patched domain containing 1 (PTCHD1) - coding DNA reference sequence

(used for variant description)

(last modified November 4, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_173495.2 in the PTCHD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021300.1, covering PTCHD1 transcript NM_173495.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5008
                                                     gctctagg       c.-1

          .         .         .         .         .         .       g.5068
 ATGCTGCGGCAGGTTCTGCACAGGGGCTTGAGGACGTGTTTCTCCCGGCTCGGCCACTTC       c.60
 M  L  R  Q  V  L  H  R  G  L  R  T  C  F  S  R  L  G  H  F         p.20

          .         .         .         .         .         .       g.5128
 ATTGCCAGTCACCCTGTCTTCTTCGCCTCGGCGCCGGTGCTCATCTCCATCCTGCTCGGC       c.120
 I  A  S  H  P  V  F  F  A  S  A  P  V  L  I  S  I  L  L  G         p.40

          .         .         .         .         .         .       g.5188
 GCCAGCTTCAGCCGCTACCAGGTCGAGGAGAGCGTGGAGCACCTGCTGGCGCCCCAGCAC       c.180
 A  S  F  S  R  Y  Q  V  E  E  S  V  E  H  L  L  A  P  Q  H         p.60

          .         .         .         .         .         .       g.5248
 AGCCTGGCCAAGATCGAGCGCAACCTCGTTAACAGCCTCTTCCCGGTCAACCGCTCCAAG       c.240
 S  L  A  K  I  E  R  N  L  V  N  S  L  F  P  V  N  R  S  K         p.80

          .         .         .         .         .         .       g.5308
 CACCGTCTCTACTCGGACCTGCAGACCCCCGGGCGCTACGGCCGGGTCATCGTCACCTCC       c.300
 H  R  L  Y  S  D  L  Q  T  P  G  R  Y  G  R  V  I  V  T  S         p.100

          .         .         .         .         .  | 02      .    g.49732
 TTCCAGAAAGCCAACATGCTGGACCAGCATCACACCGACCTGATCTTAAAG | TTGCATGCT    c.360
 F  Q  K  A  N  M  L  D  Q  H  H  T  D  L  I  L  K   | L  H  A      p.120

          .         .         .         .         .         .       g.49792
 GCTGTCACCAAGATCCAGGTTCCAAGGCCTGGTTTTAATTACACGTTTGCCCATATATGT       c.420
 A  V  T  K  I  Q  V  P  R  P  G  F  N  Y  T  F  A  H  I  C         p.140

          .         .         .         .         .         .       g.49852
 ATCCTGAATAATGATAAGACTTGCATCGTGGATGACATAGTGCACGTCCTGGAAGAGCTA       c.480
 I  L  N  N  D  K  T  C  I  V  D  D  I  V  H  V  L  E  E  L         p.160

          .         .         .         .         .         .       g.49912
 AAGAATGCTCGGGCCACCAATCGGACCAATTTTGCTATCACATACCCAATCACTCACTTA       c.540
 K  N  A  R  A  T  N  R  T  N  F  A  I  T  Y  P  I  T  H  L         p.180

          .         .         .         .         .         .       g.49972
 AAGGACGGGAGGGCTGTGTACAATGGGCACCAGCTTGGGGGCGTCACTGTGCACAGCAAA       c.600
 K  D  G  R  A  V  Y  N  G  H  Q  L  G  G  V  T  V  H  S  K         p.200

          .         .         .         .         .         .       g.50032
 GACCGGGTGAAATCTGCAGAGGCCATCCAGCTCACCTACTACCTGCAGTCAATCAACAGT       c.660
 D  R  V  K  S  A  E  A  I  Q  L  T  Y  Y  L  Q  S  I  N  S         p.220

          .         .         .         .         .         .       g.50092
 CTCAATGACATGGTGGCTGAGAGGTGGGAGTCCAGCTTCTGCGACACTGTCAGACTGTTT       c.720
 L  N  D  M  V  A  E  R  W  E  S  S  F  C  D  T  V  R  L  F         p.240

          .         .         .         .         .         .       g.50152
 CAGAAATCCAACAGCAAAGTCAAAATGTACCCTTACACGTCCTCCTCACTGAGGGAAGAT       c.780
 Q  K  S  N  S  K  V  K  M  Y  P  Y  T  S  S  S  L  R  E  D         p.260

