  P  V  S  R         p.360

          .         .         .         .         .         .       g.18448
 CAGCGGCCAAGGAGGACAGCCCAGGCCAAGGCAGGCAACCTCATGTCAGCCATGCTGCAT       c.1140
 Q  R  P  R  R  T  A  Q  A  K  A  G  N  L  M  S  A  M  L  H         p.380

          .         .         .         .         .         .       g.18508
 GTGGAGGCCCTGGAGAGGCAGCTGTTTCTGGAACCTTCTCAGGCACTTGGGCCTCCAGAG       c.1200
 V  E  A  L  E  R  Q  L  F  L  E  P  S  Q  A  L  G  P  P  E         p.400

          .         .         .         .         .         .       g.18568
 CCTCCGGAAGCCAGAGTGCCCGGCAAGGCCCAACCAGAGGTGGATACTAAGGCAGAGCCC       c.1260
 P  P  E  A  R  V  P  G  K  A  Q  P  E  V  D  T  K  A  E  P         p.420

          .         .         .         .         .         .       g.18628
 AGCCACACAGCAGCCCTCACCGCAGTGGCCCTGAAGCCACCTCCCGTGGAGCTGGAAGTC       c.1320
 S  H  T  A  A  L  T  A  V  A  L  K  P  P  P  V  E  L  E  V         p.440

          .         .         .         .         .         .       g.18688
 AACCTCCTGACCCCCGGGGCCGTTCCCCCTACAGTGGTCTCCTTTGGAACGGTGACCACC       c.1380
 N  L  L  T  P  G  A  V  P  P  T  V  V  S  F  G  T  V  T  T         p.460

          .         .         .         .         .         .       g.18748
 CCAGCTGACCGGCTGGCCTTGATAGGGGGCCTGGAGGGCTTCCTGAGCAAGATGGCAGAG       c.1440
 P  A  D  R  L  A  L  I  G  G  L  E  G  F  L  S  K  M  A  E         p.480

          .         .         .         .         .         .       g.18808
 CACAGGCAGCAGCCCGACATCAGGACCCTCACGCTACTGGCCGAGGTGGTGGAGTCCGGG       c.1500
 H  R  Q  Q  P  D  I  R  T  L  T  L  L  A  E  V  V  E  S  G         p.500

          .         .         .         .         .         .       g.18868
 AGTCCTGCAGAGTCCTTGCTGCTGGCCCTCCTGGATGAGCACCAGGTAGAGGCCGACCTG       c.1560
 S  P  A  E  S  L  L  L  A  L  L  D  E  H  Q  V  E  A  D  L         p.520

          .         .         .         .         .         .       g.18928
 ACATTCTTTAACACGCTGGTGAGAAAGAAGAGCAAGCTGGGAGACCTGGAGGGGGCCAAG       c.1620
 T  F  F  N  T  L  V  R  K  K  S  K  L  G  D  L  E  G  A  K         p.540

          .         .         .         .         .         .       g.18988
 GCGCTGTTGCCGGTCCTGGCAAAGAGGGGCCTCGTCCCCAACCTGCAGACATTCTGCAAC       c.1680
 A  L  L  P  V  L  A  K  R  G  L  V  P  N  L  Q  T  F  C  N         p.560

          .         .         .         .         .        | 07.    g.19885
 CTGGCCATCGGGTGCCACAGGCCGAAGGACGGTCTACAGCTTCTCACAGACATGAAG | AAG    c.1740
 L  A  I  G  C  H  R  P  K  D  G  L  Q  L  L  T  D  M  K   | K      p.580

          .         .         .         .         .         .       g.19945
 TCCCAGGTGACCCCCAACACTCACATCTACAGTGCCCTCATCAACGCGGCCATCAGGAAG       c.1800
 S  Q  V  T  P  N  T  H  I  Y  S  A  L  I  N  A  A  I  R  K         p.600

          .         .         .         .         .         .       g.20005
 CTGAACTACACCTATCTCATCAGCATCTTGAAGGACATGAAGCAGAACAGGGTCCCGGTG       c.1860
 L  N  Y  T  Y  L  I  S  I  L  K  D  M  K  Q  N  R  V  P  V         p.620

          .         .         .         .         .         .       g.20065
 AACGAAGTGGTCATCCGCCAGCTGGAGTTTGCAGCCCAGTACCCTCCCACCTTTGACCGG       c.1920
 N  E  V  V  I  R  Q  L  E  F  A  A  Q  Y  P  P  T  F  D  R         p.640

  | 08       .         .         .         .         .         .    g.23750
  | TACCAAGGGAAGAACACCTACCTGGAGAAGATTGACGGCTTCCGAGCCTATTACAAGCAG    c.1980
  | Y  Q  G  K  N  T  Y  L  E  K  I  D  G  F  R  A  Y  Y  K  Q      p.660

