poly-U binding splicing factor 60KDa (PUF60) - coding DNA reference sequence

(used for variant description)

(last modified June 23, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_078480.2 in the PUF60 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering PUF60 transcript NM_078480.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      tccgtgcaccggcacccagatcg       c.-61

 .         .         .         .         .         .                g.5083
 cgcgagacagcggaaggagcaagagtgggaggcgcgcgcggaggccgcgacggacgcaag       c.-1

          .         .     | 02   .         .         .         .    g.10023
 ATGGCGACGGCGACCATAGCTCTC | CAGGTCAATGGCCAGCAAGGAGGGGGGTCCGAGCCG    c.60
 M  A  T  A  T  I  A  L   | Q  V  N  G  Q  Q  G  G  G  S  E  P      p.20

          .         .         .         .         .  | 03      .    g.12482
 GCGGCGGCGGCGGCAGTGGTGGCAGCGGGAGACAAATGGAAACCTCCACAG | GGCACAGAC    c.120
 A  A  A  A  A  V  V  A  A  G  D  K  W  K  P  P  Q   | G  T  D      p.40

          .         .         .         .         .         .       g.12542
 TCCATCAAGATGGAGAACGGGCAGAGCACAGCCGCCAAGCTGGGGCTGCCTCCCCTGACG       c.180
 S  I  K  M  E  N  G  Q  S  T  A  A  K  L  G  L  P  P  L  T         p.60

          .         .        | 04.         .         .         .    g.12733
 CCCGAGCAGCAGGAGGCCCTTCAGAAG | GCCAAGAAGTACGCCATGGAGCAGAGCATCAAG    c.240
 P  E  Q  Q  E  A  L  Q  K   | A  K  K  Y  A  M  E  Q  S  I  K      p.80

          .         .         .         .         .        | 05.    g.13673
 AGTGTGCTGGTGAAGCAGACCATCGCGCACCAGCAGCAGCAGCTCACCAACCTGCAG | ATG    c.300
 S  V  L  V  K  Q  T  I  A  H  Q  Q  Q  Q  L  T  N  L  Q   | M      p.100

          .         .         .         .         | 06         .    g.15864
 GCAGCAGTGACAATGGGCTTTGGAGATCCTCTCTCACCTTTGCAATCG | ATGGCGGCTCAG    c.360
 A  A  V  T  M  G  F  G  D  P  L  S  P  L  Q  S   | M  A  A  Q      p.120

          .         .         .         .         .         .       g.15924
 CGGCAGCGGGCGCTGGCCATCATGTGCCGCGTCTACGTGGGCTCTATCTACTATGAGCTG       c.420
 R  Q  R  A  L  A  I  M  C  R  V  Y  V  G  S  I  Y  Y  E  L         p.140

          .         .         .         .         .         .       g.15984
 GGGGAGGACACCATCCGCCAGGCCTTTGCCCCCTTTGGCCCCATCAAGAGCATCGACATG       c.480
 G  E  D  T  I  R  Q  A  F  A  P  F  G  P  I  K  S  I  D  M         p.160

          .         .         . | 07       .         .         .    g.16131
 TCCTGGGACTCCGTCACCATGAAGCACAAG | GGCTTTGCCTTCGTGGAGTATGAGGTCCCC    c.540
 S  W  D  S  V  T  M  K  H  K   | G  F  A  F  V  E  Y  E  V  P      p.180

          .         .         .         .         .         .       g.16191
 GAAGCTGCACAGCTGGCCTTGGAGCAGATGAACTCGGTGATGCTGGGGGGCAGGAACATC       c.600
 E  A  A  Q  L  A  L  E  Q  M  N  S  V  M  L  G  G  R  N  I         p.200

     | 08    .         .         .         .         .         .    g.16368
 AAG | GTGGGCAGACCCAGCAACATAGGGCAGGCCCAGCCCATCATAGACCAGTTGGCTGAG    c.660
 K   | V  G  R  P  S  N  I  G  Q  A  Q  P  I  I  D  Q  L  A  E      p.220

          .         .         .         .         .         .       g.16428
 GAGGCACGGGCCTTCAACCGCATCTACGTGGCCTCTGTGCACCAGGACCTCTCAGACGAT       c.720
 E  A  R  A  F  N  R  I  Y  V  A  S  V  H  Q  D  L  S  D  D         p.240

          .         .         .         .         .         .       g.16488
 GACATCAAGAGCGTGTTTGAGGCCTTTGGCAAGATCAAGTCCTGCACACTGGCCCGGGAC       c.780
 D  I  K  S  V  F  E  A  F  G  K  I  K  S  C  T  L  A  R  D         p.260

          .         .         .        | 09.         .         .    g.16627
 CCCACAACTGGCAAGCACAAGGGCTACGGCTTCATTG | AGTACGAGAAGGCCCAGTCGTCC    c.840
 P  T  T  G  K  H  K  G  Y  G  F  I  E |   Y  E  K  A  Q  S  S      p.280

