PTK7 protein tyrosine kinase 7 (PTK7) - coding DNA reference sequence

(used for variant description)

(last modified December 24, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_002821.4 in the PTK7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering PTK7 transcript NM_002821.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    ggcggggcttggcggcggcggcggcggcgcgcggggactcg       c.-181

 .         .         .         .         .         .                g.5101
 gaggtactgggcgcgcgcggctccggctcgggacgcctcgggacgcctcggggtcgggct       c.-121

 .         .         .         .         .         .                g.5161
 ccggctgcggctgctgctgcggcgcccgcgctccggtgcgctccgcctcctgtgcccgcc       c.-61

 .         .         .         .         .         .                g.5221
 gcggagcgcagtctgcgcgcccgccgtgcgccctcagctccttttcctgagcccgccgcg       c.-1

          .         .         .         .         .         .       g.5281
 ATGGGAGCTGCGCGGGGATCCCCGGCCAGACCCCGCCGGTTGCCTCTGCTCAGCGTCCTG       c.60
 M  G  A  A  R  G  S  P  A  R  P  R  R  L  P  L  L  S  V  L         p.20

          .          | 02        .         .         .         .    g.57750
 CTGCTGCCGCTGCTGGGCG | GTACCCAGACAGCCATTGTCTTCATCAAGCAGCCGTCCTCC    c.120
 L  L  P  L  L  G  G |   T  Q  T  A  I  V  F  I  K  Q  P  S  S      p.40

          .         .         .         .         .         .       g.57810
 CAGGATGCACTGCAGGGGCGCCGGGCGCTGCTTCGCTGTGAGGTTGAGGCTCCGGGCCCG       c.180
 Q  D  A  L  Q  G  R  R  A  L  L  R  C  E  V  E  A  P  G  P         p.60

          .         .         .         .         .         .       g.57870
 GTACATGTGTACTGGCTGCTCGATGGGGCCCCTGTCCAGGACACGGAGCGGCGTTTCGCC       c.240
 V  H  V  Y  W  L  L  D  G  A  P  V  Q  D  T  E  R  R  F  A         p.80

          .         .         .         .         .         .       g.57930
 CAGGGCAGCAGCCTGAGCTTTGCAGCTGTGGACCGGCTGCAGGACTCTGGCACCTTCCAG       c.300
 Q  G  S  S  L  S  F  A  A  V  D  R  L  Q  D  S  G  T  F  Q         p.100

          .         .         .         .         .         .       g.57990
 TGTGTGGCTCGGGATGATGTCACTGGAGAAGAAGCCCGCAGTGCCAACGCCTCCTTCAAC       c.360
 C  V  A  R  D  D  V  T  G  E  E  A  R  S  A  N  A  S  F  N         p.120

         | 03.         .         .         .         .         .    g.58512
 ATCAAAT | GGATTGAGGCAGGTCCTGTGGTCCTGAAGCATCCAGCCTCGGAAGCTGAGATC    c.420
 I  K  W |   I  E  A  G  P  V  V  L  K  H  P  A  S  E  A  E  I      p.140

          .         .         .         .         . | 04       .    g.58972
 CAGCCACAGACCCAGGTCACACTTCGTTGCCACATTGATGGGCACCCTCG | GCCCACCTAC    c.480
 Q  P  Q  T  Q  V  T  L  R  C  H  I  D  G  H  P  R  |  P  T  Y      p.160

          .         .         .         .         .         .       g.59032
 CAATGGTTCCGAGATGGGACCCCCCTTTCTGATGGTCAGAGCAACCACACAGTCAGCAGC       c.540
 Q  W  F  R  D  G  T  P  L  S  D  G  Q  S  N  H  T  V  S  S         p.180

          .         .         .         .         .         .       g.59092
 AAGGAGCGGAACCTGACGCTCCGGCCAGCTGGTCCTGAGCATAGTGGGCTGTATTCCTGC       c.600
 K  E  R  N  L  T  L  R  P  A  G  P  E  H  S  G  L  Y  S  C         p.200

