parathyroid hormone 2 receptor (PTH2R) - coding DNA reference sequence

(used for variant description)

(last modified July 28, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_005048.3 in the PTH2R gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering PTH2R transcript NM_005048.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                           tcgcgccgcggcgcagcagcacgcgggttctgag       c.-181

 .         .         .         .         .         .                g.5093
 aagcgcgtggctccggcgacaagaccccaagcaccctcggccggtggcccgggcccgacc       c.-121

 .         .         .         .         .         .                g.5153
 accccagctgcgcgtcgttactggccacaagtttgctctgggccagccaagttggcaact       c.-61

 .         .         .         .         .         .                g.5213
 tggaagcttctcccgggctctggaggagggtccctgcttcttcctacagccgttccgggc       c.-1

          .         .         .         .         .         .       g.5273
 ATGGCCGGGCTGGGGGCGTCGCTCCACGTCTGGGGTTGGCTAATGCTCGGCAGCTGCCTC       c.60
 M  A  G  L  G  A  S  L  H  V  W  G  W  L  M  L  G  S  C  L         p.20

          .      | 02  .         .         .         .         .    g.26415
 CTGGCCAGAGCCCAG | CTGGATTCTGATGGCACCATTACTATAGAGGAGCAGATTGTCCTT    c.120
 L  A  R  A  Q   | L  D  S  D  G  T  I  T  I  E  E  Q  I  V  L      p.40

          .         .         .         .         .         | 03    g.35708
 GTGCTGAAAGCGAAAGTACAATGTGAACTCAACATCACAGCTCAACTCCAGGAGGGAG | AA    c.180
 V  L  K  A  K  V  Q  C  E  L  N  I  T  A  Q  L  Q  E  G  E |       p.60

          .         .         .         .         .         .       g.35768
 GGTAATTGTTTCCCTGAATGGGATGGACTCATTTGTTGGCCCAGAGGAACAGTGGGGAAA       c.240
 G  N  C  F  P  E  W  D  G  L  I  C  W  P  R  G  T  V  G  K         p.80

          .         .         .         .          | 04        .    g.35940
 ATATCGGCTGTTCCATGCCCTCCTTATATTTATGACTTCAACCATAAAG | GAGTTGCTTTC    c.300
 I  S  A  V  P  C  P  P  Y  I  Y  D  F  N  H  K  G |   V  A  F      p.100

          .         .         .         .         .         .       g.36000
 CGACACTGTAACCCCAATGGAACATGGGATTTTATGCACAGCTTAAATAAAACATGGGCC       c.360
 R  H  C  N  P  N  G  T  W  D  F  M  H  S  L  N  K  T  W  A         p.120

          .         .         .         .         .  | 05      .    g.40542
 AATTATTCAGACTGCCTTCGCTTTCTGCAGCCAGATATCAGCATAGGAAAG | CAAGAATTC    c.420
 N  Y  S  D  C  L  R  F  L  Q  P  D  I  S  I  G  K   | Q  E  F      p.140

          .         .         .         .         .         .       g.40602
 TTTGAACGCCTCTATGTAATGTATACCGTTGGCTACTCCATCTCTTTTGGTTCCTTGGCT       c.480
 F  E  R  L  Y  V  M  Y  T  V  G  Y  S  I  S  F  G  S  L  A         p.160

          .         .          | 06        .         .         .    g.41548
 GTGGCTATTCTCATCATTGGTTACTTCAG | ACGATTGCATTGCACTAGGAACTATATCCAC    c.540
 V  A  I  L  I  I  G  Y  F  R  |  R  L  H  C  T  R  N  Y  I  H      p.180

          .         .         .         .         .         .       g.41608
 ATGCACTTATTTGTGTCTTTCATGCTGAGAGCTACAAGCATCTTTGTCAAAGACAGAGTA       c.600
 M  H  L  F  V  S  F  M  L  R  A  T  S  I  F  V  K  D  R  V         p.200