          .         .         .         .         .         .       g.50212
 TTCCAGAAGACCAGCCGCGTATCAGAACGTTACCTGGTCACCAGCCTGATTCTGGTGGTT       c.840
 F  Q  K  T  S  R  V  S  E  R  Y  L  V  T  S  L  I  L  V  V         p.280

          .         .         .         .         .         .       g.50272
 ACCATGGCCATCCTGTGTTGCTCTATGCAGGACTGCGTCCGCAGCAAACCCTGGCTAGGC       c.900
 T  M  A  I  L  C  C  S  M  Q  D  C  V  R  S  K  P  W  L  G         p.300

          .         .         .         .         .         .       g.50332
 CTGCTCGGATTGGTGACCATAAGCCTGGCCACTCTCACTGCAGCCGGGATCATCAATCTT       c.960
 L  L  G  L  V  T  I  S  L  A  T  L  T  A  A  G  I  I  N  L         p.320

          .         .         .         .         .   | 03     .    g.62671
 ACTGGTGGGAAATATAATTCCACCTTCCTGGGAGTCCCTTTCGTCATGCTAG | GTCATGGA    c.1020
 T  G  G  K  Y  N  S  T  F  L  G  V  P  F  V  M  L  G |   H  G      p.340

          .         .         .         .         .         .       g.62731
 TTATATGGGACTTTTGAAATGTTATCCTCCTGGAGGAAAACTAGAGAAGACCAACATGTT       c.1080
 L  Y  G  T  F  E  M  L  S  S  W  R  K  T  R  E  D  Q  H  V         p.360

          .         .         .         .         .         .       g.62791
 AAAGAGAGAACTGCAGCAGTCTATGCAGACTCCATGCTCTCCTTTTCTCTCACCACTGCC       c.1140
 K  E  R  T  A  A  V  Y  A  D  S  M  L  S  F  S  L  T  T  A         p.380

          .         .         .         .         .         .       g.62851
 ATGTACCTGGTCACCTTTGGCATAGGGGCCAGCCCTTTCACGAACATTGAGGCAGCCAGG       c.1200
 M  Y  L  V  T  F  G  I  G  A  S  P  F  T  N  I  E  A  A  R         p.400

          .         .         .         .         .         .       g.62911
 ATTTTCTGCTGCAATTCCTGTATTGCAATCTTCTTCAACTACCTCTATGTACTCTCGTTT       c.1260
 I  F  C  C  N  S  C  I  A  I  F  F  N  Y  L  Y  V  L  S  F         p.420

          .         .         .         .         .         .       g.62971
 TATGGTTCCAGCCTAGTGTTCACTGGCTACATAGAAAACAATTACCAGCATAGTATCTTC       c.1320
 Y  G  S  S  L  V  F  T  G  Y  I  E  N  N  Y  Q  H  S  I  F         p.440

          .         .         .         .         .         .       g.63031
 TGTAGAAAAGTCCCAAAGCCTGAGGCATTGCAGGAGAAGCCGGCATGGTACAGGTTTCTC       c.1380
 C  R  K  V  P  K  P  E  A  L  Q  E  K  P  A  W  Y  R  F  L         p.460

          .         .         .         .         .         .       g.63091
 CTGACGGCCAGATTCAGTGAGGACACAGCTGAAGGCGAGGAAGCGAACACTTACGAGAGT       c.1440
 L  T  A  R  F  S  E  D  T  A  E  G  E  E  A  N  T  Y  E  S         p.480

          .         .         .         .         .         .       g.63151
 CACCTATTGGTATGTTTCCTCAAACGCTATTACTGTGACTGGATAACCAACACCTATGTC       c.1500
 H  L  L  V  C  F  L  K  R  Y  Y  C  D  W  I  T  N  T  Y  V         p.500

          .         .         .         .         .         .       g.63211
 AAGCCTTTTGTAGTTCTCTTTTACCTTATTTATATTTCCTTTGCCTTAATGGGCTATCTG       c.1560
 K  P  F  V  V  L  F  Y  L  I  Y  I  S  F  A  L  M  G  Y  L         p.520