          .         .         .         .         .         .       g.59152
 TGCGCCCACAGTGCTTTTGGCCAGGCTTGCAGCAGCCAGAACTTCACCTTGAGCATTGCT       c.660
 C  A  H  S  A  F  G  Q  A  C  S  S  Q  N  F  T  L  S  I  A         p.220

   | 05      .         .         .         .         .         .    g.59302
 G | ATGAAAGCTTTGCCAGGGTGGTGCTGGCACCCCAGGACGTGGTAGTAGCGAGGTATGAG    c.720
 D |   E  S  F  A  R  V  V  L  A  P  Q  D  V  V  V  A  R  Y  E      p.240

          .         .         .         .         .         .       g.59362
 GAGGCCATGTTCCATTGCCAGTTCTCAGCCCAGCCACCCCCGAGCCTGCAGTGGCTCTTT       c.780
 E  A  M  F  H  C  Q  F  S  A  Q  P  P  P  S  L  Q  W  L  F         p.260

          .         .         .   | 06     .         .         .    g.60776
 GAGGATGAGACTCCCATCACTAACCGCAGTCG | CCCCCCACACCTCCGCAGAGCCACAGTG    c.840
 E  D  E  T  P  I  T  N  R  S  R  |  P  P  H  L  R  R  A  T  V      p.280

          .         .         .         .         .         .       g.60836
 TTTGCCAACGGGTCTCTGCTGCTGACCCAGGTCCGGCCACGCAATGCAGGGATCTACCGC       c.900
 F  A  N  G  S  L  L  L  T  Q  V  R  P  R  N  A  G  I  Y  R         p.300

          .         .         .         .         .         .       g.60896
 TGCATTGGCCAGGGGCAGAGGGGCCCACCCATCATCCTGGAAGCCACACTTCACCTAGCA       c.960
 C  I  G  Q  G  Q  R  G  P  P  I  I  L  E  A  T  L  H  L  A         p.320

   | 07      .         .         .         .         .         .    g.61212
 G | AGATTGAAGACATGCCGCTATTTGAGCCACGGGTGTTTACAGCTGGCAGCGAGGAGCGT    c.1020
 E |   I  E  D  M  P  L  F  E  P  R  V  F  T  A  G  S  E  E  R      p.340

          .         .         .         .         .         .       g.61272
 GTGACCTGCCTTCCCCCCAAGGGTCTGCCAGAGCCCAGCGTGTGGTGGGAGCACGCGGGA       c.1080
 V  T  C  L  P  P  K  G  L  P  E  P  S  V  W  W  E  H  A  G         p.360

          .         .         .         .         .         .       g.61332
 GTCCGGCTGCCCACCCATGGCAGGGTCTACCAGAAGGGCCACGAGCTGGTGTTGGCCAAT       c.1140
 V  R  L  P  T  H  G  R  V  Y  Q  K  G  H  E  L  V  L  A  N         p.380

          .         .         .         .         .         .       g.61392
 ATTGCTGAAAGTGATGCTGGTGTCTACACCTGCCACGCGGCCAACCTGGCTGGTCAGCGG       c.1200
 I  A  E  S  D  A  G  V  Y  T  C  H  A  A  N  L  A  G  Q  R         p.400

          .         .         | 08         .         .         .    g.67613
 AGACAGGATGTCAACATCACTGTGGCCA | CTGTGCCCTCCTGGCTGAAGAAGCCCCAAGAC    c.1260
 R  Q  D  V  N  I  T  V  A  T |   V  P  S  W  L  K  K  P  Q  D      p.420

          .         .         .         .         .         .       g.67673
 AGCCAGCTGGAGGAGGGCAAACCCGGCTACTTGGATTGCCTGACCCAGGCCACACCAAAA       c.1320
 S  Q  L  E  E  G  K  P  G  Y  L  D  C  L  T  Q  A  T  P  K         p.440

          .         .         .         .   | 09     .         .    g.67886
 CCTACAGTTGTCTGGTACAGAAACCAGATGCTCATCTCAGAG | GACTCACGGTTCGAGGTC    c.1380
 P  T  V  V  W  Y  R  N  Q  M  L  I  S  E   | D  S  R  F  E  V      p.460

