protein tyrosine phosphatase, non-receptor type 1 (PTPN1) - coding DNA reference sequence

(used for variant description)

(last modified July 27, 2026)


This file was created to facilitate the description of sequence variants on transcript NM_002827.3 in the PTPN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000020.10, covering PTPN1 transcript NM_002827.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.4994
                                  ccttctgcttcaggggcggagcccctg       c.-181

 .         .         .         .         .         .                g.5054
 gcaggcgtgatgcgtagttccggctgccggttgacatgaagaagcagcagcggctagggc       c.-121

 .         .         .         .         .         .                g.5114
 ggcggtagctgcaggggtcggggattgcagcgggcctcggggctaagagcgcgacgcggc       c.-61

 .         .         .         .         .         .                g.5174
 ctagagcggcagacggcgcagtgggccgagaaggaggcgcagcagccgccctggcccgtc       c.-1

          .         .         .         .         .         .       g.5234
 ATGGAGATGGAAAAGGAGTTCGAGCAGATCGACAAGTCCGGGAGCTGGGCGGCCATTTAC       c.60
 M  E  M  E  K  E  F  E  Q  I  D  K  S  G  S  W  A  A  I  Y         p.20

     | 02    .         .         .         .         .         .    g.56066
 CAG | GATATCCGACATGAAGCCAGTGACTTCCCATGTAGAGTGGCCAAGCTTCCTAAGAAC    c.120
 Q   | D  I  R  H  E  A  S  D  F  P  C  R  V  A  K  L  P  K  N      p.40

          .         .         .     | 03   .         .         .    g.59641
 AAAAACCGAAATAGGTACAGAGACGTCAGTCCCT | TTGACCATAGTCGGATTAAACTACAT    c.180
 K  N  R  N  R  Y  R  D  V  S  P  F |   D  H  S  R  I  K  L  H      p.60

          .         .         .         .         .         .       g.59701
 CAAGAAGATAATGACTATATCAACGCTAGTTTGATAAAAATGGAAGAAGCCCAAAGGAGT       c.240
 Q  E  D  N  D  Y  I  N  A  S  L  I  K  M  E  E  A  Q  R  S         p.80

          .      | 04  .         .         .         .         .    g.63071
 TACATTCTTACCCAG | GGCCCTTTGCCTAACACATGCGGTCACTTTTGGGAGATGGTGTGG    c.300
 Y  I  L  T  Q   | G  P  L  P  N  T  C  G  H  F  W  E  M  V  W      p.100

          .         .         .         .         .     | 05   .    g.69169
 GAGCAGAAAAGCAGGGGTGTCGTCATGCTCAACAGAGTGATGGAGAAAGGTTCG | TTAAAA    c.360
 E  Q  K  S  R  G  V  V  M  L  N  R  V  M  E  K  G  S   | L  K      p.120

          .         .         .         .         .         .       g.69229
 TGCGCACAATACTGGCCACAAAAAGAAGAAAAAGAGATGATCTTTGAAGACACAAATTTG       c.420
 C  A  Q  Y  W  P  Q  K  E  E  K  E  M  I  F  E  D  T  N  L         p.140

          .         .         .         .         .         .       g.69289
 AAATTAACATTGATCTCTGAAGATATCAAGTCATATTATACAGTGCGACAGCTAGAATTG       c.480
 K  L  T  L  I  S  E  D  I  K  S  Y  Y  T  V  R  Q  L  E  L         p.160

          .   | 06     .         .         .         .         .    g.73114
 GAAAACCTTACA | ACCCAAGAAACTCGAGAGATCTTACATTTCCACTATACCACATGGCCT    c.540
 E  N  L  T   | T  Q  E  T  R  E  I  L  H  F  H  Y  T  T  W  P      p.180

          .         .         .         .         .         .       g.73174
 GACTTTGGAGTCCCTGAATCACCAGCCTCATTCTTGAACTTTCTTTTCAAAGTCCGAGAG       c.600
 D  F  G  V  P  E  S  P  A  S  F  L  N  F  L  F  K  V  R  E         p.200

          .         .         .         .         .         .       g.73234
 TCAGGGTCACTCAGCCCGGAGCACGGGCCCGTTGTGGTGCACTGCAGTGCAGGCATCGGC       c.660
 S  G  S  L  S  P  E  H  G  P  V  V  V  H  C  S  A  G  I  G         p.220