          .         .         .         .         .         .       g.63271
 CAGGTCAGTGAAGGGTCAGACCTTAGTAACATTGTAGCAACCGCGACACAAACCATTGAG       c.1620
 Q  V  S  E  G  S  D  L  S  N  I  V  A  T  A  T  Q  T  I  E         p.540

          .         .         .         .         .         .       g.63331
 TACACTACTGCCCAGCAAAAGTACTTCAGCAACTACAGTCCTGTGATTGGGTTTTACATA       c.1680
 Y  T  T  A  Q  Q  K  Y  F  S  N  Y  S  P  V  I  G  F  Y  I         p.560

          .         .         .         .         .         .       g.63391
 TATGAGTCTATAGAATACTGGAACACTAGTGTCCAAGAAGATGTTCTAGAATACACCAAG       c.1740
 Y  E  S  I  E  Y  W  N  T  S  V  Q  E  D  V  L  E  Y  T  K         p.580

          .         .         .         .         .         .       g.63451
 GGGTTTGTGCGGATATCCTGGTTTGAGAGCTATTTAAATTACCTTCGGAAACTCAATGTA       c.1800
 G  F  V  R  I  S  W  F  E  S  Y  L  N  Y  L  R  K  L  N  V         p.600

          .         .         .         .         .         .       g.63511
 TCCACTGGCTTGCCTAAGAAAAATTTCACAGACATGTTGAGGAATTCCTTTCTGAAAGCC       c.1860
 S  T  G  L  P  K  K  N  F  T  D  M  L  R  N  S  F  L  K  A         p.620

          .         .         .         .         .         .       g.63571
 CCTCAATTTTCACATTTTCAAGAGGACATCATCTTCTCTAAAAAATACAATGATGAGGTC       c.1920
 P  Q  F  S  H  F  Q  E  D  I  I  F  S  K  K  Y  N  D  E  V         p.640

          .         .         .         .         .         .       g.63631
 GATGTAGTGGCCTCCAGAATGTTTTTGGTGGCCAAGACCATGGAAACAAACAGAGAAGAA       c.1980
 D  V  V  A  S  R  M  F  L  V  A  K  T  M  E  T  N  R  E  E         p.660

          .         .         .         .         .         .       g.63691
 CTCTATGATCTCTTGGAAACCCTGAGGAGACTTTCTGTCACCTCCAAGGTGAAGTTCATC       c.2040
 L  Y  D  L  L  E  T  L  R  R  L  S  V  T  S  K  V  K  F  I         p.680

          .         .         .         .         .         .       g.63751
 GTCTTCAATCCGTCCTTTGTATACATGGATCGATATGCCTCCTCTCTGGGAGCCCCCCTG       c.2100
 V  F  N  P  S  F  V  Y  M  D  R  Y  A  S  S  L  G  A  P  L         p.700

          .         .         .         .         .         .       g.63811
 CACAACTCCTGCATCAGTGCTTTGTTCCTGCTCTTCTTCTCGGCATTCCTGGTGGCAGAT       c.2160
 H  N  S  C  I  S  A  L  F  L  L  F  F  S  A  F  L  V  A  D         p.720

          .         .         .         .         .         .       g.63871
 TCACTGATTAACGTCTGGATCACTCTCACAGTTGTGTCCGTGGAGTTTGGAGTGATAGGT       c.2220
 S  L  I  N  V  W  I  T  L  T  V  V  S  V  E  F  G  V  I  G         p.740

          .         .         .         .         .         .       g.63931
 TTCATGACATTATGGAAAGTAGAACTGGACTGCATTTCTGTGCTATGCTTAATTTATGGA       c.2280
 F  M  T  L  W  K  V  E  L  D  C  I  S  V  L  C  L  I  Y  G         p.760

          .         .         .         .         .         .       g.63991
 ATTAATTACACAATTGACAATTGTGCTCCAATGTTATCCACATTTGTTCTGGGCAAGGAT       c.2340
 I  N  Y  T  I  D  N  C  A  P  M  L  S  T  F  V  L  G  K  D         p.780

          .         .         .         .         .         .       g.64051
 TTCACAAGAACTAAATGGGTAAAAAATGCCCTGGAAGTGCATGGGGTAGCTATTTTACAG       c.2400
 F  T  R  T  K  W  V  K  N  A  L  E  V  H  G  V  A  I  L  Q         p.800