          .         .         .         .         .         .       g.67946
 TTCAAGAATGGGACCTTGCGCATCAACAGCGTGGAGGTGTATGATGGGACATGGTACCGT       c.1440
 F  K  N  G  T  L  R  I  N  S  V  E  V  Y  D  G  T  W  Y  R         p.480

          .         .         .         .         .         | 10    g.68140
 TGTATGAGCAGCACCCCAGCCGGCAGCATCGAGGCGCAAGCCCGTGTCCAAGTGCTGG | AA    c.1500
 C  M  S  S  T  P  A  G  S  I  E  A  Q  A  R  V  Q  V  L  E |       p.500

          .         .         .         .         .         .       g.68200
 AAGCTCAAGTTCACACCACCACCCCAGCCACAGCAGTGCATGGAGTTTGACAAGGAGGCC       c.1560
 K  L  K  F  T  P  P  P  Q  P  Q  Q  C  M  E  F  D  K  E  A         p.520

          .         .         .         .         .         | 11    g.70402
 ACGGTGCCCTGTTCAGCCACAGGCCGAGAGAAGCCCACTATTAAGTGGGAACGGGCAG | AT    c.1620
 T  V  P  C  S  A  T  G  R  E  K  P  T  I  K  W  E  R  A  D |       p.540

          .         .         .         .         .         .       g.70462
 GGGAGCAGCCTCCCAGAGTGGGTGACAGACAACGCTGGGACCCTGCATTTTGCCCGGGTG       c.1680
 G  S  S  L  P  E  W  V  T  D  N  A  G  T  L  H  F  A  R  V         p.560

          .         .         .         .         .         .       g.70522
 ACTCGAGATGACGCTGGCAACTACACTTGCATTGCCTCCAACGGGCCGCAGGGCCAGATT       c.1740
 T  R  D  D  A  G  N  Y  T  C  I  A  S  N  G  P  Q  G  Q  I         p.580

          .         .         | 12         .         .         .    g.70695
 CGTGCCCATGTCCAGCTCACTGTGGCAG | TTTTTATCACCTTCAAAGTGGAACCAGAGCGT    c.1800
 R  A  H  V  Q  L  T  V  A  V |   F  I  T  F  K  V  E  P  E  R      p.600

          .         .         .         .         .         .       g.70755
 ACGACTGTGTACCAGGGCCACACAGCCCTACTGCAGTGCGAGGCCCAGGGGGACCCCAAG       c.1860
 T  T  V  Y  Q  G  H  T  A  L  L  Q  C  E  A  Q  G  D  P  K         p.620

          .         .         .         .         .          | 13    g.70905
 CCGCTGATTCAGTGGAAAGGCAAGGACCGCATCCTGGACCCCACCAAGCTGGGACCCAG | G    c.1920
 P  L  I  Q  W  K  G  K  D  R  I  L  D  P  T  K  L  G  P  R  |      p.640

          .         .         .         .         .         .       g.70965
 ATGCACATCTTCCAGAATGGCTCCCTGGTGATCCATGACGTGGCCCCTGAGGACTCAGGC       c.1980
 M  H  I  F  Q  N  G  S  L  V  I  H  D  V  A  P  E  D  S  G         p.660

          .         .         .         .         .         .       g.71025
 CGCTACACCTGCATTGCAGGCAACAGCTGCAACATCAAGCACACGGAGGCCCCCCTCTAT       c.2040
 R  Y  T  C  I  A  G  N  S  C  N  I  K  H  T  E  A  P  L  Y         p.680

         | 14.         .         .         .         .         .    g.72202
 GTCGTGG | ACAAGCCTGTGCCGGAGGAGTCGGAGGGCCCTGGCAGCCCTCCCCCCTACAAG    c.2100
 V  V  D |   K  P  V  P  E  E  S  E  G  P  G  S  P  P  P  Y  K      p.700