          .         .         .         .   | 07     .         .    g.73832
 AGGTCTGGAACCTTCTGTCTGGCTGATACCTGCCTCTTGCTG | ATGGACAAGAGGAAAGAC    c.720
 R  S  G  T  F  C  L  A  D  T  C  L  L  L   | M  D  K  R  K  D      p.240

          .         .         .         .         .         .       g.73892
 CCTTCTTCCGTTGATATCAAGAAAGTGCTGTTAGAAATGAGGAAGTTTCGGATGGGGCTG       c.780
 P  S  S  V  D  I  K  K  V  L  L  E  M  R  K  F  R  M  G  L         p.260

          .         .         .         .         .         .       g.73952
 ATCCAGACAGCCGACCAGCTGCGCTTCTCCTACCTGGCTGTGATCGAAGGTGCCAAATTC       c.840
 I  Q  T  A  D  Q  L  R  F  S  Y  L  A  V  I  E  G  A  K  F         p.280

          .         .     | 08   .         .         .         .    g.74385
 ATCATGGGGGACTCTTCCGTGCAG | GATCAGTGGAAGGAGCTTTCCCACGAGGACCTGGAG    c.900
 I  M  G  D  S  S  V  Q   | D  Q  W  K  E  L  S  H  E  D  L  E      p.300

          .         .         .         .         .         .       g.74445
 CCCCCACCCGAGCATATCCCCCCACCTCCCCGGCCACCCAAACGAATCCTGGAGCCACAC       c.960
 P  P  P  E  H  I  P  P  P  P  R  P  P  K  R  I  L  E  P  H         p.320

          .         .         .         .         .         .       g.74505
 AATGGGAAATGCAGGGAGTTCTTCCCAAATCACCAGTGGGTGAAGGAAGAGACCCAGGAG       c.1020
 N  G  K  C  R  E  F  F  P  N  H  Q  W  V  K  E  E  T  Q  E         p.340

          .         .         .         .         .         .       g.74565
 GATAAAGACTGCCCCATCAAGGAAGAAAAAGGAAGCCCCTTAAATGCCGCACCCTACGGC       c.1080
 D  K  D  C  P  I  K  E  E  K  G  S  P  L  N  A  A  P  Y  G         p.360

          | 09         .         .         .         .         .    g.75963
 ATCGAAAG | CATGAGTCAAGACACTGAAGTTAGAAGTCGGGTCGTGGGGGGAAGTCTTCGA    c.1140
 I  E  S  |  M  S  Q  D  T  E  V  R  S  R  V  V  G  G  S  L  R      p.380

          .         .         .         .         .         .       g.76023
 GGTGCCCAGGCTGCCTCCCCAGCCAAAGGGGAGCCGTCACTGCCCGAGAAGGACGAGGAC       c.1200
 G  A  Q  A  A  S  P  A  K  G  E  P  S  L  P  E  K  D  E  D         p.400

          .         .         .         .         .         .       g.76083
 CATGCACTGAGTTACTGGAAGCCCTTCCTGGTCAACATGTGCGTGGCTACGGTCCTCACG       c.1260
 H  A  L  S  Y  W  K  P  F  L  V  N  M  C  V  A  T  V  L  T         p.420

          .         .     | 10   .         .                        g.77374
 GCCGGCGCTTACCTCTGCTACAGG | TTCCTGTTCAACAGCAACACATAG                c.1308
 A  G  A  Y  L  C  Y  R   | F  L  F  N  S  N  T  X                  p.435

          .         .         .         .         .         .       g.77434
 cctgaccctcctccactccacctccacccactgtccgcctctgcccgcagagcccacgcc       c.*60

          .         .         .         .         .         .       g.77494
 cgactagcaggcatgccgcggtaggtaagggccgccggaccgcgtagagagccgggcccc       c.*120

          .         .         .         .         .         .       g.77554
 ggacggacgttggttctgcactaaaacccatcttccccggatgtgtgtctcacccctcat       c.*180

          .         .         .         .         .         .       g.77614
 ccttttactttttgccccttccactttgagtaccaaatccacaagccattttttgaggag       c.*240

          .         .         .         .         .         .       g.77674
 agtgaaagagagtaccatgctggcggcgcagagggaaggggcctacacccgtcttggggc       c.*300

          .         .         .         .         .         .       g.77734
 tcgccccacccagggctccctcctggagcatcccaggcgggcggcacgccaacagccccc       c.*360

          .         .         .         .         .         .       g.77794
 cccttgaatctgcagggagcaactctccactccatatttatttaaacaattttttcccca       c.*420