          .         .         .         .         .         .       g.16687
 CAAGATGCTGTGTCTTCCATGAACCTCTTTGACCTGGGTGGCCAGTACTTGCGGGTGGGC       c.900
 Q  D  A  V  S  S  M  N  L  F  D  L  G  G  Q  Y  L  R  V  G         p.300

          .         .         .         .         .         .       g.16747
 AAGGCTGTCACACCGCCCATGCCCCTACTCACACCAGCCACGCCTGGAGGCCTCCCACCT       c.960
 K  A  V  T  P  P  M  P  L  L  T  P  A  T  P  G  G  L  P  P         p.320

          .         .         .         .         | 10         .    g.16932
 GCCGCTGCTGTGGCAGCTGCTGCAGCCACTGCCAAGATCACAGCTCAG | GAAGCAGTGGCC    c.1020
 A  A  A  V  A  A  A  A  A  T  A  K  I  T  A  Q   | E  A  V  A      p.340

          .         .         .         .         .         .       g.16992
 GGAGCAGCGGTGCTGGGTACCCTGGGCACACCTGGACTGGTGTCCCCAGCACTGACCCTG       c.1080
 G  A  A  V  L  G  T  L  G  T  P  G  L  V  S  P  A  L  T  L         p.360

          .         .         .         .         .         .       g.17052
 GCCCAGCCCCTGGGCACTTTGCCCCAGGCTGTCATGGCTGCCCAGGCACCTGGAGTCATC       c.1140
 A  Q  P  L  G  T  L  P  Q  A  V  M  A  A  Q  A  P  G  V  I         p.380

      | 11   .         .         .         .         .         .    g.17297
 ACAG | GTGTGACCCCAGCCCGTCCTCCTATCCCGGTCACCATCCCCTCGGTGGGAGTGGTG    c.1200
 T  G |   V  T  P  A  R  P  P  I  P  V  T  I  P  S  V  G  V  V      p.400

          .         .         .         .         .         .       g.17357
 AACCCCATCCTGGCCAGCCCTCCAACGCTGGGTCTCCTGGAGCCCAAGAAGGAGAAGGAA       c.1260
 N  P  I  L  A  S  P  P  T  L  G  L  L  E  P  K  K  E  K  E         p.420

          .         .         .         .         .         .       g.17417
 GAAGAGGAGCTGTTTCCCGAGTCAGAGCGGCCAGAGATGCTGAGCGAGCAGGAGCACATG       c.1320
 E  E  E  L  F  P  E  S  E  R  P  E  M  L  S  E  Q  E  H  M         p.440

          .         .         .         .         .         .       g.17477
 AGCATCTCGGGCAGTAGCGCCCGACACATGGTGATGCAGAAGCTGCTCCGCAAGCAGGAG       c.1380
 S  I  S  G  S  S  A  R  H  M  V  M  Q  K  L  L  R  K  Q  E         p.460

  | 12       .         .         .         .         .         .    g.17627
  | TCTACAGTGATGGTTCTGCGCAACATGGTGGACCCCAAGGACATCGATGATGACCTGGAA    c.1440
  | S  T  V  M  V  L  R  N  M  V  D  P  K  D  I  D  D  D  L  E      p.480

          .         .         .         .         .         .       g.17687
 GGGGAGGTGACAGAGGAGTGTGGCAAGTTCGGGGCCGTGAACCGCGTCATCATCTACCAA       c.1500
 G  E  V  T  E  E  C  G  K  F  G  A  V  N  R  V  I  I  Y  Q         p.500

          .         .         .         .         .         .       g.17747
 GAGAAACAAGGCGAGGAGGAGGATGCAGAAATCATTGTCAAGATCTTTGTGGAGTTTTCC       c.1560
 E  K  Q  G  E  E  E  D  A  E  I  I  V  K  I  F  V  E  F  S         p.520

          .         .         .         .         .         .       g.17807
 ATAGCCTCTGAGACTCATAAGGCCATCCAGGCCCTCAATGGCCGCTGGTTTGCTGGCCGC       c.1620
 I  A  S  E  T  H  K  A  I  Q  A  L  N  G  R  W  F  A  G  R         p.540

          .         .         .         .         .         .       g.17867
 AAGGTGGTGGCTGAAGTGTACGACCAGGAGCGTTTTGATAACAGTGACCTCTCTGCGTGA       c.1680
 K  V  V  A  E  V  Y  D  Q  E  R  F  D  N  S  D  L  S  A  X         p.559

          .         .         .         .         .         .       g.17927
 cagtggtccctctccccggacttgcacttgttccttgtttcctctgggttttatagtgat       c.*60

          .         .         .         .         .         .       g.17987
 acagtggtgtccccggggccaggcgcgctctgcccagcccagcctacagtgcggataaag       c.*120

          .         .         .         .         .                 g.18043
 gtgcggatgctgctggccctgaacgtccgtgtgtctgccgtcggtcctgtcaccga           c.*176

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Poly-U binding splicing factor 60KDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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