          .         .         .         .         .         .       g.72262
 ATGATCCAGACCATTGGGTTGTCGGTGGGTGCCGCTGTGGCCTACATCATTGCCGTGCTG       c.2160
 M  I  Q  T  I  G  L  S  V  G  A  A  V  A  Y  I  I  A  V  L         p.720

          .         .         .         .         .         .       g.72322
 GGCCTCATGTTCTACTGCAAGAAGCGCTGCAAAGCCAAGCGGCTGCAGAAGCAGCCCGAG       c.2220
 G  L  M  F  Y  C  K  K  R  C  K  A  K  R  L  Q  K  Q  P  E         p.740

          .         .         .  | 15      .         .         .    g.73212
 GGCGAGGAGCCAGAGATGGAATGCCTCAACG | GTGGGCCTTTGCAGAACGGGCAGCCCTCA    c.2280
 G  E  E  P  E  M  E  C  L  N  G |   G  P  L  Q  N  G  Q  P  S      p.760

          .         .         .         .         .         .       g.73272
 GCAGAGATCCAAGAAGAAGTGGCCTTGACCAGCTTGGGCTCCGGCCCCGCGGCCACCAAC       c.2340
 A  E  I  Q  E  E  V  A  L  T  S  L  G  S  G  P  A  A  T  N         p.780

          .         .         .         .         .         .       g.73332
 AAACGCCACAGCACAAGTGATAAGATGCACTTCCCACGGTCTAGCCTGCAGCCCATCACC       c.2400
 K  R  H  S  T  S  D  K  M  H  F  P  R  S  S  L  Q  P  I  T         p.800

         | 16.         .         .         .         .         .    g.73985
 ACGCTGG | GGAAGAGTGAGTTTGGGGAGGTGTTCCTGGCAAAGGCTCAGGGCTTGGAGGAG    c.2460
 T  L  G |   K  S  E  F  G  E  V  F  L  A  K  A  Q  G  L  E  E      p.820

          .         .         .         .         .         .       g.74045
 GGAGTGGCAGAGACCCTGGTACTTGTGAAGAGCCTGCAGAGCAAGGATGAGCAGCAGCAG       c.2520
 G  V  A  E  T  L  V  L  V  K  S  L  Q  S  K  D  E  Q  Q  Q         p.840

          .         .         .         .         .         .       g.74105
 CTGGACTTCCGGAGGGAGTTGGAGATGTTTGGGAAGCTGAACCACGCCAACGTGGTGCGG       c.2580
 L  D  F  R  R  E  L  E  M  F  G  K  L  N  H  A  N  V  V  R         p.860

          .         .         .         .         .         .       g.74165
 CTCCTGGGGCTGTGCCGGGAGGCTGAGCCCCACTACATGGTGCTGGAATATGTGGATCTG       c.2640
 L  L  G  L  C  R  E  A  E  P  H  Y  M  V  L  E  Y  V  D  L         p.880

  | 17       .         .         .         .         .         .    g.75410
  | GGAGACCTCAAGCAGTTCCTGAGGATTTCCAAGAGCAAGGATGAAAAATTGAAGTCACAG    c.2700
  | G  D  L  K  Q  F  L  R  I  S  K  S  K  D  E  K  L  K  S  Q      p.900

          .         .  | 18      .         .         .         .    g.87588
 CCCCTCAGCACCAAGCAGAAG | GTGGCCCTATGCACCCAGGTAGCCCTGGGCATGGAGCAC    c.2760
 P  L  S  T  K  Q  K   | V  A  L  C  T  Q  V  A  L  G  M  E  H      p.920

          .         .         .         .         .         .       g.87648
 CTGTCCAACAACCGCTTTGTGCATAAGGACTTGGCTGCGCGTAACTGCCTGGTCAGTGCC       c.2820
 L  S  N  N  R  F  V  H  K  D  L  A  A  R  N  C  L  V  S  A         p.940

          .         .         .         .         .    | 19    .    g.88527
 CAGAGACAAGTGAAGGTGTCTGCCCTGGGCCTCAGCAAGGATGTGTACAACAG | TGAGTAC    c.2880
 Q  R  Q  V  K  V  S  A  L  G  L  S  K  D  V  Y  N  S  |  E  Y      p.960