          .         .         .         .         .         .       g.77854
 aaggcatccatagtgcactagcattttcttgaaccaataatgtattaaaattttttgatg       c.*480

          .         .         .         .         .         .       g.77914
 tcagccttgcatcaagggctttatcaaaaagtacaataataaatcctcaggtagtactgg       c.*540

          .         .         .         .         .         .       g.77974
 gaatggaaggctttgccatgggcctgctgcgtcagaccagtactgggaaggaggacggtt       c.*600

          .         .         .         .         .         .       g.78034
 gtaagcagttgttatttagtgatattgtgggtaacgtgagaagatagaacaatgctataa       c.*660

          .         .         .         .         .         .       g.78094
 tatataatgaacacgtgggtatttaataagaaacatgatgtgagattactttgtcccgct       c.*720

          .         .         .         .         .         .       g.78154
 tattctcctccctgttatctgctagatctagttctcaatcactgctcccccgtgtgtatt       c.*780

          .         .         .         .         .         .       g.78214
 agaatgcatgtaaggtcttcttgtgtcctgatgaaaaatatgtgcttgaaatgagaaact       c.*840

          .         .         .         .         .         .       g.78274
 ttgatctctgcttactaatgtgccccatgtccaagtccaacctgcctgtgcatgacctga       c.*900

          .         .         .         .         .         .       g.78334
 tcattacatggctgtggttcctaagcctgttgctgaagtcattgtcgctcagcaataggg       c.*960

          .         .         .         .         .         .       g.78394
 tgcagttttccaggaataggcatttgcctaattcctggcatgacactctagtgacttcct       c.*1020

          .         .         .         .         .         .       g.78454
 ggtgaggcccagcctgtcctggtacagcagggtcttgctgtaactcagacattccaaggg       c.*1080

          .         .         .         .         .         .       g.78514
 tatgggaagccatattcacacctcacgctctggacatgatttagggaagcagggacaccc       c.*1140

          .         .         .         .         .         .       g.78574
 cccgccccccacctttgggatcagcctccgccattccaagtcaacactcttcttgagcag       c.*1200

          .         .         .         .         .         .       g.78634
 accgtgatttggaagagaggcacctgctggaaaccacacttcttgaaacagcctgggtga       c.*1260

          .         .         .         .         .         .       g.78694
 cggtcctttaggcagcctgccgccgtctctgtcccggttcaccttgccgagagaggcgcg       c.*1320

          .         .         .         .         .         .       g.78754
 tctgccccaccctcaaaccctgtggggcctgatggtgctcacgactcttcctgcaaaggg       c.*1380

          .         .         .         .         .         .       g.78814
 aactgaagacctccacattaagtggctttttaacatgaaaaacacggcagctgtagctcc       c.*1440

          .         .         .         .         .         .       g.78874
 cgagctactctcttgccagcattttcacattttgcctttctcgtggtagaagccagtaca       c.*1500

          .         .         .         .         .         .       g.78934
 gagaaattctgtggtgggaacattcgaggtgtcaccctgcagagctatggtgaggtgtgg       c.*1560

          .         .         .         .         .         .       g.78994
 ataaggcttaggtgccaggctgtaagcattctgagctgggcttgttgtttttaagtcctg       c.*1620

          .         .         .         .         .         .       g.79054
 tatatgtatgtagtagtttgggtgtgtatatatagtagcatttcaaaatggacgtactgg       c.*1680

          .         .         .         .         .         .       g.79114
 tttaacctcctatccttggagagcagctggctctccaccttgttacacattatgttagag       c.*1740

          .         .         .         .         .         .       g.79174
 aggtagcgagctgctctgctatatgccttaagccaatatttactcatcaggtcattattt       c.*1800

          .         .         .         .         .         .       g.79234
 tttacaatggccatggaataaaccatttttacaaaaataaaaacaaaaaaagcaaggtgt       c.*1860

          .         .         .         .         .         .       g.79294
 tttggtataataccttttcaggtgtgtgtggatacgtggctgcatgaccgggtgggtggg       c.*1920

          .         .         .         .         .         .       g.79354
 ggggagtgtctcagggtcttctgtgacctcacagaactgtcagactgtacagttttccaa       c.*1980

          .         .         .         .         .         .       g.79414
 cttgccatattcatgatgggtttgcattttagctgcaacaataaaatttttttctaaaga       c.*2040

                                                                    g.79421
 acatgaa                                                            c.*2047

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Protein tyrosine phosphatase, non-receptor type 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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