          .         .         .         .         .         .       g.41668
 GTCCATGCTCACATAGGAGTAAAGGAGCTGGAGTCCCTAATAATGCAGGATGACCCACAA       c.660
 V  H  A  H  I  G  V  K  E  L  E  S  L  I  M  Q  D  D  P  Q         p.220

          .         .         .          | 07        .         .    g.42924
 AATTCCATTGAGGCAACTTCTGTGGACAAATCACAATAT | ATCGGGTGCAAGATTGCTGTT    c.720
 N  S  I  E  A  T  S  V  D  K  S  Q  Y   | I  G  C  K  I  A  V      p.240

          .         .         .         .         .         .       g.42984
 GTGATGTTTATTTACTTCCTGGCTACAAATTATTATTGGATCCTGGTGGAAGGTCTCTAC       c.780
 V  M  F  I  Y  F  L  A  T  N  Y  Y  W  I  L  V  E  G  L  Y         p.260

          .         .         .         .         .         .       g.43044
 CTGCATAATCTCATCTTTGTGGCTTTCTTTTCGGACACCAAATACCTGTGGGGCTTCATC       c.840
 L  H  N  L  I  F  V  A  F  F  S  D  T  K  Y  L  W  G  F  I         p.280

          .    | 08    .         .         .         .         .    g.48965
 TTGATAGGCTGGG | GGTTTCCAGCAGCATTTGTTGCAGCATGGGCTGTGGCACGAGCAACT    c.900
 L  I  G  W  G |   F  P  A  A  F  V  A  A  W  A  V  A  R  A  T      p.300

          .     | 09   .         .         .         .         .    g.58110
 CTGGCTGATGCGAG | GTGCTGGGAACTTAGTGCTGGAGACATCAAGTGGATTTATCAAGCA    c.960
 L  A  D  A  R  |  C  W  E  L  S  A  G  D  I  K  W  I  Y  Q  A      p.320

          .         .  | 10      .         .         .         .    g.79278
 CCGATCTTAGCAGCTATTGGG | CTGAATTTTATTCTGTTTCTGAATACGGTTAGAGTTCTA    c.1020
 P  I  L  A  A  I  G   | L  N  F  I  L  F  L  N  T  V  R  V  L      p.340

          .         .         .         .         .       | 11 .    g.87185
 GCTACCAAAATCTGGGAGACCAATGCAGTTGGGCATGACACAAGGAAGCAATACAG | GAAA    c.1080
 A  T  K  I  W  E  T  N  A  V  G  H  D  T  R  K  Q  Y  R  |  K      p.360

          .         .         .         .         .         .       g.87245
 CTGGCCAAATCGACACTGGTCCTGGTCCTAGTCTTTGGAGTGCATTACATCGTGTTCGTA       c.1140
 L  A  K  S  T  L  V  L  V  L  V  F  G  V  H  Y  I  V  F  V         p.380

          .         .         .         .         .         .       g.87305
 TGCCTGCCTCACTCCTTCACTGGGCTCGGGTGGGAGATCCGCATGCACTGTGAGCTCTTC       c.1200
 C  L  P  H  S  F  T  G  L  G  W  E  I  R  M  H  C  E  L  F         p.400

          .      | 12  .         .         .         .        | 13. g.91436
 TTCAACTCCTTTCAG | GGTTTCTTTGTGTCTATCATCTACTGCTACTGCAATGGAGAG | GTT c.1260
 F  N  S  F  Q   | G  F  F  V  S  I  I  Y  C  Y  C  N  G  E   | V   p.420

          .         .         .         .         .         .       g.91496
 CAGGCAGAGGTGAAGAAGATGTGGAGTCGGTGGAACCTCTCCGTGGACTGGAAAAGGACA       c.1320
 Q  A  E  V  K  K  M  W  S  R  W  N  L  S  V  D  W  K  R  T         p.440