          .         .         .         .         .         .       g.88587
 TACCACTTCCGCCAGGCCTGGGTGCCGCTGCGCTGGATGTCCCCCGAGGCCATCCTGGAG       c.2940
 Y  H  F  R  Q  A  W  V  P  L  R  W  M  S  P  E  A  I  L  E         p.980

          .         .         .         .         .         .       g.88647
 GGTGACTTCTCTACCAAGTCTGATGTCTGGGCCTTCGGTGTGCTGATGTGGGAAGTGTTT       c.3000
 G  D  F  S  T  K  S  D  V  W  A  F  G  V  L  M  W  E  V  F         p.1000

          .         .         .         .         .   | 20     .    g.89461
 ACACATGGAGAGATGCCCCATGGTGGGCAGGCAGATGATGAAGTACTGGCAG | ATTTGCAG    c.3060
 T  H  G  E  M  P  H  G  G  Q  A  D  D  E  V  L  A  D |   L  Q      p.1020

          .         .         .         .         .         .       g.89521
 GCTGGGAAGGCTAGACTTCCTCAGCCCGAGGGCTGCCCTTCCAAACTCTATCGGCTGATG       c.3120
 A  G  K  A  R  L  P  Q  P  E  G  C  P  S  K  L  Y  R  L  M         p.1040

          .         .         .         .         .         .       g.89581
 CAGCGCTGCTGGGCCCTCAGCCCCAAGGACCGGCCCTCCTTCAGTGAGATTGCCAGCGCC       c.3180
 Q  R  C  W  A  L  S  P  K  D  R  P  S  F  S  E  I  A  S  A         p.1060

          .         .         .                                     g.89614
 CTGGGAGACAGCACCGTGGACAGCAAGCCGTGA                                  c.3213
 L  G  D  S  T  V  D  S  K  P  X                                    p.1070

          .         .         .         .         .         .       g.89674
 ggagggagcccgctcaggatggcctgggcaggggaggacatctctagagggaagctcaca       c.*60

          .         .         .         .         .         .       g.89734
 gcatgatgggcaagatccctgtcctcctgggccctgaggcccctgccctagtgcaacagg       c.*120

          .         .         .         .         .         .       g.89794
 cattgctgaggtctgagcagggcctggcctttcctcctcttcctcaccctcatcctttgg       c.*180

          .         .         .         .         .         .       g.89854
 gaggctgacttggacccaaactgggcgactagggctttgagctgggcagttttccctgcc       c.*240

          .         .         .         .         .         .       g.89914
 acctcttcctctatcagggacagtgtgggtgccacaggtaaccccaatttctggccttca       c.*300

          .         .         .         .         .         .       g.89974
 acttctccccttgaccgggtccaactctgccactcatctgccaactttgcctggggaggg       c.*360

          .         .         .         .         .         .       g.90034
 ctaggcttgggatgagctgggtttgtggggagttccttaatattctcaagttctgggcac       c.*420

          .         .         .         .         .         .       g.90094
 acagggttaatgagtctcttggcccactggtcccacttgggggtctagaccaggattata       c.*480

          .         .         .         .         .         .       g.90154
 gaggacacagcaagtgagtcctccccactctgggcttgtgcacactgacccagacccacg       c.*540

          .         .         .         .         .         .       g.90214
 tcttccccacccttctctcctttcctcatcctaagtgcctggcagatgaaggagttttca       c.*600

          .         .         .         .         .         .       g.90274
 ggagcttttgacactatataaaccgccctttttgtatgcaccacgggcggcttttatatg       c.*660

          .         .         .         .         .         .       g.90334
 taattgcagcgtggggtgggtgggcatgggaggtaggggtgggccctggagatgaggagg       c.*720

          .         .         .         .         .         .       g.90394
 gtgggccatccttaccccacacttttattgttgtcgttttttgtttgttttgtttttttg       c.*780

          .         .         .         .         .                 g.90453
 tttttgtttttgtttttacactcgctgctctcaataaataagccttttttacaacctgt        c.*839

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The PTK7 protein tyrosine kinase 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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