          .         .         .         .         .         .       g.64111
 AGTTACCTCTGCTATATTGTTGGTCTGATTCCTCTTGCAGCTGTGCCTTCAAATCTGACC       c.2460
 S  Y  L  C  Y  I  V  G  L  I  P  L  A  A  V  P  S  N  L  T         p.820

          .         .         .         .         .         .       g.64171
 TGTACACTGTTCAGGTGCTTGTTTTTAATAGCATTTGTCACCTTCTTTCACTGCTTTGCC       c.2520
 C  T  L  F  R  C  L  F  L  I  A  F  V  T  F  F  H  C  F  A         p.840

          .         .         .         .         .         .       g.64231
 ATTTTACCTGTGATACTGACTTTCCTGCCACCCTCTAAGAAAAAAAGGAAAGAGAAGAAA       c.2580
 I  L  P  V  I  L  T  F  L  P  P  S  K  K  K  R  K  E  K  K         p.860

          .         .         .         .         .         .       g.64291
 AATCCTGAGAACCGGGAGGAAATTGAGTGTGTAGAAATGGTAGATATCGATAGTACCCGT       c.2640
 N  P  E  N  R  E  E  I  E  C  V  E  M  V  D  I  D  S  T  R         p.880

          .         .                                               g.64318
 GTGGTTGACCAAATTACAACAGTGTGA                                        c.2667
 V  V  D  Q  I  T  T  V  X                                          p.888

          .         .         .         .         .         .       g.64378
 taatgtctgcttggcatattttcaccttaggtcttatcaagaccaaagagattatgttaa       c.*60

          .         .         .         .         .         .       g.64438
 tgaaacaattaaattcaaagttcttcccttttttaaagataggaaacaggcattgccaaa       c.*120

          .         .         .         .         .         .       g.64498
 aaaaaaaaaaaaaaaaaaaggaaaggacagtggggagaaatgggcctggcatattttcag       c.*180

          .         .         .         .         .         .       g.64558
 tctttaaaacaaaggagttgttatgagaattcacacacacatagacacacacacacacac       c.*240

          .         .         .         .         .         .       g.64618
 acacacacacacacacacacacacaccctgggagacctatagtctcttaaactaagatca       c.*300

          .         .         .         .         .         .       g.64678
 agtagaagaaagcttattaacaagcaggatcctgccttatccaaactgcagatgttgctg       c.*360

          .         .         .         .         .         .       g.64738
 gcattgtgacaaaacccactgattgaaaggtcaactgccaaggcagaaacacctttaagc       c.*420

          .         .         .         .         .         .       g.64798
 attgttcaaacaataaggcttccagaacttctgtagagcagtagctccagtcatggtctg       c.*480

          .         .         .         .         .         .       g.64858
 tggtttgaggttttagctgtctcacctagctccctaacactgaaggagatacttgtgaaa       c.*540

          .         .         .         .         .         .       g.64918
 gttctgaccagcaaaagcaagccagagccttggaaactgatatgtggtagagtggccatc       c.*600

          .         .         .         .         .         .       g.64978
 actcatggactaaaattgattcaccgctaaatttacccaggtgaagcagtttcgttgtct       c.*660

          .         .         .         .         .         .       g.65038
 agaatgaaattatcatattccgccattggtatgcctttaacatttgtatagtttggtttg       c.*720

          .         .         .         .         .         .       g.65098
 cttaaaacaccttaaaaccaatgacagctccagcactgcagaattggtgtgattctactt       c.*780

          .         .         .         .         .         .       g.65158
 tggaatagcttgtcacttgtcaccaaatgggtctgctttattagttacagctcttggcag       c.*840

          .         .         .         .         .         .       g.65218
 gaggatccagggacccaaaaccacagggccaaacccaaatacctggcatgatggagcaaa       c.*900

          .         .         .         .         .         .       g.65278
 agcaggtgtctacttggacccagatatagtgtctccattttaacaacaacaacaaaatag       c.*960

          .         .         .         .         .         .       g.65338
 ccagctggtacagctgtttgcattggccctacatgcattttttgcatggatatccagaaa       c.*1020