          .         .         .         .         .         .       g.23810
 TGGCTGACAGTGATGCCCGCAGAGGAAACCCCGCACCCCTGGCAGAAGTTCCGGACCAAG       c.2040
 W  L  T  V  M  P  A  E  E  T  P  H  P  W  Q  K  F  R  T  K         p.680

          .         .         .         .         .         .       g.23870
 CCCCAGGGGGACCAGGACACCGGCAAGGAGGCTGATGACGGATGTGCCCTTGGGGGCAGG       c.2100
 P  Q  G  D  Q  D  T  G  K  E  A  D  D  G  C  A  L  G  G  R         p.700

                                                                    g.23873
 TGA                                                                c.2103
 X                                                                  p.700

          .         .         .         .         .         .       g.23933
 tgggagcacagctggaacaatgtgctcggcccccagtgctctgtgggagccccaggacaa       c.*60

          .         .         .         .         .         .       g.23993
 gtgagctggtgtcacctcctgcctgggggaagagccaggccctgaggaacagccgcagcg       c.*120

          .         .         .         .         .         .       g.24053
 tgtcacaggtgttggtgaggacacacactaggcccaaggtgcctgtgctcccagcaggtc       c.*180

          .         .         .         .         .         .       g.24113
 caagtgcagctccagccacctttgcgtgtcaccttcacgggacttccagctccagctacc       c.*240

          .         .         .         .         .         .       g.24173
 tttgtgtgtcacctcacacaccacaagggggctggggcatctggtccctggggcctgggc       c.*300

          .         .         .         .         .         .       g.24233
 cgccccgccgggttccataggccgatgctctgaaagaagagacgtggggctcgagagatt       c.*360

          .         .         .         .         .         .       g.24293
 taaagattttatttttacaaatcacagctgatagacagcgaagccttccccatagagacc       c.*420

          .         .         .         .         .         .       g.24353
 gtgctccaactcgggcctggggcactgctcgctgctcccaggaagggggtggcgtgacag       c.*480

          .         .         .         .         .         .       g.24413
 gcaggaacctgcgaagtccagagtccagggtggagcgcgccagcctcagccagagcagcc       c.*540

          .         .         .         .         .         .       g.24473
 acgacagccacagtgtgtgcactcgatgatgcggccctgcaacggaggaggacagtgaga       c.*600

          .         .         .         .         .         .       g.24533
 cgatgccactgcgccacgctcgcccctgcacactcacatatgtggcaaccctcccacgaa       c.*660

          .         .         .         .         .         .       g.24593
 ggacctgccaccatgccatatagggacacacctcagaaacccttccttgacagctctgga       c.*720

          .         .         .         .         .         .       g.24653
 cagggaaaatttggctccctcatgaaggtagaaccagctgctgttgacaccgaggttaca       c.*780

          .         .         .         .         .         .       g.24713
 tctgtatgtctatttataatatgttctgcaaatccaacacacgtttgccaatcaagaaaa       c.*840

          .         .         .         .         .         .       g.24773
 agaaatcggtgtgaatgagtctcgttattctgctaagtgagcatgacagaccctgcgatg       c.*900

          .         .         .         .         .         .       g.24833
 agcagacgtggctctgctactgtttggggacttcaggggggcctctgggctggtacactc       c.*960

          .         .         .         .         .         .       g.24893
 tggtgggggaagagggcaggagactatgcacttgagtcacacccttctggcccagagccc       c.*1020

          .         .         .         .         .         .       g.24953
 cccagaaagaagggtcttgtcccccaggcctggtgcggcccaacacttggccagccagaa       c.*1080

          .         .         .         .         .         .       g.25013
 agccctagaacagtggcttgtgtttattttactttttcaagttctttttttggaagaaca       c.*1140

          .         .         .         .         .         .       g.25073
 agaccatagtttaagtaaacaggatcctctggtgaaacccaggtaagtctacagcgggct       c.*1200

          .         .         .         .         .         .       g.25133
 gttttggccacagggctgaagcagcaccccagcccaccagcccctgacctggactccttg       c.*1260

          .         .         .         .         .         .       g.25193
 tggaatctgggcactcagaggaagggggcttctgccactctgccacctgtccctgcctcc       c.*1320

          .         .         .         .         .         .       g.25253
 atcagaaaaccaacaccccagtcttccgtcggggaggcggcccttgctcgcccccactgc       c.*1380

          .         .         .         .         .         .       g.25313
 tcagtacccaagtcctcagcatccagccacagctctccattgtcagtctcactgcagcat       c.*1440

          .         .         .         .         .         .       g.25373
 aaaggggactcatgtgaagaggcccctgtgtggagctggggaaaagaaggccaggctggc       c.*1500