          .         .         .         .         .         .       g.91556
 CCGCCATGTGGCAGCCGCAGATGCGGCTCAGTGCTCACCACCGTGACGCACAGCACCAGC       c.1380
 P  P  C  G  S  R  R  C  G  S  V  L  T  T  V  T  H  S  T  S         p.460

          .         .         .         .         .         .       g.91616
 AGCCAGTCACAGGTGGCGGCCAGCACACGCATGGTGCTTATCTCTGGCAAAGCTGCCAAG       c.1440
 S  Q  S  Q  V  A  A  S  T  R  M  V  L  I  S  G  K  A  A  K         p.480

          .         .         .         .         .         .       g.91676
 ATCGCCAGCAGACAGCCTGACAGCCACATCACTTTACCTGGCTATGTCTGGAGTAACTCA       c.1500
 I  A  S  R  Q  P  D  S  H  I  T  L  P  G  Y  V  W  S  N  S         p.500

          .         .         .         .         .         .       g.91736
 GAGCAGGACTGCCTGCCACACTCTTTCCACGAGGAGACCAAGGAAGATAGTGGGAGGCAG       c.1560
 E  Q  D  C  L  P  H  S  F  H  E  E  T  K  E  D  S  G  R  Q         p.520

          .         .         .         .         .         .       g.91796
 GGAGATGATATTCTAATGGAGAAGCCTTCCAGGCCTATGGAATCTAACCCAGACACTGAA       c.1620
 G  D  D  I  L  M  E  K  P  S  R  P  M  E  S  N  P  D  T  E         p.540

          .         .         .                                     g.91829
 GGATGCCAAGGAGAAACTGAGGATGTTCTCTGA                                  c.1653
 G  C  Q  G  E  T  E  D  V  L  X                                    p.550

          .         .         .         .         .         .       g.91889
 atggacatttgtggctgactttcatgggctggtccaatggctggttgtgtgagagggctt       c.*60

          .         .         .         .         .         .       g.91949
 ggctgatactcctatgcttgagttcaaaggctgaaaattcagttaaggtgttacttaata       c.*120

          .         .         .         .         .         .       g.92009
 atagtttttaggctccatgaattggctcctgtaaatactaacgacatgaaaatgcaagtg       c.*180

          .         .         .         .         .         .       g.92069
 tcaatggagtagtttattaccttctattggcatcaagttttcctctaaattaatgtatgg       c.*240

          .         .         .         .         .         .       g.92129
 tatttgctctgtgattgttcatttttttctgctacttttgggtagaaaaaagattcaatt       c.*300

          .         .         .         .         .         .       g.92189
 gcttggctgtagctttctctcatatatatcaccctaaatataatgaagatcttttagtgt       c.*360

          .         .         .         .         .         .       g.92249
 gtatcattttccttttagaaactagtattctcttatttcttactttaatgtacttctatc       c.*420

          .         .         .         .         .         .       g.92309
 actgcatttattttgcctgtgcataggagcaattaggatctaaaaaaatatatgggaaga       c.*480

          .         .         .         .         .         .       g.92369
 taaaagatctaagaacaagtacttgctggaaaattagttggctggacattgataaaataa       c.*540

          .         .         .         .         .         .       g.92429
 tgcatttataacaattacatgtgtttctgggaacaaggaaaatttctcaaaaaagaatat       c.*600

          .         .         .         .         .         .       g.92489
 ttcacacatcccttcttttgaatggcctctttgtgaccagccagacctcaggtcttcact       c.*660

          .         .         .         .         .         .       g.92549
 ctttcttctttgtaaactatgtcatgtggaaagatttcctcagttagtgagcttgtgtct       c.*720

          .         .         .         .         .         .       g.92609
 gcaaattgattttgtttgtaatgtattttgatagcaaatcatgctgcatctatatctttt       c.*780

          .         .         .         .         .         .       g.92669
 tcttgtttgagctgttactacattgtacatggcatgtgggatcaattaaaaatttgtttt       c.*840

                                                                    g.92676
 aaaaata                                                            c.*847

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Parathyroid hormone 2 receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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