          .         .         .         .         .         .       g.65398
 catctgcccacacaaaactgcggggaaaaaaaatgaacactgaaatagttatttgctgtt       c.*1080

          .         .         .         .         .         .       g.65458
 gcttccaacttgtagtgccagtctgcctttgctgtgaaacacacctgctcagagacagag       c.*1140

          .         .         .         .         .         .       g.65518
 aggggaagaagatctttggtaagtctaagtcctgacgctgagaagctttgtaaaagtgca       c.*1200

          .         .         .         .         .         .       g.65578
 gggagataaagggccaaaagggagatagatggaaaacactggaaaaagtattcactgata       c.*1260

          .         .         .         .         .         .       g.65638
 caaatctatcaatgatggcagtccaattctcttgctaaagtggctgcacctcaccttgct       c.*1320

          .         .         .         .         .         .       g.65698
 ggtcccccccacaccttttttgatgtccttctgcgtcatcatagcaaggcccttctgtaa       c.*1380

          .         .         .         .         .         .       g.65758
 attaacaagcctagatatttatactcttgacttccagtatctacagaagaatggttcata       c.*1440

          .         .         .         .         .         .       g.65818
 gatctaaacagaaatggtttagatctaaaaaggctgtatacgttgcccaggcccctgcat       c.*1500

          .         .         .         .         .         .       g.65878
 ttctttaaatttataaaaatgaagctaaaacctggttacatttgaagcaaatatctacag       c.*1560

          .         .         .         .         .         .       g.65938
 tatttttcccttttagagatgtagcttccttagacatctgtagtggtaagcatttcccaa       c.*1620

          .         .         .         .         .         .       g.65998
 aagcatcttacctttctgaaccttagcagacatactgtgcagcttacctatcttctgcag       c.*1680

          .         .         .         .         .         .       g.66058
 aggaggaaactgagacctaggagaataaagtgactcactcaggtcacaccactaaagggt       c.*1740

          .         .         .         .         .         .       g.66118
 tttcatcatttcagcatacctaagacagggcagtccaattttcagtattctcataagatg       c.*1800

          .         .         .         .         .         .       g.66178
 gctattactcctctcaaaatgcatttccaaagtaggaacataggacttcgttggccacag       c.*1860

          .         .         .         .         .         .       g.66238
 ggcagacatttttttagtgtctggaattaaaatgtttgaggtttaggtttgccattgtct       c.*1920

          .         .         .         .         .         .       g.66298
 ttccaaaaggccaaataattcagatgtaaccacaccaagtgcaaacctgtgctttctatt       c.*1980

          .         .         .         .         .         .       g.66358
 tcacgtactgttgtccatacagttctaaatacatgtgcaggggattgtagctaatgcatt       c.*2040

          .         .         .         .         .         .       g.66418
 acacagtcgttcagtcttctctgcagacacactaagtgatcataccaacgtgttatacac       c.*2100

          .         .         .         .         .         .       g.66478
 tcaactagaagataataagctttaatctgagggcaagtacagtcctgacaaaagggcaag       c.*2160

          .         .         .         .         .         .       g.66538
 tttgcataatagatcttcgatcaattctctctccaaggggcccgcaactaggctattatt       c.*2220

          .         .         .         .         .         .       g.66598
 cataaaacacaactgaagaggggattggttttactgttaaatcatgtgttgctaaatcat       c.*2280

          .         .         .         .         .         .       g.66658
 tttctgaacagtgtgttctaaatcagtcattgatttagtgtcagccacgtggagcacctc       c.*2340

          .         .         .         .         .         .       g.66718
 ggcttaaagcagctccacaaaacctgacacaacacacacaccaattaaatggattttgtt       c.*2400

          .         .         .         .         .         .       g.66778
 gagaatttaatcattcaatttggtcaaccagaatgacttcctgtggaactctgttttatg       c.*2460

          .         .         .         .         .         .       g.66838
 acagataatagttttccaacttgattgagtctctgtataccctgggatattgtatttttt       c.*2520

          .         .         .         .         .         .       g.66898
 aatgaagggcattttcaaacttgtcaacttctcttttcagcacttgaaatgaaggcttat       c.*2580

          .         .         .                                     g.66934
 ggaattctgactgtgaaatgaatttttctattggga                               c.*2616

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Patched domain containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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