          .         .         .         .         .         .       g.25433
 agatgggcggtggggccaacaactgtgctgaggggctgcactgagcggccactgctgtga       c.*1560

          .         .         .         .         .         .       g.25493
 ctctgcctcgggccacagctgcctttcagaggggcttggaaccggatggagctcagctcc       c.*1620

          .         .         .         .         .         .       g.25553
 tgtccctcagcaccactcctgaggcgcctggcctaggagtggtacttggaacagaaagtt       c.*1680

          .         .         .         .         .         .       g.25613
 ctgaaagaagaaacacagtgggctgggcgcagtagctcatgcctgtaatcccggcacttt       c.*1740

          .         .         .         .         .         .       g.25673
 gggaggctgaggcgggtggatcacctgaggtcgggagttcgagaccagcctgagcaacat       c.*1800

          .         .         .         .         .         .       g.25733
 tgagaaaccccgtctctactaaaaatacaaaattagccaggcgtggtggtgcatgcctgt       c.*1860

          .         .         .         .         .         .       g.25793
 agtcccagctactcaggaggatgaggcaggagaaccgcttgaacccgggaggtggaggtt       c.*1920

          .         .         .         .         .         .       g.25853
 gcagtgagccaagatggcatcactgcactccagcctgggcgacaaagcaagactccgtct       c.*1980

          .         .         .         .         .         .       g.25913
 tgggggggcgggaaagatagtgatggtaatgttaaagtatcactgtgaggactgaaaggg       c.*2040

          .         .         .         .         .         .       g.25973
 acaggaactcactggttgtccttccctgatgtcaccctgccaccaccttgggattagggc       c.*2100

          .         .         .         .         .         .       g.26033
 tccccaccaccatttcctaagtgaggaaaggggttcagtaatttgcccaaaagtggagtt       c.*2160

          .         .         .         .         .         .       g.26093
 gagattgaccccagacctaacaaacacacagccacacgctgcctcacatggattcctgaa       c.*2220

          .         .         .         .         .         .       g.26153
 tacagggacccactcccacgagggagagccagcaggacatccagggacaaaacgacattc       c.*2280

          .         .         .         .         .         .       g.26213
 cagcccaaccaaataacataagatcccttgcagtcgactaaggcagaattttgagctgaa       c.*2340

          .         .         .         .         .         .       g.26273
 aacaacaccaagcttgagtgtcagacattaccacttccagcttgcttttgggcacgcggc       c.*2400

          .         .         .         .         .         .       g.26333
 agatgcagttcgtcccgaagttggtgtcccgtgtctgaatgcaccgcaggcagcacaagt       c.*2460

          .         .         .         .         .         .       g.26393
 tctcatatccttgctttttccattttgcaatcaggtttttgtctgcatagccttctttaa       c.*2520

          .         .         .         .         .         .       g.26453
 tacaatattcatagagttctgtcaaaaagatggggaaagagcatcaggccatggtctaaa       c.*2580

          .         .         .         .         .         .       g.26513
 aaccttccccacccttgatcaaaaaaagcattcaggccgggtgcagtggctcacacctgt       c.*2640

          .         .         .         .         .         .       g.26573
 aatcccagcactttgggaggccgaggcaggcggatcacctgaggtcaggagttcaggacc       c.*2700

          .         .         .         .         .         .       g.26633
 agcccggccaacatggtaaaaccccgtctctactaaaaatacaaaaattactcgggcgtg       c.*2760

          .         .         .         .         .         .       g.26693
 gtagcagctgtaatcccagctacttaggaggctgaggcaggagaatcacttgaacccagg       c.*2820

          .         .         .         .         .         .       g.26753
 aggcggaggttgtagtgacctgaggtcgtgccactggactccagcctgggtgacagcgaa       c.*2880

          .         .         .         .         .         .       g.26813
 actccatctcaaaaaaaaaaaggcattcagtattgcaacgggacagtccttggaggagga       c.*2940

          .         .         .         .         .         .       g.26873
 acaaaaaaaaaaagtacttaggccaggcaaggtgcctcacacctgtaatcccagcacttt       c.*3000

          .         .         .         .         .         .       g.26933
 tggaagccaacgccagaggatcatttgagttaagaaaccagcctgggccaagggcccatc       c.*3060

          .         .         .         .         .         .       g.26993
 tccacaaaaaatttaaaaattagctgggtgtggtggtgcacacctgtagtcacagctact       c.*3120

          .         .         .         .         .         .       g.27053
 caggaggttgaggtgagaggatcccttgagcccagaaggttgaggctgcagtgagccatc       c.*3180

          .         .         .         .                           g.27101
 attgcaccactgcactccagcctgtggaacagagcaagaccctgtttc                   c.*3228

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pentatricopeptide repeat domain 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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